Genomic Structural Variants (Methods in Molecular Biology, v838)

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Jun 132019
 

The completion of a consensus draft sequence for the human genome was the starting point for more thorough investigations of individual genome variation.  The development of array-based strategies made it possible to look at our genome in new ways and for new types of variation to be discovered and characterized. Characterization of copy number variation and other forms of structural genetic variation has highlighted the complexity of human genetic variation and also provided significant insight into the evolution and dynamic nature of our genome. Genomic Structural Variants: Methods and Protocols provides an in-depth description of the developments in our understanding of structural genetic variation and its implications for human disease, from the introduction of microarrays up to current state-of-the-art sequencing strategies. It covers the major technologies used for research and diagnostics as well as web-based resources for variation data, and it then goes into depth regarding specific regions of the genome that differ in variation content. Specific patient groups where copy number variation has been shown to be of great importance are highlighted, and implications for both pre-natal and standard diagnostics are described. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Genomic Structural Variants: Methods and Protocols provides complete comprehensive coverage of this burgeoning field.
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The Labor Progress Handbook: Early Interventions to Prevent and Treat Dystocia, 3 edition

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Jun 122019
 

The third edition of The Labor Progress Handbook builds on the success of first two editions and remains an unparalleled resource on simple, non-invasive interventions to prevent or treat difficult labor. Features new to this edition include two new chapters on third and fourth stage labor management and low-technology interventions, a complete analysis of directed versus spontaneous pushing, and additional information on massage techniques.

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Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications: Transcriptional Regulation and Chromatin R vol 2

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Jun 112019
 

Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants’ epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.
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Neonatal Intensive Care Units (NICUs): Clinical and Patient Perspectives, Levels of Care and Emerging Challenges (Neonatology Research Developments) 1st Edition

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Jun 082019
 

From World Health Organization data, the prevalence of hearing impairment among infants varies between 0.5 and 3.0 cases per thousand, but in children hospitalized in the Newborn Intensive Care Unit (NICU) and in those with other risk factors (i.e., anatomically small for gestational age, craniofacial abnormalities, intrauterine infections, family history of hearing loss, ototoxic drugs, mechanical ventilation , etc.), the prevalence is 10-20 times greater. Newborn Intensive Care Unit (NICU) can be defined as an intensive care unit for sick newborns who need specialized treatment. NICU combines equipment and advanced technology with medical staff specially trained in newborn care. The Joint Committee on Infants Hearing (JCIH) identified many risk factors in NICU infants like prolonged mechanical ventilation, asphyxia, low birth weight and ototoxic medication, and so it also considers intensive care as a whole a risk factor. The present book focuses its attention on this hearing loss risk factor, starting from risk factors and screening strategies, highlighting the various neonatal levels of care, focusing on the treatment of infants with neural tube defects and the future motor development of premature babies. This should be done until caregivers can get the attention of drug therapies used in the NICU.

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Glomerulonephritis 1st ed. 2019 Edition

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Jun 082019
 

This Handbook serves as a convenient, state-of-the-art and comprehensive resource on the pathogenesis, diagnosis, and treatment of glomerular diseases.  Clinical approaches, modalities and challenges are provided, along with new developments since the publication of Kidney Disease Improving Global Outcomes (KDIGO): Glomerulonephritis.

Chapters dedicated to glomerular diseases mirror the current classification schemes used by Nephrologists and Pathologists and will include definition and natural history, epidemiology, clinical manifestations, pathology, diagnosis, differential diagnosis, treatment (algorithms when appropriate), prognosis and future prospects and current direction of research.

Contributing authors consist of internationally renowned glomerulonephritis experts, renal pathologists and clinical nephrologists who are engaged in the management of glomerular diseases in clinical pediatric and internal medicine practices.

Glomerulonephritis fills a considerable knowledge gap for general nephrologists, providers involved with the care of patients with glomerular diseases, and researchers.  It should also be of value to medical students, interns, residents and fellows, as well as all clinicians engaged in medical education.

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Oxford Handbook of Acute Medicine (Oxford Medical Handbooks) 4th Edition, Kindle Edition

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Jun 082019
 

Current, comprehensive, and focused, the bestselling Oxford Handbook of Acute Medicine returns for its fourth edition.

Thoroughly revised and updated throughout, this trusted, quick-reference guide includes the latest evidence-based guidelines and recommended management of medical emergencies alongside new figures and clinical tips from experienced authors and a team of dedicated specialist reviewers. With a new chapter on acute medicine and the older patient, and even more distilled key points and practice tips, it is accessible to all members of the multidisciplinary team and practitioners across an even
wider range of specialties. The Oxford Handbook of Acute Medicine remains the must-have resource for all those dealing with acute illness.

Your practical guide to the presentation, causes, and management of the acutely ill patient, this Handbook will take you step-by-step through the management of the patient while awaiting specialist help, and beyond, with details of specialist treatments to help you make an informed decision about your patients’ ongoing care.

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Clinical Fluid Therapy in the Peri-Operative Setting

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Jun 062019
 

Clinical Fluid Therapy in the Peri-Operative Setting brings together some of the world’s leading clinical experts in fluid management to explain what you should know when providing infusion fluids to surgical and critical care patients. Current evidence-based knowledge, essential basic science and modern clinical practice are explained in 25 focused and authoritative chapters. Each chapter guides the reader in the use of fluid therapy in all aspects of peri-operative patient care. Guidance is given on the correct selection, quantity and composition of fluids required as a consequence of the underlying pathology and state of hydration of the patient, and the type and duration of surgery. Edited by Robert G. Hahn, a highly experienced clinician and award-winning researcher in fluid therapy, this is essential reading for all anaesthetists, intensivists and surgeons.
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Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application

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Jun 052019
 

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

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Parkinson’s Disease, Second Edition

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Jun 022019
 

In recent years, considerable advances have been made in our knowledge and understanding of Parkinson’s disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.

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Koda-Kimble and Young’s Applied Therapeutics: The Clinical Use of Drugs, Tenth Edition

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Jun 012019
 

This widely used text uses a case-based approach to help students master the fundamentals of drug therapeutics. Students will learn the basics of common diseases and disorders and develop practical problem-solving skills for devising and implementing successful drug treatment regimens.
Case studies integrated into each chapter illustrate key concepts and principles of therapeutics and give students practice in developing their own evidence-based therapeutic plans.

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