Molecular and Cellular Toxicology: An Introduction

 Toxicology  Comments Off on Molecular and Cellular Toxicology: An Introduction
Jul 232019
 

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects.

Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non–mammalian) models and the exploitation of omics methods, high throughput screening (HTS) techniques and molecular imaging technologies.

This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.

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Toxicological Testing Handbook: Principles, Applications and Data Interpretation, 2nd Edition

 Toxicology  Comments Off on Toxicological Testing Handbook: Principles, Applications and Data Interpretation, 2nd Edition
Jun 252019
 

Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on data interpretation, hazard assessment, carcinogenicity studies, and Good Laboratory Practices, new chapters regarding safety pharmacology, juvenile studies, the health safety assessment of pharmaceuticals, and health assessment strategies in the food and cosmetic industry have been added to reflect changes to regulatory requirements. Toxicological Testing Handbook, Second Edition is a must-have reference for individuals responsible for assuring the safety of new pharmaceutical, biotechnical, and chemical products and materials.
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Handbook of Toxicology, Third Edition

 Toxicology  Comments Off on Handbook of Toxicology, Third Edition
Jun 252019
 

The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more.

New to this edition:

Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics
Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology
Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty
A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty
For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.

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In Vitro Neurotoxicology: Principles and Challenges (Methods in Pharmacology and Toxicology)

 Pharmacology, Toxicology  Comments Off on In Vitro Neurotoxicology: Principles and Challenges (Methods in Pharmacology and Toxicology)
Jun 202019
 

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other’s work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will
hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
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Ovarian Toxicology (Target Organ Toxicology Series)

 Toxicology  Comments Off on Ovarian Toxicology (Target Organ Toxicology Series)
May 132019
 

In recent years, there has been an alarming increase in environmental by-products that may be harmful to ovarian function. Along with this dangerous situation, the modern trend toward delaying motherhood poses immediate concerns regarding the long-term impact of environmental risks on human fertility. The uncertainty of our reproductive future intensifies the need for a single reference that investigates the chemicals with the potential to jeopardize fertility. The only known text that deals specifically with toxicity in the ovary, Ovarian Toxicology updates our current understanding of the effects of environmental chemicals on ovarian function. This new title in the Target Organ Toxicology Series presents an overview of ovarian physiology, examines the key ovarian target sites, assesses the effects of specific chemicals demonstrated in animal studies, and evaluates related human epidemiological data. Featuring the most complete review available of ovarian metabolism of xenobiotics, chapters also discuss ovarian cancer and modeling and testing for ovarian effects. With its clear handling of data and issues that are crucial to fertility studies, this comprehensive exploration of ovarian toxicology identifies the realistic risks for damage that our environment has the potential to inflict. It will be welcomed by toxicologists and ovarian physiologists, those in the pharmaceutical industries and regulatory agencies, and postgraduate researchers striving to safeguard women’s fertility and ensure our reproductive future.
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Toxicities of Radiation Treatment for Breast Cancer: Risks and Management Strategies

 Oncology, Radiology, Toxicology  Comments Off on Toxicities of Radiation Treatment for Breast Cancer: Risks and Management Strategies
Apr 252019
 


This book is a comprehensive guide to breast toxicity. Adjuvant radiation remains standard for a majority of women who undergo breast-conserving surgery for breast cancer, and indications for post-mastectomy and regional lymph node irradiation have also broadened with recent publications. At the same time, locoregional recurrence has declined and survival has improved in recent decades. In the current era of excellent breast cancer outcomes, then, considering the balance between toxicity and outcomes becomes paramount. Several recent editorials recommend considering toxicity against the potential benefit of adjuvant radiation in tailoring radiation decisions for individual patients. Thus, a clear understanding of the potential toxicities of adjuvant radiation for breast cancer is critical to optimizing outcomes in modern breast cancer management. Here, authors have collected recent data focused on toxicity of treatment that provide an opportunity for improving this optimization. Chapters cover both acute and late toxicity of radiation for breast cancer, including tailored risk assessment for each of these potential toxicities, considerations for including risk of toxicity in management decisions, and toxicity management strategies. This is an ideal guide for radiation oncologists, residents, and oncologists seeking to optimize care for their patients.
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Comparative Pathophysiology and Toxicology of Cyclooxygenases

 Pathology, Physiology, Toxicology  Comments Off on Comparative Pathophysiology and Toxicology of Cyclooxygenases
Apr 172019
 


The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks

Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks.

Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover:

The pathophysiology of COX inhibition on bone, tendon, and ligament healing
COX inhibitors and renal system pathophysiology and mechanisms of toxicity
The pathophysiologic role of COX inhibition in the ocular system
COX inhibition and the respiratory and cardiovascular systems

The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

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Nanotoxicology: Progress toward Nanomedicine, Second Edition

 Toxicology  Comments Off on Nanotoxicology: Progress toward Nanomedicine, Second Edition
Mar 242019
 

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.
Topics include
• The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
• The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications
• Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
• Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
• Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
• Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications
• The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
• A roadmap for future research
The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

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Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body

 Toxicology  Comments Off on Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body
Mar 212019
 

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.
Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:
• Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
• Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
• Describes the intravenous route of administration for the therapeutic management of ocular disease
• Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
• Summarizes various toxicological principles and the testing of nanoproducts
Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where “practical” is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book’s goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

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Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology

 Toxicology  Comments Off on Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology
Mar 172019
 

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
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