Aug 202017
 

Tumors and Cancers: Central and Peripheral Nervous Systems (Pocket Guides to Biomedical Sciences)


By (author): Dongyou Liu

Tumors and cancers are insidious diseases characterized by an abnormal growth of cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs. Forming the first of the four volumes devoted to tumors and cancers, this volume focuses on the central and peripheral nervous systems. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its definition, biology, epidemiology, disease mechanism/pathogenesis, clinical signs, diagnosis, treatment and prognosis.

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Aug 182017
 

Radiation Safety in Radiation Oncology


By (author): K. N. Govinda Rajan

The proposed book aims to explain the basic principles, concepts and regulations behind radiation protection and their application in the field of radiation oncology practice. This book will be useful to all those students, teachers and practicing professionals involved in the field of radiation oncology namely a) the radiation oncology physicists b) therapy technologists c) radiation oncologists d) oncology nurses and e) regulators undergoing IAEA training in regulations. The main target audience for the book are the medical physics students doing undergraduate or graduate program in radiation oncology physics and the teachers who teach the subject in the academic institutions.

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Aug 182017
 

An Introduction to Physical Oncology: How Mechanistic Mathematical Modeling Can Improve Cancer Therapy Outcomes (Chapman & Hall/CRC Mathematical and Computational Biology)


By (author): Vittorio Cristini, Eugene Koay, Zhihui Wang

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome.

This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

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Aug 172017
 

Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies (Tumor Dormancy and Cellular Quiescence and Senescence)


In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.
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Aug 152017
 

The Voice of Breast Cancer in Medicine and Bioethics (Philosophy and Medicine)


Features: The Voice of Breast Cancer in Medicine and Bioethics Philosophy and Medicine

Unlike any other volume focusing on women’s health issues, this collection brings together a wealth of cross-disciplinary perspectives to bear on the intersection of breasts and medicine.

Among other works on similar subject matters, the academic versatility of this volume is unparalleled. This collection can serve as a textbook in a wide range of courses including those in philosophy, women’s studies, biology, psychology, literature, history, and medicine.

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Aug 152017
 

Patient-Derived Mouse Models of Cancer: Patient-Derived Orthotopic Xenografts (PDOX) (Molecular and Translational Medicine)


This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section.
Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
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Aug 142017
 

Contemporary Oral Oncology: Oral and Maxillofacial Reconstructive Surgery


This is the third of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume is devoted to the reconstructive surgical techniques used in patients with oral cancer. Following introductory chapters outlining the general principles of reconstructive surgery in the oral cavity and the planning of maxillofacial reconstruction, detailed descriptions of the options and techniques employed in reconstruction of each of the functional subunits are provided. Important technologic advances are also discussed, including image-guided surgery, robotic surgery, and tissue-engineered and prefabricated approaches. Finally, the current status of facial transplantation for maxillofacial reconstruction is reviewed. This volume is intended for both trainees and practicing surgeons.

Ove

rview on all volumes:

Volume 1: Biology, Epidemiology, Etiology, and Prevention

Volume 2: Diagnosis and Management

Volume 3: Oral and Maxillofacial Reconstructive Surgery

Volume 4: Rehabilitation and Supportive Care

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Aug 092017
 

Handbook of Oncology Social Work: Psychosocial Care for People with Cancer


The development of this inaugural Handbook of Oncology Social Work: Psychosocial Care for People With Cancer provides a repository of the scope of oncology social workers’ clinical practice, education, research, policy and program leadership in the psychosocial care of people with cancer and their families. It focuses on the unique synergy of social work perspectives, values, knowledge, and skills with the psychosocial needs of cancer patients, their families, and the health care systems in which they are treated. It addresses both the science and art of psychosocial care and identifies the increasing specialization of oncology social work related to its unique knowledge base, skills, role, and the progressive complexity of psychosocial challenges for patients with cancer.

This Handbook equips the reader with all that we know today in oncology social work about patient and family centered care, distress screening, genetics, survivorship, care coordination, sociocultural and economic diversity, legal and ethical matters, clinical work with adults living with cancer, cancer across the lifespan, their caregivers and families, pediatrics, loss and grief, professional career development, leadership, and innovation. Our hope is that in reading this Handbook you will identify new areas where each of you can leave your mark as innovators and change agents in our evolving field of practice.

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Aug 062017
 

Extracellular Matrix in Tumor Biology (Biology of Extracellular Matrix)


This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression.  The book addresses researchers working on cancer biology or ECM, and oncologists alike.
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Aug 062017
 

Development of Oral Cancer: Risk Factors and Prevention Strategies


This book aims to provide the reader with a complete understanding of the development of oral cancer by explaining the role of a wide variety of implicated risk factors and identifying their gene targets and key regulators. Some of the discussed risk factors are well known, including smoking, alcohol, betel quid chewing, and oncoviruses such as high-risk human papillomaviruses and Epstein-Barr virus; however, careful attention is also paid to less widely recognized factors, such as Qat chewing and yerba Mate consumption. The book concludes by describing and evaluating the most important strategies currently available for the prevention of oral carcinogenesis in humans. In presenting the most up-todate research and knowledge on these topics, this book will serve as a valuable source of up-to-date information for oncologists, cancer scientists, and medical students.

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