May 232017
 

Mechanisms of Molecular Carcinogenesis – Volume 2


Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. 

This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.

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May 232017
 

Uterine Cancer: Screening, Diagnosis, and Treatment (Current Clinical Oncology)


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For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.
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May 212017
 

Thyroid Cancer: From Emergent Biotechnologies to Clinical Practice Guidelines


The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

  • Technologically-advanced diagnostic procedures and therapeutic interventions
  • Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI
  • Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer
  • How CPG contain knowledge gaps and produce uncertainty
  • Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

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May 192017
 

Prostate Cancer (Radiation Medicine Rounds)


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This issue of Radiation Medicine Rounds examines the latest advances in the use of radiation medicine in treatment of prostate cancer Prostate cancer is the most common cancer in males and radiation therapy is a major tool in the management of the disease. This issue of Radiation Medicine Rounds includes reviews of all major recent advances in treatment of favorable, intermediate and high-risk prostate cancer as well as newer modalities such as brachytherapy, stereotactic body radiation therapy, and proton beam radiotherapy. Articles also review current knowledge in the areas of new biomarkers, risk stratification, and risk stratification. This issue of RMR will provide the practitioner with a full current overview of the present best practices and recent research in management of this complex and challenging disease.

Radiation Medicine Rounds features:

  • In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine
  • Each issue edited by an authority in that subject area
  • Each issue focused on a single major topic in Radiation Medicine, providing coverage of advances in radiation science, radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcome studies

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May 192017
 

Hodgkin Lymphoma: A Comprehensive Overview (Hematologic Malignancies)


This book examines in detail the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the management appropriate in special clinical circumstances, including in the elderly, pregnant women, and those with lymphocyte-predominant disease. Careful attention is devoted to the emerging individually tailored treatment strategies that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The second edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by the key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
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May 172017
 

Personalized Management of Gastric Cancer: Translational and Precision Medicine


This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment.

The book’s four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors’ experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.

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May 152017
 

Cancer in Adolescents and Young Adults (Pediatric Oncology)


This is the second edition of the only book to be devoted exclusively to the total cancer picture in adolescents and young adults (AYA), now expanded from the age range 15-29 to that of 15–39 years. For each of the diverse spectrum of cancers encountered in the AYA group, the epidemiology, natural progression, diagnostic approaches, and treatment options are described, with special emphasis on strategies for early detection and prevention. Comparison is made with management of both younger and older patients, and model programs are presented that address common diagnostic, staging, treatment, and psychosocial shortcomings in the AYA group. Detailed attention is also paid to principles and practices of care, with consideration of psychosocial and quality of life issues, social support systems, rehabilitation, late effects, insurance, and economic aspects of health care, among other topics. The authors make compelling arguments for integrated strategies that allow young adults to benefit from the combined expertise of pediatric and adult oncologists in systems that identify both the complex disease and the social issues specific to this population. 

The proposed models of care include relationships with other specialties that do not specifically target this age group, i.e., infectious disease, endocrinology, pulmonary medicine, nephrology, gastroenterology, thoracic and abdominal surgery, urology, otolaryngology, and neurosurgery. New patterns of communication are advocated and endorsed as essential for productive interaction involving these specialties. References are extensive and are oriented toward users in pediatric hematology-oncologymedical oncology, radiation oncology, surgical oncology, gynecologic oncology, oncology nursing, psycho-oncology, social work, epidemiology, public health and health services research. The contributing authors are from the United States, the United Kingdom, Canada, Italy, France, Israel, Switzerland and Australia, Germany, Japan and the Netherlands.p>

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May 102017
 

Clinical Radiation Oncology: Indications, Techniques, and Results


This fully updated and enhanced third edition offers a highly practical, application-based review of the biological basis of radiation oncology and the clinical efficacy of radiation therapy.

  • Revised edition of the classic reference in radiation oncology from Dr. C.C. Wang, whose practical approach to clinical application was legendary
  • Includes the latest developments in the field: intensity modulated radiation therapy (IMRT), image guided radiation therapy, and particle beam therapy  
  • Includes two brand new chapters Palliative Radiotherapy, and Statistics in Radiation Oncology
  • Features a vibrant and extremely comprehensive head and neck section  
  • Provides immediately applicable treatment algorithms for each tumor
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May 062017
 

Stop Breast Cancer Before it Starts


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By (author): Samuel S. Epstein MD

With pink buckets of Kentucky Fried Chicken, “I’m here for the boobs” t-shirts and coffee cups, and a pink ribbon celebrity dunk tank on TheEllen Degeneres Show, a Mardi Gras culture has arisen around a deadly disease over the last decade. The highly marketed pink ribbon, criticized for being tied to pharmaceutical interests, presents breast cancer as normal and pretty in pink. Yet, the statistics of breast cancer remain the same. 

Expert on the preventative causes of cancer, Dr. Samuel S. Epstein has been watching the debates around breast cancer for more than four decades. He asks, with all the talk about early detection, mammograms, improved treatment, and the race for the cure, why don’t we ever hear about breast cancer prevention? Dr. Epstein knows the substantial research that has directly associated many factors of daily life with the development of the disease. The steps that can be taken to prevent it are often amazingly simple, but rarely make the headlines. Here, the evidence is presented and preventative choices are carefully and accesibly outlined. In presenting this critical information that all Americans should know about, Stop Breast Cancer Before it Starts empowers women to take charge of their health and make a real difference in the fight against cancer.

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May 062017
 

Pancreatology: A Clinical Casebook


This clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text.
Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.
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Release date May 12, 2017.

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