Helicobacter Pylori Protocols (Methods in Molecular Medicine)

 Genetics  Comments Off on Helicobacter Pylori Protocols (Methods in Molecular Medicine)
May 252018

Helicobacter pylori Protocols offers an outstanding collection of state-of-the-art protocols for the identification and molecular manipulation of H. pylori. The authoritative contributors supply detailed and readily reproducible protocols for the culturing of H. pylori, for the isolation and restriction endonuclease digestion of H. pylori chromosomal DNA, and for the transformation and insertional mutagenesis of H. pylori. They also provide molecular epidemiological techniques, including ribotyping, PCR-RFLP, and RAPD-PCR. These procedures have been developed by leading practitioners to solve the difficult technical problems created by the application of the powerful bacterial genetic and molecular cloning techniques to H. pylori.
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Understanding Breast Cancer Genetics

 Genetics, Oncology  Comments Off on Understanding Breast Cancer Genetics
May 212018

Health & Sickness – Consumer Health –>
This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually.
Why are some women more vulnerable than others? The interplay between genetics and environment is suspected.
Thus this book for general readers will help them understand the genetic bases of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on.
Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered.
Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman’s understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included.
Barbara T. Zimmerman did her graduate work in experimental pathology and her post-doctoral research in the cellular and molecular processes of disease. Widely published, she is the manager of the Denver-based firm Biomedical Communication and Consulting.





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Hereditary Colorectal Cancer: Genetic Basis and Clinical Implications

 Genetics, Oncology  Comments Off on Hereditary Colorectal Cancer: Genetic Basis and Clinical Implications
May 192018

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.
This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.







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Clinical Cardiogenetics, 2nd Edition

 Cardiovascular, Genetics  Comments Off on Clinical Cardiogenetics, 2nd Edition
May 172018

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic.

The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner.

The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately.

Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included.

This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as:

Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?





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Facilitating the Genetic Counseling Process: Practice-Based Skills, Second Edition

 Genetics  Comments Off on Facilitating the Genetic Counseling Process: Practice-Based Skills, Second Edition
May 142018

Now in its revised and updated second edition, this text provides a practical way of teaching genetic counseling helping skills. The contents can be used by genetic counselor educators and supervisors to facilitate student professional development, including gaining knowledge about basic helping skills; practicing using the skills specific to genetic counseling services; and understanding one’s self as a professional in training. New topics include: the Reciprocal-Engagement Model (REM) of genetic counseling practice; research findings about genetic counselor professional development, values, compassion fatigue, burnout, and distress; expanded discussion of patient factors; and more attention to cultural issues. Every chapter contains updated literature, and both revised and new structured activities and written exercises.
Salient features of this second edition include:• An “active” and “cooperative” pedagogical approach, with numerous structured activities and exercises emphasizing student self-reflection and engagement with core content.• Inclusion of skills which comprise key elements within three competency domains for accreditation of genetic counseling training programs in North America: genetics expertise and analysis; interpersonal, psychosocial, and counseling skills and assessment; and professional development and practice.• Content grounded in a widely-cited, empirically-derived model of genetic counseling practice.• Inclusion of patient scenarios and roles for skills practice based on genetic counseling cases and reflecting recent developments in genetic knowledge, testing, and technologies.







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Thrive in Genetics

 Genetics  Comments Off on Thrive in Genetics
Mar 272018

The Thrive in Bioscience guides are written to help students achieve exam success in all core areas of bioscience.

Each title in the series encourages students to follow four simple steps to maximize learning potential:

Step 1: Review the facts
The revision guides are designed to make learning quick and effective:
* Information is set out in bullet points, making content easy to take in.
* Clear, uncluttered illustrations illuminate key points.
* Key concept panels summarize essential learning points.

Step 2: Check your understanding
Students are encouraged to:
* Complete the questions at the end of chapters and answer online multiple-choice questions to reinforce their learning.
* Use the online flashcard app to master essential terms and phrases.

Step 3: Take note of extra advice
Revision tips–and hints for getting higher grades on exams–are presented throughout.

Step 4: Go the extra mile
Students can explore the suggestions for further reading to take their understanding one step further.

Features of the Thrive in Bioscience Series:
* Written by a group of highly experienced educators
* Succinct writing style and clear, bulleted presentation
* Carefully developed artwork that reinforces key points
* Extensive in-text pedagogy–including review questions–that supports active learning.








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Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, Second Edition

 Genetics  Comments Off on Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, Second Edition
Mar 202018

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers.
In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.

Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.








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Cleft Lip and Palate Treatment: A Comprehensive Guide

 Genetics, Surgery  Comments Off on Cleft Lip and Palate Treatment: A Comprehensive Guide
Mar 112018

The aim of this book is to discuss cleft lip and palate deformities in a comprehensive way, presenting it from the basics to the most clinically and surgically relevant issues. First, the basic concepts of embryology and pathogenesis of the facial deformities will be discussed. Special attention will be paid to the genetics underlying this condition. Following that, basic principles of surgical treatment through the most recent advances in the field will be presented, along with most important evidences from the literature and the personal experience of the editors and authors.
Cleft Lip and Palate Treatment presents the state of the art and advances in the field and is intended to serve as a comprehensive guide for a broad audience. All the specialties involved in the comprehensive care of these craniofacial deformities will be presented in this book.








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Minerals for the Genetic Code: An Exposition & Anaylsis of the Dr. Olree Standard Genetic Periodic Chart & the Physical

 Genetics  Comments Off on Minerals for the Genetic Code: An Exposition & Anaylsis of the Dr. Olree Standard Genetic Periodic Chart & the Physical
Mar 092018

In this cutting-edge book, the connection is made between the physical, chemical and biological aspects of minerals and subatomic particles in the life process, and assignment is made of the specific mineral that governs each entry in the genetic code.
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BRS Biochemistry, Molecular Biology, and Genetics

 Genetics  Comments Off on BRS Biochemistry, Molecular Biology, and Genetics
Feb 252018

BRS Biochemistry, Molecular Biology, and Genetics is an excellent aid for USMLE Step 1 preparation and for coursework in biochemistry, molecular biology, and genetics. Fully updated for its sixth edition, chapters are written in an outline format and include pedagogical features such as bolded key words, figures, tables, algorithms, and highlighted clinical correlates. USMLE-style questions and answers follow each chapter and a comprehensive exam appears at the end of the book.



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