Oncology Clinical Trials: Successful Design, Conduct, and Analysis

 Oncology  Comments Off on Oncology Clinical Trials: Successful Design, Conduct, and Analysis
Jun 252020
 

Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benefit future patients. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives,

Oncology Clinical Trials, provides a comprehensive guide for both early-career and senior oncology investigators into the successful design, conduct and analysis of an oncology clinical trial.

Oncology Clinical Trials covers how to formulate a study question, selecting a study population, study design of Phase I, II, and III trials, toxicity monitoring, data analysis and reporting, use of genomics, cost-effectiveness analysis, systemic review and meta-analysis, and many other issues. Many examples of real-life flaws in clinical trials that have been reported in the literature are included throughout. The book discusses clinical trials from start to finish focusing on real-life examples in the development, design and analysis of clinical trials.

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Breast Cancer: A Multidisciplinary Approach to Diagnosis and Managmenet

 Oncology  Comments Off on Breast Cancer: A Multidisciplinary Approach to Diagnosis and Managmenet
Jun 232020
 

Over the course of the last decade, the treatment of breast cancer has evolved quite rapidly. New scientific and clinical advances have modified the standard of care and led to improved patient outcomes. At the same time, the treatment of breast cancer has become increasingly complex, requiring the comprehensive review and assessment of multiple issues, genetics, radiology, surgery, reconstruction, fertility radiation, chemotherapy, and more. As a result the harmony and open communication between these specialties facilitated by a multidisciplinary team approach are crucial in providing the best care to patients and ensuring successful treatment.

Breast Cancer: A Multidisciplinary Approach to Diagnosis and Management, by a multidisciplinary team of authors representing a range of disciplines, is a review for physicians, fellows, nurses, physician assistants, physical therapists, and all health care providers involved in the treatment of breast cancer. Breast Cancer: A Multidisciplinary Approach to Diagnosis and Management summarizes the state-of-the-art issues related to the treatment of breast cancer and describes an approach for optimal multidisciplinary care for women are at higher risk of or who have been diagnosed with breast cancer.

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Small Cell Carcinomas: Causes, Diagnosis and Treatment

 Oncology, Respiratory Medicine  Comments Off on Small Cell Carcinomas: Causes, Diagnosis and Treatment
Jun 152020
 

Small cell carcinoma is a type of cancer that almost always effects the lungs. Small cell carcinoma is almost always caused by smoking, but exposure to large amounts of asbestos is also a risk factor. Small cell carcinoma usually effects men more than women and while not a common type of lung cancer, is considered very deadly. Unlike other types of cancer, small cell carcinoma is not staged on a numerical scale but rather as simply limited or extensive. Limited stage refers to cancer that is contained within the lungs or bronchial tubes only. Extensive stage indicates the cancer has spread to areas outside of the chest. Limited stage small cell carcinoma is rare because it is usually not diagnosed until it has become extensive. Symptoms of small cell carcinoma lung cancer are similar to other types of lung cancer and may include chronic coughing, wheezing, shortness of breath, sputum production, and possibly weight loss. This new book gathers the latest research from around the globe on this disease.
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Gynecological Cancer Management: Identification, Diagnosis and Treatment

 Ob/Gynae, Oncology  Comments Off on Gynecological Cancer Management: Identification, Diagnosis and Treatment
Jun 142020
 

This concise and practical guide enables the gynecologist to differentiate between benign and malignant gynecologic conditions to determine the best management options for the patient.
Over the past three decades, as the specialty of obstetrics and gynecology has matured into a broad and diverse group of skills and disciplines, it has become apparent that there are diagnoses and conditions in gynecologic oncology where the obstetrician-gynecologist has a level of uncertainty, or lack of confidence in his ability or knowledge base to adequately manage the patient and therefore refers the patient to a gynecologic oncologist.
This text portrays the advances in the field and reviews the current management of a number of gynaecologic conditions to give the reader the confidence needed to deal with these issues. The distinguides Editors have crafted the book to include:
Case vignettes to provide clinical context
Pathology notes to aid diagnostic outcomes
Management guidance for obgyn practitioners to enable the best outcome for their patients
Each topic is introduced with a concise overview followed by case-based scenarios which discuss the specific management of common problems.
Providing the general gynecologist with the current clinical information necessary to manage conditions and identify the situations where consultation or referral to a gynecologic oncologist would be in the patient’s best interest.

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Stages of Cancer Development (The Biology of Cancer)

 Oncology  Comments Off on Stages of Cancer Development (The Biology of Cancer)
Jun 112020
 

Stages of Cancer Development follows the evolution of cancer from a single genetically altered cell, through the stages of hyperplasia (uncontrolled cell division), dysplasia (genetic changes that lead to an excess of cells in the affected region), carcinoma in situ (additional changes that make cells appear abnormal and allow them to spread over a larger region, affecting cell function), to full-blown cancer (focusing on malignant tumors that have the ability to invade surrounding tissues and spread throughout the body). This book presents a complex topic in a clear and approachable manner, making it an invaluable guide for student research.

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Skin Cancer (The Biology of Cancer)

 Dermatology, Oncology  Comments Off on Skin Cancer (The Biology of Cancer)
Jun 112020
 

Skin cancer is the most common of all cancers; doctors detect it in about 1 million Americans every year. Skin Cancer examines this disease, which, if found early, is usually cured by relatively simple surgery. Readers also gain valuable insight into how they can lower their risk for skin cancer, such as by reducing exposure to ultraviolet (UV) radiation from sunlight.

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Diagnosis and Treatment of Cancer (The Biology of Cancer)

 Oncology  Comments Off on Diagnosis and Treatment of Cancer (The Biology of Cancer)
Jun 112020
 

“Diagnosis and Treatment of Cancer” helps readers understand the nature of cancer and the different types of cancer. Comprehensive and accessible, this book explains the various methods used to detect and diagnose the disease. An in-depth chapter is dedicated to each of the key methods of treatment – cell transplant and biological therapy, chemotherapy, radiation, surgery, and alternative therapies.

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Causes of Cancer (The Biology of Cancer)

 Oncology  Comments Off on Causes of Cancer (The Biology of Cancer)
Jun 112020
 

Causes of Cancer delves into the many factors responsible for causing cancer, from environmental conditions to abnormal in vitro and in vivo developments to viruses and cancers caused by exposure to radiation. This richly informative book also empowers readers by highlighting how avoiding exposure to particular carcinogens may prevent certain forms of cancer.

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Cancer Genetics (The Biology of Cancer)

 Genetics, Oncology  Comments Off on Cancer Genetics (The Biology of Cancer)
Jun 112020
 

Cancer Genetics demonstrates how cancer cells differ from normal cells in structure and function. It examines specific cancer-related genes, such as oncogenes and tumor suppressor genes, and discusses inherited syndromes that are associated with cancer, including certain forms of breast cancer. New research into the human genome and the possibility that particular genes confer a susceptibility to cancer are some of the other intriguing topics examined in this book.

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Disease Control Priorities, Third Edition (Volume 3): Cancer

 Oncology  Comments Off on Disease Control Priorities, Third Edition (Volume 3): Cancer
Jun 072020
 

Volume 3, Cancer, presents the complex patterns of cancer incidence and death around the world and evidence on effective and cost-effective ways to control cancers. The DCP3 evaluation of cancer will indicate where cancer treatment is ineffective and wasteful, and offer alternative cancer care packages that are cost-effective and suited to low-resource settings. Main messages from the volume include:
-Quality matters in all aspects of cancer treatment and palliation.
-Cancer registries that track incidence, mortality, and survival – paired with systems to capture causes of death are important to understanding the national cancer burden and the effect of interventions over time.
-Effective interventions exist at a range of prices. Adopting ‘resource appropriate’ measures which allow the most effective treatment for the greatest number of people will be advantageous to countries.
-Prioritizing resources toward early stage and curable cancers is likely to have the greatest health impact in low income settings.
-Research prioritization is no longer just a global responsibility.

Providing cancer treatment requires adequate numbers of trained healthcare professionals and infrastructure beyond what is available in most LMICs, especially low income countries. Careful patient monitoring is a requirement of good quality cancer care and this often involves laboratory tests in addition to clinical examination. Even if financing were immediately available to build or expand a cancer control system, reaching capacity will take many years.

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