Fundamentals of Nuclear Pharmacy, Sixth Edition

 Pharmacology  Comments Off on Fundamentals of Nuclear Pharmacy, Sixth Edition
Oct 112019
 

Established as a classic text on nuclear chemistry and pharmacy, Fundamentals of Nuclear Pharmacy has been thoroughly revised with new information added covering innovations in imaging technology and clinical applications in the field. The Sixth Edition also eliminates outdated information from previous editions on radiopharmaceuticals now discontinued from the market. Dr. Gopal B. Saha’s books have continually been praised for their clarity and accuracy while setting new standards for making complex theoretical concepts readily understandable to the reader. Like past editions, this book is intended to be used as a textbook on nuclear chemistry and pharmacy for nuclear medicine residents and students and as a reference book for nuclear medicine physicians and radiologists. New sections in the Sixth Edition include: • PET/CT and SPECT/CT • Digital Imaging • Exploratory IND • Nanoparticle Imaging • Treatment of liver cancer with 90Y-TheraSpheres and 90Y-SIR-Spheres • Treatment of Non-Hodgkin’s lymphoma with 131I-Bexxar
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Drug Delivery Research Advances

 Pharmacology  Comments Off on Drug Delivery Research Advances
Oct 082019
 

Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection.Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.
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Biologically Active Natural Products: Pharmaceuticals (Repost)

 Pharmacology  Comments Off on Biologically Active Natural Products: Pharmaceuticals (Repost)
Oct 082019
 


Biologically Active Natural Products: Pharmaceuticals demonstrates the connections between agrochemicals and pharmaceuticals and explores the use of plants and plant products in the formulation and development of pharmaceuticals. Experts from around the world examine a multitude of topics, including evaluation of extracts from tropical plants for potential anticancer activity and cancer chemopreventive activity; use of Chinese lacquer tree sap products as pharmaceutical intermediates; and new approaches to drug discovery from the rainforest.
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Pharmacology of Neurotransmitter Release

 Neurology/Neurosurgery, Pharmacology  Comments Off on Pharmacology of Neurotransmitter Release
Oct 032019
 

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
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The Metabolic Syndrome: Pharmacology and Clinical Aspects

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on The Metabolic Syndrome: Pharmacology and Clinical Aspects
Sep 202019
 

The metabolic syndrome is a common syndrome affecting about 20 % of the adult population in Europe, and probably the prevalence is of the same magnitude in other industrialised countries worldwide. It is mainly caused by western lifestyle resulting in abdominal obesity, but also a genetic predisposition plays a role. This syndrome, which is linked to leisure lifestyle and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are heavily needed. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in the daily clinic.

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Excipient Toxicity and Safety (Drugs and the Pharmaceutical Sciences)

 Pharmacology  Comments Off on Excipient Toxicity and Safety (Drugs and the Pharmaceutical Sciences)
Sep 182019
 

This book reviews the history, regulatory status, pharmacopeial specifications, and harmonization of pharmaceutical excipients in the United States and Europe, and provides a comprehensive understanding of the current scientific basis for safety evaluation and risk assessment. Examines excipients as a unique class of products and explores new procedures for determining toxicity! A timely and unique addition to the pharmaceutical literature, containing over 570 citations that support and enhance the text, Excipient Toxicity and Safety ·identifies the differences between excipients (inactive ingredients), food ingredients, and drug products ·evaluates issues of dose administration, species selection, and study design for various routes of exposure ·provides detailed information on the historical uses of excipients in drug formulations ·clarifies the Safety Committee of the International Pharmaceutical Excipients Council’s (IPEC) guidelines and technical specifications for conducting tests for each route of exposure ·explains how data generated in toxicity models are applied to identify hazards in drug formulations ·details exposure assessment to link hazard identification with risk ·considers the requirements and importance of purity specifications ·and much more! Excipient Toxicity and Safety is a blue-ribbon reference ideal for pharmacists; toxicologists; pharmacologists; analytical chemists; quality control, quality assurance, and regulatory compliance managers; and upper-level undergraduate and graduate students in these disciplines.

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The Challenge of CMC Regulatory Compliance for Biopharmaceuticals, Third Edition

 Pharmacology  Comments Off on The Challenge of CMC Regulatory Compliance for Biopharmaceuticals, Third Edition
Sep 052019
 

Biopharmaceuticals (i.e., biological medicines sourced from genetically-engineered living systems) for treatment of human diseases have become a significant percentage of the pharmaceutical industry. And not just the recombinant DNA-derived proteins and monoclonal antibodies (both from the innovators and biosimilars); but now, an increasing awareness of the importance of gene therapy and genetically engineered cellular medicinal products.
These biopharmaceuticals are being developed by many companies whose Chemistry, Manufacturing & Control (CMC) teams have varying degrees of familiarity or experience with the CMC strategy and regulatory compliance requirements for these challenging products. Companies clearly plan out the strategy for their clinical study plans, but frequently, the development of a strategy for CMC is an afterthought. Coupled with the complexity of the biopharmaceutical manufacturing processes and products, and this can be a recipe for disaster. The third edition of this book provides insights and practical guidance for the CMC teams to develop an acceptable cost-effective, risk-based CMC regulatory compliance strategy for all biopharmaceuticals (recombinant proteins, monoclonal antibodies, genetically engineered viruses and genetically engineered human cells) from early clinical stage development through market approval. The third edition of this book provides added coverage for the biosimilars, antibody drug conjugates (ADCs), bispecific antibodies, genetically engineered viruses, and genetically engineered cells. This third edition of the book also addresses the heightened pressure on CMC regulatory compliance timelines due to the introduction of expedited clinical pathways moving the clinical development closer to a seamless phase process (e.g., FDA Breakthrough Therapy designation, CBER Regenerative Medicine Advanced Therapy (RMAT) designation, EMA Priority Medicines (PRIME) designation). The Challenge of CMC Regulatory Compliance for Biopharmaceuticals is essential, practical information for all pharmaceutical development scientists, Manufacturing and Quality Unit staff, Regulatory Affairs personnel, and senior management involved in the manufacture of biopharmaceuticals.

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Introduction to pharmacology

 Pharmacology  Comments Off on Introduction to pharmacology
Aug 312019
 

The first edition of Introduction to Pharmacology has over recent years become a highly influential text among students wishing to acquire a knowledge of pharmacology without having to refer to the larger, more detailed, traditional pharmacology volumes. This revised and updated second edition contains significant new material to bring the reader up-to-date with the latest practices and principles in pharmacology.Exploring the basic principles in both the therapeutic and toxicological aspects of drug use, the book employs contemporary examples of medication, supplemented with an increased number of accurate and easy-to-interpret figures and diagrams. Additionally, Introduction to Pharmacology presents the important concept of understanding the limitations surrounding the drugs that cure, replace physiological inadequacies, or treat symptoms, and which have led to the system of drug classification. The broad scope of the book also encompasses the role of the FDA, drugs in sport, and the use of animals for drug experimentation. A clear and accessible book, Introduction to Pharmacology builds on the strengths of the first edition and is an invaluable reference for all students interested in this subject.
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Clinical Physiology and Pharmacology: The Essentials

 Pharmacology, Physiology  Comments Off on Clinical Physiology and Pharmacology: The Essentials
Aug 312019
 


This book is an accessible collection of case study scenarios ideal for physiology and pharmacology revision for pharmacy, medical, biomedical science, clinical science and healthcare students. Clearly structured and organized by major organ system, the book emphasises ways in which key signs and symptoms of disease inform diagnosis and the choice of treatment, together with the relevant pharmacological mechanisms. Each chapter has a clinical focus and includes clear learning outcomes, key points and model answers with detailed explanations designed to enhance students’ understanding of the physiology and pharmacology underpinning each case study scenario.50 topics are covered and the cases presented include an extensive range of psychological, neurological, endocrine, cardiovascular, respiratory, renal, gastrointestinal and reproductive disorders, their symptoms, complications and usual treatment along with the actions and uses of some widely- used drugs.An essential revision text designed to help students apply their theoretical knowledge to real-life casesRealistic case studies focusing on commonly occurring conditions and diseasesModel answers throughoutLearning outcomes provided at the beginning of each chapterKey learning points presented in the cases follow each model answerHelps students to understand the relevance and clinical implications of the topics studied in physiology and pharmacology coursesReinforces  major concepts and definitionsIncludes a glossary with a full list of drugs and disorders to support the text
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Antimicrobial pharmacodynamics in theory and clinical practice

 Pharmacology  Comments Off on Antimicrobial pharmacodynamics in theory and clinical practice
Aug 172019
 

Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practice.
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