Sep 182017
 

Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease (Handbook of Experimental Pharmacology)


Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

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Sep 172017
 

Healing Anxiety with Herbs


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By (author): Harold Bloomfield

More than 65 million Americans suffer annually from anxiety and insomnia, and one out of every two people will experience some form of mild to moderate anxiety for at least a two-week period during their lifetime. More people suffer from anxiety than any other mental health problem, yet fewer than than 25 percent of them receive adequate help. Until recently, the only choice for many was to suffer in silence or take synthetic, often addictive, tranquilizers and sleeping pills.

Finally, there is an alternative. In Healing Anxiety with Herbs, leading psychiatrist and bestselling author Harold H. Bloomfield, M.D., presents a revolutionary approach that is safe, natural and medically proven. Dr. Bloomfield begins by explaining what anxiety is — an exaggerated stress response stemming from the brain’s alarm system — and the many forms it can take, from muscle aches and nausea to chronic worry, persistent insomnia and even depression. He provides dozens of quick, easy-to-follow exercises along with his own proven Natural Self-Healing program to help individuals evaluate their own level of anxiety and discover the best way to treat it.

As Dr. Bloomfield shows, in many cases the best and safest remedies are natural herbs. Medical studies have shown that kava can relieve mild to moderate anxiety as effectively as Valium-like tranquilizers — but without sedation, memory impairment or threat of addiction. Hypericum (Saint-John’s-wort), which can be just as effective as synthetic antidepressants for mild to moderate depression, can also be used to alleviate anxiety. Valerian extract can provide a good night’s sleep without the morning hangover or rebound insomnia of prescription sleeping pills. Gingko biloba is a “brain booster” that is useful as a daily supplement for anyone over the age of 40 who is dealing with the angst of aging. The ginsengs and ashwaganda can help to strengthen the nervous sytem and protect against stress. Hospitals in Britain are using lavender oil aromatherapy to calm patients before surgery. Evening primrose oil and Traditional Chinese Medicinal herbs can help to treat Attention Deficit Disorder (ADD).

Recommended dosages of herbal extracts for anxiety relief are presented. Why go on suffering when you can put an end to your troubles — the right way — now? Clear, informative and based on the most up-to-date scientific findings, Healing Anxiety with Herbs offers an eye-opening program that will help you overcome anxiety, insomnia and stress so you can start to live naturally and feel healthy today.

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Sep 152017
 

Metronomic Chemotherapy: Pharmacology and Clinical Applications


This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
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Sep 152017
 

Pharmacology of Mitochondria (Handbook of Experimental Pharmacology)


This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.
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Sep 102017
 

A Handbook of Applied Statistics in Pharmacology


By (author): Katsumi Kobayashi, K. Sadasivan Pillai

Statistics plays an important role in pharmacology and related subjects such as toxicology and drug discovery and development. Improper statistical tool selection for analyzing the data obtained from studies may result in wrongful interpretation of the performance or safety of drugs. This book communicates statistical tools in simple language. The examples used are similar to those that scientists encounter regularly in their research area. The authors provide cognitive clues for selection of appropriate tools to analyze the data obtained from the studies and explain how to interpret the result of the statistical analysis.

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Sep 042017
 

Antimicrobial Chemotherapy


By (author): Roger Finch, Peter Davey, Mark H. Wilcox, William Irving

Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents.

Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices.

This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.

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Sep 042017
 

Computational Systems Pharmacology and Toxicology (Issues in Toxicology)


The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment.
This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics.
This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

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Sep 032017
 

Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences)


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This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting. The book contains current applications and procedures to identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids, increase drug bioavailability, enhance the permeability, solubility, strength, and function of drug formulations, examine protein-protein exchanges and reactions, and calculate pKa values.
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Sep 022017
 

Drug Design: Principles and Applications


This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.

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Sep 012017
 

A Lifecycle Approach to Knowledge Excellence in the Biopharmaceutical Industry (Biotechnology and Bioprocessing)


This book addresses the rapidly emerging field of Knowledge Management in the pharmaceutical, medical devices and medical diagnostics industries. In particular, it explores the role that Knowledge Management can play in ensuring the delivery of safe and effective products to patients. The book also provides good practice examples of how the effective use of an organisation’s knowledge assets can provide a path towards business excellence.

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