Jun 192017
 

The Genetics of Health: Understand Your Genes for Better Health


Features: ATRIA
By (author): Sharad P. Paul MD

Take charge of your health by understanding the connection between our evolutionary past and our future wellbeing with this practical guide to personalized health and nutrition—from distinguished physician Dr. Sharad Paul.

Recognized as one of the best in his field, surgeon, academic, and philanthropist, Dr. Sharad Paul combines everyday health with evolutionary biology and explains how to improve your overall wellness by following a diet and exercise plan according to your gene type. Starting with our brains, this book covers everything from skin and muscles, to hearts, diets, and stress management. Throughout, Dr. Paul shares key information and provides steps to improve our daily wellbeing—impacting everything from our energy levels to memory retention to our overall longevity.

Our evolutionary past and genetic makeup determine how and why the body works the way it does and how it all combines to make us unique individuals. Presenting a compelling blend of medical mysteries, patient stories, and science, Dr. Paul has developed a revolutionary approach to wellness that will result in beautiful skin at any age, a healthier diet for muscle endurance and skeletal strength, a more resilient and efficient heart, better mood and memory balance, and more.
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Jun 182017
 

Male Infertility: Understanding, Causes and Treatment


This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.    

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Jun 132017
 

Stroke Genetics


This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.

Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

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Jun 122017
 

Bone Morphogenetic Proteins: Systems Biology Regulators (Progress in Inflammation Research)


This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes.

This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

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Jun 112017
 

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Jun 072017
 

Genetic Disorders (Compact Research: Drugs) by Peggy J Parks (2009-12-01)


By (author): Peggy J Parks

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Jun 052017
 

Molecular Genetics of Thalassemia Syndromes (Colloquium Series on Genomic and Molecular Medicine)


By (author): Reena Das, Prashant Sharma

This book reviews the molecular genetics of the thalassemia syndromes, inherited hemoglobin disorders that comprise the commonest monogenic disorders globally. Thalassemias are found in high frequencies in tropical regions corresponding to the malaria belt. Beta thalassemia traits show high HbA2 by HPLC, and ?-globin mutations (commonly point mutations) are detected by using ARMS-PCR, reverse dot-blot analysis and ?-globin gene sequencing. Globally >300 ? globin gene mutations exist, however regional mutations are limited to 5-6 common ones. Alpha globin gene defects can only be identified by molecular tests, the exception being HbH disease that shows “golf ball” appearance in HbH preparation, pre-integration peaks on HPLC and a fast-moving band on hemoglobin electrophoresis. Multiplex Gap-PCR identifies common ?-globin gene deletions. Specific PCR across the junction caused by the unequal crossing over can detect ?-gene triplication. However, heterozygosity or homozygous triplication cannot be resolved by this technique. Non-deletional ?-thalassemia can be characterized by specific ?-globin gene sequencing. Identification of unusual deletions requires Multiplex Ligation-dependent Probe Amplification. In conclusion, the molecular characterization of human globin gene disorders is required to resolve the phenotypically heterogeneous thalassemia syndromes. Molecular analysis is also an important tool to prevent these disorders by offering prenatal screening in regions with a high disease burden.
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May 112017
 

History of Human Genetics: Aspects of Its Development and Global Perspectives


Written by 30 authors from all over the world, this book provides a unique overview of exciting discoveries and surprising developments in human genetics over the last 50 years.

The individual contributions, based on seven international workshops on the history of human genetics, cover a diverse range of topics, including the early years of the discipline, gene mapping and diagnostics. Further, they discuss the status quo of human genetics in different countries and highlight the value of genetic counseling as an important subfield of medical genetics.

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May 082017
 

Medical Genetics in the Clinical Practice of ORL (Advances in Oto-Rhino-Laryngology, Vol. 70)


Experts in otorhinolaryngology as well as medical genetics have contributed their reviews to this comprehensive compilation. Introductory chapters deal with basic genetics followed by chapters devoted to specific disorders. The gamut of otorhinolaryngological diseases from both adult and pediatric practice is covered. Included are common disorders such as hearing loss, cleft lip and palate, and thyroid cancers as well as further chapters on rare disorders such as Usher syndrome, neurofibromatosis type 2 and paraganglioma. Also, emerging fields of genetic investigation including otitis media, chronic rhinosinusitis and gene therapy are discussed. The contributions focus on diagnosis and management, as well as practical issues like how to order genetic testing or refer to a medical geneticist or genetic counselor. This publication will serve as an educational and reference text for both adult and pediatric otorhinolaryngologists, as well as medical geneticists and genetic counselors. It will provide readers with an understanding of the current state of genetic disorders seen in ORL practice, allow for accurate diagnosis, and improve patient management.
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May 042017
 

Parental Responsibility in the Context of Neuroscience and Genetics (International Library of Ethics, Law, and the New Medicine)


Should parents aim to make their children as normal as possible to increase their chances to “fit in”? Are neurological and mental health conditions a part of children’s identity and if so, should parents aim to remove or treat these? Should they aim to instill self-control in their children? Should prospective parents take steps to insure that, of all the children they could have, they choose the ones with the best likely start in life?

This volume explores all of these questions and more. Against the background of recent findings and expected advances in neuroscience and genetics, the extent and limits of parental responsibility are increasingly unclear. Awareness of the effects of parental choices on children’s wellbeing, as well as evolving norms about the moral status of children, have further increased expectations from (prospective) parents to take up and act on their changing responsibilities. 

The contributors discuss conceptual issues such as the meaning and sources of moral responsibility, normality, treatment, and identity. They also explore more practical issues such as how responsibility for children is practiced in Yoruba culture in Nigeria or how parents and health professionals in Belgium perceive the dilemmas generated by prenatal diagnosis.

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