Obesity: Pathogenesis, Diagnosis, and Treatment

 Pathology  Comments Off on Obesity: Pathogenesis, Diagnosis, and Treatment
Aug 192019
 


This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment.
Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.

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Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation

 Pathology  Comments Off on Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation
Aug 052019
 

Unmet healthcare needs of young populations and individuals in suboptimal health conditions are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded. The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame between both conditions is the operational area for predictive diagnosis and identification of persons at risk by innovative screening programmes followed by the most cost-effective personalised treatment possible, namely primary prevention tailored to the person.
The book propagates the paradigm change from delayed, costly but frequently ineffective medical services to the holistic approach by predictive, preventive and personalised medicine clearly demonstrating multifaceted benefits to the individual, healthcare sector and society as a whole.
The book is focused on the needs of
young people: teenagers, adolescents and young adults;
regardless of the age, individuals in suboptimal health conditions, who are interested in remaining healthy by optimising their modifiable risk factors – both endogenous and exogenous ones;
several patient cohorts demonstrating similar phenotype of Flammer syndrome.
The book is based on the multi-professional expertise, scientific excellence and practical experiences of the world-acknowledged experts in Flammer syndrome, predictive diagnostics, targeted prevention and personalised medicine, amongst others. The topic of this book is particularly relevant to general practitioners, experts in non-communicable diseases, phenotyping, genotyping, multilevel diagnostics, targeted prevention, personalised medicine, as well as the readers interested in advancing their health literacy.

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Atherosclerosis Pathogenesis and Microvascular Dysfunction

 Microbiology, Pathology  Comments Off on Atherosclerosis Pathogenesis and Microvascular Dysfunction
Aug 052019
 

This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned.
Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.

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Recent Advances in Cannabinoid Physiology and Pathology

 Pathology, Physiology  Comments Off on Recent Advances in Cannabinoid Physiology and Pathology
Aug 022019
 

The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development.
This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.

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Neoplastic Gastrointestinal Pathology: An Illustrated Guide

 Gastroenterology/Hepatology, Pathology  Comments Off on Neoplastic Gastrointestinal Pathology: An Illustrated Guide
Aug 012019
 

Approximately 20 million gastrointestinal tract biopsies are performed each year in the United States. While many of these are straightforward, some are histologically subtle or involve a complex differential diagnosis. This concise visual guide to the full range of neoplastic gastrointestinal specimens provides the practicing pathologist or trainee with a clear analysis and diagnosis of both common and potentially misleading variants of disease. The authors cover the full tubular GI tract with over 600 high-quality images and a concise description of the key features of each entity: definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and special clinical considerations. Images depict differential diagnosis features, frequently seen variants that can potentially lead to misclassification or misdiagnosis, and correlated molecular and immunologic techniques.

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Renal Pathophysiology: The Essentials (Renal Patholophysiology: The Essentials)

 Pathology, Physiology  Comments Off on Renal Pathophysiology: The Essentials (Renal Patholophysiology: The Essentials)
Jul 302019
 


This text offers medical students a case-based approach to learning mechanisms of renal disease. Each chapter covers a disease and begins with a patient case, followed by discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed in the text require students to apply their knowledge, and detailed answers to the questions are given. This edition includes a full-color insert and an appendix of normal lab values.

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Karch’s Pathology of Drug Abuse, Fifth Edition

 Pathology  Comments Off on Karch’s Pathology of Drug Abuse, Fifth Edition
Jul 242019
 

Written in the same accessible manner as previous editions, the fifth edition of Karch’s Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs.

The Fifth Edition Now Features:
Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values
Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch’s Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse.

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Atlas of Gross Pathology: With Histologic Correlation

 Pathology  Comments Off on Atlas of Gross Pathology: With Histologic Correlation
Jul 242019
 

This atlas provides a comprehensive illustration and description of a wide range and number of pathologic processes and diseases affecting all the major organs of the body. Emphasis is placed on how the anatomic structure of different organs may determine the pattern of involvement by disease processes and how such patterns may aid in the correct diagnosis of the gross pathology. In some cases, multiple illustrations of disease processes are given to show evolution of the disease. Histologic illustrations of selected gross lesions are also included where relevant. The atlas is illustrated with more than 1,200 color photomicrographs. Atlas of Gross Pathology is essential for practicing pathologists, but can also provide a solid foundation for surgeons, internists, and obstetricians/gynecologists.
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Topographical and Pathotopographical Medical Atlas of the Pelvis, Spine, and Limbs

 Pathology  Comments Off on Topographical and Pathotopographical Medical Atlas of the Pelvis, Spine, and Limbs
Jul 222019
 

Written by an experienced and well-respected physician and professor, this new volume, building on the previous volume, Ultrasonic Topographical and Pathotopographical Anatomy, and its sequels, also available from Wiley-Scrivener, presents the ultrasonic topographical and pathotopographical anatomy of the pelvis, spine, and limbs, offering further detail into these important areas for use by medical professionals.
This series of atlases of topographic and pathotopographic human anatomy is a fundamental and practically important book designed for doctors of all specializations and students of medical schools. Here you can find almost everything that is connected with the topographic and pathotopographic human anatomy, including original graphs of logical structures of topographic anatomy and development of congenital abnormalities, topography of different areas in layers, pathotopography, computer and magnetic resonance imaging (MRI) of topographic and pathotopographic anatomy. Also you can find here new theoretical and practical sections of topographic anatomy developed by the author himself which are published for the first time. They are practically important for mastering the technique of operative interventions and denying possibility of iatrogenic complications during operations.
This important new volume will be valuable to physicians, junior physicians, medical residents, lecturers in medicine, and medical students alike, either as a textbook or as a reference. It is a must-have for any physician’s library

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Male Reproductive Cancers: Epidemiology, Pathology and Genetics

 Epidemiology, Genetics, Oncology, Pathology, Reproductive Health  Comments Off on Male Reproductive Cancers: Epidemiology, Pathology and Genetics
Jul 192019
 

Male Reproductive Cancers: Epidemiology, Pathology and Genetics presents a thoughtful, comprehensive and up-to-date overview of the etiology of the prostate gland and the testes, summarizing decades of research in the three most important etiological disciplines: epidemiology, pathology and genetics. This book is comprised of four distinct sections: Epidemiology, Pathology, Molecular Genetics, and Inherited Susceptibility, with each section divided into chapters categorized by disease. Section A reviews the epidemiology of prostate and testicular cancer, with an emphasis on clinical and environmental factors associated with these diseases. Section B begins by describing various pathological features of prostate cancer, followed by descriptions of the wide variety of testicular cancers as well as a brief section on the use of tumor markers for monitoring disease. Section C focuses on somatic genetic changes in prostate and testicular cancers using new technologies such as comparative genomic hybridization and gene expression profiling. Section D concentrates on the progress made toward understanding inherited susceptibility to prostate cancer and to testicular cancer.
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