Emphasizing their emerging capabilities, this volume provides a strong foundation for an understanding of how micro- and nanotechnologies used in biomedical research have evolved from concepts to working platforms.
Volume editor Christopher Love has assembled here a highly interdisciplinary group of authors with backgrounds ranging from chemical engineering right up to materials science to reflect how the intersection of ideas from biology with engineering disciplines has spurred on innovations. In fact, a number of the basic technologies described are reaching the market to advance the discovery and development of biopharmaceuticals.
The first part of the book focuses on microsystems for single-cell analysis, examining tools and techniques used to isolate cells from a range of biological samples, while the second part is dedicated to tiny technologies for modulating biological systems at the scale of individual cells, tissues or whole organisms. New tools are described which have a great potential for (pre)clinical development of interventions in a range of illnesses, such as cancer and neurological diseases.
Besides describing the promising applications, the authors also highlight the ongoing challenges and opportunities in the field.
About the Author
J Christopher Love:
Ph.D., Harvard University, 2004
B.S., University of Virginia, 1999
Massachusetts Institute of Technology
Department of Chemical Engineering
Honors and Awards
Camille Dreyfus Teacher-Scholar Award, 2012
Two NIH Single-Cell Analysis Program awards, 2012
Popular Science’s ‘Brilliant 10, 2010
W.M. Keck Distinguished Young Scholar for Medical Research, 2009
Dana Scholar for Human Immunology, 2009
Life Sciences Research Foundation Postdoc Fellow (Gilead Sciences), 2004
Foresight Distinguished Student Award in Nanotechnology, 2000
Natl. Defense Science and Engineering Graduate Fellow, 1999-2002
Barry S. Goldwater Scholarship, 1998
Phi Beta Kappa, 1998
The Love Lab is exploring the heterogeneity present in populations of cells and characterizing the dynamic biological responses of individual cells subjected to defined perturbations. We develop new processes for analyzing large numbers of individual living cells quantitatively and dynamically. The primary approach uses simple technologies, based on soft lithography or unconventional nanofabrication, to measure multiple characteristics of single cells, and from those data, we aim to construct detailed profiles that describe the state and evolution of the cell itself or the multicellular population of which it is a member. The applications for these technologies that we are pursuing include clonal selection for bioprocess manufacturing, discovery of new immunotherapies, and immunological monitoring for diagnosis and biomedical research in clinical immunology.
The lab itself is an interdisciplinary and team-oriented environment. We apply concepts and techniques from surface chemistry, materials science, physics, and chemical engineering to address biological questions in immunology, microbiology, systems biology, and bioprocess engineering. Particular areas of emphasis in clinical immunology presently are infectious diseases and autoimmune disorders. We value expertise from a range of backgrounds relevant to these areas of research.
The long-term objectives of our work are to understand how heterogeneity in populations of cells affects their collective behaviors as a system, and to gain insights into the biological variations present in unique and rare cells from those populations. We also aim to facilitate the transfer of these technologies into clinical laboratories for extended use in biomedical research.
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