Cancer Stem Cell Resistance to Targeted Therapy

 Oncology  Comments Off on Cancer Stem Cell Resistance to Targeted Therapy
Aug 192019
 

This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment.
The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells.

This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

GET IT FREE HERE

http://nitroflare.com/view/4C947A9A58707A8/3030166236.epub

http://nitroflare.com/view/FFEAEB4F25DDA47/3030166236.pdf

ALTERNATIVE LINK

https://filejoker.net/nae5nqhxguis

https://filejoker.net/g8mmqqhnjmzo

Share Button

Early Breast Cancer: From Screening to Multidisciplinary Management, Third Edition

 Oncology  Comments Off on Early Breast Cancer: From Screening to Multidisciplinary Management, Third Edition
Aug 182019
 

First Prize, BMA Medical Book Awards 2013

Breast cancers are now detected earlier and are thus more likely to be confined to the breast itself and regional nodes. Many of these tumours will have minimal proclivity for hematogenous dissemination and formation of micrometastases. On the other hand, some patients have micrometastatic diseases which can remain dormant and be activated many years after initial diagnosis.

Early Breast Cancer: From Screening to Multidisciplinary Management discusses the principles and practice of breast cancer management with respect to both screen-detected and symptomatic disease. It provides readers with sound understanding and critical insight into many aspects of the disease from epidemiology, genetics, and screening to pathology, diagnosis, treatment, and prevention. This latest edition continues the general ethos of the second edition with an emphasis on early screening and continued development of the multidisciplinary team.

GET IT FREE HERE

http://nitroflare.com/view/DA095F44C1AE9ED/1841848859.pdf

ALTERNATIVE LINK

https://filejoker.net/iecsx80gde30

Share Button

Cancer bioinformatics: From therapy design to treatment

 Oncology  Comments Off on Cancer bioinformatics: From therapy design to treatment
Aug 172019
 

“The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book.”—Dieter Naf, Jackson Laboratory, USACancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences.This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Vegetables, whole grains, and their derivatives in cancer prevention

 Oncology  Comments Off on Vegetables, whole grains, and their derivatives in cancer prevention
Aug 172019
 

Vegetables, Whole Grains and their Derivatives in Cancer Prevention looks in detail at the evidence regarding the effects and mechanisms of action of potentially cancer-preventive components and their sources from plant kingdom. The book covers current knowledge on certain foods and their constituents in cancer prevention, such as cruciferous and green leafy vegetables, nuts and seeds, whole grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium constituents, and capsaicinoids from chilli peppers. It focuses not only on single compounds but aims to widen the view by discussing a whole-diet approach in cancer prevention. A single component may lose its chemopreventive efficacy when isolated from the food matrix and in many cases isolated and concentrated components as supplements may actually induce tumor development. Apart from describing the effects and mechanisms of action, the chapters also contain information on intake, bioavailability, metabolism and possible toxic effects of foods and components presented. Evaluation and comparison of the data from mechanistic studies in vitro with those from animal experiments in vivo form a basis for applying the current knowledge to human nutrition in the field of carcinogenesis. With contributions from leading experts in the field, this book is an invaluable resource for scientists and professionals working in cancer research, as well as individuals involved in food and nutrition.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

PI3K-mTOR in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)

 Oncology  Comments Off on PI3K-mTOR in Cancer and Cancer Therapy (Cancer Drug Discovery and Development)
Aug 172019
 

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.​

GET IT FREE HERE

http://nitroflare.com/view/34DD394D909EE94/3319342096.PDF

ALTERNATIVE LINK

https://filejoker.net/an4qya0nwlq3

Share Button

Harrisons Manual of Oncology 2 Edition

 Oncology  Comments Off on Harrisons Manual of Oncology 2 Edition
Aug 162019
 

Publisher’s Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.

A CONCISE YET THOROUGH OVERVIEW OF THE MEDICATIONS AND APPROACHES USED IN CANCER CARE–BACKED BY THE AUTHORITY OF HARRISON’S
Harrison’s Manual of Oncology is a carry-anywhere guide to the care of patients with cancer. Enhanced by the latest published results, this valuable clinical companion features numerous tables and succinct, outline-style text that puts important information at your fingertips. You will find content that goes beyond the treatment of primary or metastatic disease to encompass the treatment of all therapeutic complications.
The opening sections of Harrison’s Manual of Oncology are devoted to the classes of agents used to treat cancer and reviews their pharmacology and mechanisms of action. This section is followed by a detailed discussion of the diagnosis, staging, and treatment of all major types of cancer. There is a strong focus on symptom management and complications of treatment, including pain, nausea and vomiting, anemia, febrile neutropenia, metabolicemergencies, thrombosis, psychological issues, and end-of-life care.

GET IT FREE HERE

http://nitroflare.com/view/586507E7C018068/0071793259.PDF

ALTERNATIVE LINK

https://filejoker.net/gos7h6et55m9

Share Button

Recent Advances in the Treatment of Colorectal Cancer

 Oncology  Comments Off on Recent Advances in the Treatment of Colorectal Cancer
Aug 162019
 

This book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment.
Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.

GET IT FREE HERE

http://nitroflare.com/view/4F1487C7B04E26B/9811330492.epub

http://nitroflare.com/view/BC81632F2DE54C0/9811330492.pdf

ALTERNATIVE LINK

https://filejoker.net/121xf7f5ohu3

https://filejoker.net/5lztuisxl8bd

Share Button

Fighting Cancer with Knowledge and Hope: A Guide for Patients, Families, and Health Care Providers, Second Edition

 Oncology  Comments Off on Fighting Cancer with Knowledge and Hope: A Guide for Patients, Families, and Health Care Providers, Second Edition
Aug 022019
 

Anyone who is diagnosed with cancer receives a frightening blow, and in many cases the diagnosis is accompanied by a bewildering array of treatment choices. In this invaluable book, a compassionate and knowledgeable physician explains what cancer is, which factors determine a patient’s prognosis, how cancer treatments work to eradicate cancer, why they sometimes fail, and what patients can do to optimize their own survival. The second edition of this essential resource for patients and their families discusses new treatment options that have become available, including targeted therapies, immune therapies, and personalized cancer medicine. Information on the types of medicines used to fight cancer has been completely updated and revised; also included is a new section on alternative cancer therapies. Winner of the 2010 American Medical Writers Association Medical Book Award in the Health Care Professionals–Nonphysician category Winner of the 2010 Will Solimene Award for Excellence in Medical Communication, given by the New England Chapter of the American Medical Writers Association

GET IT FREE HERE

http://nitroflare.com/view/251A2D3CB85BF23/0300190611.pdf

ALTERNATIVE LINK

https://filejoker.net/s74ked79bwd9

Share Button

Anal Cancer: A Comprehensive Guide

 Oncology  Comments Off on Anal Cancer: A Comprehensive Guide
Jul 312019
 

This book is a comprehensive overview of the epidemiology, pathogenesis, and treatment options available for anal cancer. Anal cancer is a relatively rare disease, but one increasing in incidence. Strides have been made in developing treatment paradigms through clinical trials, and proper management requires multidisciplinary interaction between radiation oncologists, surgeons, and medical oncologists as well as other physicians, nurses, and other medical professionals. The book thus covers all aspects of the disease to give clinicians and their teams the information necessary to develop a treatment program that focuses on improved patient outcomes. Chapters cover evaluation of the patient and cancer staging, current standard treatments, epidemiology, pathogenesis, issues involved in survivorship, and ongoing and future avenues of research into disease biology and novel treatments. This book is an ideal resource for clinicians involved in the care of patients with anal cancer.
ALTERNATIVE LINK
Share Button

Berries and cancer prevention

 Oncology  Comments Off on Berries and cancer prevention
Jul 312019
 

Berries are popularly consumed worldwide as fresh, processed, and other derived forms. Research conducted over the last decade and a half has provided significant and convincing evidence to support the cancer preventive potential of these colorful fruits. Berries and their phytochemical constituents work through multiple mechanisms to reduce the malignant properties of cancer cells in laboratory studies. Further, diets of various berry formulations, including freeze dried berries, have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans. Providing an unprecedented compilation of current information, this book, Berries and Cancer Prevention: 1) Describes the major groups of bioactive compounds in berries and their antioxidant potential 2) Describes the cancer inhibitory effects of berry extracts and individual components in vitro, and discusses their mechanisms of action on a cellular and molecular level 3) Discusses the cancer-inhibitory effects of berries and berry components on tumor development in animals 4) Discusses recent results on the cancer-inhibitory effects of berries and berry components in humans and describes their mechanisms of action; 5) Discusses the relative merits of the use of whole berries, freeze-dried berries, berry extracts and individual berry components for cancer prevention, particularly in humans. The editors anticipate that this book would be useful for researchers, academicians and trainees associated with departments of nutrition, dietetics, food science and technology, cancer biology, cancer prevention, public health, family medicine, osteopathy, dentistry, etc. It should also be useful for practitioners, dieticians, and others involved in daily patient health care. We also expect that individuals involved in various roles in the berry industry including berry production, product development, marketing and sales, would benefit from this book. The public has a strong interest in healthy foods and dietary interventions for cancer prevention, and we hope that many of those individuals will also find this book of great interest.
ALTERNATIVE LINK
Share Button