Jan 132017
 

Immunotherapy for Gastrointestinal Cancer


This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy.

Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection.  The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed.  Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage.

Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.  

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Jan 092017
 

Lewin, Weinstein and Riddell’s Gastrointestinal Pathology and its Clinical Implications (2 Volume set) (Gastrointestinal Pathophysiology (Lewin))


By (author): Robert Riddell MD, Dhanpat Jain MD

Lewin Gastrointestinal Pathology and Its Clinical Implications, Second Edition

This comprehensive, two-volume resource highlights the practical aspects of the pathology of biopsies and gross specimens, the clinical/pathological correlation, and differential diagnoses, and the ways in which these affect the management of patients with gastrointestinal disorders. The authors provide valuable insights on many important areas of gastrointestinal pathology, and openly address controversies within the specialty. This all-inclusive work stands alone in its illustrative quality and in its emphasis on the clinical implications of patient management as related to pathologic findings.

The Second Edition has been completely revised to reflect two decades of advances in the field. The book’s focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management. Major revisions of the chapters on colitis and gastritis feature new approaches to treatment. Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices. 

NEW to the Second Edition…

  • Completely revised content reflects two decades of advances in the field.
  • Focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management
  • Major revisions of the chapters on colitis and gastritis feature new approaches to treatment.
  • Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices.
Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:
  • Complete content with enhanced navigation
  • A powerful search that pulls results from content in the book, your notes, and even the web
  • Cross-linked pages, references, and more for easy navigation
  • Highlighting tool for easier reference of key content throughout the text
  • Ability to take and share notes with friends and colleagues
  • Quick reference tabbing to save your favorite content for future use


Pick up your copy today!


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Jan 062017
 

Signaling Pathways in Liver Diseases


Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

  • Autophagy
  • Notch Pathway
  • P13K/PTEN Signaling in Liver Diseases
  • Sirtuins
  • Hepcidin and Iron
  • Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
  • Oxidative Stress and Signaling in the Liver.

Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.

Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

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Jan 032017
 

Nuclear Hepatology: A Textbook of Hepatobiliary Diseases


Features: Used Book in Good Condition
By (author): Gerbail T. Krishnamurthy, S. Krishnamurthy

Since the publication of the first edition of Nuclear Hepatology almost 10 years ago, new advances have taken place, both in our understanding of liver pathophysiology and various imaging modalities. A unique feature of imaging of physiology is that it enables quanti- cation. Since liver physiology is complex, quantification has been a challenge. Many p- lications in the past have often included quantification based on home-made software not available for others. Thus, the comparison of results from one center to another becomes difficult, if not impossible. The second edition of Nuclear Hepatology addresses these issues. Sophisticated software for liver and gallbladder function has been tested and va- dated through many of our previous publications. Now that software is FDA approved and available for others through a commercial company, it is hoped that future publications of imaging of liver and gallbladder physiology would routinely include quantification. Although the function of the hepatocyte is complex, it can be broadly divided into two main categories, substrate uptake at the basolateral border and intracellular transit prior to excretion into the canaliculi. The earliest manifestation of hepatocellular injury occurs in the form of prolongation of the intracellular transit time, which occurs long before the disruption of the basolateral border with subsequent rupture and death. The liver enzymes are released into circulation after the death of the hepatocyte.
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Dec 312016
 

Pathology of Pediatric Gastrointestinal and Liver Disease


Pathology of Pediatric Gastrointestinal and Liver Disease provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. With an emphasis on clinical-pathological correlation, the book includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts. Among the topics considered are malabsorption and motility disorders, immunodeficiencies, including AIDS, developmental malformations, food allergies, cystic diseases of the liver, hepatic tumors, and esophageal and pancreatic disorders. Many new illustrations and electron micrographs are included in this edition, and the high-quality endoscopic and radiographic images permit ready correlation with the pathologic principles under discussion.

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Dec 292016
 

The Gastrointestinal System at a Glance


Features: Used Book in Good Condition
By (author): Satish Keshav, Adam Bailey

This concise introduction to the gastrointestinal system encapsulates the fundamental facts and principles of this rapidly growing and changing specialty. Written by experienced clinicians and teachers, the text covers the basic concepts of both the science surrounding the gastrointestinal system and the basics of clinical practice in an accessible, lucid format.

Now fully supported by a companion website at www.ataglanceseries.com/gastro containing interactive MCQs and downloadable digital flashcards, The Gastrointestinal System at a Glance is the ideal revision aid for medical and allied health students, and provides valuable insight for anyone seeking a comprehensive and concise guide to this subject area.

  • Fully revised and updated to include further coverage of diagnostic and therapeutic endoscopy, revised liver chapters and a new chapter on embryology
  • Now in full colour throughout
  • Supported by a companion website containing interactive self-assessment and digital flashcards – perfect for both study and revision
  • Provides an integrated approach to both the basic and clinical science of this core specialty
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Dec 282016
 

Zoom Gastroscopy: Magnifying Endoscopy in the Stomach


By (author): Kenshi Yao

Since magnifying endoscopy of the stomach, or zoom gastroscopy, was first performed at the beginning of the 21st century , there have been numerous findings in the field worldwide. The author of this volume has developed a standardized magnifying endoscopy technique that enables endoscopists to constantly visualize the microanatomy (subepithelial capillaries and the epithelial structure) within the stomach. With this technology, it has become easy to obtain magnified endoscopic findings. Techniques differ, however, depending upon the endoscopist. Endoscopists around the world do not have a standardized magnifying endoscopy technique, which is mandatory for the scientific analysis of their findings. In addition, there is no logical explanation for how and which microanatomies are visualized by magnifying endoscopy with narrow-band imaging in the glandular epithelium of the stomach. This inconsistency results in considerable confusion among researchers and clinicians and a lack of terminology for the purposes of analysis. As magnifying endoscopy with narrow-band imaging (NBI) becomes more popular throughout the world, there is increased demand for a specialized reference book focused on this subject. The aims of the present volume, Zoom Gastroscopy: Magnifying Endoscopy in the Stomach, are manifold: (1) to illustrate the standard magnifying endoscopic technique that can visualize subepithelial mucosal microvessels as small as capillaries, the smallest unit of blood vessels in the human body, (2) to explain the optical phenomena and principles for NBI and its application to magnifying endoscopy, (3) to clarify which microanatomies are visualized by magnifying endoscopy with NBI and how this is achieved, and (4) to present a diagnostic system so called “VS classification system” for early gastric neoplasias. With a single author, the book consistently uses uniform anatomical terms to describe endoscopic findings, providing an essential reference for endoscopists in the world.

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Dec 242016
 

Cotton and Williams’ Practical Gastrointestinal Endoscopy


By (author): Adam Haycock, Jonathan Cohen, Brian P. Saunders, Peter B. Cotton, Christopher B. Williams

Translated into seven languages, Cotton and Williams’ Practical Gastrointestinal Endoscopy has for the last 25 years been the basic primer for endoscopy around the world, providing clear, clinical and practical guidance on the fundamentals of endoscopy practice, from patient positioning and safety, how to perform different endoscopic procedures, and the latest in therapeutic techniques and advances in technology.

It’s key strength and reason for its popularity is its step-by-step, practical approach, especially with the use of outstanding colour artwork to illustrate the right and wrong ways to perform endoscopy. Add to this the weight and expertise of its author team, led by Peter Cotton and Christopher Williams, and the final result is an essential tool for all gastroenterologists and endoscopists, particularly trainees looking to improve their endoscopic technique.

Joining Peter Cotton, Christopher Williams and Brian Saunders in the seventh edition are two exciting stars in UK and US endoscopy, Adam Haycock and Jonathan Cohen.  New to this edition are:

  • Approximately 35 high-quality videos illustrating optimum endoscopy practice, all referenced via “video eyes” in the text
  • Self-assessment MCQs to test main learning points 
  • An online clinical photo imagebank to complement the line illustrations, perfect for downloading into scientific presentations 
  • Key learning points in every chapter
  • Much more information on mucosal resection techniques and small bowel endoscopy—for capsule and “deep” enteroscopy
  • The latest recommendations and guidelines from the ASGE, ASG, UEGW and BSG.

Cotton and Williams’ Practical Gastrointestinal Endoscopy, seventh edition is fully modernised, masterful as ever, and once again, the number one endoscopy manual for a whole new generation of gastroenterologists and endoscopists.

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Dec 232016
 

Hepatitis B Virus: Methods and Protocols (Methods in Molecular Biology)


This volume serves as a reference for the dissemination of advances made in the study of Hepatitis B Virus (HBV). Hepatitis B Virus: Methods and Protocols details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems, analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection, cloning, and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery. The book also covers classical methods for resolution of extracellular viral particles by native gel electrophoresis, and methods for detecting HBV antigens in drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Hepatitis B Virus: Methods and Protocols is a valuable tool for researchers to use toward their advanced studies in HBV.

 

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Dec 222016
 

Gastrointestinal Anatomy and Physiology: The Essentials


Gastroenterologists require detailed knowledge regarding the anatomy of the GI system in order to understand the disturbances caused by diseases they diagnose and treat. 

Gastrointestinal Anatomy and Physiology will bring together the world’s leading names to present a comprehensive overview of the anatomical and physiological features of the gastrointestinal tract. 

Full colour and with excellent anatomical and clinical figures throughout, it will provide succinct, authoritative and didactic anatomic and physiologic information on all the key areas, including GI motility, hepatic structure, GI hormones, gastric secretion and absorption of nutrients. 

GI trainees will enjoy the self-assessment MCQs, written to the level they will encounter during their Board exams, and the seasoned gastroenterologist will value it as a handy reference book and refresher for re-certification exams

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