Fetal and Neonatal Eye Pathology

 Pathology  Comments Off on Fetal and Neonatal Eye Pathology
Mar 262020
 

This richly illustrated book discusses the fetal eye, offering a brief introduction to the topic and discussing its development and treatment. The high-quality reference images allow the morphological fetal age to be determined, and the authors provide examples of artifacts and real-world findings to simplify histopathological diagnosis. The book also discusses findings in fetal eyes, presenting typical examples of common malformations, including clinical and histological pictures as well as additional findings from other specialties (such as neuropathology, genetics). In addition, it covers non-specific ocular malformations. It particularly addresses documentation and interpretation of cases of suspected Shaken-Baby Syndrome, which is of forensic importance. In the context of retinopathy of prematurity, histopathological and clinical findings are correlated.
The book provides reference images of fetal development and guidelines on grossing and handling fetal eyes, and also explores the complicated topic of artifacts, including case illustrations with comprehensive information concerning other specialties. Lastly it discusses clinically and forensically relevant findings in newborns. It guides ophthalmic and pediatric pathologists in the interpretation of ocular findings, helping to narrow down differential diagnoses in fetal pathology, while at the same time serving as a valuable tool for specialists who do not have a great deal of experience in the examination of fetal eyes.

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Dermatopathology

 Dermatology, Pathology  Comments Off on Dermatopathology
Mar 262020
 

This book introduces the principles of microscopic pathology of acquired skin diseases in a concise, yet comprehensive manner. The underlying mechanisms of the different diseases are discussed with reference to modern knowledge about immunology, molecular biology, and inflammatory response to infections and injury. The book is abundantly illustrated.
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Histology for Pathologists, 4th edition

 Histology, Pathology  Comments Off on Histology for Pathologists, 4th edition
Mar 122020
 

A strong grounding in basic histology is essential for all pathologists. However, there had always been a gap between histology and pathology in which histologic information specifically for the pathologist was often lacking. Histology for Pathologists deals with the microscopic features of normal human tissues, from the perspective of the surgical pathologist. This is the only text that uses human (vs. animal) tissues for the histology. It is the best reference in the literature for information on normal histology, and, as such, is essential for all clinical pathologists. Written by pathologists for pathologists, the new edition will update the pathologist’s understanding of normal histology up to date with the incremental advances made in the last five years. The 3rd edition has become a “classic” purchased by virtually all residents beginning their pathology training, as well as pathologists in practice. The 4th edition will build on that substantial foundation.
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ECG Interpretation: From Pathophysiology to Clinical Application: From Pathophysiology to Clinical Application

 Pathology, Physiology  Comments Off on ECG Interpretation: From Pathophysiology to Clinical Application: From Pathophysiology to Clinical Application
Mar 072020
 

This simple paperback teaches electrocardiography from a pathophysiologic basis. The book is small in format, concise, and can be utilized as a reference – chapter by chapter or read throughout. Ten case studies are highlighted at the end of the book.
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Color Atlas of Gross Placental Pathology

 Pathology  Comments Off on Color Atlas of Gross Placental Pathology
Mar 072020
 

This atlas is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology. With 186 illustrations, 154 in color, this atlas contains a wealth of important information for pathologists examining the placenta. The book is highly recommended for all those engaged in pathologic examination of the placenta. The text is concise, and the book provides a rapid reference for pathologists.
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History of the European Association for Haematopathology

 Hematology, Pathology  Comments Off on History of the European Association for Haematopathology
Feb 292020
 

Because of progress in immunology, specifically the discovery of the B- and T-lymphocyte systems, it was imperative to rethink the concepts of malignant lymphomas, which resulted in the development of new lymphoma classifications. One of these was the Kiel classification, proposed by the European Lymphoma Club in 1974. During the following years the classification was refined, correlated with clinical findings, discussed at length, and put to the test against other classifications. It was soon widely accepted in Europe and later sparked the founding of the European Association for Haematopathology in Geneva, Switzerland, in 1988. In 2001 the Kiel classification was incorporated into the new WHO classification.
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West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response

 Immunology, Infectious Diseases, Pathology  Comments Off on West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response
Feb 252020
 

In West Nile Encephalitis Virus Infection, leading scientists and researchers discuss the West Nile virus, a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Its appearance in the Western Hemisphere in 1999, and the corresponding increase in global disease burden over the last decade has been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. While the topics in this book are focused on the West Nile virus, they are broad in scope ranging from understanding vector transmission patterns to the dynamics of structural transitions of proteins on the surface of the virion. The editor and contributors of West Nile Encephalitis Virus Infection offer their expertise in this up-to-date and cutting-edge anthology, which will be of broad use to readers from a variety of backgrounds including clinical infectious disease, epidemiology, virology, immunology, and vector biology.
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A Matter of Life and Death: Inside the Hidden World of the Pathologist

 Pathology  Comments Off on A Matter of Life and Death: Inside the Hidden World of the Pathologist
Feb 252020
 

True tales of microscopic detective work that catches killers both human and pathogen: “More fascinating than fiction. Forget CSI, this is the real thing” (Val McDermid).

A Matter of Life and Death profiles some of the world’s most eminent and pioneering pathologists. This is a hidden world, yet one we will all inevitably encounter at some time in our lives, for pathology lies at the cornerstone of modern medicine. It is pathologists who are responsible for recognizing new diseases such as AIDS, SARS or bird flu, and for diagnosing which cancer a patient is suffering from. Beyond this, it is pathologists who must explain the cause of death at the autopsy table.

A Matter of Life and Death tells fascinating stories of mysterious illnesses and miraculous scientific breakthroughs. But it is also crammed full of extraordinary characters – from the forensic anthropologist with his own Body Farm in Tennessee to the doctor who had a heart-and-lung transplant and ended up using her own lungs for research.

“If you’re interested in criminal investigation, this is the must-read of the year. Probably of the decade.”—Val McDermid, author of Insidious Intent

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Osteoporosis: Pathophysiology and Clinical Management Edition 3

 Pathology, Physiology  Comments Off on Osteoporosis: Pathophysiology and Clinical Management Edition 3
Feb 172020
 

Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care.
In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.

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https://nitroflare.com/view/8DF12B69FB45D14/3319692860.pdf

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Endometrial Cytology with Tissue Correlations

 Ob/Gynae, Pathology  Comments Off on Endometrial Cytology with Tissue Correlations
Feb 162020
 

As compared with cytology’s use in other organ systems, direct cytological examination of the endometrium is not a widely practiced diagnostic procedure. This is an anomaly, because the endometrium is exceedingly available for cytological sampling, cytological sampling is comparably simple to perform, and, from the patient’s perspective, it is a gentle procedure as compared to other methods of specimen attainment. Over the years, as we personally gained more and more experience with specimen acquisition, processing and interpretation, we have come to look upon endometrial cytology as an effective method for ensuring endometrial normalcy and discovering and diagnosing malignant and premalignant states. In comparing endometrial cytology to endometrial biopsy, we have found that, in samples obtained by individuals experienced in specimen collection, cytology outperforms outpatient biopsy with regard to the patient’s tolerance of the procedure, adequacy of sampling among postmenopausal women, and detection of occult neoplasms. By devising a highly effective technical strategy to ensure the simultaneous creation of cell blocks and cytological samples from a single collection (that is detailed in the technical appendix of this work), we have moved endometrial brush collection into an arena of significance equaling—indeed exceeding—other methods of specimen collection and interpretation. Cytology, even in the absence of cell blocks, performs equally as well as biopsy in detecting outspoken hyperplasia or carcinoma. If nothing else, by reliably identifying benign, normal endometrial states, it serves to exclude more than 70% of women from unnecessary follow up testing with a high degree of confidence. Because brush sampling of the endometrium is limited to a depth of 1.5 to 2 mm, the method is not definitive for the detection of endometrial polyps, fibroids, stromal tumors, or tumors of the uterine wall musculature. However, endometrial cytology is useful for detecting benign estrogen-excess states such as disordered proliferation and various degrees of benign hyperplasia, for separating these states from frankly neoplastic states such as EIN and cancer, but not for subclassifying benign hyperplastic states in the absence of cell block preparations. When endometrial brushing with liquid fixation is used in conjunction with other techniques such as immunohistochemistry, concomitant biopsy or, more practically, hysteroscopy or sonohysterography, endometrial benignancy can be assured with a very high level of confidence (> 99%); indeed, manufacturing concomitant cell blocks of endometrial tissue fragments and using immunohistochemistry in selected cases significantly enhances the diagnostic specificity of the technique. In a woman with a patent cervix, endometrial brushing successfully collects material, even from late postmenopausal atrophic endometrium. It allows for the detection of serious diseases such as endometrial intraepithelial carcinoma under conditions where suction biopsy might miss or otherwise obviate the diagnosis. This work focuses on the background, collection technique, and reliability of endometrial cytology; it then overviews diagnostic criteria and diagnostic pitfalls encountered in the day-to-day practice of the art. Since endometrial cytology interpretation relies on intuiting tissue patterns from cytology preparations, a great deal of time is spent on cytohistological correlations and, where effective as part of a diagnostic strategy, on ancillary immunohistochemical staining. The discussion moves from normal states of the endometrium, through otherwise benign changes induced by an altered hormonal milieu or surface irritants, into neoplastic premalignant and malignant endometrial conditions. Finally, fixative and slide preparation techniques, that we deem as expeditiou
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