Comparative Pathophysiology and Toxicology of Cyclooxygenases

 Pathology, Physiology, Toxicology  Comments Off on Comparative Pathophysiology and Toxicology of Cyclooxygenases
Apr 172019
 


The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks

Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks.

Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover:

The pathophysiology of COX inhibition on bone, tendon, and ligament healing
COX inhibitors and renal system pathophysiology and mechanisms of toxicity
The pathophysiologic role of COX inhibition in the ocular system
COX inhibition and the respiratory and cardiovascular systems

The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

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Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health

 Pathology, Physiology  Comments Off on Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health
Apr 042019
 

Combining two separate textbooks entitled Essentials of Human Physiology for Pharmacy and Essentials of Pathophysiology for Pharmacy into one cohesive volume, this new book seamlessly integrates material related to normal human physiology and pathophysiology into each chapter.

Chapters include:

Study objectives at the beginning of each chapter;
Summary tables, flow charts, diagrams, and key definitions;
Real life case studies to emphasize clinical application and stimulate student critical thinking;
An emphasis on the rationale for drug therapy;
Simple, straightforward language.
Written by authors with extensive teaching experience in the areas, Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health is a concise learning instrument that will guide students in pharmacy and allied health programs.

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Principles of Anatomy and Physiology, 13th Edition

 Anatomy, Physiology  Comments Off on Principles of Anatomy and Physiology, 13th Edition
Apr 032019
 

The thirteenth edition of the phenomenally successful Principles of Anatomy and Physiology continues to set the standard for the discipline. The authors maintained a superb balance between structure and function and continue to emphasize the correlations between normal physiology and pathophysiology, normal anatomy and pathology, and homeostasis and homeostatic imbalances. The acclaimed illustration program continues to be refined and is unsurpassed in the market. The thirteenth edition is fully integrated with a host of innovative electronic media, including WileyPlus 5.0 (access purchased separately.) No other text and package offers a teaching and learning environment as rich and complete.

Five Interesting Functions of the Human Body

-Most forms of color blindness, an inherited inability to distinguish between certain colors, result from the absence or deficiency of one of the types of cones. The most common type is red-green color blindness, in which red cones or green cones are missing. As a result, the person cannot distinguish between red and green. Prolonged vitamin A deficiency and the resulting below-normal amount of rhodopsin may cause night blindness or nyctalopia, an inability to see well at low light levels.

-Women often have a keener sense of smell than men do, especially at the time of ovulation. Smoking seriously impairs the sense of smell in the short term and may cause long-term damage to olfactory receptors. With aging the sense of smell deteriorates. Hyposmia, a reduced ability to smell, affects half of those over age 65 and 75% of those over age 80. Hyposmia also can be caused by neurological changes, such as a head injury, Alzheimer disease, or Parkinson disease; certain drugs, such as antihistamines, analgesics, or steroids; and the damaging effects of smoking.

-Damage to the cerebellum can result in a loss of ability to coordinate muscular movements, a condition called ataxia. Blindfolded people with ataxia cannot touch the tip of their nose with their finger because they cannot coordinate movement with their sense of where a body part is located. Another sign of ataxia is a changed speech pattern due to uncoordinated speech muscles. Cerebellar damage may also result in staggering or abnormal walking movements. People who consume too much alcohol show signs of ataxia because alcohol inhibits activity of the cerebellum. Such individuals have difficulty in passing sobriety tests. Ataxia can also occur as a result of degenerative diseases (multiple sclerosis and Parkinson disease), trauma, brain tumors, and genetic factors, and as a side effect of medication prescribed for bipolar disorder.

-After death, the cellular membranes become leaky. Calcium ions leak out of the sarcoplasmic reticulum into the sarcoplasm and allow myosin heads to bind to actin. ATP synthesis ceases shortly after breathing stops, however, so the cross-bridges cannot detach from actin. The resulting condition, in which muscles are in a state of rigidity (cannot contract or stretch), is called rigor mortis (rigidity of death). Rigor mortis begins 3-4 hours after death and lasts about 24 hours; then it disappears as proteolytics enzymes from lysosomes digest the cross-bridges.

-A dislocated mandible can occur in several ways. Anterior displacements are the most common and occur when the condylar processes of the mandible pass anterior to the articular tubercles. Common causes are extreme mouth opening, as in yawning or taking a large bite, dental procedures, or general anesthesia. Posterior displacement can be caused by a direct blow to the chin. Superior displacements can be caused by a direct blow to the chin. Superior displacements are typically caused by a direct blow to a partially opened mouth. Lateral dislocations are usually associated with mandibular fractures.

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Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health

 Pathology, Pharmacology, Physiology  Comments Off on Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health
Mar 312019
 

Combining two separate textbooks entitled Essentials of Human Physiology for Pharmacy and Essentials of Pathophysiology for Pharmacy into one cohesive volume, this new book seamlessly integrates material related to normal human physiology and pathophysiology into each chapter.

Chapters include:

– Study objectives at the beginning of each chapter;
– Summary tables, flow charts, diagrams, and key definitions;
– Real life case studies to emphasize clinical application and stimulate student critical thinking;
– An emphasis on the rationale for drug therapy;
– Simple, straightforward language.

Written by authors with extensive teaching experience in the areas, Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health is a concise learning instrument that will guide students in pharmacy and allied health programs.

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Exercise and Sports Pulmonology: Pathophysiological Adaptations and Rehabilitation

 Pathology, Physiology  Comments Off on Exercise and Sports Pulmonology: Pathophysiological Adaptations and Rehabilitation
Mar 172019
 

This book provides an innovative and comprehensive overview of the relationship between lung and exercise, both in healthy, active subjects and in subjects with chronic respiratory diseases. It investigates in detail the central role of the lungs during exercise and illustrates the impact of respiratory impairment due to both acute and chronic lung diseases on performance. Further, the book presents the latest evidence-based findings, which confirm that exercise is an effective and safe form of prevention and rehabilitation in respiratory diseases.

The first section describes the changes in the respiratory system during exercise and the contribution of respiration to exercise, while readers will learn how to perform a respiratory assessment in the second section. The third section addresses a broad range of chronic respiratory diseases and the (in)ability of those affected to play sports and perform exercise, thus providing a basis for individual assessments. The last two sections focus on respiratory training, rehabilitation and the relationship between respiration and the environment, e.g. in high-altitude and underwater sports.

The book will appeal to a wide readership, including pulmonologists, sport medicine physicians, physiotherapists and trainers, as well as instructors and students in exercise science.

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Anatomy & Physiology, 5th Edition

 Anatomy, Physiology  Comments Off on Anatomy & Physiology, 5th Edition
Mar 042019
 

Expand your students’ knowledge of anatomy and physiology and how it applies to practical treatments with the new edition of this bestselling book by Helen McGuinness.

• Boost exam chances with essential support for the new Beauty Therapy qualifications
• Prepare for success with exam-style questions and tips on technique
• Cover all anatomy and physiology requirements in Beauty Therapy, with updated information for the latest Level 2 and Level 3 qualifications
• Feel confident that core material is covered by Helen McGuinness’s expert authorship, in the book’s fifth edition
• Combine this text with the new accompanying workbook and revision guide (sold separately), which includes activities for learner self-study, revision and exam practice

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Anatomy and Physiology

 Anatomy, Physiology  Comments Off on Anatomy and Physiology
Mar 022019
 

Anatomy and Physiology is a dynamic textbook for the yearlong Human Anatomy and Physiology course taught at most two- and four-year colleges and universities to students majoring in nursing and allied health. A&P is 29 chapters of pedagogically effective learning content, organized by body system, and written at an audience-appropriate level. The lucid text, strategically constructed art, inspiring career features, and links to external learning tools address the critical teaching and learning challenges in the course. Color is used for pedagogical effect in A&P. Most art will consist of elegant black line, with the strongest line illustrating the most important structure(s) and shading used to show dimension and shape. Color (used only when needed) highlights and clarifies the primary anatomical or functional point of the illustration. Student focus is drawn to the most important learning point in each illustration, without distraction from excessive gradients, shadows, and loud highlights. The online book provides students with links to surgical videos, histology, interactive diagrams, and cadaver imagery at critical junctures. This book is available online for free at openstaxcollege dot org

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Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis, and Perinatal Management

 Cardiovascular, Genetics, Physiology  Comments Off on Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis, and Perinatal Management
Feb 262019
 

The third edition of this established reference is the product of the combined efforts of many professionals – obstetricians, pediatric cardiologists, sonographers, molecular biologists, and medical physicists – and is a comprehensive guide intended for anyone interested in scanning the fetal cardiac system.

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Microbial Physiology, Fourth Edition

 Microbiology, Physiology  Comments Off on Microbial Physiology, Fourth Edition
Feb 082019
 

The Fourth Edition of Microbial Physiology retains the logical, easy-to-follow organization of the previous editions. An introduction to cell structure and synthesis of cell components is provided, followed by detailed discussions of genetics, metabolism, growth, and regulation for anyone wishing to understand the mechanisms underlying cell survival and growth. This comprehensive reference approaches the subject from a modern molecular genetic perspective, incorporating new insights gained from various genome projects.Content: Chapter 1 Introduction to Microbial Physiology (pages 1–26): Chapter 2 Macromolecular Synthesis and Processing: DNA, RNA, and Protein Synthesis (pages 27–100): Chapter 3 Bacterial Genetics: DNA Exchange, Recombination, Mutagenesis, and Repair (pages 101–170): Chapter 4 Microbial Physiology in the Genomic Era: A Revolutionary Tale (pages 171–193): Chapter 5 Regulation of Prokaryotic Gene Expression (pages 194–238): Chapter 6 Bacteriophage Genetics (pages 239–276): Chapter 7 Cell Structure and Function (pages 277–349): Chapter 8 Central Pathways of Carbohydrate Metabolism (pages 350–367): Chapter 9 Energy Production and Metabolite Transport (pages 368–393): Chapter 10 Metabolism of Substrates Other Than Glucose (pages 394–411): Chapter 11 Fermentation Pathways (pages 412–433): Chapter 12 Photosynthesis and Inorganic Metabolism (pages 434–449): Chapter 13 Lipids and Sterols (pages 450–474): Chapter 14 Nitrogen Metabolism (pages 475–502): Chapter 15 Biosynthesis and Metabolism of Amino Acids (pages 503–544): Chapter 16 Purines and Pyrimidines (pages 545–560): Chapter 17 Bacterial Cell Division (pages 561–581): Chapter 18 Microbial Stress Responses (pages 582–611): Chapter 19 Bacterial Differentiation (pages 612–647): Chapter 20 Host–Parasite Interactions (pages 648–675):
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Vanders Renal Physiology, Eighth Edition

 Physiology  Comments Off on Vanders Renal Physiology, Eighth Edition
Feb 062019
 

The best review of renal physiology available for USMLE Step 1–completely updated with the latest research

A Doody’s Core Title for 2015!

Written in a clear, concise, logical style, thistrusted text reviews the fundamental principles of thestructure, function and pathologies of the human kidney that are essential for an understanding of clinical medicine. Combining the latest research with a fullyintegrated teaching approach, the eighth edition of Vander’s Renal Physiology features revised sections that explain how the kidneys affect other body systems and how they in turn are affected by these systems. Each chapter is filled with the tools you need to truly learn key concepts rather than merely memorize facts.

Features:

Begins with the basics and works up to advanced principles
Focuses on the logic of renal processes
Includes the most current research on the molecular and genetic principles underlying renal physiology
Explains the relationship between blood pressure and renal function
Presents the normal functions of the kidney with clinical correlations to disease states
Includes study questions with an answer key at the endof each chapter
Features learning aids such as flow charts, diagrams, key concept clinical examples, boxed statements to emphasize major points, learning objectives, and review questions with answers and explanations

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