Mar 282017
 

Unusual Cases in Peritoneal Surface Malignancies


This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies which have originated from different primaries, such as breast cancer, small bowel cancers and imatinib resistant GISTosis and sarcomas and pseudomyxoma. The book provides the most up-to-date information on current approaches such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Given the increasing evidence that the patients who may benefit from this treatment modality avoid potential lethal course of these diseases, the book explores the application of these approaches to a number of types of malignancy.

The first chapters explore Benign Multicystic Mesothelioma and Pseudomyxoma Peritonei arising from unusual primaries. Among other explored topics are peritoneal metastases from serous papillary uterine carcinoma, sarcoma and from unusual origins.

This book is valuable for surgical oncologists who deal with the management of peritoneal surface malignancies.

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Mar 262017
 

Clinical Trials in Ovarian Cancer


Features: Clinical Trials in Ovarian Cancer
By (author): Christine S. Walsh M.D.

When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research.   
 
Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches. 
 
The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care. 
 
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Mar 262017
 

Oncologic Imaging: Spine and Spinal Cord Tumors


By (author): Heung Sik Kang, Joon Woo Lee, Eugene Lee

This book is a detailed guide to image interpretation in patients with spine and spinal cord tumors that will enable clinicians and residents to improve their diagnostic abilities. The book opens by introducing basic concepts in the imaging of spinal tumors, namely the compartmental approach and the histologic basis for the different imaging appearances. These concepts are explained with the aid of representative cases and schematic illustrations. The second part of the book represents a “training step” in which various spinal tumors are described in detail, focusing on the imaging findings. Representative cases are presented with radiographic, CT, and MR images; in addition, schematic illustrations and pathologic or operative images are included in selected cases. The third part is a “practice step” describing tips for correct imaging diagnosis. Individual chapters in this part focus on incidence-, age-, location-, and imaging pattern-based approaches to bone, extradural, intradural extramedullary, intramedullary, and pediatric spinal tumors. The presented cases will enhance the reader’s understanding of the different tumor patterns and assist in solving diagnostic problems that may be encountered in daily practice.
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Mar 262017
 

Liquid Biopsies in Solid Tumors (Cancer Drug Discovery and Development)


This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.


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Mar 242017
 

Renal Cell Carcinoma: Molecular Features and Treatment Updates


This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an “orphan disease” in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.

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Mar 232017
 

Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide


This book provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians and researchers with an interest in the management of thyroid nodules and cancer, including both surgeons and endocrinologists.  The book reviews new data about risk factors for nodular disease and cancer, details the management of toxic and non-toxic benign thyroid nodular disease, discusses controversies in the management of indeterminate thyroid nodules and cancer, and reviews the latest data on use of molecular testing for diagnosis and prognosis.  Lastly, the book reviews the management of difficult-to-treat thyroid cancers.
Management of Thyroid Nodules and Differentiated Thyroid Cancer: A Practical Guide will serve as a useful resource for physicians and researchers dealing with, and interested in thyroid nodular disease and cancer.  It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.  All chapters are written by experts in their fields and include the most up to date scientific and clinical information. 
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Mar 232017
 

CBT for Psychological Well-Being in Cancer: A Skills Training Manual Integrating DBT, ACT, Behavioral Activation and Motivational Interviewing


Features: CBT for Psychological Well Being in Cancer A Skills Training Manual Integrating Dbt ACT Behavioral Activation and Motivational Interviewing
By (author): Mark Carlson

CBT for Psychological Well-Being in Cancer is the first clinical manual to target psychological well-being in cancer by combining skill sets from DBT and other well-researched approaches, providing clinical material in a clear session-by-session structure organized by topic.

  • The first skills training manual in the field to provide an integrated session-by-session outline that clinicians can customize for their own needs
  • Adaptive and contextualist in approach – Carlson integrates skill sets from DBT, ACT, behavioral activation, and motivational Interviewing to promote efficacy and cost-effectiveness
  • The text provides a unique range of resources to support for clinicians, including session guides, specific interventions, client handouts, and invaluable measurement and tracking tools for those clinicians required to report outcomes
  • The content can be flexibly deployed by clinicians into their existing work to meet the needs of specific patients in individual or group treatment contexts, by selecting the most appropriate sessions, skills, and handouts
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Mar 232017
 

Textbook of Uncommon Cancer


The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist.

  • Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce
  • Fully revised with new material and an evidence-based, teach-by-example approach
  • Provides insight on real-world decision making in the clinical setting
  • Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview
  • Extensively illustrated in full color throughout, including heat maps to show gene expression
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Mar 232017
 

Cardiac Management of Oncology Patients: Clinical Handbook for Cardio-Oncology


This book is designed for clinical cardiologists and other physicians working with cardiac patients, where specific specialized teams of cardio-oncologists are not available and who are called to perform a clinical consultation to evaluate both the cardiac condition and the eligibility for chemotherapy or radiotherapy treatment, and to evaluate if a cancer treatment produces toxic effects on a patient treated with chemo or radiotherapy and if appearance of new symptoms is due to this treatment. In recent years, progress in oncologic therapy has resulted in important developments and the prognostic improvement of patients with malignancy. The cornerstone of chemotherapy are the anthracyclines (and the analogue Mitoxantrone), that are direct cellular toxic agents and that are among the most powerful anti-neoplastic drugs, but their cardiac toxicity is well known. Significant breakthroughs in cancer therapy have also been achieved with the introduction of signalling inhibitors, such as VEGF inhibitors, HERB2 inhibitors or TK inhibitors used alone or in combination with direct cellular toxic drugs. However, these signalling inhibitors may interact also with cardiovascular signalling and therefore may have functional or structural effects on the myocardium. This can be permanent or reversible, with impairment of the global conditions and important side effects, and increase both morbidity and mortality and worsening of quality of life. Chemotherapy and radiotherapy can have acute detrimental effects that can be present for years after treatment and that can lead to cardiac consequences also after long periods of no clinic sequelae. Patient numbers with cancer problems will dramatically increase in the next years and thus every cardiologist will need to have the correct information and the skills to manage these situations in the correct way. This book will provide these tools for them.
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Feb 052017
 

Colposcopy of Female Genital Tract


This book aims to promote awareness of and highlight the screening modalities and various treatment options available for the management of cervical pre-invasive lesions. Cervical cancer is the leading cause of malignancy among women worldwide, and deaths due to cervical cancer represent a global health problem. Yet the risk of cervical malignancy can be decreased substantially if the premalignant conditions of the cervix are recognized and treated in a timely manner.

Colposcopy is the gold standard for the diagnosis of cervical dysplasia. Accordingly, the book details the fundamentals of colposcopy and colposcopic assessment of the normal and abnormal cervix. With preventive oncology taking front stage, colposcopy has become one of the most important diagnostic tools available. With chapters contributed by respected experts in this field, the book offers vital insights into colposcopy and an essential guide to comprehensive strategies for the early detection of cervical cancer.

The main text is complemented by ample illustrations for clarity and a better understanding of the subject. Case discussions on various clinical scenarios will further ensure good clinical practices, which will in turn translate into reduced risk of cervical cancer. 

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