Jan 302017
 

Developmental and Reproductive Toxicology: A Practical Approach, Third Edition


The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics.

The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches.

Developmental and Reproductive Toxicology, Third Edition:

  • Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies.
  • Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity.
  • Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference.
  • Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment.

This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

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Jan 162017
 

Stem Cell-Derived Models in Toxicology (Methods in Pharmacology and Toxicology)


This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. 
Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
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Jan 012017
 

Genotoxicity and DNA Repair: A Practical Approach (Methods in Pharmacology and Toxicology)


Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.

Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.

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Dec 242016
 

Toxicology of Cyanides and Cyanogens: Experimental, Applied and Clinical Aspects


The basic and applied toxicology of cyanides and cyanogens has widespread commercial, occupational, environmental, clinical, forensic, military, and public health implications.  This book provides a detailed and updated reference describing the properties, uses, general and human toxicology, clinical recognition, diagnosis and medical management, and countermeasures is therefore required in academic, medical, occupational, environmental, medico-legal, regulatory, emergency response, and military arenas. Edited by a world-renowned team of experts from academia, defense and industry, this book will be an invaluable reference for professionals, researchers and students in cyanide and cyanogens.
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Dec 242016
 

microRNAs in Toxicology and Medicine


By (author): Saura C. Sahu

During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of human diseases including cancer. 

microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of up-to-date developments in this emerging research area, presented by internationally recognized investigators. It focuses on the role of microRNA in biology and medicine with a special emphasis on toxicology. 

Divided into six parts, topics covered include:

  • microRNA and toxicology – including environmental toxicants and perturbation of miRNA signaling; microRNA, and Disease States featuring microRNAs in drug-induced liver toxicity, microRNAs and Inflammation the regulatory role of microRNA in mutagenesis, microRNAs and cancer, and the role of microRNAs in tumor progression and therapy, as well as current understanding of microRNAs as therapeutic targets in cancer
  • microRNAs and disease states
  • microRNAs and stem cells
  • microRNAs and genomics
  • microRNAs and epigenomics
  • microRNAs and biomarkers – including body fluid microRNAs as toxicological biomarkers, cell-free microRNAs as biomarkers in human diseases, and circulating microRNAs as biomarkers of drug-induced pancreatitis

microRNAs in Toxicology and Medicine is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors, and regulators in academia, medical settings, industry, and government.

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Dec 212016
 

Clarke’s Analytical Forensic Toxicology


Features: Used Book in Good Condition

This second edition of Clarke’s Analytical Forensic Toxicology offers a fresh perspective on the drugs and poisons that you are most likely to encounter in forensic toxicology, with a focus on collection, extraction and analysis. With additional features incorporated from the fourth edition of Clarke’s Analysis of Drugs and Poisons this text is fully updated to reflect the advances in analytical and forensic toxicology. New and extended chapters include: sampling, storage and stability; in-utero exposure to drugs of abuse; drug-facilitated sexual assault; and extraction. Providing unrivalled comprehensive coverage of analytical forensic toxicology, this book is a crucial resource for students of forensic science, toxicology, clinical pharmacology and analytical chemistry. It is an invaluable tool for teachers in these subject areas and a key resource for those working in forensic science laboratories.
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Dec 162016
 

Perry’s The Chemotherapy Source Book


Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs.  Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification. 

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Dec 062016
 

Validation of Alternative Methods for Toxicity Testing (Advances in Experimental Medicine and Biology)


This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology.

 

Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment.

 

This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.

 

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Dec 042016
 

Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications


By (author): Professor and Chair Dr Yunbo Li

This is a book that takes a unique approach to integrating knowledge in antioxidants from essentials to advances, and from basic research to clinical applications. This book presents scientific information on antioxidants in an organised, cogent, and in-depth manner. The consistent format of writing, the full-colour illustrations, and the comprehensive list of references make the book accessible and engaging. Besides its value as a textbook for undergraduate and graduate students in life science, “Antioxidants in Biology and Medicine” will also be a useful reference for biomedical research scientists, clinicians, and other health professionals.
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Nov 282016
 

Toxic Trauma: A Basic Clinical Guide


By (author): David J. Baker

Winner of BMA Medical Book Award, Highly Commended in Public Health

Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins. 

Praise for the first edition

“Toxic Trauma is a welcome addition to the literature. . . . Although written for clinicians, the book contains chapters that should be read by administrators and other health care professionals to ensure they understand and can inform the public in a balanced manner about the logistic considerations, and widespread consequences across systems when an event does occur. Any healthcare library should consider this book an essential text.”

–Michael Nurok, American Journal of Disaster Medicine

“This book excels as a reference for those interested in learning about and designing systems to better handle toxic trauma.”

–Michael D. Zwank, Doody’s Book Reviews

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