The 8-Week Blood Sugar Diet: How to Beat Diabetes Fast (and Stay Off Medication)

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on The 8-Week Blood Sugar Diet: How to Beat Diabetes Fast (and Stay Off Medication)
Jan 182020
 

A groundbreaking guide to defeating diabetes without drugs—including a step-by-step diet plan, recipes, and the science behind why the program works—from #1 New York Times bestseller Dr. Michael Mosley whose life-changing FastDiet series brought on “a health revolution” (New York Times).

The 8-Week Blood Sugar Diet is a radical new approach to the biggest health epidemic threatening us today…

Our modern diet, high in low-quality carbohydrates, is damaging our bodies—producing a constant overload of sugar in our bloodstream that clogs up our arteries and piles hidden fat into our internal organs. The result has been a doubling in the number of type 2 diabetics, as well as a surge in those with a potentially hazardous condition—prediabetes. It is now known that even moderately elevated blood sugar levels can trigger heart disease, stroke, dementia, and cancer.

Scientists have recently demonstrated that you can prevent and even reverse type 2 diabetes with a simple change in diet and lifestyle.

Drawing on the work of Professor Roy Taylor—one of the UK’s foremost diabetes experts—and his own experience as a one-time diabetic, Dr. Michael Mosley presents a groundbreaking, science-based, 8-week plan for diabetics who want to reverse their condition (and then stay off medication). He also offers a more flexible regime for people interested in the extensive health benefits to be gained from lowering their blood sugar levels and shedding dangerous fat.

As Dr. Mosley says, it is never too late to act…

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on New Horizons in Predictive Drug Metabolism and Pharmacokinetics
Jan 152020
 

Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk.
Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.
Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.

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Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues
Dec 292019
 

Although noninvasive, continuous monitoring of glucose concentration in blood and tissues is one of the most challenging areas in medicine, a wide range of optical techniques has recently been designed to help develop robust noninvasive methods for glucose sensing. For the first time in book form, the Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties.

This handbook presents methods that improve the accuracy in glucose prediction based on infrared absorption spectroscopy, recent studies on the influence of acute hyperglycemia on cerebral blood flow, and the correlation between diabetes and the thermo-optical response of human skin. It examines skin glucose monitoring by near-infrared spectroscopy (NIR), fluorescence-based glucose biosensors, and a photonic crystal contact lens sensor. The contributors also explore problems of polarimetric glucose sensing in transparent and turbid tissues as well as offer a high-resolution optical technique for noninvasive, continuous, and accurate blood glucose monitoring and glucose diffusion measurement.

Written by world-renowned experts in biomedical optics and biophotonics, this book gives a complete, state-of-the-art treatise on the design and applications of noninvasive optical methods and instruments for glucose sensing.

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A Case-Based Guide to Clinical Endocrinology

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on A Case-Based Guide to Clinical Endocrinology
Dec 172019
 

In A Case-Based Guide to Clinical Endocrinology, Second Edition, a renowned group of distinguished clinicians once again provides stimulating instruction and insights into a wide variety of endocrine topics, teaching readers modern management of the conditions described and offering targeted entry into the literature. Importantly, many of the important elements in the current curriculum for clinical endocrine training as recommended by the Association of Program Directors in Clinical Endocrinology, Diabetes and Metabolism are covered in this text. Thoroughly updated, this new edition not only covers new treatment approaches but also emphasizes the latest investigative advances in both imaging and molecular diagnostics. To reinforce learning and retention of knowledge, a question-based approach is used in many of the case studies. Students, residents, fellows, and practitioners will find this reference to be an efficient way to review their understanding and increase their skills and abilities in patient investigation and management. An invaluable contribution to the field, A Case-Based Guide to Clinical Endocrinology, Second Edition, offers the same comprehensive volume of thought-provoking case-studies that made the first edition of significant importance to all clinicians who treat patients with endocrine disorders.

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Phytotherapy in the Management of Diabetes and Hypertension

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Phytotherapy in the Management of Diabetes and Hypertension
Dec 112019
 

Phytotherapy in the Management of Diabetes and Hypertension is a good addition to existing volumes detailing knowledge of hyperglycemia therapy. This e-book emphasizes the basic biochemistry behind diabetes mellitus and hypertension, along with the control or remediation of these conditions through a cost effective, safe, easy-going, easy-adaptable method validated by scientific research. This e-book contains 7 chapters dealing with various aspects of these diseases and their Phytotherapy treatment and life style management. Phytotherapy can give patients long term benefits with less or no side effects. Hence, this e-book is an authentic alternative or complementary therapeutic compendium to physicians and patients. This book will also be useful to students, teachers, researchers, clinicians and general readers interested in learning about applied phytotherapy.
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The Metabolic Syndrome:: Epidemiology, Clinical Treatment, and Underlying Mechanisms

 Endocrinology/Metabolism/Diabetes Mellitus, Epidemiology  Comments Off on The Metabolic Syndrome:: Epidemiology, Clinical Treatment, and Underlying Mechanisms
Dec 102019
 

This book covers the most important clinical and bench science aspects of metabolic syndrome. It will be of value to all of those seeking a comprehensive update on the metabolic syndrome. Furthermore, it will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.
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Neural Metabolism In Vivo

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Neural Metabolism In Vivo
Dec 062019
 

From the preface:
“Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain.  Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels.  Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen….
This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations.  Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section.  Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes.  However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough.  Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.”
– In-Young Choi and Rolf Gruetter

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Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry

 Endocrinology/Metabolism/Diabetes Mellitus, Neurology/Neurosurgery, Psychiatry  Comments Off on Epigenetics and Neuroendocrinology: Clinical Focus on Psychiatry
Nov 292019
 

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

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Cardiovascular Endocrinology:: Shared Pathways and Clinical Crossroads

 Cardiovascular, Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Cardiovascular Endocrinology:: Shared Pathways and Clinical Crossroads
Nov 212019
 

Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology.
Offering a wealth of information, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads provides a range of insights, including a novel view of the hormonal regulation of the vascular system and the disruption of the nitric oxide signaling system. It also addresses the role of fatty acids and cytokines in the development of this problem. Importantly, this unique title also provides a state-of-the-art update on the importance of other hormones such as thyroid hormone and steroids, as well as the pathophysiology of cardiovascular disease and controversies surrounding the use of hormone replacement therapy.
In all, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads is a first-of-its-kind title that discusses and summarizes important clinical topics in cardiology and endocrinology. It offers clinicians and researchers an important resource for navigating the increasingly interrelated pathways of cardiovascular and endocrinologic disorders. The authors discuss a range of important issues from epidemiology to bench research to translation of this research to clinical practice.

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Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches

 Endocrinology/Metabolism/Diabetes Mellitus, Radiology  Comments Off on Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
Nov 182019
 

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.

The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

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