Data Monitoring in Clinical Trials: A Practical Perspective, 2nd Edition

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Feb 222019
 

The authoritative guide for Data Monitoring Committees–fully revised and updated

The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees.

Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight.

Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making.

* Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees

* Illustrates the types of challenging issues Data Monitoring Committees face in practical situations

* Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations

* Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research

* Expands treatment of current journal publications addressing DMC issues

Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.

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Myocardial Preservation: Translational Research and Clinical Application

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Feb 212019
 


This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic.

Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

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Encyclopedia of Human Body Systems 2 volume set

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Feb 212019
 

This encyclopedia is a concise yet comprehensive guide to the systems of the human body that is accessible to the lay reader.

• Features over 150 pictures, anatomical drawings, tables, and diagrams
• Provides entertaining sidebars and interesting facts throughout the encyclopedia
• Contains a bibliography and index to aid in study
• The comprehensive glossary contains more than 600 terms used in the text

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Chaperokine Activity of Heat Shock Proteins

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Feb 212019
 


Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity.

The book Chaperokine Activity of Heat Shock Proteins provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain.

To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

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Viral Hepatitis: Acute Hepatitis

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Feb 212019
 

This book presents up-to-date, practically oriented information on major topics in acute hepatitis. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. The book opens by examining the local and global epidemiology of acute hepatitis. Detailed attention is then paid to each of acute hepatitis A, acute hepatitis B, acute hepatitis C, hepatitis D co-infection, and hepatitis E. Acute Hepatitis will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.
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Treating Adolescent Substance Use: A Clinician’s Guide

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Feb 212019
 

Clinicians are now facing new substance use-related challenges such as the opioid crisis, a changing political landscape regarding marijuana, and the emergence of new delivery devices such as e-cigarettes. Unfortunately, it is more critical than ever that clinicians caring for adolescents have a proficiency in treating substance use. This book is a comprehensive clinical guide that discusses the prevalence of substance use among adolescents and young adults, as well as prevention strategies, available screening methods, practical treatment applications and their outcomes. Using a multidisciplinary approach with inclusion of authors from diverse clinical backgrounds, this definitive guide provides the best practices for treating adolescent substance use disorders from medical, behavioral, and social standpoints. Supplemented with case examples and written by experts in the field, Treating Adolescent Substance Use appeals to all clinicians that treat adolescent patients.
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Intraspinal Variations of Nerve Roots

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Feb 202019
 

The main purpose of this book is to provide the reader with a better understanding of spinal nerve root injuries caused by various pathologies (e.g. disc herniation, space-occupying lesions, trauma etc.). The standard anatomical description of spinal nerve roots origin, course and arrangement (described in the first chapters of the book) is now strongly influenced by the frequent findings of their intraspinal extradural and intradural connecting branches and by other variations, which are considered to be the major cause of the surgical therapy failures. Intraspinal extradural and intradural neuroanatomical roots variations may affect in fact the clinical picture, diagnosis, and surgical treatment; their recognition can minimize the damage to neural structures in the spinal anaesthesia, in spinal operations, in spondylosurgery, in endoscopic surgery, laser discectomy, etc. Their aetiology is unknown and it has to be elucidated, and they are rarely found during the usual preoperational examinations, a reason that encouraged various anatomical dissection studies finalized to their description. The data shown in this book will be surely helpful for traumatologists, orthopaedists, spinal surgeons, neurosurgeons, plastic surgeons and for all those dealing with intraspinal variations of nerve roots.
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Diagnosis and Treatment of Vestibular Disorders

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Feb 202019
 

This text reviews the current understanding of vestibular anatomy allowing for a framework of reference, and how it’s applied to vestibular testing, diagnosis and management of dizziness. Vestibular testing is an important tool in the evaluation and management of the patient with dizziness. It aids in establishing a diagnosis and determining the side or site of the lesion. In addition, it guides practitioners in selection of treatment and allows the ability of the patient’s condition to be evaluated over its time course. Common vestibular pathologies such as benign positional vertigo, Meniere’s disease, multisensory imbalance, vestibular neuritis, superior canal dehiscence, and vestibular migraine will be addressed in a concise and understandable manner. The text follows a clear format in which the etiology, pathophysiology, diagnostic features and medical or surgical management of such pathologies are discussed. The book gains increased importance as superior canal dehiscence and vestibular migraine are relatively new hot topics. Lastly, relatively rare entities such as bilateral vestibular hypofunction, pediatric vestibular disorders and central vestibular disorders are discussed. This text serves as a complete reference for clinicians, students and researchers interested in this common and severe disorder allowing for improved patient care and advancement of knowledge in the field. Chapters are written by acknowledged experts, allowing summary review of the newest and most up-to-date understanding of scientific information.

Diagnosis and Treatment of Vestibular Disorders will be an invaluable resource for otolaryngologists, neurologists, otologists and neurotologists, basic science and translational researchers with interests in the vestibular system, fellows and residents in aforementioned fields, and general practitioners with an interest in patients with symptoms of dizziness.

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Slice Girls

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Feb 202019
 

When Dr Joan Arakkal chooses to specialise in orthopaedics while training in India, a field traditionally occupied by men, she slots into the world of bones with relative ease.

But when her career takes her to the UK, and then Australia, she encounters the ‘bonemen’ – a boy’s club whose members are easily identified in the hospital corridors by their loud voices and self-assured swagger, who wield a stranglehold on orthopaedics.

Joan is totally unprepared for the obstacles and prejudices she encounters – but the tables are turned when she suffers a health scare of her own, which ultimately gives her the perspective she needs to speak and fight without fear.

A provocative reflection on the discrimination and sexism entrenched in the surgical community, and particularly the world of orthopaedics, Slice Girls shines light on a surgical path that is made needlessly challenging for women, and finds that while women are ready for surgery, it forces the question: is surgery ready for women?

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Biophysical Properties in Glaucoma: Diagnostic Technologies

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Feb 192019
 

This book provides an overview on new insights in glaucoma, the latest technological developments, scientific achievements, and novel research leading to new paradigms in glaucoma diagnosis. Readers will discover a broad picture starting from theoretical perspectives in diagnostic criteria followed by practical examination and clinical interpretations while highlighting potential pitfalls and limitations in analysis. Non-invasive, modern technologies allowing visualization and quantification of various parts of the human eye are fast evolving and improving interpretation of modern diagnostic possibilities are essential to fill the gap between sophisticated equipment, complex clinical data, and the need for precision-medicine based interpretation. Issues such as the importance of intraocular, intracranial, and ocular perfusion pressures (IOP, ICP, OPP) in the pathogenesis of glaucoma; and imaging modalities for examination of the optic nerve head, retinal fiber layer, and visual field assessment in glaucoma are explored in these chapters. The problem-based learning approach presented herein offers a succinct go-to-guide to read and discover answers.
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