The Molecular Epidemiology of Human Viruses

 Epidemiology  Comments Off on The Molecular Epidemiology of Human Viruses
Feb 152019
 

Advances in DNA sequencing and phylogenetic inference have created powerful methods to investigate many dangerous human viruses. The Molecular Epidemiology Of Viruses provides a comprehensive introduction to the use of genetic methods in molecular epidemiology and in-depth examples of analyses from many viruses.This book is of interest to researchers in the fields of infectious disease, virology, microbiology, evolutionary biology, epidemiology and molecular biology as well as anyone interested in tracking the spread of disease.
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Genetic and Molecular Epidemiology of Multiple Myeloma

 Epidemiology, Genetics  Comments Off on Genetic and Molecular Epidemiology of Multiple Myeloma
Feb 152019
 

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma. This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.
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Epidemiology of Work Related Diseases, Second Edition

 Epidemiology  Comments Off on Epidemiology of Work Related Diseases, Second Edition
Feb 082019
 

This comprehensive, well referenced text provides an up to date review of what is known scientifically about occupational and environmental causes of sickness, disability, and death. It also includes information on the scientific methods used in acquiring this knowledge, making it a complete reference for both clinicians in occupational medicine, and researchers. Content: Chapter 1 Occupational Epidemiology (pages 1–6): Corbett McDonaldChapter 2 Metals and Chemicals (pages 7–39): Corbett McDonald and Pier BertazziChapter 3 Ionising Radiation (pages 41–57): Yutaka Hosoda and Sumiko SasagawaChapter 4 Electromagnetic Fields (pages 59–84): Gilles TherlaultChapter 5 Asbestos (pages 85–108): Corbett McDonaldChapter 6 Man?Made Mineral Fibres (pages 109–122): Paolo BoffettaChapter 7 Silica (pages 123–148): Carl ShyChapter 8 Asthma (pages 149–174): Anthony Newman TaylorChapter 9 Dermatoses (pages 175–194): Pieter?Jan Coenraads and Henriette SmitChapter 10 Neurobehavioural Disorders (pages 195–214): Olav AxelsonChapter 11 Noise and Vibration (pages 215–232): Peter PelmearChapter 12 Back and Limb Disorders (pages 233–265): Hilkka Riihimaki and Eira Viikari?JunturaChapter 13 Injuries at Work (pages 267–281): Craig ZwerlingChapter 14 Work Stress (pages 283–308): Benjamin Amick and Stanislav KaslChapter 15 Work in Agriculture (pages 309–329): James Merchant and Stephen ReynoldsChapter 16 Work and Pregnancy (pages 331–359): Alison McDonaldChapter 17 Occupation and Infertility (pages 361–380): Nicola CherryChapter 18 Study Design (pages 381–407): Corbett McDonald and Harvey CheckowayChapter 19 Assessment of Exposure (pages 409–435): Bruce CaseChapter 20 Measurement of Outcome (pages 437–461): Peter WesterholmChapter 21 Molecular Assessment of Exposure, Effect, and Effect Modification (pages 463–484): Andrew PoveyChapter 22 Evaluation of Preventive Measures (pages 485–510): Nicola CherryChapter 23 Analysis and Interpretation (pages 511–532): Geoffrey BerryChapter 24 Setting Health?Based Standards: From the Occupational to the General Environment (pages 533–537): Anthony Seaton
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Research Methods in Community Medicine: Surveys, Epidemiological Research, Programme Evaluation, Clinical Trials, Sixth Edition

 Epidemiology  Comments Off on Research Methods in Community Medicine: Surveys, Epidemiological Research, Programme Evaluation, Clinical Trials, Sixth Edition
Feb 022019
 

A simple and systematic guide to the planning and performance of investigations concerned with health and disease and with health careContent: Chapter 1 First Steps (pages 1–12): Chapter 2 Types of Investigation (pages 13–34): Chapter 3 Stages of an Investigation (pages 35–37): Chapter 4 Formulating the Objectives (pages 39–48): Chapter 5 The Objectives of Evaluative Studies (pages 49–60): Chapter 6 The Study Population (pages 61–68): Chapter 7 Control Groups (pages 69–76): Chapter 8 Sampling (pages 77–90): Chapter 9 Selecting Cases and Controls for Case?Control Studies (pages 91–99): Chapter 10 The Variables (pages 101–108): Chapter 11 Defining the Variables (pages 109–116): Chapter 12 Definitions of Diseases (pages 117–123): Chapter 13 Scales of Measurement (pages 125–132): Chapter 14 Composite Scales (pages 133–142): Chapter 15 Methods of Collecting Data (pages 143–150): Chapter 16 Reliability (pages 151–160): Chapter 17 Validity (pages 161–178): Chapter 18 Interviews and Self?Administered Questionnaires (pages 179–192): Chapter 19 Constructing a Questionnaire (pages 193–202): Chapter 20 Surveying the Opinions of a Panel: Consensus Methods (pages 203–207): Chapter 21 The Use of Documentary Sources (pages 209–224): Chapter 22 Planning the records (pages 225–232): Chapter 23 Planning the Handling of Data (pages 233–239): Chapter 24 Pretests and Other Preparations (pages 241–245): Chapter 25 Collecting the Data (pages 247–250): Chapter 26 Statistical Analysis (pages 251–257): Chapter 27 Interpreting the Findings (pages 259–268): Chapter 28 Making Sense of Associations (pages 269–296): Chapter 29 Application of the Study Findings (pages 297–304): Chapter 30 Writing a Report (pages 305–311): Chapter 31 Rapid Epidemiological Methods (pages 313–324): Chapter 32 Clinical Trials (pages 325–344): Chapter 33 Programme Trials (pages 345–355): Chapter 34 Community?Oriented Primary Care (pages 357–372): Chapter 35 Using the Web for Health Research (pages 373–381):
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Sepsis and Organ Dysfunction: Epidemiology and Scoring Systems Pathophysiology and Therapy

 Epidemiology, Pathology, Physiology  Comments Off on Sepsis and Organ Dysfunction: Epidemiology and Scoring Systems Pathophysiology and Therapy
Jan 212019
 

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism’s homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.
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Epidemic of Medical Errors and Hospital-Acquired Infections: Systemic and Social Causes

 Epidemiology, Infectious Diseases  Comments Off on Epidemic of Medical Errors and Hospital-Acquired Infections: Systemic and Social Causes
Dec 132018
 


Medical error as defined in Epidemic of Medical Errors and Hospital-Acquired Infections: Systemic and Social Causes encompasses many categories including, but not limited to, medical error, hospital-acquired infections, medication errors, deaths from misdiagnosis, deaths from infectious diarrhea in nursing homes, surgical and post-operative complications, lethal blood clots in veins, and excessive radiation from CT scans.

When the deaths from these categories are counted they become the leading cause of fatality to Americans, outpacing cancer and heart disease. Add the numbers of fatalities (mortality) to the millions each year who are injured (morbidity) and whose quality of life is forever effected, and an epidemic of harm is defined.

The book describes the many systemic and social causes of medical error and iatrogenic events, all of which are cited in the peer-review science, that have a direct effect on the epidemic of patient injury, but are rarely or never considered. These systemic causes include factory medicine (for-profit medicine), staffing ratios in clinical and non-clinical departments, shift work, healthcare working conditions, lack of accountability, legal issues that conflict with patient safety issues, bullying and hierarchical relationships, training of healthcare workers that never rises to the level of risk, and injury to healthcare workers. The premise of the book is that if the systemic or social causes are not considered or changed, then medical error will continue to be an epidemic and no substantial impact in the numbers will be realized.

An expert with 30 years of experience as a health and safety officer in healthcare and as an activist for community health and safety issues, editor and author William Charney explores the issues surrounding medical errors and examines the science behind possible solutions. He presents an efficient dialogue that produces a more systemic exploration and targeting of the causes of medical error and drives an exacting message: we are dealing with an epidemic of harm, and unless systemic issues are solved, little will change to subdue the epidemic.

Information on the June 2012 Conference on the Epidemic of Medical Errors & Hospital Acquired Infections in the US and Canada: the Systemic Causes can be found on the CRC Press Issuu page.

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Managerial Epidemiology

 Epidemiology  Comments Off on Managerial Epidemiology
Nov 282018
 

Managerial Epidemiology provides a solid balance of baseline materials on epidemiologic methods with a focus on tools and skills required to succeed as a healthcare manager. Logically organized, this first edition centers in on the purpose and focus ‘managerial epidemiology’, thus broadening the definition and scope of Epidemiology from the distribution, spread, and containment of health problems in populations to the planning, organization, and management of health services. Written specifically for current and future healthcare managers and masters students in Health Administration, this text is designed to develop hands-on, data-driven, analytic management skills. Managerial Epidemiology helps readers understand that epidemiologic data on incidence and prevalence in conjunction with administrative data on cost and quality are necessary to enhance access and delivery of high quality services in a cost-effective and efficient manner. Written with clarity and currency in mind, Manag
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Epidemiological Studies of Specified Rare and Intractable Disease

 Epidemiology  Comments Off on Epidemiological Studies of Specified Rare and Intractable Disease
Nov 252018
 

This book presents research findings from epidemiological studies investigating chronic and intractable diseases with unidentifiable causes from a clinical perspective. Each chapter provides the latest findings on specific diseases, including procedures for their study, insights into their causes, risk factors and preventive factors providing a foundation for new ideas and further development as well as establishing treatment procedures. Epidemiological Studies of Specified Rare and Intractable Disease(Nanbyo in Japanese) is a valuable resource for both new and established researchers as well as students who are seeking information on public health and on environmental and clinical epidemiology.
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Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health

 Epidemiology  Comments Off on Osteoporosis: A Lifecourse Epidemiology Approach to Skeletal Health
Nov 112018
 

This is the first book to document comprehensively the ‘state of the art’ in the lifecourse epidemiology of osteoporosis. In detailed chapters, expert contributors describe the current and projected future burden of disease, developments in the understanding of risk factors for osteoporosis from cradle to grave, the underlying mechanisms, and advances in approaches to risk assessment and treatment. It is essential reading for all students on postgraduate courses in bone health, as well as an important reference for practitioners and researchers in osteoporosis, epidemiology, and related fields

About the Author
Nicholas C Harvey MA MB BChir PhD FRCP is Professor of Rheumatology and Clinical Epidemiology at the MRC Lifecourse Epidemiology Unit, University of Southampton, and leads a world class programme of research focused on the lifecourse epidemiology of bone and joint disease. His work is investigating the translation of epidemiological observations linking early life influences with later bone health into potential novel public health strategies (e.g. gestational vitamin D supplementation) aimed at optimising childhood bone mineral accrual and reducing risk of later fracture; elucidation of underlying mechanisms; and investigation of novel risk factors for poor bone health in older age. He has won several awards at national and international meetings, is an investigator on >£50m grant funding and has published over 150 peer-reviewed papers. He is Vice-Chair of the International Osteoporosis Foundation Committee of Scientific Advisors, Musculoskeletal Lead for the UK Biobank Imaging Enhancement, and a member of the American Society for Bone and Mineral Research Professional Practice Committee, National Osteoporosis Society (UK) Scientific Programme Committee, UK Bone Research Society Committee, Arthritis Research UK PRC and UK NIHR Regional RfPB Panel.

Cyrus Cooper OBE DL FMedSci is Professor of Rheumatology and Director of the MRC Lifecourse Epidemiology Unit, Vice-Dean of the Faculty of Medicine at the University of Southampton and Professor of Musculoskeletal Science at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford.

He leads an internationally competitive programme of research into the epidemiology of musculoskeletal disorders, most notably osteoporosis. His key research contributions have been discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood, demonstration that maternal vitamin D insufficiency is associated with suboptimal bone mineral accrual in childhood, characterisation of the definition and incidence rates of vertebral fractures and leadership of large pragmatic randomised controlled trials of calcium and vitamin D supplementation in the elderly as immediate preventative strategies against hip fracture.

He is President of the International Osteoporosis Foundation, Chair of the BHF Project Grants Committee, an emeritus NIHR Senior Investigator and Associate Editor of Osteoporosis International. He has previously served as Chairman of the Scientific Advisors Committee, International Osteoporosis Foundation; Chairman, MRC Population Health Sciences Research Network; Chairman of the National Osteoporosis Society of Great Britain; and past-President of the Bone Research Society of Great Britain. He has worked on numerous Department of Health, European Community and World Health Organisation committees and working groups and has published extensively (over 900 research papers; h-index=119) on osteoporosis and rheumatic disorders and has pioneered clinical studies on the developmental origins of peak bone mass. In 2015, he was awarded an OBE for services to medical research.

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Epidemiology and Biostatistics: An Introduction to Clinical Research, Second Edition

 Epidemiology  Comments Off on Epidemiology and Biostatistics: An Introduction to Clinical Research, Second Edition
Nov 092018
 

This is a concise introduction to epidemiology and biostatistics written specifically for medical students and first-time learners of clinical research methods. It presents the core concepts of epidemiology and of biostatistics and illustrates them with extensive examples from the clinical literature. It is the only book on the market written to speak directly to medical students and first-time biomedical researchers by using language and examples that are easy to understand.
This newly updated second edition is extensively rewritten to provide the clearest explanations and examples. There is also a sister-text, a 150-problem workbook of practice problems that can be purchased alongside this textbook. The author continues to provide a text that is attractively fast-paced and concise for use in condensed courses, such as those taught in medical school.

The book is an excellent review for the epidemiology section of the United States Medical Licensing Examination Part I which all medical students must take at the end of the second year.

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