Organ Allocation: Proceedings of the 30th Conference on Transplantation and Clinical Immunology, 2–4 June, 1998

 Immunology  Comments Off on Organ Allocation: Proceedings of the 30th Conference on Transplantation and Clinical Immunology, 2–4 June, 1998
Jan 152019
 

Over the last few years, transplantation knowledge and techniques, as well as insights into pharmacology, have improved, thus enabling greater access to transplantation for patients. The pool of organs for transplantation is stable, and therefore insufficient to cope with the growing demand. To adjust demand and resources in the most equitable way, organ procurement and allocation have been organized nationally and often across borders. The national and international organ exchange programs were studied and discussed during the Congress on Organ Allocation, from which this book is derived. This book describes the state of the art in the management of waiting lists and the allocation of organs in transplantation. It includes chapters on the possibilities of expanding the pool of available cadaver organs. It also analyzes the results of transplantation of cadaver organs from older donors and marginal, non-heart beating donors. Transplantation policies based on the offering of organs by living donors are also described, as is the impact of delayed graft function on organ allocation.

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Diabetic Renal-Retinal Syndrome: 21st Century Management Now

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetic Renal-Retinal Syndrome: 21st Century Management Now
Jan 152019
 

After a decade or longer, approximately one-third of individuals with either type 1 or type 2 diabetes commence a downhill course in which decreasing renal function and failing vision define a Renal-Retinal Syndrome, dominating all aspects of life and presaging early death. Only a generation ago, survival after onset of end-stage renal disease (ESRD) in diabetes was limited because rehabilitation was preempted by blindness, limb amputation, stroke, and heart disease. By 1998, however, team management has improved the outlook, with preserved sight and return to work and home responsibilities, usually for a decade or longer, following kidney transplantation and laser photocoagulation. Recognition of the critical requirement for blood pressure regulation and metabolic control are central themes in management. In this unique book, the accomplishments of ophthalmologists, nephrologists, diabetologists, transplant surgeons, and basic scientists are blended into a strategic approach that may be readily applied by all those caring for diabetic patients. Each of twenty-one presentations suitable for primary care physicians, as well as for subspecialists concerned with macrovascular and microvascular complications of diabetes, is placed in perspective by an introductory editorial analysis. Promising near-term innovative therapies, including insertion of genetically engineered beta cells or polymer-coated islets of Langerhans, interdiction of kinins that promote retinal angiogenesis, and prevention of synthesis of advanced glycosylated endproducts (AGEs), are presented in detail. While comprehensive care of diabetic patients reflects multiple incremental advances that in sum afford major benefit, this text envisions further remarkable changes likely to suppress and possibly entirely prevent the Diabetic Renal-Retinal Syndrome.
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Improving the Regulatory Review Process: Assessing Performance and Setting Targets

 Miscellaneous  Comments Off on Improving the Regulatory Review Process: Assessing Performance and Setting Targets
Jan 152019
 

At a time when it is becoming usual for medicines to be developed for a global market and pharmaceutical companies are endeavouring to expedite the drug development process, Regulatory Authorities are concentrating on improving their efficiency and effectiveness. Therefore, it is not surprising that questions are being asked as to how performance might be measured and compared between different authorities who are now often in receipt of dossiers that have been submitted to several agencies at the same time. Issues such as ‘what target should be set for the review of new medicines?’ and `how can quality be assured?’ are now considered to be of critical importance. The twelfth CMR International Workshop, held in January 1997, provided the opportunity for Regulatory Authority and industry personnel from Europe, North America, Australia and Japan to openly discuss experiences and exchange views on how to improve the review process. The proceedings of this meeting provide a comprehensive overview of the current review process in different countries and the need for performance measures and targets. This volume summarises the many suggestions that were debated at the Workshop, and includes chapters on measuring performance, and on the integration of quality into the review process.
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The Practices of Human Genetics

 Genetics  Comments Off on The Practices of Human Genetics
Jan 152019
 

That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the “Molecular Biology of Homo sapiens.
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Immunosuppression under Trial: Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3–4 June, 1999

 Immunology  Comments Off on Immunosuppression under Trial: Proceedings of the 31st Conference on Transplantation and Clinical Immunology, 3–4 June, 1999
Jan 152019
 

Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.
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Germ-Line Intervention and Our Responsibilities to Future Generations

 Miscellaneous  Comments Off on Germ-Line Intervention and Our Responsibilities to Future Generations
Jan 152019
 

In contemporary ethical discussion widespread concern about the potential risks of genetic engineering is raising new and fundamental questions about our responsibilities towards unborn generations. Newly acquired knowledge in genetic engineering techniques has brought about not only potential benefits but also immense risks for the well-being of both present and future generations. This book raises a number of ethical issues concerning the impact of genetic engineering on generations yet to be born. The four topical areas that constitute the focus of the volume, namely (1) from laboratory to germ-line therapy, (2) the concept of human nature: theological and secular perspectives, (3) genetic intervention and the common heritage view, and (4) social responsibilities of geneticists towards future generations, raise intriguing ethical and legal questions, as well as important policy issues. As much as any set of issues, they reflect the hopes and fears, prejudices and uncertainties that people associate with germ-line intervention and the future of human kind.
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Atlas of Practical Cardiac Applications of MRI

 Cardiovascular  Comments Off on Atlas of Practical Cardiac Applications of MRI
Jan 142019
 

Glossary 4 Chapter 1: Basics of Cardiac Magnetic Resonance and 6 Normal Views 1. 1 Definition and Physical Basics 6 a. Definition and historical background 6 b. Physical basics 6 1. 2 Technical Modalities 10 a. Spin echo 12 b. Gradient echo 12 c. Fast gradient echo 13 d. Specialized techniques 13 e. Techniques under clinical investigation 13 1. 3 Study Methodology: Normal Anatomy 13 a. Technical equipment 13 b. Medical personnel 13 c. Preparation of the patient 13 d. Normal MRI anatomy 17 References 17 Chapter 2: Ventricular Morphology and Function: Study of 26 Cardiomyopathies 2. 1 Morphological Study of Heart Chambers 26 a. Left ventricle 26 b. Right ventricle 31 2. 2 Ventricular Function 31 a. Left ventricular function 31 b. Right ventricular function 33 2. 3 Cardiomyopathies 33 a. Dilated cardiomyopathy 33 b. Hypertrophic cardiomyopathy 33 c. Restrictive cardiomyopathy 35 d. Arrhythmogenic dysplasia of the right ventricle 35 References 35 (f) Chapter 3: Acquired Diseases of the Aorta 38 I c 3. 1 Technical Aspects of the Aortic Study by MRI: Imaging the Normal Aorta 38 3. 2 Aortic Aneurysm 43 3. 3 Aortic Dissection and Related Entities OJ 43 a. Strategy for the study of aortic dissection by MRI 43 I b. Differential diagnosis of aortic dissection by MRI 47 References 49 c o U . ;jj Chapter 4: Study of Valvular Heart Disease 54 4. 1 Introduction 54 4. 2 Velocity Calculation and Flow Quantitation 54 4.
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Nephrology and Geriatrics Integrated: Proceedings of the Conference on Integrating Geriatrics into Nephrology held in Jasper, A

 Geriatrics, Nephrology  Comments Off on Nephrology and Geriatrics Integrated: Proceedings of the Conference on Integrating Geriatrics into Nephrology held in Jasper, A
Jan 142019
 

Because of many advances in medicine and biotechnology, an increasing number of individuals are surviving into old age, and we are now challenged to apply sophisticated medical knowledge to the care of the elderly citizen. In nephrology, individuals older than 65 are the fastest-growing group of patients requiring dialysis. Similarly, in increasing numbers, elderly persons present themselves with renal complaints to their family doctor, the geriatrician or the nephrologist. In August 1998, with the financial support of the John A. Hartford Foundation, leaders in geriatrics, nephrology and urology met in Jasper, Alberta, for one week to discuss their areas of special knowledge and to learn from each other. Geriatricians learned from nephrologists, nephrologists learned from geriatricians, and both came to see that they had much in common. All participants discovered a common interest, challenge and commitment, namely, to provide the best renal care to a progressively aging population and to teach their fellows the principles of the other collaborating specialties. This book contains all the papers presented at this meeting and also the text of group discussions on Training and Education, Special Clinical Problems in Geriatric Patients, and Recommendations in Basic and Clinical Research. Nephrology and Geriatrics Integrated will prove useful to both nephrologists and geriatricians in their efforts to manage the renal complaints of the elderly, who come to them in increasing numbers.
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Pain Management and Anesthesiology: Papers presented at the 43rd Annual Postgraduate Course in Anesthesiology, February 1998

 Anesthesiology  Comments Off on Pain Management and Anesthesiology: Papers presented at the 43rd Annual Postgraduate Course in Anesthesiology, February 1998
Jan 142019
 

 

Pain Management and Anesthesiology contains the presentations made at the 43rd Annual Postgraduate Course in Anesthesiology sponsored by the University of Utah and held at Snowbird, Utah, USA, February 20-24, 1998. This volume addresses recent advances in the understanding of the basic science and clinical management of pain. The textbook includes sections on recent advances in the understanding of pain signal processing, as well as reviews of the clinical management of acute, chronic, cancer-related, and pediatric pain. In addition, this text includes a discussion of the behavioral assessment and treatment of the pain patient. This textbook is the sixteenth in a continuing series documenting the proceedings of the postgraduate course.
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Fundamental Approaches to the Management of Cardiac Arrhythmias

 Cardiovascular  Comments Off on Fundamental Approaches to the Management of Cardiac Arrhythmias
Jan 142019
 

This new edition provides up-to-date comprehensive coverage of the rapidly evolving field of clinical cardiac electrophysiology. It is designed for physicians, cardiologists, cardiac electrophysiologists, and allied professionals practising or learning the speciality of clinical cardiac electrophysiology. This textbook – written entirely by two practising authorities in the field – offers a cohesive and comprehensive summary of the principles and practice of clinical cardiac electrophysiology. The authors emphasize the clinical approach to the patient and provide a fundamental, yet thorough, discussion of the primary therapeutic modalities used today in a state-of-the-art electrophysiology laboratory, including the latest pharmacotherapy options, catheter ablation treatment, and the newest implantable devices. The authors provide the reader with a concise, organized discussion of the management of patients with benign to life-threatening arrhythmias using the newest concepts, equipment, and techniques of diagnostic and therapeutic electrophysiology.
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