Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
Jan 262020
 

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

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Pharmacotherapy of Diabetes: New Developments: Improving Life and Prognosis for Diabetic Patients

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on Pharmacotherapy of Diabetes: New Developments: Improving Life and Prognosis for Diabetic Patients
Jan 242020
 

Diabetes is a huge and growing healthcare worry, especially in Western countries. The treatment of both types – 1 and 2 – of this disease has changed radically over the past few years. This work provides an overview of all the changes that will come to be implemented in clinical practice. Summarizing all aspects of treatment, this book delineates the large amount of research work that has been completed over the last few years into the relief of complications in diabetes and vascular medicine in general.
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Modern Pharmaceutics, Two Volume Set, Fifth Edition

 Pharmacology  Comments Off on Modern Pharmaceutics, Two Volume Set, Fifth Edition
Jan 232020
 

This new edition brings you up-to-date on the role of pharmaceutics and its future paradigms in the design of medicines. Contributions from over 30 international thought leaders cover the core disciplines of pharmaceutics and the impact of biotechnology, gene therapy, and cell therapy on current findings. Modern Pharmaceutics helps you stay current with the basic sciences, systems, applications, and advances in drug development—from materials used in formulations and dosage form design and manufacture, to testing in clinical trials.

Improve research and development strategies with brand new content on:
• methods of in vivo imaging of dosage forms
• excipients, tablets, and aerosols—from physical chemistry to dosage form
• solid state drug delivery
• biotechnology-based pharmaceuticals
• modern evaluation techniques for medicinal products
• pharmaceutical nanotechnology
• pharmaceutical physics
• pediatric and geriatric medication
• routes of administration
• paradigms in pharmaceutical research

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Applied Therapeutics – The Clinical Use of Drugs (Koda Kimble and Youngs Applied Therapeutics) North American 11th Edition

 Pharmacology  Comments Off on Applied Therapeutics – The Clinical Use of Drugs (Koda Kimble and Youngs Applied Therapeutics) North American 11th Edition
Jan 222020
 

Continually revised and updated for over 40 years, Applied Therapeutics: The Clinical Use of Drugs is the gold standard for patient-centered drug therapeutics. With its acclaimed case-based approach, the Eleventh Edition promotes mastery and application of the fundamentals of drug therapeutics. Featuring contributions from more than 200 experienced clinicians, every chapter has been revised and updated to reflect our ever-changing knowledge of drugs and the application of this knowledge to the individualized therapy of patients. As you progress from the General Principles section to chapters on specific diseases, you will benefit from practical problem-solving techniques that help you devise effective evidence-based drug treatment plans.
Given the evolving educational needs of students, this edition has been thoughtfully revised to align with the five Institute of Medicine (IOM) core competencies (patient-centered care, interdisciplinary teams, evidence-based practice, quality improvement, and informatics), as well as current pharmacy educational outcomes and the North American Pharmacist Licensure Examination (NAPLEX) competency statements. These strategies ensure relevance to contemporary pharmacy and preparation for pharmacy practice.
Features to help design safe, effective drug therapy and prepare students for evidence-based practice:

  • Approximately 900 case studies challenge you to integrate and apply therapeutic principles in the context of specific clinical situations, cultivating the critical-thinking skills needed to optimize patient outcomes.
  • Core Principles listed at the beginning of each chapter keep you focused on key content and direct you to specific case studies that enable you to explore critical concepts and gain further understanding of how they apply to evidence-based decision making.
  • New chapters address important recent topics and developments. Drug interactions, pharmacogenomics and personalized medicine, and interprofessional education and practice are included in General Principles; systemic lupus erythematosus in Immunologic Disorders; developmental disorders in Psychiatric Disorders and Substance Abuse; and prostate cancer in Hematology and Oncology. In addition, a chapter has been redesigned to focus on Care of the Critically Ill Adult, which now complements the chapter on Care of the Critically Ill Child.

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Chemotherapy Regimens and Cancer Care (Vademecum)

 Oncology, Pharmacology  Comments Off on Chemotherapy Regimens and Cancer Care (Vademecum)
Jan 182020
 

This handbook is a concise, thorough, and portable reference guide to the multitude of complex chemotherapy protocols and other frequently utilized medications in the field of Hematology/Oncology. Its inclusion of commonly used oncology regimens, guidelines for supportive care during administration and sections on pain control, antibiotic use and antiemesis guidelines set it apart from other ?chemotherapy handbooks?. The authors have prepared this book with the intention of improving the care of those suffering from cancer.

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Schizophrenia and Mood Disorders: The New Drug Therapies in Clinical Practice

 Pharmacology  Comments Off on Schizophrenia and Mood Disorders: The New Drug Therapies in Clinical Practice
Jan 172020
 

This authoritative resource comprehensively covers the use of drug therapies in the treatment of mood disorders and schizophrenia. It is divided into three sections. The first two, Schizophrenia and Depression and Mania give detailed accounts of specific drug therapies, whilst the third section, Key Issues in Clinical Psychopharmacology covers a variety of current topics such as considerations for young, old and pregnant patients, substance misuse and pharmacoeconomics. The inclusion of the most up-to-date knowledge, best practices, and clinical pearls from internationally renowned contributors ensure that this is a critical resource for clinicians prescribing for their patients.

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Pharmacological Treatment of Chronic Stable Angina Pectoris

 Cardiovascular, Pharmacology  Comments Off on Pharmacological Treatment of Chronic Stable Angina Pectoris
Jan 152020
 

This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The goal of this book is to update clinicians on recent data on the medical management of patients with CSA. Ischemic heart disease remains a major public health problem. Chronic stable angina is the initial manifestation of ischemic heart disease in approximately one half of patients. Stable coronary artery disease is generally characterized by episodes of reversible myocardial demand/supply mismatch, related to ischaemia or hypoxia, which are usually inducible by exercise, emotion or other stress and reproducible―but, which may also be occurring spontaneously. Such episodes of ischaemia/hypoxia are commonly associated with transient chest discomfort (angina pectoris). The aim of the management of CSA is to reduce symptoms and improve prognosis. The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education. All patients with stable angina should be offered optimal medical treatment, defined as one or two anti-anginal drugs as necessary, plus drugs for secondary prevention of cardiovascular disease. Regarding the role of revascularization, randomised trials provide compelling evidence that myocardial revascularisation by coronary artery bypass grafting or by percutaneous coronary intervention improves symptoms of angina relative to continued medical treatment.

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Practical Statistics for Pharmaceutical Analysis: With Minitab Applications

 Pharmacology  Comments Off on Practical Statistics for Pharmaceutical Analysis: With Minitab Applications
Jan 152020
 

This is an introductory statistics book designed to provide scientists with practical information needed to apply the most common statistical tests to laboratory research data. The book is designed to be practical and applicable, so only minimal information is devoted to theory or equations. Emphasis is placed on the underlying principles for effective data analysis and survey the statistical tests. It is of special value for scientists who have access to Minitab software. Examples are provides for all the statistical tests and explanation of the interpretation of these results presented with Minitab (similar to results for any common software package). The book is specifically designed to contribute to the AAPS series on advances in the pharmaceutical sciences. It benefits professional scientists or graduate students who have not had a formal statistics class, who had bad experiences in such classes, or who just fear/don’t understand statistics. Chapter 1 focuses on terminology and essential elements of statistical testing. Statistics is often complicated by synonyms and this chapter established the terms used in the book and how rudiments interact to create statistical tests. Chapter 2 discussed descriptive statistics that are used to organize and summarize sample results. Chapter 3 discussed basic assumptions of probability, characteristics of a normal distribution, alternative approaches for non-normal distributions and introduces the topic of making inferences about a larger population based on a small sample from that population. Chapter 4 discussed hypothesis testing where computer output is interpreted and decisions are made regarding statistical significance. This chapter also deasl with the determination of appropriate sample sizes. The next three chapters focus on tests that make decisions about a population base on a small subset of information. Chapter 5 looks at statistical tests that evaluate where a significant difference exists. In Chapter 6 the tests try to determine the extent and importance of relationships. In contrast to fifth chapter, Chapter 7 presents tests that evaluate the equivalence, not the difference between levels being tested. The last chapter deals with potential outlier or aberrant values and how to statistically determine if they should be removed from the sample data. Each statistical test presented includes an example problem with the resultant software output and how to interpret the results. Minimal time is spent on the mathematical calculations or theory. For those interested in the associated equations, supplemental figures are presented for each test with respective formulas. In addition, Appendix D presents the equations and proof for every output result for the various examples. Examples and results from the appropriate statistical results are displayed using Minitab 18Ò. In addition to the results, the required steps to analyze data using Minitab are presented with the examples for those having access to this software. Numerous other software packages are available, including based data analysis with Excel.

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on New Horizons in Predictive Drug Metabolism and Pharmacokinetics
Jan 152020
 

Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk.
Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.
Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.

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Nijkamp and Parnham’s Principles of Immunopharmacology

 Immunology, Pharmacology  Comments Off on Nijkamp and Parnham’s Principles of Immunopharmacology
Jan 082020
 

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.
The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.

Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.

The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

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