Divided into five expansive sections, this guide provides an in-depth review of crystal-induced arthritis and related disorders. Providing a historical perspective throughout, this work includes detailed descriptions of the clinical features of these diseases, as well as a current overview of their identification, epidemiology, genetics, and underlying pathophysiology. This authoritative guide also reviews case studies, current diagnostic tools, and the prevalence of these conditions while introducing new and emerging therapies for disease management.
A comprehensive and practical resource for analyses of crossover designs
For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases.
This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design.
Provides exact test procedures and interval estimators, which are especially of use in small-sample cases.
Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages.
Each chapter is self-contained, allowing the book to be used a reference resource.
Uses real-life examples to illustrate the practical use of test procedures and estimators
Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size.
Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.
This volume places emphasis on the intricate interplay between creatine and creatine kinase function on one hand and proper brain function, neurodegenerative disease and/or neuroprotection on the other. The book, compiled by outstanding experts, provides a key reference summarizing the state-of-the-art in creatine and creatine kinase research. It is a must-read for understanding the links between creatine metabolism and neuroprotection as well as neurodegenerative disease.
This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored.
Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.
This volume highlights the role of proteostasis in human health and associated disease model systems, reflecting its rising importance which has led to the development of new technologies to obtain insight into underling protein mechanistic events. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Proteostasis: Methods and Protocols aims to become a reference book on proteostasis in human health.
The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.
Basic Statistics and Epidemiology is a straightforward primer in basic statistics that emphasizes its practical use in epidemiology and public health, providing an understanding of essential topics such as study design, data analysis and statistical methods used in the execution of medical research.
Assuming no prior knowledge, the clarity of the text and care of presentation ensure those new to, or challenged by, these topics are given a thorough introduction without being overwhelmed by unnecessary detail. An understanding and appreciation of statistics is central to ensuring that professional practice is based on the best available evidence, in order to treat and help most appropriately the wider community. By reading this book, students, researchers, doctors, nurses and health managers will have the knowledge necessary to understand and apply the tools of statistics and epidemiology to their own practice.
The groundbreaking, award-winning investigation into Lyme disease?the science, history, medical politics, and patient experience?now with a brand new chapter.
When Pamela Weintraub, a science journalist, learned that her oldest son tested positive for Lyme disease, she thought she had found an answer to the symptoms that had been plaguing her family for years?but her nightmare had just begun. Almost everything about Lyme disease turned out to be deeply controversial, from the microbe causing the infection, to the length and type of treatment and the kind of practitioner needed.
On one side of the fight, the scientists who first studied Lyme describe a disease transmitted by a deer tick that is hard to catch but easy to cure no matter how advanced the case. On the other side, rebel doctors insist that Lyme and a soup of “co-infections” cause a complicated spectrum of illness often dramatically different – and far more difficult to treat – than the original researchers claim. Instead of just swollen knees and a rash, patients can experience exhaustion, disabling pain, and a “Lyme fog” that leaves them dazed and confused. As patients struggle for answers, once-treatable infections become chronic. In this nuanced picture of the intense controversy and crippling uncertainty surrounding Lyme disease, Pamela Weintraub sheds light on one of the angriest medical disputes raging today. The most comprehensive book ever written about the past, present and future of Lyme disease, Cure Unknown exposes the ticking clock of a raging epidemic and the vulnerability we all share.
Each of the 16 chapters potentially stand alone in value to the reader, but together they integrate public health and medical care delivery topics effectively… Whatever comes to pass until the release of the next edition, this text will certainly poise future healthcare leaders to steady themselves for the rapidly changing healthcare environment.
Zachary Pruitt, PhD, Journal of Health Administration Education
Health care managers, practitioners, and students must both operate as effectively as they can within the daunting and continually evolving system at hand and identify opportunities for reform advances… Health Care Delivery in the United States has been an indispensable companion to those preparing to manage this balance. The present edition demonstrates once again why this volume has come to be so prized. It takes the long view ?± charting recent developments in health policy, and putting them side-by-side with descriptions and analysis of existing programs in the United States and abroad.”
??Sherry Glied, PhD, Dean and Professor of Public Service, NYU Wagner, From the Foreword
This fully updated and revised 11th edition of a highly esteemed survey and analysis of health care delivery in the United States keeps pace with the rapid changes that are reshaping our system. Fundamentally, this new edition presents the realities that impact our nation’s achievement of the so-called Triple Aim: better health and better care at a lower cost. It addresses challenges and responses to the Affordable Care Act (ACA), the implementation of Obamacare, and many new models of care designed to replace outmoded systems. Leading scholars, practitioners, and educators within population health and medical care present the most up-to-date evidence-based information on health disparities, vulnerable populations, and immigrant health; nursing workforce challenges; new information technology; preventive medicine; emerging approaches to control health care costs; and much more.
Designed for graduate and advanced undergraduate students of health care management and administration and public health, the text addresses all of the complex core issues surrounding our health care system in a strikingly readable and accessible format. Contributors provide an in-depth and objective appraisal of why and how we organize health care the way we do, the enormous impact of health-related behaviors on the structure, function, and cost of the health care delivery system, and other emerging and recurrent issues in health policy, health care management, and public health. The 11th edition features the writings of such luminaries as Michael K. Gusmano, Carolyn M. Clancy, Joanne Spetz, Nirav R. Shah, Michael S. Sparer, and Christy Harris Lemak, among others. Chapters include key words, learning objectives and competencies, discussion questions, case studies, and new charts and tables with concrete health care data. Included for instructors is an Instructor’s Manual, PowerPoint slides, Syllabus, Test Bank, Image Bank, Supplemental e-chapter on the ACA, and a transition guide bridging the 10th and 11th editions.
Integration of the ACA throughout the text, including a supplementary e-chapter devoted to this major health care policy innovation
The implementation of Obamacare
Combines acute and chronic care into organizations of medical care
Nursing workforce challenges
Health disparities, vulnerable populations, and immigrant health
Strategies to achieve the Triple Aim (better health and better care at lower cost)
New models of care including accountable care organizations (ACOs), patient homes, health exchanges, and integrated health systems
Emerging societal efforts toward creating healthy environments and illness prevention
Increasing incentives for efficiency and better quality of care
By (author): Kenrad E. Nelson, Carolyn Masters Williams
Now in its third edition, this comprehensive volume is recognized as the most authoritative review of the epidemiology of infectious disease. Divided into five sections that cover methods in infectious disease epidemiology, airborne transmission, diarrheal diseases, blood and body fluid as a reservoir of infectious diseases, vectorborne and parasite disease, the book includes ‘state-of-the-art’ chapters on methodological issues, pathogenesis, and comprehensive reviews of virtually all known infectious diseases. New to the Third Edition: 1. All chapters updated with significant new information 2. HIV chapter completely updated including results of trials of Male Circumcision, HIV-vaccines, female condoms, Microbicides and new drugs 3. New chapter on Infectious Disease Eradication (e.g. Smallpox, Polio, Measles) 4. New chapter on Pneumococcal Disease (with material on S. pneumonia moved from the ARI and Vaccine chapters) 5. Influenza chapter updated with new material on H1/N1 and control/prevention of Influenza during a pandemic 6. Consolidation of material from the chapters on Outbreaks and Surveillance. 7. Nosocomial Infection chapter is shortened and updated with a new section on nosocomial/community MRSA 8. Malaria chapter updated with new information on bed nets, prophylactic therapy of pregnant women and other high risk populations as well as new detailed examination of the organization, implementation, and accomplishments of the WHO?Roll-Back Malaria program; and a new description of the 5th Human Malaria parasite?P.knowlesi and its Epidemiology. 9. STD chapter is updated with new information on the rapid diagnosis of STDs using urine PCR-methods as well as new information on partner prophylacitic treatment of STDs 10. New information in Chickengunya virus, Enterovirus 71, Nipah and Hendra virus infections to the Emerging infections chapter. 11. Hepatitis chapter is revised with new information on HEV virus 12. New brief chapter discussing the various models of behavioral change that are useful in Infectious Diseases research?e.g. Health Belief model etc.