Jan 302017
 

Developmental and Reproductive Toxicology: A Practical Approach, Third Edition


The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics.

The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches.

Developmental and Reproductive Toxicology, Third Edition:

  • Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies.
  • Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity.
  • Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference.
  • Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment.

This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

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Jan 072017
 

A Practical Guide to Basic Laboratory Andrology (Cambridge Medicine (Paperback))


By (author): Lars Björndahl, David Mortimer, Christopher L. R. Barratt, Jose Antonio Castilla, Roelof Menkveld, Ulrik Kvist, Juan G. Alvarez, Trine B. Haugen

This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes pertinent quality control considerations, as well as the optimum presentation of results. In addition to the comprehensive ‘basic’ semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. Throughout the handbook the interpretation of laboratory results in the clinical context is highlighted, and safe laboratory practice is emphasized. It is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.
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Dec 292016
 

Pelvic Pain: Causes, Symptoms and Treatments (Human Anatomy and Physiology: Pain and Its Origins, Diagnosis and Treatments)


Presents topical research in the study of pelvic pain, including myofascial pain syndrome in the pelvic floor; hormonal modulation of genitourinary pain; the pathophysiology of endometriosis associated with pelvic pain; chronic non-bacterial prostatits; physical therapy for women with pelvic pain; and, more.
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Dec 102016
 

Intra-Uterine Insemination: Evidence Based Guidelines for Daily Practice (Reproductive Medicine and Assisted Reproductive Techniques)


Intra-uterine insemination (IUI) is a widely used fertility treatment for couples with unexplained and male subfertility. Although it is less invasive and less expensive than l other treatment options such as in vitro fertilization, several factors affect its outcome. In addition, IUI remains controversial due to concerns about some of the possible aspects of treatment, including side-effects such multiple pregnancies. This comprehensive evidence-based book from an international IUI expert team explores all of these topics and provides clear guidelines for daily practice.

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Oct 242016
 

Reproductive Rights and Technology (Library in a Book)


Features: Used Book in Good Condition
By (author): Rachel Kranz

From the advent of the Pill to in vitro fertilization, from Roe v. Wade to the Freedom of Choice movement, the reproductive rights of women have always been a highly volatile, hotly debated subject. Reproductive Rights and Technology addresses this important and emotionally charged issue. As with the other titles in the Library in a Book series, it provides a historical overview, reference resource, and research guide that can be useful not only to students, teachers, and librarians but also to journalists, media people, and members of the public interested in the impact that this issue has on our society. This volume examines reproductive issues from a wide variety of perspectives and disciplines – including science, technology, history, economics, politics, social attitudes, religion, and philosophy. Readers will also discover the range of reproductive technologies currently available, how their development has been affected by people’s beliefs and values, and the circumstances under which these techniques are made available. This addition to the critically acclaimed Library in a Book series will be of great use to everyone concerned with the issues of reproduction, childbearing, and women’s rights.
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Oct 232016
 

WHO Classification of Tumours of the Female Reproductive Organs (IARC WHO Classification of Tumours)


By (author): International Agency for Research on Cancer

WHO Classification of Tumours of Female Reproductive Organs is the sixth volume in the Fourth Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome.

Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 91 authors from 19 countries, contains more than 400 color images and tables, and more than 2100 references.

This book is in the series commonly referred to as the “Blue Book” series.

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Oct 212016
 

Androgen Action: Methods and Protocols (Methods in Molecular Biology)


Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells.Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.

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Aug 202016
 

Male Reproductive Dysfunction


By (author): Basu

1. Brief Historical Preview of Reproductive Science, 2. Basic Information on Male Reproductive Anatomy and Physiology, 3. Endocrinal aspect of Male Reproductive System, 4. Erection, Orgasm, and Ejaculation, 5. Management of Erectile Dysfunction, 6. Basic Information on Male Infertility and Working up Patients, 7. Semen Analysis, 8. Other Investigations of a case of Male Infertility, 9. Varicocele and Male Infertility, 10. Other causes of Male Infertility, 11. Medical and Non-Surgical Management in Male Infertility, 12. Role of Surgery in Male Infertility, 13. Role of Assisted Reproduction in Male Infertility, 14. Psychological aspect of Infertility.
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Aug 152016
 

Role of Folliculo-luteal Function in Human Reproduction


By (author): György Siklósi

This book is the first to explain fully the crucial role of folliculo-luteal function in recurrent miscarriage, unexplained infertility, preterm birth, intrauterine growth retardation, preeclampsia, random chromosomal abnormalities, and age-related reproductive disorders. In addition it describes treatments to avoid these conditions and proposes a novel method, “hormonal wedge resection”, that can successfully cure infertility associated with polycystic ovary syndrome. Importantly, the conclusions drawn in this book are based on the therapeutic results observed in a representative patient population.

The method developed by the author to quantitatively diagnose the hormonal insufficiency of ovulatory cycles (folliculo-luteal insufficiency, FLI) has made it possible to recognize the formerly unclear importance of this function in human reproduction. Folliculo-luteal function determines the conditions of placentation and thus the features of the developed placenta and the outcome of pregnancy. Different grades of FLI are associated with consequences of varying severity that can be prevented by normalization of folliculo-luteal function prior to conception. This book will be required reading for all obstetricians and gynecologists.

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Aug 142016
 

Reproductive Epidemiology: Principles And Methods


Features: Used Book in Good Condition
By (author): Ray M. Merrill

Reproductive Epidemiology introduces epidemiology students and health practitioners to a range of methodologies used to collect data and conduct analysis on reproductive epidemiology. The focus is to provide guidance on the use of methods appropriate for challenging and sensitive research topics, including sexual behavior, abortion, illicit drug use, and sexual abuse.
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