This volume strives to give oncologists and other medical practitioners a thorough picture of the oncology patient. It’s designed to show that psychological needs of the patient are an important aspect that should be considered for optimizing the effects of cancer treatment, no less than genetic, immunological, physiological and other medical features that are often considered as necessary components of personalized medicine. Using evidence-based information, the book describes the different ways cancer touches upon a person’s life, including emotional, physical, and social changes, important decisions, and support structure. It also details the phases every cancer patient encounters along the way, from getting tested and waiting for the diagnosis, to treatments, survival, and confronting one’s mortality.
Psycho-oncology for the Clinician will serve to contribute to the further scientific development of psycho-oncology, expand its use as a treatment modality, strengthen its status as an essential component of cancer care, and promote the acceptance of psycho-oncology as the new evidence-based constituent of personalized medicine in oncology.
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This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis.
The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques.
Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
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The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies.
It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.
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Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors—a hallmark of unrestrained growth—results in the passive accumulation of nanoparticles within tumors.
Cancer Nanotechnology: Principles and Applications in Radiation Oncology is a compilation of research in the arena of nanoparticles and radiation oncology, which lies at the intersection of disciplines as diverse as clinical radiation oncology, radiation physics and biology, nanotechnology, materials science, and biomedical engineering. The book provides a comprehensive, cross-disciplinary survey of basic principles, research techniques, and outcomes with the goals of eventual clinical translation.
• A general introduction to fabrication, preferential tumor targeting, and imaging of nanoparticles
• The specific applications of nanomaterials in the realms of radiation therapy, hyperthermia, thermal therapy, and normal tissue protection from radiation exposure
• Outlooks for future research and clinical translation including regulatory issues for ultimate use of nanomaterials in humans
Reflecting profound advances in the application of nanotechnology to radiation oncology, this comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. Along with various computational and experimental techniques, each chapter highlights the most promising approaches to the use of nanoparticles for radiation response modulation.
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A state-of-the-art, multidisciplinary approach to cancer and aging
With the majority of cancers occurring in individuals over the age of 65 against a backdrop of an expanding aging population, there is an urgent need to integrate the areas of clinical oncology and geriatric care.
This timely work tackles these issues head-on, presenting a truly multidisciplinary and international perspective on cancer and aging from world-renowned experts in geriatrics, oncology, behavioral science, psychology, gerontology, and public health.
Unlike other books on geriatric oncology that focus mainly on treatment, Cancer and Aging Handbook: Research and Practice examines all phases of the cancer care continuum, from prevention through evidence-based diagnosis and treatment to end-of-life care. Detailed clinical and research information helps guide readers on effective patient care as well as caregiver training, research, and intervention. Coverage includes:
• Epidemiology of cancer in older adults, plus the unique physical, mental, and social issues involved
• Strategies and guidelines for prevention, screening, and treatment of older individuals with cancer
• The most common cancers in the elderly, including breast, colorectal, lung, prostate, and ovarian cancer
• Cancer survivorship in older adults as well as the all-critical issues of palliative care and pain management
• Emerging topics such as caregiver and family issues, different models of care, and cost considerations
An essential resource for clinicians and caregivers as well as researchers interested in this evolving field, Cancer and Aging Handbook is also useful for public health professionals and policymakers who need to formulate services and allocate resources for the growing population of older cancer patients.
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With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate research goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Readers are provided with a realistic view of what is known and what is yet to be uncovered on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health.
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new perspective on the link between inflammation and cancer
Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods.
A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include:
A general overview of inflammation-related cancer
The biochemistry of inflammation and its effects on DNA
Molecular biology and the role of microRNA in carcinogenesis
Specific causative agents including oncogenic viruses, asbestos, and nanomaterial
Anti-inflammatories, nutraceuticals, and other preventative measures
A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.
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While a number of books have looked at the intersection between human health in general and other topics, such as climate change or diet, this book focuses specifically on cancer as it impacts and is impacted by social justice issues. The massive explosion of research knowledge of cancer immunology and genomics is holding out great promise of therapeutic advances, yet other human actions―climate change, pollution, business decisions, advertising – are fostering health inequalities as well as increasing risks. Those involved in cancer care and research are in a unique position to let their experiences and knowledge inform the public, yet very often have not taken strong public roles when it comes to discussing issues surrounding tobacco, climate change and health risks, financial toxicity of treatments, and diet choices.
Written by a multidisciplinary team of authors and for medical oncologists, cancer researchers, occupational health workers, and related medical students, residents, and fellows, this book encourages oncologists to address public health care and the societal issues associated with cancer risk. This volume discusses the overarching theme of environmental justice and oncology, focuses on business and cancer (such as clinical trials, drug development and profits, and global disparities), as well as animals and cancer.
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Includes practical guidance on challenging areas such as addressing psychosocial issues, establishing screening and prevention strategies, managing late effects in cancer survivors and many more
Easy-to-read outline format makes referencing in the clinical setting quick and convenient
Practical clinical vignettes with self-assessment Q&A accompany chapters in Part II
Clinical pearls highlight survivorship guidelines and their application
Provides management guidelines and detailed disease surveillance strategies for site-specific cancers
Includes digital access to the e-book