Pattern Analysis of the Human Connectome

 Miscellaneous  Comments Off on Pattern Analysis of the Human Connectome
Nov 182019
 

This book presents recent advances in pattern analysis of the human connectome. The human connectome, measured by magnetic resonance imaging at the macroscale, provides a comprehensive description of how brain regions are connected. Based on machine learning methods, multiviarate pattern analysis can directly decode psychological or cognitive states from brain connectivity patterns.
Although there are a number of works with chapters on conventional human connectome encoding (brain-mapping), there are few resources on human connectome decoding (brain-reading). Focusing mainly on advances made over the past decade in the field of manifold learning, sparse coding, multi-task learning, and deep learning of the human connectome and applications, this book helps students and researchers gain an overall picture of pattern analysis of the human connectome. It also offers valuable insights for clinicians involved in the clinical diagnosis and treatment evaluation of neuropsychiatric disorders.

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Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies

 Immunology  Comments Off on Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies
Nov 182019
 

Today, nature is used as a source of inspiration for the development of new techniques for solving complex problems in various domains, from engineering to biology, with innovative adaptations under investigation. The Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies provides the latest empirical research findings, theoretical frameworks, and technologies of natural computing and artificial immune systems (AIS). An excellent reference source for professionals, researchers, and academicians within the AIS and natural computing fields, this comprehensive collection written by leading international experts proposes new ideas, methods, and theories to solve problems of engineering and science.
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Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches

 Endocrinology/Metabolism/Diabetes Mellitus, Radiology  Comments Off on Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
Nov 182019
 

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.

The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

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Mechanisms and Emerging Therapies in Tremor Disorders

 Neurology/Neurosurgery  Comments Off on Mechanisms and Emerging Therapies in Tremor Disorders
Nov 182019
 

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
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FDA-speak : a glossary and agency guide

 Miscellaneous  Comments Off on FDA-speak : a glossary and agency guide
Nov 182019
 

Often thought of as a subdialect of American “governmentese,” FDA-Speak is a language unique to healthcare regulators and those regulated. If you have any involvement with the US Food and Drug Administration, or if they have involvement with you, you need to speak the language. This revised and updated edition of FDA-Speak retains the original easy-to-use glossary format, but now includes more than three times the number of entries in the first edition, defining more than 2,500 acronyms and technical/regulatory words to which the FDA has applied its own distinctive meaning. FDA-Speak provides the definitive listing of all of the regulatory words, phrases, and acronyms important to development, manufacture, quality control, marketing, import/export, and registration of pharmaceuticals, diagnostic products, medical devices, software, veterinary products, biologics, nutrition and dietary supplements, and bulk chemicals. Don’t miss the all-new section of appendices that will guide you to information you need on the FDA website.
Appendices include:
Laws Enforced by the FDA; FDA Organization Charts and Contact Information; FDA Field Operations Index and Inspection Guides; FDA Forms; FDA Guidance Documents; DSMA Staff Directory.

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Phytochemicals, Signal Transduction, and Neurological Disorders

 Neurology/Neurosurgery  Comments Off on Phytochemicals, Signal Transduction, and Neurological Disorders
Nov 182019
 

This book offers comprehensive information on bioavailability and mechanism of action of phytochemicals in the brain, and traces the molecular mechanism associated with beneficial effects of phytochemicals in neurotraumatic and neurodegenerative diseases.
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Ultrasound Imaging: Advances and Applications

 Radiology  Comments Off on Ultrasound Imaging: Advances and Applications
Nov 182019
 

Diagnostic and Therapeutic Ultrasound has recently taken an explosive growth for better safer, economic, mobile and high quality healthcare.  This technology is very appealing for medical applications because it is non-ionizing, non-invasive and it is available in most of the medical and clinical facilities. Its low cost, when compared with other medical image modalities, makes it one of the preferred tools for medical monitoring, follow-up and diagnosis. Besides the traditional fields of Cardiology and Obstetrics, where it is extensively used for long time, it has became also very useful in the diagnosis of diseases of the prostate, liver and coronaries and carotids atherosclerosis.
However, Ultrasound images present poor quality, very low signal to noise ratio and a lot of artifacts.  The extraction of useful information from Ultrasound data for diagnosis is a challenge task that makes this medical image modality a very active field of research. The difficulties are being overcome and novel and advanced methods are being proposed for detection, characterization and segmentation of abnormalities in several organs.  In fact, Ultrasound application range is vast, covering almost all organs of the human body, including the brain where Tran-cranial Doppler Ultrasound is very important to assess the brain vasculature.
This book presents some of the recent advances in Ultrasound imaging technology covering several organs and techniques in a Biomedical Engineering (BME) perspective. The focus of the book is in the algorithms, methodologies and systems developed by multidisciplinary research teams of engineers and physicians for Computer-Aided Diagnosis (CAD) purposes.
Cardiovascular and Cancer, the most common life-threatening diseases in western countries, are two of the most important topics focused in the book. However, other advanced issues are also presented such as Intravascular Ultrasound, 3D US and Ultrasound in Computer-Aided Surgery (CAS).  Some chapters are direct contributions from medical research groups where Ultrasound has also received great attention in the last decade. By this, new techniques based on Ultrasound were introduced in the clinical practice for diagnosis and therapeutics, mainly in hospital facilities.

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The Local Cardiac Renin-Angiotensin Aldosterone System Ed 2

 Cardiovascular  Comments Off on The Local Cardiac Renin-Angiotensin Aldosterone System Ed 2
Nov 182019
 

Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system.
Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.
Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.
Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner`s Scientific Director of Research.

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Collateral Circulation of the Heart

 Cardiovascular  Comments Off on Collateral Circulation of the Heart
Nov 182019
 

The sober explanation for this book is a call by the Springer-Verlag, London, to edit a publication on ‘The functional relevance of the collateral circulation’ of the heart. Alternatively, it could be ‘sold’ as the result of my intention to reduce entropy of 18 years of scientific work on the topic of the coronary circulation, which was itself meant to diminish the amount of ‘useless’ energy. Such a process of reducing disarray in a system with the aim of grasping it better is related to simplification, which carries the risk of introducing error. This can be exemplified by the historic view of angina pectoris, which used to be simplified as being always fatal, thus obscuring for nearly two centuries the view of a ‘self-healing’ mechanism such as the collateral circulation of the heart. It would be na?¨ve, to assume the present work to be free of erroneous oversimplification, because the very nature of scientific work is related to generating (simple) hypotheses with their subsequent falsification. In that context and bluntly, my primary interest in the field of the collateral circulation was not initiated with a vision of eradicating the consequences of coronary artery disease (CAD) by promoting the growth of natural bypasses. The time for such sizeable ideas had passed in the 1970s with the start of the work by Wolfgang Schaper.
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Practical Carotid Artery Stenting

 Miscellaneous  Comments Off on Practical Carotid Artery Stenting
Nov 182019
 

In the management of vascular disease, there has been an inexorable drive towards less invasive endovascular treatment options. Endovascular treatment of carotid stenosis for stroke is no exception. Several sizeable multicentre trials are running concurrently, which are comparing carotid endarterectomy (CEA), the “gold standard,” with the less invasive alternative, carotid stenting (CAS) for low-risk patients with symptomatic carotid stenoses who are considered to be surgical candidates. The endovascular option is in itself a newcomer but state-of-the-art CAS with regards use of all the available technical refinements, to include low-profile monorail dedicated systems with contemporary pharmacological support, is perhaps all but five years old. There is considerable interest from clinicians from a variety of clinical backgrounds and from industry in this technique and, therefore, scope for a contemporary practical guide.
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