Chromosomal Instability in Cancer Cells

 Oncology  Comments Off on Chromosomal Instability in Cancer Cells
Nov 122019
 

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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Sexual Health (Essential Clinical Skills for Nurses)

 Sexual Medicine  Comments Off on Sexual Health (Essential Clinical Skills for Nurses)
Nov 122019
 

Sexual health is a prominent public health issue and nurses are often the first point of contact for people wanting treatment for, or advice about, sexual health. This practical guide for newly qualified student nurses and pre-registration nursing students is based around the RCN’s core sexual health competencies and outlines the skills needed to deliver optimum care for clients.Sexual Health explores a range of issues, including sexually transmitted infections, teenage pregnancy, contraception, abortion, legal and ethical issues, sexual assault and rape, and the role of the nurse in sexual health. Together with epidemiology, facts and figures the book also includes scenarios which nurses can relate to in their practice.Key Features:* In the Essential Clinical Skills for Nurses series* Concise, practial guide for newly qualified nurses* Each chapter provides further resources and useful websites* Focuses on key skills and knowledge acquired by nurses
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The Normal and Pathological Fetal Brain: Ultrasonographic Features

 Neurology/Neurosurgery, Pathology, Radiology  Comments Off on The Normal and Pathological Fetal Brain: Ultrasonographic Features
Nov 122019
 

This book provides assistance in preparing for and conducting screening or diagnostic ultrasound examinations of the fetal brain in all stages of pregnancy. Readers are provided with: abundantly illustrated descriptions of studies conducted on normal brain structures using all conventional and 3D/4D ultrasound techniques; a detailed description of the main structures of the brain; photographs of fetal pathology specimens that may be used to compare the results of imaging techniques with the anatomical reality; and practical advice and technical tips. The second part of this book presents a clear and informative overview of fetal brain pathologies, combining a wealth of detailed images and precise descriptions.

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The Spectrum of Psychotic Disorders: Neurobiology, Etiology & Pathogenesis

 Neurology/Neurosurgery, Pathology  Comments Off on The Spectrum of Psychotic Disorders: Neurobiology, Etiology & Pathogenesis
Nov 122019
 

The spectrum of psychotic disorders encompasses as many as 25 different etiologies, ranging from the primary psychoses through those secondary to medical conditions, drugs and medications, and sensory impairments. This book provides a one-stop, comprehensive review of these disorders and gives quick comparisons for diagnostic decision-making to help with difficult differential diagnoses. Every chapter is uniformly structured to show comparisons between each disorder of presentation, course, and underlying neuropathology. Evidence for each etiology is also rated, indicating the confidence level the reader can place in the current findings. The international team of authors also examines data supporting a unitary neurobiological model of psychosis and the hypothesis that psychosis is a neurobiological syndrome similar to aphasia or apraxia. This book represents a paradigm shift in understanding, classifying and diagnosing these disorders, providing directions for future research and treatment. It will be of great interest to psychiatrists and neuroscientists alike.
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Obstructive Airway Diseases : Role of Lipid Mediators

 Miscellaneous  Comments Off on Obstructive Airway Diseases : Role of Lipid Mediators
Nov 122019
 

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states.
Topics discussed include:
– Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options
– What constitutes a lipid and how it is broken down to generate biologically active mediators
– The role of enzymes in the process of lipid mediator synthesis
– The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation
– Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid
– Proresolution lipid mediators in inflammatory airway disease conditions
– The role of sphingosine and ceramide in inflammatory airway disease
– Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers
The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research.
Punit Srivastava maintains a blog with additional information about the book and his work.

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Drug Abuse and Addiction in Medical Illness: Causes, Consequences and Treatment

 Psychiatry  Comments Off on Drug Abuse and Addiction in Medical Illness: Causes, Consequences and Treatment
Nov 122019
 

Drug abuse and addiction are common in clinical practice. Often they interfere with patient treatment or require an alternative approach. Drug Abuse and Addiction in Medical Illness: Causes, Consequences, and Treatment is a major contribution to the literature, a gold standard title offering a comprehensive range of topics for those who care for patients with addiction, conduct research in this area, or simply have an interest in the field.   Offering state-of-the-art information for all those working with drug abusing or addicted patients, or for those interested in this topic from other research perspectives, the volume is a first of its kind book – rich, comprehensive, yet focused, addressing the needs of the very active theoretical, basic, and clinical research in the field. Comprised of 46 chapters organized in four sections and developed by the leading international experts, Drug Abuse and Addiction in Medical Illness: Causes, Consequences, and Treatment covers virtually every core, as well as contemporary, topic on addiction, from the established theories to the most modern research and development in the field.  Enhancing the educational value of the volume, every chapter includes an abstract and two boxes summarizing learning objectives and directions for future research.  Drug Abuse and Addiction in Medical Illness: Causes, Consequences, and Treatment discusses the topic in a authoritative, systematic manner and is an indispensable reference for all clinicians and researchers interested in this rapidly changing field.
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Neurological Complications of Systemic Cancer and Antineoplastic Therapy

 Neurology/Neurosurgery, Oncology  Comments Off on Neurological Complications of Systemic Cancer and Antineoplastic Therapy
Nov 122019
 

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.

Highlights include:

– The pathophysiology and molecular biology of cancer and the metastatic phenotype

– Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses

– Metabolic and nutritional disorders

– CNS infections

– Neurological complications of immunotherapy and bone marrow transplants

Additional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy.

Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

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The Manual of Dermatology

 Dermatology  Comments Off on The Manual of Dermatology
Nov 122019
 

The Manual of Dermatology was developed by Dr. Cafardi at the University of Alabama at Birmingham, Department of Dermatology, and covers broad dermatological topics necessary for any dermatology resident treating patients. Topics include alopecia, medication dosing and management pearls, fungal disorders, genodermatoses, differential diagnoses of various skin diseases, management of infections, surgical anatomy and tips, HIV dermatology, pediatric dermatology, and skin cancer management and terminology. The practicality of this book is unique and includes key clinical data for residents, making it essential as a reference for quick differential diagnoses, work-up tips, management, and treatment options.
This quick reference offers a more practical approach to dermatology, with drug names and dosing, and more information on mycology/onychomycosis than any other handbook on the market. The Manual of Dermatology is portable, comprehensive, easily accessible, and is based upon algorithms, tables, and pearls taught to dermatology medical students, making it a vital resource in all university medical libraries across the country.

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Chemotherapy-induced neuropathic pain

 Neurology/Neurosurgery, Oncology  Comments Off on Chemotherapy-induced neuropathic pain
Nov 122019
 

There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.
Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.
The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

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Biomaterials in Regenerative Medicine and the Immune System

 Immunology  Comments Off on Biomaterials in Regenerative Medicine and the Immune System
Nov 112019
 

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

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