Mar 252017
 

Histamine Receptors as Drug Targets (Methods in Pharmacology and Toxicology)


This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques.

Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
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Mar 252017
 

Biosimilar Drug Product Development (Drugs and the Pharmaceutical Sciences)


When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

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Mar 222017
 

Process Scale Purification of Antibodies


Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.

•    Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing
•    Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification
•    Emphasizes antibodies and innovative chromatography methods for processing

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Mar 222017
 

Transporters as Drug Targets, Volume 70 (Methods and Principles in Medicinal Chemistry)


As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.
Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation.
With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.
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Mar 212017
 

Dictionary of Pharmaceutical Medicine


By (author): Gerhard Nahler

This dictionary defines various terms typically used in pharmaceutical medicine. A new, 4th edition includes adaptations of the text to the steadily increasing regulatory requirements, particularly in the area of genetics/gene therapy, product quality (e.g., protection against falsified medicines) and of product safety (pharmacovigilance). Further evolving areas that are covered by the 4th edition are typical “grey zones” (health effects often borderline to medicinal products) such as cosmetics and dietary supplements where misleading information is prohibited on one hand but where any health claims need formal authorisation on the other. These but also other areas are reviewed and presented in an updated and – if justified – in an enlarged form.

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Feb 282017
 

Fundamentals of Clinical Psychopharmacology, Fourth Edition


Fundamentals of Clinical Psychopharmacology provides up-to-date, evidence-based and unbiased information about psychopharmacology. It spans the range of the discipline, from mode of action and side effects of drugs to meta-analyses of clinical trials. It is anchored to practice guidelines produced by the UK National Institute for Health and Care Excellence (NICE) and the British Association for Psychopharmacology (BAP). Care has been taken to provide an international perspective that makes it equally useful to practitioners in the US and other countries.

The book grew out of BAP courses that set the standard for professional psychopharmacological education in the UK. This latest edition is fully updated and provides, in a concise and easy-to-read format, key facts about currently used psychotropic drugs, set in the context of the neuroscience of the disorders they treat. It also includes a new chapter on the principles of psychiatric prescribing.

Key references, including the clinical studies discussed, are provided at the end of the chapter along with suggestions for further reading. Intended to be a frequently updated, affordable, concise and practical resource, it meets the needs of trainees and practitioners seeking to keep abreast of the state of the art in psychopharmacology.

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Feb 272017
 

Get Ahead! Basic Sciences: 500 SBAs


By (author): Priya Jeevananthan, Anna Kowalewski

Ideal for medical students studying basic sciences, Get ahead! Basic Sciences: 500 SBAs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion EMQ volume, an essential resource for your basic sciences exams.

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Feb 272017
 

Get Ahead! Basic Sciences: 100 EMQs


Features: CRC Press
By (author): Anna Kowalewski, Priya Jeevananthan

Ideal for medical students studying basic sciences, Get ahead! Basic Sciences: 100 EMQs covers anatomy, physiology, pharmacology and biochemistry, including clinical-based themes. Questions are accompanied by explanations to guide further review, making this, along with the companion SBA volume, an essential resource for your basic sciences exams.

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Feb 232017
 

Advances in Pulmonary Drug Delivery


The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

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Feb 232017
 

Introduction to Market Access for Pharmaceuticals


Market access is the fourth hurdle in the drug development process and the primary driver for global income of any new drug. Without a strategy in place for pricing, showing value for effectiveness and an understanding of the target purchasers’ needs, the drug will fail to reach its intended market value. Introduction to Market Access for Pharmaceuticals is based on an accredited course in this area, taken from the European Market Access University Diploma (EMAUD), and is affiliated with Aix Marseille University.

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