This book provides an introductory and general overview of advances in polymers towards their employment as antimicrobial materials. The author describes current approaches for avoiding microbial contamination, toward macro-molecular antibiotics, and prevention of antibiotic-resistant bacteria by use of polymers. He establishes the remaining issues and analyzes existing methodologies for treating bacterial infections and for preparing antimicrobial materials.
The book outlines first the importance of Extra Cellular Matrix (ECM), which is a natural surface for most of cells. In the following chapters the influence of biological, chemical, mechanical, and physical properties of surfaces in micro and nano-scale on stem cell behavior are discussed including the mechanotransduction. Biomimetic and bioinspired approaches are highlighted for developing microenvironment of several tissues, and surface engineering applications are discussed in tissue engineering, regenerative medicine and different type of biomaterials in various chapters of the book.
This book brings together innovative methodologies and strategies adopted in the research and development of Advanced Surfaces in Stem Cell Research. Well-known worldwide researchers deliberate subjects including:
Extracellular matrix proteins for stem cell fate
The superficial mechanical and physical properties of matrix microenvironment as stem cell fate regulator
Effects of mechanotransduction on stem cell behavior
Modulation of stem cells behavior through bioactive surfaces
Influence of controlled micro and nanoengineered surfaces on stem cell fate
Nanostructured polymeric surfaces for stem cells
Laser surface modification techniques and stem cells applications
Plasma polymer deposition: a versatile tool for stem cell research
Application of bioreactor concept and modeling techniques in bone regeneration and augmentation treatments
Substrates and surfaces for control of pluripotent stem cell fate and function
Application of biopolymer-based, surface modified devices in transplant medicine and tissue engineering
Silk as a natural biopolymer for tissue engineering
This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.
This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies. Antibiotics: Methods and Protocols guides readers through chapters on production and design, mode of action, and response and susceptibility. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Antibiotics: Methods and Protocols aims to inspire scientific work in the exciting field of antibiotic research.
This book describes how assistive technology can help handicapped, elderly and acutely sick people to manage their daily lives better and stay safe in the home. It discusses how safety is understood from an ethical, technical and social perspective, and offers examples of the problems that users, their helpers and professional carers have with assistive technology in everyday situations.
The book provides insights from user-centred research and uses photographs to illustrate the main topic: how users and technology can work together to ensure safety. User-focused and combining experience with research, the book will interest users of these kinds of technology, health professionals who might introduce and/or prescribe them, engineers who develop and sell assistive technological gadgets, and architects who build safe homes – as well as researchers and students who work in these fields. It provides an overview of the existing technology, examines ways to test its effectiveness from the point of view of users, health professionals and researchers from different fields (architecture, education, engineering, facility management, medicine, nursing, occupational therapy, rehabilitative medicine, physiotherapy, social science and speech therapy), and lists useful addresses, websites and literature
Here is a unique resource that provides a comprehensive and highly readable summary of the basic concepts and clinical applications in sleep medicine, written for all professionals involved in health care.
Sleep medicine encompasses an unusually board spectrum of contributions from biology, technology, and medicine. This volume summarizes the considerable mass of knowledge that has been accumulated in the field and imparts its major findings in a manner that is comprehensive yet not overwhelming. Edited by an eminent sleep researcher and with contributions from leading experts in the field, the volume provides a basic grounding in sleep medicine and covers the fascinating complexity of the field. It separates figure from ground for those who are newcomers to the field and who are seeking guideposts for further research.
Sleep problems are frequently co-morbid with other medical conditions, and clinicians need to be alert to this interconnectedness and to recognize which difficulties are primary and which are not. Synoposis of Sleep Medicine will be a valuable tool for clinicians in many specialties for addressing diagnostic problems in sleep medicine.
The volume is the first of its kind, rich yet comprehensive and focused and one that is sure to meet the needs of both basic and clinical research for some years to come.
This book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage a reality. The movie is about a submarine and its crew members being shrunk to microscopic size and ventured into the body. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie while explaining how it is implemented in this first-of-a-kind interventional facility.
This is the first book that explains the fundamentals of navigation of therapeutic agents in the vascular network. The scope of the book is twofold: (1) to initiate readers into various technologies, including, but not limited to, nanotechnology, robotics, and biochemistry (more importantly, it shows how critical the integration of all these disciplines is to solving problems that indeed require a multidisciplinary environment); (2) to inspire the younger generation by showing that science and technology can bring one everywhere with the power to transform fiction to reality that can help humankind.
This innovative book discusses current findings on regulatory disorders in infants and offers practical guidelines for diagnosis and intervention. Focusing on core infant and toddler concerns including crying, sleeping, feeding, clinginess, and aggression, it presents a developmental continuum from normal to disturbed behavior regulation and examines science-based strategies for halting this trajectory. Case examples and widely used tools illustrate diverse approaches to assessment and diagnosis, emphasizing nuances of parent-infant interactions and parents‘ reactions that may fail to answer, or may even exacerbate, the child’s distress. And chapters outline counseling and therapy options for infants and parents, so that persistent problems do not become entrenched in children’s future behavior or lead to long-term family dysfunction.
Among the topics covered:
Approaches to diagnosing regulatory disorders in infants.
Feeding disorders in infants and young children.
Developmentally appropriate vs. persistent defiant and aggressive behavior.
Treatment approaches for regulatory disorders.
Video and video feedback in counseling and therapy.
Regulatory Disorders in Infants is an essential resource for clinicians and practitioners as well as researchers and graduate students in clinical child and school psychology, pediatrics, social work, psychiatry, and family studies.
Because the investigation of cold cases is usually an arduous and time-consuming task, most law enforcement agencies in the United States are not able to dedicate the resources necessary to support the cold case investigation process. However, when those cases are fully pursued and prosecuted, they often result in convictions and lengthy prison terms. Cold Cases: Evaluation Models with Follow-up Strategies for Investigators, Second Edition saves law enforcement time by providing detailed guidelines for determining if a cold case is solvable, and if so, how to organize, manage, and evaluate the investigation. It also provides techniques for developing investigative strategies to complement the evaluation process and resolve the crime.
This second edition featuresa new revised model and methodology for investigating cold cases suitable for all police and public safety agencies?large or small, domestic or international. This new model is more expeditious and convenient for departments that have less manpower and experience in dealing with cold cases. It emphasizes the prioritization of cold cases based on the availability of physical evidence and the chances of deriving matches from said evidence and an identified person of interest.
Additional topics covered in the second edition include:
How cases go cold
Strategies for creating a cold case unit
Cold case investigations in a Dutch educational environment?a chapter written by members of the Dutch Police Academy
New forensic science technologies, including DNA, CODIS, and AFIS
Case studies demonstrating advances in suspectology
Strategies for effective investigative interviewing
Challenges posed by staged crime scenes in cold cases
How to craft a cold case evaluation report
The expert authors of this book maintain The Center for the Resolution of Unresolved Crimes and conduct training and consulting worldwide. Their practical book is designed to help law enforcement agencies resurrect long-forgotten cases, bringing closure to victims and holding accountable those who are responsible.
This book is part of the Advances in Police Theory and Practice series
This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine.
• Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics
• Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline
• Written by an expert team with extensive experience in the business, basic and applied science of stem cell research
This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.