Immunological Aspects of Gastroenterology

 Gastroenterology/Hepatology, Immunology  Comments Off on Immunological Aspects of Gastroenterology
Jan 172019
 

Diseases of the gastrointestinal tract are common. There is increasing appreciation of the importance of the immune system in the pathogenesis of a number of these diseases. This book covers basic aspects of innate and adaptive immunity in the gastrointestinal tract, oral tolerance, and cellular and molecular mechanisms of acute and chronic inflammation. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease. Other topics include mucosal immunisation and intestinal transplantation immunology. The readership of this book includes clinicians, scientists, and students interested in the gastrointestinal tract.
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GIS for Emergency Preparedness and Health Risk Reduction

 Emergency  Comments Off on GIS for Emergency Preparedness and Health Risk Reduction
Jan 172019
 

Geographical Information Systems (GIS) have developed rapidly in recent years and now provide powerful tools for the capture, manipulation, integration, interrogation, modelling, analysis and visualisation of data – tools that are already used for policy support in a wide range of areas at almost all geographic and administrative levels. This holds especially for emergency preparedness and health risk reduction, which are all essentially spatial problems. To date, however, many initiatives have remained disconnected and uncoordinated, leading to less powerful, less compatible and less widely implemented systems than might otherwise have been the case. The important matters discussed here include the probabilistic nature of most environmental hazards and the semi-random factors that influence interactions between these and human exposures; the effects of temporal and spatial scales on hazard assessment and imputed risk; the effects of measurement error in risk estimation and the stratification of risks and their impacts according to socioeconomic characteristics; and the quantification of socioeconomic differences in vulnerability and susceptibility to environmental hazards.
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Excitation-Contraction Coupling and Cardiac Contractile Force

 Cardiovascular  Comments Off on Excitation-Contraction Coupling and Cardiac Contractile Force
Jan 162019
 

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait’ of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force&endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.
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Dialysing for Life: The Development of the Artificial Kidney

 Nephrology  Comments Off on Dialysing for Life: The Development of the Artificial Kidney
Jan 162019
 

Seeing a patient die under his hands because there is no adequate treatment causes an emotion and a frustration in a doctor, which sometimes stimulates him to try to develop a new type of treatment. Seeing so many wounded young soldiers die due to renal failure in World War I incited the German doctor Georg Haas to try to develop an artificial kidney. He had to give up in despair in 1928. Ten years later doctor Willem Kolff saw a young man die in his ward in the University Hospital of Groningen due to renal failure. By that time two essential factors for an artificial kidney had become available: a drug to keep the blood from clotting outside of the body and an efficient dialysing membrane through which waste substances can pass from the blood into the dialysing fluid. Kolff succeeded in creating the rotating artificial kidney which he started using in the town hospital of Kampen in 1943. The rotation of this artificial kidney started a revolution that made it possible for thousands of kidney patients all over the world to keep on living – and sometimes to forget their disease for the time being. In addition it gave rise to the development of other artificial organs such as the heart-lung machine, the artificial heart and the artificial eye. Doctor Jacob van Noordwijk, the author of this book, was Kolff’s first assistant in the treatment of the first 15 patients. How Kolff succeeded in spite of all the limitations imposed by the German occupation of the Netherlands and in spite of the absence of antibiotics and other medical tools which are common nowadays makes a story which may sound incredible. Yet it did happen and visitors to the town of Kampen can still see the hospital building where it all took place.
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Manual of Cancer Pain

 Oncology  Comments Off on Manual of Cancer Pain
Jan 162019
 

This manual covers basic information which should enable the successful diagnosis and treatment of 90 per cent of patients with pain due to cancer. Our aim has been not to trivialize the problem, which remains complex and in some cases difficult to solve, but to help all health care professionals involved in the care of cancer patients who are not pain specialists, to understand and be able to manage most of the situations they see in their clinical practice.
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Renal Failure: Diagnosis & Treatment

 Nephrology  Comments Off on Renal Failure: Diagnosis & Treatment
Jan 162019
 

Renal Failure, Diagnosis & Treatment is a practical book that provides a comprehensive description of the evaluation of renal insufficiency. It teaches the physician how to recognise the tell-tale signs of the diseases that cause kidney failure and how to confirm their presence in an efficient manner. Major teaching points are reinforced by the presentation of 20 problem cases for the reader’s diagnosis. The book also details the general management of the patient with renal failure and the treatment of various causative diseases.
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Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy

 Cardiovascular  Comments Off on Cardiac Positron Emission Tomography: Viability, Perfusion, Receptors and Cardiomyopathy
Jan 162019
 

Myocardial viability has become one of the most important issues in clinical cardiology. In particular, absence or presence of viability may be decisive in patient management, and the decision to perform angioplasty (PTCA) or bypass surgery (CABG) is frequently based on the accurate assessment of viability. Although echocardiography and conventional nuclear medicine techniques may provide valuable information on viability, positron emission tomography (PET) is currently considered to be the gold standard for the assessment of myocardial viability. The simultaneous evaluation of myocardial metabolism and perfusion allows precise delineation and accurate quantification of residual myocardial viability in affected regions. In addition, accurate quantification of myocardial perfusion alone may provide insight into the basic mechanisms of syndrome X and may assist in the appropriate clarification of this clinically complicated, but frequently occurring phenomenon. Besides that, cardiac PET may deepen our insight into metabolism and perfusion of cardiac muscle disease, particularly in hypertrophic cardiomyopathy. Furthermore, receptor imaging studies with PET will become important as the study of cardiac neurohumoral regulation in heart failure has gained in interest. Cardiac Positron Emission Tomography: Viability, Perfusion,Receptors and Cardiomyopathy describes the most recent developments in cardiac PET as these are related to myocardial viability and myocardial perfusion studies of syndrome X. The value of PET for receptor imaging and cardiac muscle disease is also discussed. For cardiologists, nuclear medicine physicians, radiochemists, physiologists, technicians and basic researchers interested in understanding the most recent achievements in cardiovascular PET.
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Current and Future Immunosuppressive Therapies Following Transplantation

 Immunology  Comments Off on Current and Future Immunosuppressive Therapies Following Transplantation
Jan 162019
 

This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.

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Handbook of Phenomenology and Medicine

 Miscellaneous  Comments Off on Handbook of Phenomenology and Medicine
Jan 162019
 

 

As the fields of philosophy of medicine and bioethics have developed in the United States, the philosophical perspective of phenomenology has been largely ignored. Yet, the central conviction that informs this volume is that phenomenology provides extraordinary insights into many of the issues that are directly addressed within the world of medicine. Such issues include: the nature of medicine itself; the distinction between immediate experience and scientific conceptualization; the nature of the body – and the implications of embodiment in the realm of clinical practice; the meaning of health, illness and disease; the problem of intersubjectivity – particularly with respect to achieving successful communication with another; the complexity of decision-making in the clinical context (and in the realm of medical ethics); the possibility of empathic understanding; the theory and method of clinical practice; and the essential characteristics of the therapeutic relationship – i.e. the relationship between the sick person and the one who professes to help. Some of the authors who have contributed to this volume are philosophers, some are engaged in other academic disciplines, and several are practicing healthcare professionals.
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Ultrasonography in Ophthalmology 14: Proceedings of the 14th SIDUO Congress, Tokyo, Japan 1992

 Ophthalmology  Comments Off on Ultrasonography in Ophthalmology 14: Proceedings of the 14th SIDUO Congress, Tokyo, Japan 1992
Jan 162019
 

Ultrasonography in Ophthalmology 14 presents a selection of the papers presented at the 14th SIDUO Congress, Tokyo, Japan, 1992. The papers have been grouped into the following subjects: instrumentation and techniques, biometric ultrasound, diagnosis of intraocular disease, and diagnosis of orbital and periorbital disease. Audience: All those involved in ophthalmic ultrasonography.
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