Mar 262017
 

Orofacial Pain Biomarkers


This book provides up-to-date information on all aspects of orofacial pain biomarkers. It opens by presenting background information on clinical phenotypes and the neurobiological substrates underlying chronic orofacial pain and by explaining the potential role of biomarkers in the diagnosis, prognostic evaluation, and treatment of orofacial pain. The main section of the book examines the contribution of human and animal studies to the field of biomarkers for orofacial pain and discusses biomarkers for masticatory muscle pain, temporomandibular joint pain, neuropathic face pain, and autonomic nervous system involvement in trigeminal facial pain. The potential impacts of the immune system on orofacial pain biomarkers and candidate gene phenotypes with possible links to chronic orofacial pain conditions are also addressed, and differences and similarities between saliva and serum biomarkers for pain are explained as well. The final section covers research-related issues in assessment methods and statistical analyses used in evaluating biomarkers, identifies future challenges and suggests new directions in the field.
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Mar 262017
 

Functional Analytic Psychotherapy Made Simple: A Practical Guide to Therapeutic Relationships (The New Harbinger Made Simple Series)


By (author): Gareth Holman PhD, Jonathan Kanter PhD, Mavis Tsai PhD, Robert Kohlenberg PhD

Cowritten with the founders of functional analytic psychotherapy, Functional Analytic Psychotherapy Made Simple offers a practical, behavioral treatment approach focused on client interpersonal relationships and the therapeutic relationship.
 
Functional analytic psychotherapy (FAP) is a research-based treatment for mental health disorders and has been shown to enhance the quality of interpersonal relationships. If you’re a therapist, how you relate to your clients can have a profound impact on treatment outcomes. This book integrates the latest research on the importance of the therapist-client relationship with the new science of social connection into a user-friendly, flexible clinical framework.
 
In this book, you’ll find an introduction to the conceptual foundations and clinical practice of FAP, with an emphasis on practical clinical scenarios and personal reflection. You’ll learn the theoretical basis of FAP in contextual behavioral science and how to apply functional analysis—the core assessment method of behavior therapy—to the therapeutic relationship. You’ll learn to understand the therapeutic relationship and social connection in terms of the Awareness, Courage, and Love model. You’ll also learn how to balance authenticity and compassion with strategy and case conceptualization to make your therapeutic relationships more compassionate, flexible, and effective. And finally, you’ll discover how to apply principles to effectively cope with challenging moments in the therapeutic relationships—such as how to address ineffective behavior happening in the therapy interaction from the first moment of therapy, what to do when therapy does not seem to be progressing, and how to end therapy well. 
 
No matter your treatment background, this book will provide invaluable strategies for adopting functional analytic psychotherapy in your practice, enhancing relationships with your clients, and improving overall treatment outcomes.
 
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Mar 262017
 

Emerging Trends in Neuro Engineering and Neural Computation (Series in BioEngineering)


This book focuses on neuro-engineering and neural computing, a multi-disciplinary field of research attracting considerable attention from engineers, neuroscientists, microbiologists and material scientists. It explores a range of topics concerning the design and development of innovative neural and brain interfacing technologies, as well as novel information acquisition and processing algorithms to make sense of the acquired data. The book also highlights emerging trends and advances regarding the applications of neuro-engineering in real-world scenarios, such as neural prostheses, diagnosis of neural degenerative diseases, deep brain stimulation, biosensors, real neural network-inspired artificial neural networks (ANNs) and the predictive modeling of information flows in neuronal networks. The book is broadly divided into three main sections including: current trends in technological developments, neural computation techniques to make sense of the neural behavioral data, and application of these technologies/techniques in the medical domain in the treatment of neural disorders.

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Mar 262017
 

Liquid Biopsies in Solid Tumors (Cancer Drug Discovery and Development)


This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.


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Mar 262017
 

Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases (Progress in Inflammation Research)


As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature.

Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success?

In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

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Mar 262017
 

Medical Toxicology: Antidotes and Anecdotes


By (author): Steven M. Marcus

A collection of challenging and unusual cases from the author’s extensive experience as a Medical Toxicologist, these cases demonstrate medical problem solving and differential diagnosis in action from the perspective of an experienced clinician. Written in an engaging style and giving a fascinating account of some complex cases from real practice, this book will provide a good supplementary learning text for graduate students or those at an early stage in their professional career.
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Mar 262017
 

Indoor Air Quality in Healthcare Facilities (SpringerBriefs in Public Health)


This interdisciplinary guide offers background, research findings, and practical strategies for assessing and improving air quality in hospitals and other healthcare settings. Positing good air quality as critical to patient and staff well-being, it identifies disease-carrying microbes, pollutants, and other airborne toxins and their health risks, and provides localized interventions for reducing transmission of pathogens. Effective large-scale approaches to air quality control are also outlined, from green building materials to hygienic HVAC and air treatment practices. Its thoroughness of coverage makes this book a vital resource for professionals involved in every aspect of health service facilities, from planning and construction to maintenance and management.

Among the topics covered:

  • Existing guidelines in indoor air quality: the case study of hospital environments
  • Hospital environments and epidemiology of healthcare-associated infections
  • Analysis of microorganisms in hospital environments and potential risks
  • Legionella indoor air contamination in healthcare environments
  • HVAC system design in healthcare facilities and control of aerosol contaminants
  • Assessment of indoor air quality in inpatient wards

Indoor Air Quality in Healthcare Facilities imparts up-to-date expertise to a variety of professional readers, including hospitals’ technical and management departments, healthcare facilities’ chief medical officers, hospital planners, sport and thermal building designers, public health departments, and students of universities and schools of hygiene.

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Mar 252017
 

Harrison’s Endocrinology, 4E (Harrison’s Specialty)


By (author): J. Larry Jameson

Endocrinology – with all the authority of Harrison’s

Featuring a superb compilation of chapters related to endocrinology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s.  You will find 36 chapters from 50 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.

Features:

• Divided into six sections that reflect the physiologic roots of endocrinology: Introduction to Endocrinology; Pituitary, Thyroid, and Adrenal Disorders; Reproductive Endocrinology; Diabetes Mellitus, Obesity, Lipoprotein Metabolism; Disorders Affecting Multiple Endocrine Systems; and Disorders of Bone and Calcium Metabolism
• Coverage of discoveries emanating from genetics and molecular biology, along with the latest drugs that are transforming the field
• Integration of pathophysiology with clinical management
• High-yield board review questions make this text ideal for keeping current or preparing for the boards
• Valuable appendix of laboratory values of clinical importance

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Mar 252017
 

Integrated Modular Treatment for Borderline Personality Disorder: A Practical Guide to Combining Effective Treatment Methods


Features: CAMBRIDGE UNIVERSITY PRESS
By (author): W. John Livesley

This clinical guide describes a different way to treat borderline personality disorder. Rather than using the currently available therapies, the author presents a trans-theoretical approach that combines the essential elements of all effective treatments. The book offers a framework for understanding the nature and origins of borderline personality disorder that is used to define treatment targets and strategies. Building on this foundation, systems for organizing treatment are presented around change mechanisms common to all effective therapies. Interventions are presented in modules, allowing therapists to select treatment according to the needs of patients. Treatment is explained by dividing therapy into phases, each addressing different problems. Methods are described to promote engagement, manage suicidality, treat crises, improve emotional regulation, restructure maladaptive interpersonal behaviours, construct a new sense of self and identity, and build a life worth living. The volume will interest mental health professionals from all disciplines and different levels of expertise.
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Mar 252017
 

Cognitive Neuroscience of Memory Consolidation (Studies in Neuroscience, Psychology and Behavioral Economics)


This edited volume provides an overview the state-of-the-art in the field of cognitive neuroscience of memory consolidation. In a number of sections, the editors collect contributions of leading researchers . The topical focus lies on current issues of interest such as memory consolidation including working and long-term memory. In particular, the role of sleep in relation to memory consolidation will be addressed. The target audience primarily comprises research experts in the field of cognitive neuroscience but the book may also be beneficial for graduate students.
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