Managing BRCA Mutation Carriers

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Jul 192018
 

As there are a number of nuances in terms of how to manage mutation carriers (both with and without a concomitant diagnosis of breast cancer), this text provides a comprehensive, state-of-the art review of this field. It represents a valuable resource for a myriad of clinicians and healthcare personnel who interface with these patients. The text discusses the latest recommendations for genetic counseling and risk assessment, provides a framework for considering reducing risk in mutation carriers who do not present with a concomitant diagnosis of breast cancer, and finally elucidates the many considerations of managing a breast cancer patient with a BRCA mutation. The text presents a multidisciplinary approach gleaning insights from imaging, breast surgery, gynecology, plastic surgery, medical oncology, radiation oncology and psycho-oncology.

Managing BRCA Mutation Carriers will be a useful resource for physicians and healthcare providers from a myriad of disciplines who manage BRCA mutation carriers. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.

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Atlas of Minimally Invasive Facelift: Facial Rejuvenation with Volumetric Lipofilling

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Jul 182018
 

This atlas provides a concise overview of the principle of fat grafting and its clinical applications to treat aging in the central areas of the face in a minimally invasive manner. The authors start with a short description of the anatomical basis of facial aging and by presenting current facial rejuvenation techniques. Here the emphasis is on the process of harvesting and preparing macro-, micro-, intradermal and nano-fat for injection. Thanks to the book’s numerous illustrations and short descriptions, readers will find valuable information on where and how to inject the fat combined with the authors’ individual techniques and refinements. Aging is a major issue in today’s society. Facial rejuvenation procedures seek to enhance the final outcome and durability of surgery and to minimize drawbacks. The current trend is to use less invasive methods requiring fewer incisions, which produce more natural-looking results. This atlas shows the authors’ personal techniques to help achieve that goal.
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Ruptured Abdominal Aortic Aneurysm: The Definitive Manual

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Jul 172018
 
This manual is designed to serve as the standard for the management of patients with ruptured abdominal aortic aneurysm (AAA) by means of modern techniques. All aspects are covered, from pathogenesis, clinical presentation, and diagnosis through to initial management, operative strategies, postoperative complications, outcomes and quality of life issues. The book is based on the experience gained at a leading U.S. institution (Harborview Medical Center, University of Washington) that treats up to 40 patients with ruptured AAA annually and is highly respected for its expertise in this medical emergency. The team at Harborview Medical Center has recently shown that the implementation of a structured protocol for the management of ruptured AAA, with emphasis on an “endovascular-first” strategy, dramatically reduces mortality and complications. This has led to a sea change in the way in which patients are managed. There is an increasing hunger for information on these codified protocols and Ruptured Abdominal Aortic Aneurysm: The Definitive Manual will be invaluable for both surgeons and critical care physicians.
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Atlas of Non-Gynecologic Cytology

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Jul 162018
 

Cytology is a unique subspecialty in anatomic pathology, and plays a critical role in the diagnosis of a variety of benign and malignant lesions by using minimally invasive procedures, such as fine needle aspiration, brushing, washing and lavage. Cytology not only provides an accurate diagnosis of the lesion based on the cytomorphological evaluation at cellular level, but also provides material for molecular characterization of a tumor for targeted therapy. In the era of personalized medicine, cytology has continued to grow and evolve as an important diagnostic tool. For example, some types of procedures are routinely used, diagnostic criteria have become more refined, and certain terminology has been changed based on current WHO classifications. Therefore, it is necessary to update our knowledge and terminology in cytology.
In this volume, we have retained the quality and the clarity of the series, and like the other volumes, this volume aims to be concise and comprehensive yet clinically relevant to daily practice. Although this volume is written by multiple authors, all chapters follow a similar format: brief introduction of the specific organ/system (including types of specimens and techniques to obtain samples), description of normal findings, and a practice approach to diagnose benign and malignant lesions. In each chapter, the key cytomorphological feature and main differential diagnoses of the lesion are summarized in a concise table. Images in each chapter are instructive and clearly represent findings. Where necessary, we have also illustrated the important ancillary tests, such as flow cytometry, immunohistochemistry and molecular analysis, which are crucial for an accurate diagnosis and targeted therapy. The updated knowledge, including key cytomorphological features, current terminology and molecular diagnostic tests, is the highlight of this volume.

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http://nitroflare.com/view/D3D5B97879EA9EA/3319896733.pdf

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Atlantoaxial Fixation Techniques: Commonly Used and New Techniques (Translational Medicine Research)

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Jul 162018
 

This book introduces posterior atlantoaxial fixation techniques and their biomechanical stability and clinical outcomes. Based on the full review of established techniques, authors discusses their advantages and disadvantages. Furthermore, the author discusses how to use the basic theories of translational medicine to achieve the modification of the posterior atlantoaxial fixation. It also proposes the modification of integrative “screw and hooks” and “long screw tail”. Readers can learn the basic techniques of posterior atlantoaxial fixation and the major requirements.
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Arthroscopic Transosseous Rotator Cuff Repair: Tips and Tricks

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Jul 132018
 

The book offers a comprehensive and up-to-date guide to the cutting edge arthroscopic transosseous techniques for the treatment of rotator cuff tears, which are gradually taking over from the common open surgical approach, defined as the gold standard for RCR. With the help of numerous figures, it presents step by step a novel all-arthroscopic anchorless transosseous suture technique that is less invasive and easier to perform. After discussing the etiopathogenesis, histopathology and radiological classification of rotator cuff tears, the book reviews all possible arthroscopic procedures and explores in detail suture management, describing single and double tunnel options. It also examines the complications and post-operative rehabilitation and imaging, while the closing chapter addresses the economic aspects of daily use. Intended primarily for arthroscopic surgeons interested in the field of shoulder joint repair, this exhaustive guide is also a valuable resource for residents and shoulder specialists.
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Regulation of Heat Shock Protein Responses (Heat Shock Proteins)

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Jul 132018
 

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I – HSP and Stress Responses; Section II – Chaperone Functions of HSP; Section III – HSP in Human Diseases; Section IV – Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
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Clinical Urodynamics in Childhood and Adolescence

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Jul 122018
 

This book aims to impart all the practical knowledge required in order to evaluate and treat children with anatomical, neurological, and functional incontinence. It explains how appropriate choice of management in childhood depends first of all on a correct diagnosis, then on thorough urodynamic evaluation, and finally on sound assessment of the condition of the individual patient.
The full range of relevant pathologies are considered and all of the treatment options are extensively discussed, including behavioral therapy, rehabilitation, physiotherapy, pharmacotherapy, neuromodulation, endoscopic procedures, and surgical reconstruction. Careful attention is paid to the impacts that treatments performed during childhood may have on later adult life, including on fertility and pregnancy, with a view to ensuring that the reader will be in a position to time treatments correctly, thereby avoiding adverse effects, and possess all the information needed to address the concerns of patients and their families. The book will be of value to pediatricians, urologists, nurses, physiotherapist, students, and all others with an interest in the field.

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http://nitroflare.com/view/99728006BD56938/3319421913.pdf

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Activation of Viruses by Host Proteases (May 2018 Release)

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Jul 102018
 

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy.
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Basic Applied Bioinformatics

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Jul 052018
 

An Accessible Guide that Introduces Students in All Areas of Life Sciences to Bioinformatics

Basic Applied Bioinformatics provides practical guidance in bioinformatics and helps students to optimize parameters for data analysis and then to draw accurate conclusions from the results. In addition to parameter optimization, the text will also familiarize students with relevant terminology. Basic Applied Bioinformatics is written as an accessible guide for graduate students studying bioinformatics, biotechnology, and other related sub-disciplines of the life sciences.

This text outlines the basics of bioinformatics, including pertinent information such as downloading molecular sequences (nucleotide and protein) from databases; BLAST analyses; primer designing and its quality checking, multiple sequence alignment (global and local using freely available software); phylogenetic tree construction (using UPGMA, NJ, MP, ME, FM algorithm and MEGA7 suite), prediction of protein structures and genome annotation, RNASeq data analyses and identification of differentially expressed genes and similar advanced bioinformatics analyses. The authors, Chandra Sekhar Mukhopadhyay, Ratan Kumar Choudhary, and Mir Asif Iquebal are noted experts in the field and have come together to provide updated information on bioinformatics.

Salient features of this book include:

Accessible and updated information on bioinformatics tools
A practical step-by-step approach to molecular-data analyses
Information pertinent to study a variety of disciplines including biotechnology, zoology, bioinformatics and other related fields
Worked examples, glossary terms, problems and solutions.

Basic Applied Bioinformatics gives students studying bioinformatics, agricultural biotechnology, animal biotechnology, medical biotechnology, microbial biotechnology, and zoology an updated introduction to the growing field of bioinformatics

About the Authors
Chandra Sekhar Mukhopadhyay is an Assistant Scientist (Senior Scale) at the School of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU) at Ludhiana, Punjab, India.

Ratan Kumar Choudhary is an Assistant Professor at the School of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU) at Ludhiana, Punjab, India.

Mir Asif Iquebal is a Scientist at the Centre for Agricultural Bioinformatics, Indian Council of Agricultural Research-Indian Agricultural Statistics and Research Institute (ICAR-IASRI) at Pusa, New Delhi, India.

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http://nitroflare.com/view/0FBAB53A496A2E6/Basic_Applied_Bioinformatics.pdf

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