Cardiovascular Endocrinology:: Shared Pathways and Clinical Crossroads

 Cardiovascular, Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Cardiovascular Endocrinology:: Shared Pathways and Clinical Crossroads
Nov 212019
 

Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology.
Offering a wealth of information, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads provides a range of insights, including a novel view of the hormonal regulation of the vascular system and the disruption of the nitric oxide signaling system. It also addresses the role of fatty acids and cytokines in the development of this problem. Importantly, this unique title also provides a state-of-the-art update on the importance of other hormones such as thyroid hormone and steroids, as well as the pathophysiology of cardiovascular disease and controversies surrounding the use of hormone replacement therapy.
In all, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads is a first-of-its-kind title that discusses and summarizes important clinical topics in cardiology and endocrinology. It offers clinicians and researchers an important resource for navigating the increasingly interrelated pathways of cardiovascular and endocrinologic disorders. The authors discuss a range of important issues from epidemiology to bench research to translation of this research to clinical practice.

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Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches

 Endocrinology/Metabolism/Diabetes Mellitus, Radiology  Comments Off on Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
Nov 182019
 

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.

The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

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Minimally Invasive Therapies for Endocrine Neck Diseases

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Minimally Invasive Therapies for Endocrine Neck Diseases
Nov 142019
 

This handy book offers a complete overview of current minimally invasive techniques for the management of endocrine diseases of the neck, reflecting how, in the past few years, the development of various ultrasound-guided procedures and endoscopic/video-assisted surgical techniques has changed the approach to thyroid and parathyroid diseases. The book opens by describing the main diagnostic tools for thyroid, parathyroid and cervical lymph nodes, focusing especially on the new technologies for tissue characterization. The different minimally invasive treatment procedures involving either a percutaneous approach (ethanol injection, laser thermal ablation, radiofrequency thermal ablation, high-intensity focused ultrasound) or minimally invasive surgery are then described in detail.

The volume is intended for all clinicians and surgeons with an interest in the field of endocrinology and neck surgery. It provides a synthetic but clear description of the various available techniques from a technical point of view and discusses the main issues concerning each of them, permitting comparative evaluation in order to identify the best option in a particular case. It also reports the evidence available in the current literature.

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Diabetic Nephropathy: Methods and Protocols

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetic Nephropathy: Methods and Protocols
Nov 142019
 

This book provides a toolkit of novel research approaches for investigators to study diabetic nephropathy, including critical experimental models from the fly to the fish, cells in culture, and in vivo mammalian approaches. The collection also explores powerful techniques to image the kidney, such as traditional histological techniques as well as electron, confocal, and two-photon microscopy, pathophysiology of the diabetic kidney, and gene editing and regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Diabetic Nephropathy: Methods and Protocols seeks to foster new research directions and inspire ideas to enhance our understanding of diabetic nephropathy and to develop treatments for this condition.

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Diabetic Bone Disease: Basic and Translational Research and Clinical Applications

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetic Bone Disease: Basic and Translational Research and Clinical Applications
Nov 142019
 

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

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Nov 122019
 

Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab.
Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

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High Calorie Diet and the Human Brain: Metabolic Consequences of Long-Term Consumption

 Endocrinology/Metabolism/Diabetes Mellitus, Neurology/Neurosurgery  Comments Off on High Calorie Diet and the Human Brain: Metabolic Consequences of Long-Term Consumption
Nov 082019
 

The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.
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Type 2 Diabetes in Adults of All Ages, 2nd Edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Type 2 Diabetes in Adults of All Ages, 2nd Edition
Nov 062019
 

If you have recently been diagnosed with type 2 diabetes, you will need to make some changes in your life that seem unwelcome and unnecessary. There is a wide range of treatments for this form of diabetes, from dietary adjustment and increased activity through to tablets and the use of insulin. Each new stage can lead to anxiety and a feeling that you are not in control.

The best way to deal with diabetes is to develop a thorough understanding of the condition and how it affects you personally. This comprehensive reference book will provide you with all the information you need to put you in the driving seat so you can cope with any eventuality you may encounter.

Controlling your diabetes is the key to avoiding long-term health problems. If you can follow a healthy diet, control your weight and understand your medications you can look forward to good health and well-being for many years to come!

With this practical book you can take control of your health in the best way possible, because the greatest expert on your diabetes should be you.

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Nov 052019
 

Endocrine Pathophysiology offers a comprehensive introduction to diseases of the endocrine system. Rather than providing an overwhelming amount of content on one subject, this book serves as a bridge between basic endocrine physiology and endocrine disorders. Included in the text are case studies covering a variety of endocrine disorders in both inpatient and outpatient settings. With the changes in many medical school curriculums to a clinically-based curriculum, this book provides a cutting-edge approach to endocrine pathophysiology.

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Brain Glycogen Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Brain Glycogen Metabolism
Nov 022019
 

This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.
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