Cardiovascular Clinical Trials: Putting the Evidence into Practice

 Cardiovascular  Comments Off on Cardiovascular Clinical Trials: Putting the Evidence into Practice
Feb 212019
 

The pace of therapeutic advances in the treatment of cardiovascular diseases is rapid, and new clinically-relevant information appears with such frequency that it can be extremely challenging for clinicians to keep up. Still, knowledge and interpretation of major clinical trials is crucial for the range of clinicians who manage cardiovascular patients, especially since important trial evidence often needs to be implemented soon after it is published.

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Cardiovascular Magnetic Resonance Imaging, 2nd edition

 Cardiovascular, Radiology  Comments Off on Cardiovascular Magnetic Resonance Imaging, 2nd edition
Feb 202019
 

The significantly updated second edition of this important work provides an up-to-date and comprehensive overview of cardiovascular magnetic resonance imaging (CMR), a rapidly evolving tool for diagnosis and intervention of cardiovascular disease. New and updated chapters focus on recent applications of CMR such as electrophysiological ablative treatment of arrhythmias, targeted molecular MRI, and T1 mapping methods. The book presents a state-of-the-art compilation of expert contributions to the field, each examining normal and pathologic anatomy of the cardiovascular system as assessed by magnetic resonance imaging. Functional techniques such as myocardial perfusion imaging and assessment of flow velocity are emphasized, along with the exciting areas of artherosclerosis plaque imaging and targeted MRI. This cutting-edge volume represents a multi-disciplinary approach to the field, with contributions from experts in cardiology, radiology, physics, engineering, physiology and biochemistry, and offers new directions in noninvasive imaging. The Second Edition of Cardiovascular Magnetic Resonance Imaging is an essential resource for cardiologists and radiologists striving to lead the way into the future of this important field.
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Heart Solution for Women: A Proven Program to Prevent and Reverse Heart Disease

 Cardiovascular  Comments Off on Heart Solution for Women: A Proven Program to Prevent and Reverse Heart Disease
Feb 172019
 

Heart disease remains the number one killer of women, outpacing breast cancer, diabetes, and stroke, with one in four women receiving a diagnosis in her lifetime. And the problem is only getting worse.

Dr. Mark Menolascino has been on the front lines of cardiac research for most of his life, running a highly successful clinic where he takes a holistic, personalized approach to reversing disease and jump-starting health. Most of his patients are women struggling with symptoms and illnesses that stem from the most important, life-giving organ in the body: the heart. In Heart Solution for Women, Dr. Menolascino explores the many ways our hearts are the pathway to overall health. While the classic risk factors for heart disease—obesity, high cholesterol, high blood pressure, stress, and poor diet—are critical components, symptoms of the disease manifest differently in women’s bodies and can go misdiagnosed for years. They include depression, anxiety and panic attacks, poor sleep, and widespread pain, and can be masked during pregnancy, post-pregnancy, and menopause only to appear with great force later in life.

Featuring the latest research on gut, brain, and hormone health and including answers to the most common heart-health misunderstandings, Heart Solution for Women finally gives women the tools to succeed, feel great in their bodies, and add years to their lives.

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Cardiac Cell Biology

 Cardiovascular  Comments Off on Cardiac Cell Biology
Feb 162019
 

Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.
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Heart Proteomics: Methods and Protocols

 Cardiovascular  Comments Off on Heart Proteomics: Methods and Protocols
Feb 152019
 

The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.
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Cardiac Adaptations: Molecular Mechanisms

 Cardiovascular  Comments Off on Cardiac Adaptations: Molecular Mechanisms
Feb 142019
 

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
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Current Indications for the Implantable Cardioverter Defibrillator

 Cardiovascular  Comments Off on Current Indications for the Implantable Cardioverter Defibrillator
Feb 112019
 

In this book, well-known physicians, Bocker, Eckardt and Breithardt have put together a succinct and focused book that compliments the CATA Series well. Implantation of defibrillators has evolved dramatically since its introduction by Mirowski in 1980. Technological improvements in devices and leads included a gradual reduction in the size of the device, the introduction of the endocardial approach in 1988, the biphasic waveform and antitachycardia pacing in 1991, pectoral implantation in 1995, inclusion of DDD pacing in 1996 and the delivery of atrial therapies in 1998. Since the first implantation, a huge body of information on the impact of implantable cardioverter defibrillators (ICD) on prognosis has become available, first as observational studies and later as prospective randomized trials. At the present time, there is a large evidence base from the several ICD trials, although it was not always certain that such a large body of ICD evidence would accumulate.Content: Chapter 1 Introduction (pages 1–2): Chapter 2 Evolution of Guidelines for Defibrillator Therapy (pages 2–4): Chapter 3 Background of ICD Therapy (pages 4–9): Chapter 4 Current Indications for ICD Therapy (pages 9–60): Chapter 5 Legal Implications of Defibrillator Guidelines (pages 60–62):
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Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult

 Cardiovascular, Pediatrics  Comments Off on Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult
Feb 102019
 

Echocardiography is essential in the practice of pediatric cardiology. A clinical pediatric cardiologist is expected to be adept at the non-invasive diagnosis of congenital heart disease and those who plan to specialize in echocardiography will need to have knowledge of advanced techniques. Echocardiography in Pediatric and Congenital Heart Disease addresses the needs of trainees and practitioners in this field, filling a void caused by the lack of material in this fast-growing area. This new title comprehensively covers the echocardiographic assessment of congenital heart disease, from the fetus to the adult, plus acquired heart disease in children. Topics covered include: ultrasound physics laboratory set-up a protocol for a standard pediatric echocardiogram quantitative methods of echocardiographic evaluation, including assessment of diastolic function in depth coverage of congenital cardiovascular malformations acquired pediatric heart disease topics of special interest, such as 3D echocardiography, transesophageal echocardiography, and fetal echocardiography The approach of this book is a major advancement for educational materials in the field of pediatric cardiology, and greatly enhances the experience for the reader. An accompanying DVD with moving images of the subjects covered in the textbook will further enhance the learning experience.Content: Chapter 1 Ultrasound Physics (pages 1–14): Piet Claus and Jan D’HoogeChapter 2 Laboratory Function, Instrumentation, Patient Preparation and Patient Safety (pages 15–21): Richard A. HumesChapter 3 Nomenclature and Segmental Approach to Congenital Heart Disease (pages 22–33): Tal GevaChapter 4 The Normal Pediatric Echocardiogram (pages 34–50): Wyman W. Lai and H. Helen KoChapter 5 Structural Measurements and Adjustment for Growth (pages 51–62): Thierry Sluysmans and Steven D. ColanChapter 6 Hemodynamic Measurements (pages 63–75): Steven D. ColanChapter 7 Echocardiographic Evaluation of Systolic Function (pages 76–94): Luc L. Mertens, Javier Ganame and Benedicte EyskensChapter 8 Diastolic Ventricular Function Assessment (pages 95–116): Peter C. FrommeltChapter 9 Pulmonary Venous Anomalies (pages 117–142): David W. BrownChapter 10 Systemic Venous Anomalies (pages 143–157): Leo Lopez and James C. HuhtaChapter 11 Anomalies of the Atrial Septum (pages 158–174): Tal GevaChapter 12 Anomalies of the Ventricular Septum (pages 175–187): Geoffrey A. Forbus and Girish S. ShiraliChapter 13 Tricuspid Valve and Right Atrial Anomalies (pages 188–213): Ulrike E. Salzer?MuharChapter 14 Mitral Valve and Left Atrial Anomalies (pages 214–229): James C. Nielsen and Sharon E. O’BrienChapter 15 Common Atrioventricular Canal Defects (pages 230–248): Meryl S. CohenChapter 16 Anomalies of the Right Ventricular Outflow Tract and Pulmonary Valve (pages 249–263): Matthew S. Lemler and Claudio RamaciottiChapter 17 Pulmonary Atresia with Intact Ventricular Septum (pages 264–282): Jami C. LevineChapter 18 Abnormalities of the Ductus Arteriosus and Pulmonary Arteries (pages 283–296): Theresa A. TacyChapter 19 Anomalies of the Left Ventricular Outflow Tract and Aortic Valve (pages 297–314): John M. SimpsonChapter 20 Hypoplastic Left Heart Syndrome (pages 315–338): David J. Goldberg and Jack RychikChapter 21 Aortic Arch Anomalies: Coarctation of the Aorta and Interrupted Aortic Arch (pages 339–361): Jan Marek, Matthew Fenton and Sachin KhambadkoneChapter 22 Tetralogy of Fallot (pages 362–384): Shubhika Srivastava and Ira A. ParnessChapter 23 Truncus Arteriosus (pages 385–397): Mark B. Lewin and Jack C. SalernoChapter 24 Transposition of the Great Arteries (pages 398–416): Luc L. Mertens, Manfred Otto Vogt, Jan Marek and Meryl S. CohenChapter 25 Double?Outlet Ventricle (pages 417–438): Leo LopezChapter 26 Physiologically “Corrected” Transposition of the Great Arteries (pages 439–455): Erwin OechslinChapter 27 Functionally Univentricular Heart (pages 457–475): Stephane L. J. Moniotte and Catherine BarreaChapter 28 Cardiac Malpositions and Heterotaxy Syndrome (pages 476–501): Irene D. Lytrivi and Wyman W. LaiChapter 29 Congenital Anomalies of the Coronary Arteries (pages 502–522): J. Rene HerlongChapter 30 Vascular Rings and Slings (pages 523–536): Andrew J. PowellChapter 31 Connective Tissue Disorders (pages 537–546): Julie De Backer, Ann De Paepe, Bart Loeys and Harry C. DietzChapter 32 Cardiac Tumors (pages 547–555): Michele A. FrommeltChapter 33 Dilated Cardiomyopathy and Myocarditis (pages 557–580): Carolyn T. SpencerChapter 34 Hypertrophic Cardiomyopathy (pages 581–596): Colin J. McMahon and Javier GanameChapter 35 Restrictive Cardiomyopathy and Pericardial Disease (pages 597–618): Cecile Tissot, Christina Phelps and Adel K. YounoszaiChapter 36 Other Anomalies of the Ventricular Myocardium (pages 619–633): Mary Etta E. KingChapter 37 Kawasaki Disease (pages 635–647): Erik C. MichelfelderChapter 38 Rheumatic Fever (pages 648–656): Luciana T. YoungChapter 39 Infective Endocarditis (pages 657–668): Manfred Otto VogtChapter 40 Transesophageal Echocardiography (pages 669–686): J. Geoffrey StevensonChapter 41 3D Echocardiography (pages 687–716): Folkert Jan Meijboom, Annemien van den Bosch and Jackie McGhieChapter 42 Fetal Echocardiography (pages 717–744): Lisa K. HornbergerChapter 43 Vascular Ultrasound Imaging in Children (pages 745–753): Elif Seda Selamet Tierney and Tajinder P. SinghChapter 44 The Echocardiographic Assessment of Pulmonary Arterial Hypertension (pages 754–764): Jeffrey F. Smallhorn
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Overcoming Congestive Heart Failure: I Fully Recovered. You can too!

 Cardiovascular  Comments Off on Overcoming Congestive Heart Failure: I Fully Recovered. You can too!
Feb 102019
 

The American Heart Association says that Cardiovascular disease accounts for nearly 836,546 deaths in the US. That’s about 1 of every 3 deaths in the US. Cardiovascular diseases claim more lives each year than all forms of cancer and Chronic Lower Respiratory Disease combined.

In 2016, I was diagnosed with Congestive Heart Failure and became yet another such statistic. However, by making certain lifestyle changes, improving my diet, and following a very specific whole food supplement protocol, I was able to fully recover!
I invite you to join me on my personal journey as I battled congestive heart failure from utter despair to full recovery. I share the details of my personal experience with you and tell you exactly what I did to regain my health.

If you or a loved one have been diagnosed with congestive heart failure, you need to read this book. It could literally save your life or the life of a loved one.

 

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The Nuts and Bolts of Cardiac Resynchronization Therapy

 Cardiovascular  Comments Off on The Nuts and Bolts of Cardiac Resynchronization Therapy
Feb 032019
 

The Nuts and Bolts of Cardiac Resynchronization TherapyBy Tom Kenny, RNVice President, Clinical Education and Training, St. Jude Medical, Austin, TX, USACardiac resynchronization therapy (CRT) is an exciting new option for a growing number of heart failure patients, but CRT systems present special challenges to clinicians, even those accustomed to working with pacemakers. Now, Tom Kenny demystifies the field in this timely, easy-to-understand paperback.The Nuts and Bolts of Cardiac Resynchronization Therapy concentrates on the practical aspects of how these devices work and how to follow the growing number of patients who are using them to fight heart failure. Designed specifically for the non-specialist, the book explains how the device works, how and why CRT-paced ECGs look different, and how to test for proper function of a CRT system. It also includes a systematic (numbered sequence) guide to follow-up that you can use in the clinic.This practical reference offers:clear, straightforward explanations that require no prior training in device therapy many CRT ECGs to familiarize you with what you will encounter in practice a generous illustration program that includes diagrams, charts, and anatomy pictures to reinforce the text sensible advice on daily issues and troubleshooting systems current references to the latest clinical studies and device technology accessible information, organized for ease of navigation a helpful glossary at the end of the bookBoth practicing and prospective clinicians will find CRT much less daunting when The Nuts and Bolts of Cardiac Resynchronization Therapy is close at hand.Content: Chapter 1 Understanding Heart Failure (pages 1–5): Chapter 2 Cardiovascular Anatomy of the Healthy Heart (pages 6–10): Chapter 3 Cardiac Physiology and Heart Failure (pages 11–16): Chapter 4 Causes of Heart Failure (pages 17–22): Chapter 5 The Neurohormonal Model of Heart Failure (pages 23–26): Chapter 6 An Overview of Heart Failure Drugs (pages 27–33): Chapter 7 Ventricular Dyssynchrony (pages 34–37): Chapter 8 Arrhythmias in Heart Failure Patients (pages 38–53): Chapter 9 Indications for CRT (pages 54–63): Chapter 10 Types of CRT Systems (pages 64–71): Chapter 11 Implant Procedures (pages 72–78): Chapter 12 Basic Programming (pages 79–86): Chapter 13 Advanced Programming (pages 87–92): Chapter 14 Basic ECG Interpretation for CRT Systems (pages 93–102): Chapter 15 CRT System Optimization (pages 103–108): Chapter 16 Troubleshooting the Non?Responder (pages 109–115): Chapter 17 Defibrillation Basics (pages 116–124): Chapter 18 Advanced Defibrillation Functions (pages 125–134): Chapter 19 Advanced CRT ECG Analysis (pages 135–143): Chapter 20 DFT Management in CRT?D Patients (pages 144–149): Chapter 21 Atrial Fibrillation (pages 150–157): Chapter 22 CRT in Post?AV Nodal Ablation Patients (pages 158–162): Chapter 23 Special CRT Device Features (pages 163–168): Chapter 24 Diagnostics (pages 169–176): Chapter 25 A Systematic Guide to CRT Follow?Up (pages 177–185): Chapter 26 Troubleshooting (pages 186–189):
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