IVF Children: The First Generation: Assisted Reproduction and Child Development

 Reproductive Health  Comments Off on IVF Children: The First Generation: Assisted Reproduction and Child Development
Dec 022019
 

In the last decade alone, advances in assisted reproduction have increased dramatically. The miracle of babies born through in vitro fertilization no longer seems so miraculous. However, information about the continued emotional and physical development of IVF children is hard to find, and once found, can be difficult to interpret.
IVF Children: The First Generation: Assisted Reproduction and Child Development comprehensively reviews the current knowledge about the physical and mental outcomes of children conceived through IVF techniques. The author examines all of the studies relevant to the development and well being of IVF children and discusses the results and implications of these studies from every angle. More importantly for the busy staff of fertility clinics, Dr. Sutcliffe explores how to interpret what is known from these studies to qualify the studies’ validity and use their results.
In contrast to many other books devoted to techniques involved in ART, this book addresses what is known about the ultimate outcome of the children born after employing the various ART methods for conception. The author draws together the available data and provides an in-depth analysis of the results. He expertly blends scientific theory and clinical outcomes to provide a handbook also useful for counselling families. IVF Children: The First Generation: Assisted Reproduction and Child Development provides guidance to professionals and parents/prospective parents alike in selecting the fertility treatment that best meets their needs.
About the author: Dr. Alastair Sutcliffe is an academic pediatrician with clinical practice in the Royal Free Hospital Campus of University College London and was awarded his Doctorate in 2000. He was the first person to study children who were cryopreserved as embryos and for the past five years, has been studying a group of ICSI conceived children throughout the UK. These children are currently being assessed in the biggest developmental study in the field. His work is now recognized worldwide as having made an important contribution to assessing outcomes of new types of in vitro fertilization.

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Posttranslational Protein Modifications in the Reproductive System

 Reproductive Health  Comments Off on Posttranslational Protein Modifications in the Reproductive System
Nov 292019
 

This book’s aim is to increase the awareness of a great variety of posttranslational modifications in the male and female reproductive system. Some of the most intriguing reproductive strategies, mechanisms, and pathways involving PTM are discussed, with an added angle of evolutionary conservation and diversity. The book also chapters on sperm-egg binding, as well as on histone modification in both the embryo and sperm. Chapters are also devoted to protein ubiquitination, the regulation of sperm function during fertilization in mammals and tubulin modifications in gametes and embryos. There are no other current books on posttranslational protein modifications as they relate to reproduction, making this contribution unique in the field. It is useful for both researchers and graduate students alike.
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Male Infertility in Reproductive Medicine : Diagnosis and Management

 Reproductive Health  Comments Off on Male Infertility in Reproductive Medicine : Diagnosis and Management
Nov 192019
 

This useful illustrated text summarizes for an audience of clinicians in Reproductive Medicine the practical essentials of what they need to know about diagnosis and management of the infertile male patient, whether they need to instruct or liaise with a colleague or undertake the procedures themselves.

Botros Rizk, MD, FRCOG, FRCS, HCLD, FACOG, FACS, is Professor and Head of Reproductive Endocrinology and Infertility, Medical and Scientific Director of In Vitro Fertilization and Assisted Reproduction, University of South Alabama, Mobile, Albama, USA; Distinguished Adjunct Scientific Director, IVF Michigan, Rochester Hills, Michigan, USA; and President Elect, Middle East Fertility Society. Ashok Agarwal, PhD is Director of the Andrology Center, Director of Research at the American Center for Reproductive Medicine at Cleveland Clinic, and Professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, USA. Edmund S Sabanegh, Jr, MD, is Chairman of the Department of Urology and Director of the Center for Male Fertility, Cleveland Clinic, USA.

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Endometrial Gene Expression: An Emerging Paradigm for Reproductive Disorders

 Reproductive Health  Comments Off on Endometrial Gene Expression: An Emerging Paradigm for Reproductive Disorders
Nov 172019
 

The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions.

This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis.

Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.

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Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine

 Genetics, Reproductive Health  Comments Off on Screening the Single Euploid Embryo: Molecular Genetics in Reproductive Medicine
Nov 142019
 

Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence―from ovulation induction to luteal support―aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.

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Preservation of Human Oocytes (Reproductive Medicine and Assisted Reproductive Techniques)

 Reproductive Health  Comments Off on Preservation of Human Oocytes (Reproductive Medicine and Assisted Reproductive Techniques)
Oct 282019
 

Oocyte cryopreservation entails important potential advantages for humanIVF, offering a less ethically disputable alternative to embryo cryopreservation,simplifying and making safer oocyte donation, and giving an opportunity forfertility preservation to women at risk of premature ovarian failure as an effectof genetic factors or chemo- or radiotherapies. Oocyte cryopreservation couldalso meet the expectations of women wishing to preserve their fertility forsocial reasons. In the last few years, advances in cryopreservationmethodologies have dramatically improved the efficiency of oocytecryopreservation, leading to the birth of over a thousand babies andchallenging the supremacy of embryo cryopreservation as the preferredform of fertility preservation. This text has been conceived with the aim of offering a comprehensive view of the state of the art of oocyte cryopreservation. It covers fundamental concepts of low temperature storage (controlled rate slow cooling andvitrification), aspects of oocyte physiology relevant to the process ofcryopreservation, essential biological and clinical evidence, and ethicalimplications of oocyte cryopreservation, thereby providing a completeoverview of progress in this strategy in assisted reproduction.
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Ethnic Differences in Fertility and Assisted Reproduction

 Reproductive Health  Comments Off on Ethnic Differences in Fertility and Assisted Reproduction
Sep 202019
 

Over the past 10 years, studies have shown that the rates of fertility vary in different ethnic groups. Ethnic differences also play a significant role in the outcome of assisted reproductive technology (ART) cycles. In the United States, minority groups–African Americans, Hispanics (mainly Mexicans and Central Americans), East Asians (Chinese, Japanese, Koreans, Philippinos) and South Asians (Indians, Pakistanis, and Bengalis)–have significantly lower chances of live births compared to Caucasian women. Birth outcome data collected by the Society for Assisted Reproductive Technology shows a worsening trend in conception rates between the years 1999-2000 and 2004-2006, raising more concern that the disparity in fertility rates between minority groups and white women is widening over time. This comprehensive book serves to answer the questions that arise when managing infertility in a multi-ethnic population. An expert assembly of key leaders in the field of reproductive medicine imparts insight and clinical experience in order to identify and analyze the possible causes of racial disparities in fertility outcome. Some of the reviewed causes include higher Body Mass Index (BMI), tubal diseases, metabolic syndrome, and fibroids in African Americans; tubal disease and higher early pregnancy loss in Hispanics; higher incidence of diminished ovarian reserve and lower BMI in East Asians; and higher incidence of polycystic ovarian disease (PCOS) in South Asians. The book also provides a review of data on access to care and ART services in developing countries. A thoughtful combination of evidence-based medicine and advanced treatment options, this book is sure to distinguish itself as the definitive reference on ethnic differences in assisted reproduction.
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Ultrasound Imaging in Reproductive Medicine: Advances in Infertility Work-up, Treatment and ART Edition 2

 Radiology, Reproductive Health  Comments Off on Ultrasound Imaging in Reproductive Medicine: Advances in Infertility Work-up, Treatment and ART Edition 2
Jul 312019
 

Now in an updated edition, this is the most comprehensive book on modern ultrasound imaging in assisted reproductive technology (ART) and reproductive medicine. Fully revised and expanded, it covers emerging technologies possible with the improvement in ultrasound equipment. 3-D monitoring of ovarian follicles, bidirectional vibrant color and Doppler, and improved 3-D and 4-D imaging of reproductive structures are discussed. MRI-guided ultrasound procedures are covered, and comparisons of 3-D imaging with MRI imaging for uterine anomalies is reviewed with an emphasis on the advantages of 3-D performed in the gynecologist’s office, and as a less expensive modality.
The overall approach of the original edition is maintained, starting with ultrasound safety and technique and diagnosis of the ovary, uterus and fallopian tubes (both normal and pathologic), followed by both male and female infertility and ART treatments and procedures. Ultrasound monitoring of follicular development, the endometrium, and as an aid in embryo transfer to maximize IVF success rates are reviewed. Topics new to this edition include updated information on the diagnosis of benign and malignant adnexal masses, 3-D follicle monitoring, and the diagnosis of adenomyosis and endometriosis, including deep inseminated endometriosis. Additionally, the evaluation of endometrial receptivity, the use of contrasts for fallopian tube patency, controversies regarding septate uterus versus arcurate uterus with the use of 3-D ultrasound, and 3-D ultrasound with saline infusion sonogram and early pregnancy ultrasound are all discussed.
An excellent resource for reproductive medicine and ART specialists, gynecologists and ultrasonographers alike, Ultrasound Imaging in Reproductive Medicine, Second Edition covers all that clinicians need to know about the role of ultrasound, from the first time a woman comes into the clinic for treatment, including ART, to early pregnancy monitoring. See better, do ART better.

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Male Reproductive Cancers: Epidemiology, Pathology and Genetics

 Epidemiology, Genetics, Oncology, Pathology, Reproductive Health  Comments Off on Male Reproductive Cancers: Epidemiology, Pathology and Genetics
Jul 192019
 

Male Reproductive Cancers: Epidemiology, Pathology and Genetics presents a thoughtful, comprehensive and up-to-date overview of the etiology of the prostate gland and the testes, summarizing decades of research in the three most important etiological disciplines: epidemiology, pathology and genetics. This book is comprised of four distinct sections: Epidemiology, Pathology, Molecular Genetics, and Inherited Susceptibility, with each section divided into chapters categorized by disease. Section A reviews the epidemiology of prostate and testicular cancer, with an emphasis on clinical and environmental factors associated with these diseases. Section B begins by describing various pathological features of prostate cancer, followed by descriptions of the wide variety of testicular cancers as well as a brief section on the use of tumor markers for monitoring disease. Section C focuses on somatic genetic changes in prostate and testicular cancers using new technologies such as comparative genomic hybridization and gene expression profiling. Section D concentrates on the progress made toward understanding inherited susceptibility to prostate cancer and to testicular cancer.
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The Zero Trimester: Pre-Pregnancy Care and the Politics of Reproductive Risk

 Ob/Gynae, Reproductive Health  Comments Off on The Zero Trimester: Pre-Pregnancy Care and the Politics of Reproductive Risk
Jul 122019
 

In the United States, a healthy pregnancy is now defined well before pregnancy begins. Public health messages encourage women of reproductive age to anticipate motherhood and prepare their bodies for healthy reproduction—even when pregnancy is not on the horizon. Some experts believe that this pre-pregnancy care model will reduce risk and ensure better birth outcomes than the prenatal care model. Others believe it represents yet another attempt to control women’s bodies.

The Zero Trimester explores why the task of perfecting pregnancies now takes up a woman’s entire reproductive life, from menarche to menopause. Miranda R. Waggoner shows how the zero trimester rose alongside shifts in medical and public health priorities, contentious reproductive politics, and the changing realities of women’s lives in the twenty-first century. Waggoner argues that the emergence of the zero trimester is not simply related to medical and health concerns; it also reflects the power of culture and social ideologies to shape both population health imperatives and women’s bodily experiences.

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