The aim of this book is to help the reader achieve the correct diagnosis in the emergency setting, which continues to remain a challenge, given the variety of potential clinical presentations. Diagnostic failure is the largest reason for delays in provision of appropriate treatment, which can be life-saving, and the largest source of clinical complaints and untoward incidents leading to poor clinical outcomes and to litigation.
In this book, the readers will find diagnostic checklists, organised according to potential emergency presentations and classified under body systems, including atypical presentations, lists of differential diagnoses and guidance to pattern recognition.
Apart from providing an aide-memoire for a range of presentations, it is hoped that the book will allow for better quality and informed referrals, especially between health care providers.
This book is aimed as a rapid reference guide for all levels of medical staff working in emergency and acute care settings in the English-speaking world, but may also benefit nursing professionals and medical students.
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Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis.
Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR.
In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.
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Cytology is a unique subspecialty in anatomic pathology, and plays a critical role in the diagnosis of a variety of benign and malignant lesions by using minimally invasive procedures, such as fine needle aspiration, brushing, washing and lavage. Cytology not only provides an accurate diagnosis of the lesion based on the cytomorphological evaluation at cellular level, but also provides material for molecular characterization of a tumor for targeted therapy. In the era of personalized medicine, cytology has continued to grow and evolve as an important diagnostic tool. For example, some types of procedures are routinely used, diagnostic criteria have become more refined, and certain terminology has been changed based on current WHO classifications. Therefore, it is necessary to update our knowledge and terminology in cytology.
In this volume, we have retained the quality and the clarity of the series, and like the other volumes, this volume aims to be concise and comprehensive yet clinically relevant to daily practice. Although this volume is written by multiple authors, all chapters follow a similar format: brief introduction of the specific organ/system (including types of specimens and techniques to obtain samples), description of normal findings, and a practice approach to diagnose benign and malignant lesions. In each chapter, the key cytomorphological feature and main differential diagnoses of the lesion are summarized in a concise table. Images in each chapter are instructive and clearly represent findings. Where necessary, we have also illustrated the important ancillary tests, such as flow cytometry, immunohistochemistry and molecular analysis, which are crucial for an accurate diagnosis and targeted therapy. The updated knowledge, including key cytomorphological features, current terminology and molecular diagnostic tests, is the highlight of this volume.
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Therapeutic strategies to assess and promote readiness for transition to college are discussed in case-based chapters, which include case history, analysis of transition, clinical pearls, literature review, and helpful resources for clinicians, patients, and families. Filling a significant gap in the literature, Promoting Safe and Effective Transitions to College for Youth with Mental Health Conditions: A Case-Based Guide to Best Practices delivers essential information for psychiatrists, psychologists, and other mental health professionals who work with children, adolescents, and their families before, during, and after the transition to college.
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Exercises for Perfect Posture is the complete guide to achieving healthy posture, providing everything from fitness programs and exercises designed to realign your spine and strengthen your shoulders, neck and back as well as guidance on how to redesign your work space to be more ergonomic.
Good posture is foundational to good health. Poor posture can lead to shoulder discomfort, neck pain, and even chronic conditions such as carpel tunnel syndrome if left uncorrected. Yet the modern lifestyle and the modern workplace together make it very difficult to maintain healthy, natural posture throughout the day. Humans were not meant to spend all their time sitting down, and the “disease of inactivity” has reached near-epidemic proportions.
Exercises for Perfect Posture corrects deficiencies in your posture through resistance exercises, flexibility, and cardiovascular activities that will fit any schedule.
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by Kathy Morrison MSN RN CNRN SCRN (Author)
“[This] quick reference text to guide nurses is a ‘must-have’ as this disease tests our health care delivery system… Fast Facts for Stroke Care Nursing, Second Edition provides a succinct yet comprehensive review.”
–Linda Littlejohns, MSN, RN, FAAN, SCRN, CNRN
Neuroscience Clinical Nurse Consultant
From the Foreword
The second edition of this practical, pocket-sized reference has been updated to include the groundbreaking changes to stroke care protocols. Stroke is the fifth leading cause of death in the United States today and leading preventable cause of long-term disability. This resource fills in the gaps left in neuroscience content in nursing school and streamlines an often intimidating, but critically important, area of care.
Featuring diagnostic tests, cutting-edge treatments, and standards for best practice, Fast Facts for Stroke Care Nursing, Second Edition distills the lengthy and often complex national stroke care guidelines into a clear, easily digestible format. This guide can be used as a staff education resource or as a concise review for SCRN or SNRN certification exams, as well as a refresher for nurses seeking the essentials of stroke care. Content starts with stroke care improvements, covers moving through acute care to postacute care, and finishes with practical pointers for performance improvement.
New to the Second Edition:
Updated diagnostics with additional MR, CT, and transcranial Doppler options
Modified Rankin Scale score
Expands upon the neurological assessment with tips for completing it
New acute hemorrhagic stroke intervention and 2015 landmark studies on thrombectomy
New large-vessel occlusion tools, routing plans, and certification programs for prehospital personnel
Expanded use of telemedicine
Information for advanced practice providers
Changes to the prehospital phase, the acute treatment phase, and the population affected by stroke
Reflects current standards of the American Heart Association, American Stroke Association, and The Joint Commission
Provides crucial information at a glance about diagnostic tests, state-of-the-art treatments, and best practice standards
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This book evaluates trends arising in “-Omics” sciences in terms of their current and potential future application to therapeutic design and understanding of disease. Chapters consider the impact of pharmacogenomics and bioinformatics on drug development, as well as trends in genomics, as applied to understanding of neurodegenerative and lung disease, psychiatry and oncology.
Following the genome studies released in early part of this century, the advent of the -Omics sciences (genomics and pharmacogenomics, proteomics, metabolomics, transcriptomics) has seen the expansion of a vast knowledgebase with utility in preventing and treating disease, and improving health for all. Bioinformatics and improved pharmacogenetic understanding forge a path for improved drug discovery and design methods accounting for differences in delivery and disposition across populations.
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