cGMP: Generators, Effectors and Therapeutic Implications

 Pharmacology  Comments Off on cGMP: Generators, Effectors and Therapeutic Implications
Feb 082018
 

 

After the discovery of endogenous NO formation in the late ’80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

 

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http://nitroflare.com/view/6BC7899130D9D67/cGMP_Generators%2C_Effectors_and_Therapeutic_Implications.pdf

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Recent surveys demonstrate a high and possibly increasing prevalence of mental disorders in prisoners. They have an increased risk of suffering from a mental disorder that transcends countries and diagnoses.

 Psychiatry  Comments Off on Recent surveys demonstrate a high and possibly increasing prevalence of mental disorders in prisoners. They have an increased risk of suffering from a mental disorder that transcends countries and diagnoses.
Feb 082018
 

 

Recent surveys demonstrate a high and possibly increasing prevalence of mental disorders in prisoners. They have an increased risk of suffering from a mental disorder that transcends countries and diagnoses.

 

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http://nitroflare.com/view/FE74CBEE50EAC25/9400700857.pdf

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The SAGES Manual on the Fundamental Use of Surgical Energy

 Surgery  Comments Off on The SAGES Manual on the Fundamental Use of Surgical Energy
Feb 082018
 

 

The SAGES Manual on the Fundamental Use of Surgical Energy (FUSE) emphasizes good communication and promotes best practice for the use of electrosurgical, ultrasonic, and microwave energy sources in the operating theatre.

 

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Patch-Based Techniques in Medical Imaging: Third International Workshop

 Uncategorized  Comments Off on Patch-Based Techniques in Medical Imaging: Third International Workshop
Feb 082018
 

 

This book constitutes the refereed proceedings of the Third International Workshop on Patch-Based Techniques in Medical Images, Patch-MI 2017, which was held in conjunction with MICCAI 2017, in Quebec City, QC, Canada, in September 2017.
The 18 regular papers presented in this volume were carefully reviewed and selected from 26 submissions. The papers are organized in topical sections on multi-atlas segmentation; segmentation; Alzheimer’s disease; reconstruction, denoising, super-resolution; tumor, lesion; and classification, retrival.

 

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http://nitroflare.com/view/1F59A0B26A44318/3319674331.pdf

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Investigating the Human Genome

 Genetics  Comments Off on Investigating the Human Genome
Feb 082018
 

 

Leading medical genetics scholar Moyra Smith reviews curret and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role.

 

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http://nitroflare.com/view/E544DBB3FA05E4F/0132168146.pdf

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Drug Therapy in Cardiology

 Cardiovascular  Comments Off on Drug Therapy in Cardiology
Feb 082018
 

 

At nearly every cardiology conference, whether in Europe or in the U.S., new clinical trial data is published. At times, so much information is published that the busy clinical cardiologist does not have time to keep abreast of the latest and preferred therapies.

 

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http://nitroflare.com/view/CE36C2208C4C779/185317629X.pdf

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Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface

 Pharmacology  Comments Off on Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface
Feb 082018
 

 

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies―this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.
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Homeopathy and its Kindred Delusions

 Hematology  Comments Off on Homeopathy and its Kindred Delusions
Feb 082018
 

 

When a physician attempts toconvince a person, who has fallen into the Homoeopathic delusion, of the emptiness of its pretensions, he is often answered by a statement of cases in which its practitioners are thought to have effected wonderful cures.

The main object of the first of these Lectures is to show, by abundant facts, that such statements, made by persons unacquainted with the fluctuations of disease and the fallacies of observation, are to be considered in general as of little or no value in establishing the truth of a medicaldoctrine or the utility of a method of practice.Those kind friends who suggest to a person suffering from a tedious complaint, that he “Had better try Homoeopathy,” are apt to enforce their suggestion by adding, that “at any rate it can do no harm.”

Thismay or may not be true as regards the individual. But it always does very great harm to the community to encourage ignorance, error, or deception in a profession which deals with the life and health of our fellow-creatures. Whether or not those who countenance Homoeopathy are guilty of this injustice towards others, the second of these Lectures may afford them some means of determining.To deny that good effects may happen from the observance of diet and regimen when prescribed by Homoeopathists as well asby others, would be very unfair to them.

But to suppose that men with minds so constituted as to accept such statements and embrace such doctrines as make up the so-called science of Homoeopathy are more competent than others to regulate the circumstanceswhich influence the human body in health and disease, would be judging very harshly the average capacity of ordinary practitioners.

 

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http://nitroflare.com/view/D5286E76080ED30/Homeopathy_and_its_Kindred_Delusion_-_Oliver_Wendell_Holmes.epub

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The End of Old Age: Living a Longer, More Purposeful Life

 Geriatrics  Comments Off on The End of Old Age: Living a Longer, More Purposeful Life
Feb 082018
 

 

The acclaimed author of How We Age, whose “descriptive powers are a gift to readers” (Sherwin Nuland), presents a hopeful and practical model of aging–a guide to understanding how we can all make the journey better.

As one of America’s leading geriatric psychiatrists, Dr. Marc Agronin sees both the sickest and the healthiest of seniors. He observes what works to make their lives better and more purposeful and what doesn’t. Many authors can talk about aging from their particular vantage points, but Dr. Agronin is on the front lines as he counsels and treats elderly individuals and their loved ones on a daily basis. The latest scientific research and Dr. Agronin’s first-hand experience are brilliantly distilled in The End of Old Age–a call to no longer see aging as an implacable enemy and to start seeing it as a developmental force for enhancing well-being, meaning, and longevity.

Throughout The End of Old Age, the focus is squarely on “So what does this mean for me and my family?” In the final part of the book, Dr. Agronin provides simple but revealing charts that you can fill out to identify, develop, and optimize your unique age-given strengths. It’s nothing short of an action plan to help you age better by improving how you value the aging process, guide yourself through stress, and find ways to creatively address change for the best possible experience and outcome.

 

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http://nitroflare.com/view/C4FC8B84CE69D52/The_End_of_Old_Age_-_Marc_E._Agronin_M.D_.epub

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Complementary Therapies in Maternity Care: An Evidence-Based Approach

 Ob/Gynae  Comments Off on Complementary Therapies in Maternity Care: An Evidence-Based Approach
Feb 082018
 

 

 

 

The complete textbook on complementary therapies in maternity care, this book addresses how midwives and other birth professionals can use or advise on complementary therapies for pregnant, labouring and new mothers.

Almost 90% of women may be using complementary therapies during pregnancy and birth, and increasingly midwives and doulas incorporate therapies into their care of women, so it is vital that they and other professionals in the maternity care field are aware of safe and appropriate use based on contemporary evidence. Therapies covered include acupuncture, herbal medicine, homeopathy, aromatherapy, reflexology, yoga, massage and hypnosis.

This complete guide to complementary therapies in pregnancy and childbirth covers safety, effectiveness, evidence, benefits and risks, legal, ethical and professional issues based on accurate and up-to-date research.

 

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http://nitroflare.com/view/27699AAC1FF5464/1848193289.epub

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