Jul 242017
 

Muscle Biophysics: From Molecules to Cells (Advances in Experimental Medicine and Biology)


Features: Used Book in Good Condition

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.
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Jul 242017
 

Scleritis (Essentials in Ophthalmology)


This book offers a concise but comprehensive overview of scleritis, with up-to-date information on all aspects, including diagnosis and treatment. Fundamental features of the pathogenesis of scleral inflammation are first discussed as a basis for understanding the therapeutic strategies. Detailed descriptions are then provided of clinical manifestations, the complications that can arise during the course of the disease process, and the best way to manage them. An individual chapter is devoted to infectious scleritis and its management, this being an uncommon but serious condition that may result not only in loss of vision but also in loss of the globe itself. The diagnostic approach to and various management options for scleritis are then discussed extensively, with coverage of local and systemic therapy and new strategies, including biologics. Apart from the potential impact on vision, inflammation of the sclera carries a risk of association with systemic diseases, some of which can prove fatal if not promptly recognized and managed. This book is designed to allow ophthalmologists to easily identify the condition and the signs indicative of a more severe problem. It will thereby assist in safe and effective management, and help in preserving vision and life.

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Jul 242017
 

Microbial Biomass Process Technologies and Management


By (author): Basanta Kumara Behera, Ajit Varma

This book describes how microbes can be used as effective and sustainable resources to meet the current challenge of finding suitable and economical solutions for biopharmaceuticals, enzymes, food additives, nutraceuticals, value added biochemicals and microbial fuels, and discusses various aspects of microbial regulatory activity and its applications. It particularly focuses on the design, layout and other relevant issues in industrial microbe applications. Moreover, it discusses the entire microbial-product supply chain, from manufacturing sites to end users, both in domestic and international markets, providing insights into the global marketing of microbes and microbial biomass-derived products. Further, it includes topics concerning the effective production and utilization of eco-friendly biotechnology industries. It offers a valuable, ready-to-use guide for technologists and policymakers developing new biotechnologies.

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Jul 232017
 

Christensen’s Physics of Diagnostic Radiology


Features: Medical, Radiology
By (author): Thomas S. Curry III MD, James E. Dowdey PhD, Robert E. Murry Jr. PhD

The Fourth Edition of this text provides a clear understanding of the physics principles essential to getting maximum diagnostic value from the full range of current and emerging imaging technologies. Updated material added in areas such as x-ray generators (solid-state devices), xerography (liquid toner), CT scanners (fast-imaging technology) and ultrasound (color Doppler).

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Jul 232017
 

Breast Disease: Diagnosis and Pathology


This first of two volumes provides and in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The book is organised in themed parts exploring topics such as epidemiology, risk factors, genetic biomarkers, pathological evaluation of tumors and biopsy techniques.

With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.

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Jul 232017
 

Network Medicine: Complex Systems in Human Disease and Therapeutics


Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.

Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.

By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

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Jul 232017
 

Underground Clinical Vignettes: Biochemistry: Classic Clinical Cases for USMLE Step 1 Review


Features: Used Book in Good Condition
By (author): Vikas Bhushan, Vishal, M.D. Pall, Tao Le, Jose M. Fierro, Hoang Nguyen

USMLE Step 1 Review Blackwell’s Underground Clinical Vignettes (subject, ed.) is your primary source for clinically relevant, case-based material essential for Step 1 review. Each Clinical Vignette simulates USMLE format, and includes classic buzzwords in Hx, PE, lab, imaging and pathology. This revised edition contains: Carefully selected cases templated to fit the way you are tested and taught to think – Valuable links to Step 1 and 2 Atlases for emphasis on photographic case studies – 50+ new cases compatible with the updated content of USMLE Step 1 Study with the student-to-student publisher you can trust! Blackwell’s Underground Clinical Vignettes Step 1 Series: Anatomy, 3e 0-632-04541-8Behavioral Sciences, 3e 0-632-04543-4Biochemistry, 3e 0-632-04545-0Microbiology V.I, 3e 0-632-04547-7Microbiology V.II, 3e 0-632-04549-3Pathophysiology V.I, 3e 0-632-04551-5Pathophysiology V.II, 3e 0-632-04553-1Pathophysiology V.III, 3e 0-632-04555-8Pharmacology, 3e 0-632-04557-4Basic Science Color Atlas 0-632-04635-X Perfect for medical students – physician assistants, nurse practitioners and related health professionals will also find Undergrond Clinical Vignettes valuable. Available at Medical Bookstores everywhere! Or contact:1-800-449-2758email: csbooks@blacksci.com
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Jul 232017
 

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection


Features: Used Book in Good Condition

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.
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Jul 232017
 

Applications of Microdialysis in Pharmaceutical Science


Discover new and emerging applications for microdialysis in drug evaluation

Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include:

  • Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases

  • Continuous measurement of glucose concentrations in diabetics

  • Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs

  • Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs

  • Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution

  • Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring

Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.

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Jul 232017
 

Maldynia: Multidisciplinary Perspectives on the Illness of Chronic Pain


Whether initiated by injury or disease, induced and sustained by changes in the nervous system, or manifested by society and culture, chronic pain can change one’s first-person experience of the body and the world, and ultimately impacts cognitions, emotions, and behavior. Many fine medical books address the causes and management of chronic intractable pain, but rarely do they focus on the ways that such pain creates illness and is experienced and expressed by persons in pain.

Maldynia: Multidisciplinary Perspectives on the Illness of Chronic Pain is about chronic pain that has progressed to a multidimensional illness state in and of itself. Although often dismissed as such, this pain is not imaginary, but rather represents an interaction of neurobiological processes, emotional and behavioral responses, and socio-cultural effects and reactions that become enduring elements in the life and world of the pain patient, and often remain enigmatic for those who provide care.

Taking a comprehensive approach that covers science, humanities, and culture, this volume emphasizes the need for researchers, clinicians, and caregivers to regard the ways in which chronic intractable pain becomes illness and affects a patient’s biological, social, and psychological states, as well as his or her sense of self. Edited by neuroscientist and neuroethicist James Giordano, this book contains 17 insightful chapters representing medicine, neuroscience, psychology, philosophy, ethics, history, art, and the ministry.

This exceptional volume also looks at representations of pain in and through the arts, addresses the assignation of values and meaning in pain assessment and treatment, and considers ways to conjoin the sciences and humanities so as to inform the practice of pain medicine and improve the care of those suffering the illness of chronic pain.

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