Pain Killer: An Empire of Deceit and the Origin of America’s Opioid Epidemic, 2nd Edition

 Epidemiology  Comments Off on Pain Killer: An Empire of Deceit and the Origin of America’s Opioid Epidemic, 2nd Edition
Jun 132018
 

Between 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by Purdue Pharma’s aggressive marketing of OxyContin. Families, working class and wealthy, have been torn apart, businesses destroyed, and public officials pushed to the brink.

In Pain Killer, Pulitzer Prize–winning New York Times reporter Barry Meier exposes the roots of the most pressing health epidemic of the twenty-first century. Powerful narcotic painkillers, or opioids, were once used as drugs of last resort for pain sufferers. Purdue turned OxyContin into a billion-dollar blockbuster by launching an unprecedented marketing campaign claiming that the drug’s long-acting formulation made it safer to use than traditional painkillers for many types of pain. That illusion was quickly shattered as drug abusers learned that crushing an Oxy could release its narcotic payload all at once. Even in its prescribed form, Oxy proved fiercely addictive. As OxyContin’s use and abuse grew, Purdue concealed what it knew from regulators, doctors, and patients.

Here are the people who profited from the crisis and those who paid the price, those who plotted in boardrooms and those who tried to sound alarm bells. A country doctor in rural Virginia, Art Van Zee, took on Purdue and warned officials about OxyContin abuse. An ebullient high school cheerleader, Lindsey Myers, was reduced to stealing from her parents to feed her escalating Oxy habit. A hard-charging DEA official, Laura Nagel, tried to hold Purdue executives to account. The drugmaker’s owners, Raymond and Mortimer Sackler, whose names adorn museums worldwide, made enormous fortunes from the commercial success of OxyContin.

In this updated edition of Pain Killer, Barry Meier breaks new ground in his decades-long investigation into the opioid epidemic. He takes readers inside Purdue to show how long the company withheld information about the abuse of OxyContin and gives a shocking account of the Justice Department’s failure to alter the trajectory of the opioid epidemic and protect thousands of lives. Equal parts crime thriller, medical detective story, and business exposé, Pain Killer is a hard-hitting look at how a supposed wonder drug became the gateway drug to a national tragedy.

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Epidemics and War

 Epidemiology  Comments Off on Epidemics and War
Jun 032018
 

Through its coverage of 19 epidemics associated with a broad range of wars across time and place that blends medical knowledge, demographics, and geographic and medical information with historical and military insights, this book reveals the complex relationship between epidemics and wars throughout history.

• Provides readers with a broad understanding of the relationship between disease and epidemics and their impact upon (and by) wars
• Helps non-medical professionals grasp some of the important elements of specific epidemics―such as disease vectors and common factors assisting diffusion―through explanations in easily understood language
• Blends the perspective from humanistic and social science studies with critical information from science on topics that have continually impacted nations and societies over the ages
• Clarifies the confusing details of similar yet different diseases for readers without medical or scientific backgrounds

About the Author
Rebecca M. Seaman, PhD, is dean of social sciences and humanities at Olympic College in Bremerton, WA.

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Textbook of Epidemiology

 Epidemiology  Comments Off on Textbook of Epidemiology
May 272018
 

Epidemiological research is an important tool for the improvement of preventive and curative healthcare. A valid study design, unbiased study conduct and proper interpretation of study results are essential, as these provide the foundation for evidence-based medicine. This book provides guidance on how to design, conduct and interpret human population-based medical research. It reflects the diversity in the field and will therefore discuss the methodology of etiological, diagnostic, prognostic and intervention research. This textbook is written for bachelor’s and master’s degree students receiving training in the biomedical sciences and for practitioners in the medical and allied professions. It will also serve as a reference manual for those with basic or advanced experience of epidemiology.
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World Epidemics : A Cultural Chronology of Disease From Prehistory to the Era of Zika, Second Edition

 Epidemiology  Comments Off on World Epidemics : A Cultural Chronology of Disease From Prehistory to the Era of Zika, Second Edition
May 092018
 


In its expanded second edition, this chronology examines the effects of epidemic illness and death on human culture from 2700 BCE to 2017. Entries summarize incidents of contagion across the globe, including symptoms, treatment, prevention and demographics, as well as biographical information on notable people who identified and battled disease. Entries feature citations from personal and public documents along with maps, charts comparing types of infection, and estimated populations affected by each epidemic.

“This chronology offers researchers a basic overview of the prevalence of disease during specific historical periods…. Scurvy, black lung, tuberculosis, and unknown contagious infections described in ancient writings receive entries along with better known scourges such as smallpox, plague, and HIV/AIDS.” – Booklist

“this fascinating book is an impressive collection of information that has been finely distilled into a 420-page chronology…the index is invaluable…absorbing…useful glossary…particularly useful to anyone doing preliminary research on a historical disease or epidemic…highly recommended” – Reference Reviews

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Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment

 Epidemiology, Pathology, Physiology  Comments Off on Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment
May 032018
 

A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists.

Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors.

This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.

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Timebomb:The Global Epidemic of Multi-Drug Resistant Tuberculosis

 Epidemiology  Comments Off on Timebomb:The Global Epidemic of Multi-Drug Resistant Tuberculosis
May 012018
 

Two billion people – one-third of the world’s population – are infected with latent tuberculosis. Ten percent of those infected will develop active TB in their lifetimes. A scourge supposedly defeated by antibiotics half a century ago, tuberculosis kills more people today than ever before in history. And the numbers aren’t getting any better. Worse yet this ancient disease is undergoing a metamorphosis, adapting to our misused medications, growing stronger, becoming unbeatable – becoming multi-drug-resistant.

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Lyme: The First Epidemic of Climate Change

 Epidemiology  Comments Off on Lyme: The First Epidemic of Climate Change
Apr 222018
 

Lyme disease is spreading rapidly around the globe as ticks move into places they could not survive before. The first epidemic to emerge in the era of climate change, the disease infects half a million people in the US and Europe each year, and untold multitudes in Canada, China, Russia, and Australia.

Mary Beth Pfeiffer shows how we have contributed to this growing menace, and how modern medicine has underestimated its danger. She tells the heart-rending stories of families destroyed by a single tick bite, of children disabled, and of one woman’s tragic choice after an exhaustive search for a cure.

Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity’s role in a modern scourge.

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A Brief History of Blood and Lymphatic Vessels

 Epidemiology  Comments Off on A Brief History of Blood and Lymphatic Vessels
Apr 162018
 

This book provides a comprehensive account of vascular biology and pathology and its significance for health and disease. It systematically and chronologically explains how we came to our current understanding of the vasculature and it´s function today, and describes in an entertaining way the diverse flaws and turns in science and medicine from the past. It thereby offers a complete and well-studied history on vascular biology and medicine. The book has an easy-to-read style and is written for students as well as scientists, physicians and lecturers in the field of biomedicine, human physiology, cardiology and hematology.

 

 

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Alzheimer’s Disease Decoded: The History, Present, and Future of Alzheimer’s Disease and Dementia

 Epidemiology  Comments Off on Alzheimer’s Disease Decoded: The History, Present, and Future of Alzheimer’s Disease and Dementia
Apr 122018
 

The book aims to present, educate and inform individuals about Alzheimer’s disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer’s. It adopts a ‘global’ perspective on Alzheimer’s disease, and include epidemiological data and science from countries around the world.Alzheimer’s disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer’s disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer’s disease research.Most books on the market that focus on Alzheimer’s disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.Dr. Jefferson Chen MD, PhD, co-author, participated in the world’s first surgical clinical trial using shunts to treat Alzheimer’s disease. His first-hand involvement in a clinical trial for patients with Alzheimer’s disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer’s disease lends a unique perspective.This book with appeal to a wide audience, regardless of their scientific or educational background.
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Umbrella Reviews!: Evidence Synthesis with Overviews of Reviews and Meta-Epidemiologic Studies

 Epidemiology  Comments Off on Umbrella Reviews!: Evidence Synthesis with Overviews of Reviews and Meta-Epidemiologic Studies
Apr 112018
 

Explains how to read, interpret, and independently conduct umbrella reviews
Written by a multinational team of contributors who provide a multidisciplinary and multidimensional approach
First book to be devoted solely to umbrella reviews

This book is an ideal guide to umbrella reviews, overviews of reviews, and meta-epidemiologic studies for evidence synthesis. Research is conducted at different levels: primary research consists of original studies while secondary research comprises qualitative reviews, systematic reviews, and meta-analyses. Recently, a novel further level of research has been introduced, based on the analysis and pooling of reviews and meta-analysis. This book is the first to focus solely on this new type of research design, which permits a comprehensive and powerful synthesis of scientific evidence in medicine as well as in many other fields in order to inform decision-making. All aspects are covered, including review design and registration, the searching, abstracting, appraisal, and synthesis of evidence, the appraisal of moderators and confounders, and state of the art reporting. Case studies in a range of medical specialties are then presented. The hands-on approach of the book, written by a multinational team of experts, will enable the reader to interpret and independently conduct umbrella reviews.

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