Jul 232017
 

Nitrite and Nitrate in Human Health and Disease (Nutrition and Health)


This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.

The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function.

Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

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Jul 232017
 

The Politics of Drugs: Perceptions, Power and Policies


By (author): Susanne MacGregor

This book explores the complexities of drugs policy in Britain, contradicting the over simplified representation found in the public sphere. It focuses on developments in Britain since the Misuse of Drugs Act of 1971, covering debates at national level and local experiences set in international and European context, emphasizing the interconnectivity between people and countries in this global age. Several institutions and networks are examined to illustrate how they shape the policy process as vessels for ideas and interests and as spaces for individual action. MacGregor discusses arguments around drug policy reform, in particular the role of politicians, the media and advocacy organizations. Her aim is to encourage a more open and intelligent conversation on drugs policy and to question whether the institutional architecture in place is fit for purpose given the great increase of substances available and the underlying variety of conditions and interests currently competing for attention and resources. The is a must read for all scholars of Politics, Medicine and Social Science interested in the current debate raging around British Drug Policy.
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Jul 232017
 

Current Essentials of Surgery


By (author): Gerard M. Doherty

Essential coverage of surgery! In the popular one-disorder-per-page format, this pocket guide features bulleted, high-yield information on over 400 common surgical diagnoses. With key equations and formulae, a clinical pearl per page, plus references, this book truly is essential in critical care.
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Jul 232017
 

Osteoarthritic Joint Pain


By (author): Novartis Foundation

Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; severe, chronic joint pain is often the central factor that causes patients to seek medical attention. Within the affected joint, there is focal degradation and remodelling of articular cartilage, new bone formation (osteophytes) and mild synovitis.

Several mechanisms are thought to contribute to osteoarthritic joint pain. These include mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength also influence the severity and duration of joint pain in osteoarthritis. Within the nervous system, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined, and there is limited information on the phenotype of sensory neurons in the OA joint. Importantly, there is no relation between clinical severity, as measured by radiographic changes, and the presence and severity of joint pain. Patients with severe joint pain may have normal joint architecture as determined by X-ray, whereas patients with considerable evidence of joint remodelling may not have significant joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise, corrective shoes and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis.

This book brings together contributions from key investigators in the area of osteoarthritic joint pain.  It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of osteoarthritic joint pain, identify key studies needed to advance understanding of the problem, highlight possible intervention points and indicate future pathways towards a better treatment of osteoarthritic joint pain.

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Jul 232017
 

Model Organisms in Spinal Cord Regeneration


This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.
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Jul 232017
 

Sepsis: Definitions, Pathophysiology and the Challenge of Bedside Management (Respiratory Medicine)


This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.?

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Jul 232017
 

Respiratory Outcomes in Preterm Infants: From Infancy through Adulthood (Respiratory Medicine)


This book presents pulmonary outcomes of prematurity, from their emergence in infancy through to their consequences in adulthood. With an increasing number of preterm births and more infants surviving, there is now a larger population of adults with lung disease originating in infancy requiring specialized care. Looking at the whole group of preterm infants, not just those with bronchopulmonary dysplasia, this text covers a wide spectrum of pulmonary outcomes, including: pulmonary hypertension, wheezing, and alterations in sleep. The chapter authors focus on critically appraising what is and is not known about each outcome and suggest key questions that still need to be answered. Respiratory Outcomes in Preterm Infants: Sequelae from Infancy through Adulthood is an ideal reference for the multidisciplinary group that cares for these preterm infants and the adults they become, including: neonatologists, pediatric pulmonologists, pediatricians, adult pulmonologists, primary care physicians, nurses, and fellows.

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Jul 232017
 

Compendium of Biophysics


By (author): Andrey B. Rubin

Following up on his first book, Fundementals of Biophysics, the author, a well-known scientist in this area, builds on that foundation by offering the biologist or scientist an advanced, comprehensive coverage of biophysics.  Structuring the book into four major parts, he thoroughly covers the biophysics of complex systems, such as the kinetics and thermodynamic processes of biological systems, in the first part.  The second part is dedicated to molecular biophysics, such as biopolymers and proteins, and the third part is on the biophysics of membrane processes.  The final part is on photobiological processes.

This ambitious work is a must-have for the veteran biologist, scientist, or chemist working in this field, and for the novice or student, who is interested in learning about biophysics.  It is an emerging field, becoming increasingly more important, the more we learn about and develop the science.  No library on biophysics is complete without this text and its precursor, both available from Wiley-Scrivener. 

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Jul 232017
 

Peripheral Retinal Degenerations: Optical Coherence Tomography and Retinal Laser Coagulation


This book provides an illustrated guide to peripheral retinal degenerations and the role of spectral domain coherence tomography (SD-OCT) in diagnosis and treatment. The book discusses 73 clinical cases and gives detailed information on the principles of SD-OCT and its application in the imaging of peripheral retina. 

Peripheral Retinal Degenerations: Optical Coherence Tomography and Retinal Laser Coagulation, 2nd edition, discusses a broad range of retinal pathologies such as chorioretinal degenerations, posterior vitreous detachment, vitreoretinal adhesions and tractions and includes a plethora of high-quality clinical images throughout. Ophthalmologists and retinal specialists will find this updated edition to be the perfect didactic resource for furthering skills and knowledge in this clinical area.  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Jul 222017
 

Brain Injury and Returning to Employment: A Guide for Practitioners


By (author): James Japp

`Brain Injury and Returning to Employment attempts to give the professional a broad introduction to dealing with clients who have suffered a brain injury of some sort. Although aimed at a wide range of professionals, from careers guidance workers through to social workers, the focus of the book is always on how the injury incurred affects the person’s ability to return to work…This book certainly provides the reader with a thorough introduction to this complex area. The information provided is detailed and holistic; never does Japp focus on just the physical implications of an injury. He sees the injury in the broadest sense how it affects the person emotionally and then how this impacts on their ability to work…It provides good practical advice: for example, when to pass to other professionals, such as occupational psychologists. There is also an excellent section on health and safety that takes the guidance worker through the items that would need thinking about when helping a person back to the working world.’ – Newscheck

`Japp has a talent for cutting straight through to the heart of a particular problem for a TBI client and for their case manager. He helps us to understand the problem and offers practical suggestions…He describes the importance of introducing appropriate strategies to overcome potential difficulties. This is where Japp admirably fills the gap between the assessment and the practice. It is in this respect that Japp’s book is so exceptional. He takes a factor such as concentration – a problem which the practitioner invariably encounters in cases of TBI – and he helps to unpick some of the difficulties in understanding its effects and how to help a client…Japp goes on with many valuable suggestions about working with employers. He remains positive and encouraging to the client and the practitioner throughout…It is especially gratifying to find such an exceptional book in the British canon of brain injury vocational rehab where the market has tended to be dominated for so long by American studies.’ – Rehabilitation Network (www.rehabilitation-network.org)

`This is thought to be the first ever guide on how healthcare and professionals from other sectors can support people with acquired brain injury to return to employment…In this publication, Japp offers effective occupational techniques to address impaired memory, attention and cognitive functions, the difficulties people have with planning and organising themselves, and speech and communication difficulties. He also deals with the environmental, emotional, physical and psychological barriers to work re-integration. This should be of use not only to healthcare professionals, but also to professionals in social care, careers and training settings in general.’ – Care and Health Magazine

The multi-disability nature of acquired brain injury and its complex effects make the return to employment particularly problematic. Brain Injury and Returning to Employment provides a clear overview of the cognitive and psychological difficulties associated with brain injury and discusses how people affected by it can prepare for and remain in employment.

The author offers effective occupational techniques to address impaired memory, attention and executive functions, and difficulties with organisation and planning skills, as well as the speech impairments commonly associated with acquired brain injury. He also examines the environmental, emotional, physical and psychological barriers to work reintegration and offers a range of solutions to these problems, including mentoring relationships with colleagues.

This book will be essential reading for professionals working with brain-injured individuals in the fields of psychology, occupational therapy, employment advisory services and human resources.

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