Pharmaco-Complexity: Non-Linear Phenomena and Drug Product Development

 Pharmacology  Comments Off on Pharmaco-Complexity: Non-Linear Phenomena and Drug Product Development
Apr 032020
 

This book is intended to stimulate readers to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.

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Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1

 Pharmacology  Comments Off on Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1
Mar 312020
 

Until the latter part of the 19th century, the majority of known drugs were either herbs or extracts of active ingredients from botanical sources. At this point, the world witnessed two major cornerstone achievements that laid the foundation of modern drug discovery and development: the emergence of pharmacology as a contemporary science through the work of Schmiedeberg (considered by many as the father of modern pharmacology) at the University of Strasbourg, and Wöhler’s landmark synthesis of urea from ammonium cyanate (the first synthesis of an ‘organic’ molecule from an ‘inorganic’ source) which heralded the birth of modern organic chemistry. Drug discovery has evolved from relying on luck, accident and serendipity to a complex endeavor that is at the interface of several disciplines (e.g. pharmacology, biology, chemistry), and is built on the understanding of mechanisms and causes of diseases.
This book is produced to celebrate the evolution of drug discovery and development. It will prove useful to synthetic organic chemists in both pharmaceutical industry and in academia, and can serve as a teaching tool to students who want to learn and understand the processes and challenges of drug discovery and development with real examples from top pharmaceutical companies. The chapters contain citations of a large number of valuable selected references to the primary literature. The book highlights the tireless efforts of discovery and process chemists, and their roles in the advancement of drug discovery and development.
The chapters presented in this book are written by a selected group of outstanding, very accomplished medicinal and process chemists with noted experiences and diverse backgrounds, representing some of the top pharmaceutical companies. The chapters highlight examples of emerging concepts, new developments and challenges arising in the discovery of new drug candidates and the development of new practical synthetic chemistry processes to produce these drug candidates on large scale. The discovery of each drug or drug candidate is presented by the discovery chemist(s) and the process chemist(s) who developed the drug. These writing teams describe the drug’s development to give the reader a complete story of drug discovery and development.

 

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Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems 11th Edition

 Pharmacology  Comments Off on Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems 11th Edition
Mar 282020
 

Succeed in your course with Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, the most comprehensive source on this subject available today!

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Pharmacological Basis of Acute Care

 Pharmacology  Comments Off on Pharmacological Basis of Acute Care
Mar 252020
 

This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed  protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management.
The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors.
The editors have used a different perspective – that of normalizing abnormal physiological processes with pharmacological agents – to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.

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The Sanford Guide to Antimicrobial Therapy – 48th Edition

 Infectious Diseases, Microbiology, Pharmacology  Comments Off on The Sanford Guide to Antimicrobial Therapy – 48th Edition
Mar 202020
 

The 48th edition of the leading clinical reference on treatment of infectious diseases and anti-infective drug information will be released in late winter or early spring. Helpful in day-to-day practice and as a component of your organization’s antimicrobial stewardship program, the Sanford Guide provides valuable guidance in the age of antibiotic resistance. Popular with physicians, pharmacists, physician assistants, nurse practitioners, and other clinicians, the Sanford Guide to Antimicrobial Therapy provides information that is convenient, concise, and reliable.

Available in print in pocket size, spiral bound and large library editions.

Coverage includes:

Clinical syndromes
pathogens
bacterial
fungal
mycobacterial
parasitic
viral
Anti-infective agents
dosing
pediatric adjustments
renal adjustments
adverse affects
activity
pharmacology
interactions
Preventative therapy

What’s new in 2018:
Table 1: meningitis, otitis media, diarrhea, cystitis, UTIs, endocarditis, CAP/HAP/VAP, SBP, appendicitis, pharyngitis, sinusitis, bites, oroya fever/verruga peruna, necrotizing fasciitis, septic shock, thrombophlebitis, botulism
Table 2: resistant bacteria, including GNB
Table 3: duration of therapy updated throughout
Table 4: organism coverage expanded, drugs added (new and old)
Table 5B: complete update
Table 9A: recent drugs added
Table 10A: recent drugs added, e.g., mero-vabor, delaflox, pip-tazo dosing updated, colistin dosing updated, including inhalation (10F)
Table 11: Isavuconazole indications and dosing
Table 13: giardia, leishmaniasis, microsporidiosis, malaria, trematodes, cestodes; antiparasitic drug updates (13B, 13D)
Table 14A: MERS, enterovirus, HSV aseptic meningitis, influenza
Table 14B: new HCV, CMV drugs
Table 14C: new ARV drugs
Table 14F: updated HCV treatment regimens and recommendations
Table 15A: post-splenectomy bacteremia, asplenia, sickle cell disease
Table 15B: colorectal, OB-Gyn, ophthalmic and general comments
Table 16: added peds dosing for additional antibacterials, ARVs, antivirals
Table 17: renal adjustments for ceftaz-avi, mero-vabor, delaflox
Table 17C: updated obesity dose adjustments
Table 17D: NEW list of antibacterials with no need to adjust dose for obesity
Table 19: comprehensive update to treatment of CAPD peritonitis
Table 22: added recent drugs

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Novel Drug Delivery Technologies: Innovative Strategies for Drug Re-positioning

 Pharmacology  Comments Off on Novel Drug Delivery Technologies: Innovative Strategies for Drug Re-positioning
Mar 162020
 

The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications.
Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

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Cardiovascular Diseases: From Molecular Pharmacology to Evidence-Based Therapeutics

 Cardiovascular, Pharmacology  Comments Off on Cardiovascular Diseases: From Molecular Pharmacology to Evidence-Based Therapeutics
Mar 092020
 

Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases.

• Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and treat cardiovascular diseases
• Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology
• Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases
• Uses case presentations and study questions to enhance understanding of the material
• Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues

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Drugs of Abuse: Pharmacology and Molecular Mechanisms

 Pharmacology  Comments Off on Drugs of Abuse: Pharmacology and Molecular Mechanisms
Mar 072020
 

Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction.

Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment.

Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain.

Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse.

– Explores how the chemical make-up of drugs interact with the brain and can lead to addiction

– Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others.

– Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse

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Immunogenicity of Biopharmaceuticals

 Immunology, Pharmacology  Comments Off on Immunogenicity of Biopharmaceuticals
Mar 072020
 

Immunogenicity of Biopharmaceuticals is the first book to comprehensively address the potential of an immune response to biopharmaceuticals. It is intended to give a broad overview of the current state-of-the-art regarding this subject. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

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Psychopharmacology for Mental Health Professionals: An Integrative Approach Edition 2

 Pharmacology, Psychiatry  Comments Off on Psychopharmacology for Mental Health Professionals: An Integrative Approach Edition 2
Mar 022020
 

Master the basics of psychopharmacology with PSYCHOPHARMACOLOGY FOR MENTAL HEALTH PROFESSIONALS, Second Edition. Concise yet comprehensive, this counseling text covers the basic principles of psychopharmacology, commonly prescribed psychotropic drugs for adults, and psychotropic medications prescribed to children. Psychological, cultural, and social issues related to psychopharmacology are also addressed. Numerous case examples, study questions, bolded key terms, and a glossary help you understand and applying the material. Practical information about how to talk with clients about medication and compliance as well as hands-on information about how to approach collaboration with prescribing professionals prepares you to apply what you have learned to practice. This edition includes new material on psychosocial treatments that complement the most prescribed medications, expanded discussion of medication of children and the elderly, a new chapter on drug replacement therapies, reference to changes in the DSM-5, and more.
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