Hydrogen Peroxide Metabolism in Health and Disease

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Hydrogen Peroxide Metabolism in Health and Disease
Feb 192018
 

Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.

 

 

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Correlation-based Network Analysis of Cancer Metabolism: A New Systems Biology Approach in Metabolomics

 Endocrinology/Metabolism/Diabetes Mellitus, Oncology  Comments Off on Correlation-based Network Analysis of Cancer Metabolism: A New Systems Biology Approach in Metabolomics
Feb 062018
 

With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.

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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus, Oncology  Comments Off on Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism
Feb 012018
 

 

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.​
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Clinical Strategies in the Management of Diabetic Retinopathy: A step-by-step Guide for Ophthalmologists

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Clinical Strategies in the Management of Diabetic Retinopathy: A step-by-step Guide for Ophthalmologists
Jan 302018
 

 

With the advent of effective treatments for diabetic retinopathy (DR), a new era in the management of DR has been opened up. Amid the deluge of approved treatments and promising new strategies, however, clinicians may find it difficult to choose the appropriate practice in each individual case. The purpose of this easy-to-use and richly illustrated manual is to assist ophthalmologists in making decisions in the entire management of DR based on the best available evidence. Practical and complete recommendations are provided to guide clinicians in diagnosis, decision-making, and treatment. The manual includes practical algorithms and case histories relating to all stages of DR that clearly explain the progression of the disease and will help the clinician to choose the best therapeutic approach. It will be an ideal resource for ophthalmologists aiming to provide optimal clinical management for this sight-threatening disease.
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Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment

 Endocrinology/Metabolism/Diabetes Mellitus, Pathology, Physiology  Comments Off on Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment
Jan 262018
 

The purpose of this book is to bring together the latest findings on metabolic disorders that are strongly implicated in various critically ill patients. Since the beginning of the 20th century, maintaining the “milieu intérieur” has been a major challenge for intensivists. In addition to considerable technological developments in intensive care units, important advances in our understanding of metabolic disorders observed in critically ill patients have been made during the 10 last years.
Today, the intensivit can’t ignore these disorders when selecting the most appropriate treatment for an illness. Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing the physician to understand, diagnose and treat these metabolic disorders. Water, electrolyte, acid-base, glycemic and endocrinologic problems, as well as metabolic abnormalities observed in renal, cerebral and hepatic failure are presented in different chapters. The last part of the book is devoted to modern nutritional concepts, the consequences of energy modifications, mitochondrial dysfunction, hypothermia, oxidative stress and ischemia reperfusion, which open the way for new therapies.​

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ABC of Diabetes (6th edition)

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on ABC of Diabetes (6th edition)
Jan 082018
 

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Problem-Free Diabetes: Controlling Diabetes With the Help of the Power of Your Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Problem-Free Diabetes: Controlling Diabetes With the Help of the Power of Your Metabolism
Dec 282017
 

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Practical Diabetes Care, 4rd Edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Practical Diabetes Care, 4rd Edition
Dec 282017
 

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The Metabolic Syndrome in Clinical Practice

 Cardiovascular, Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on The Metabolic Syndrome in Clinical Practice
Dec 222017
 

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Psychoneuroendocrinology: The Scientific Basis of Clinical Practice

 Endocrinology/Metabolism/Diabetes Mellitus, Psychiatry  Comments Off on Psychoneuroendocrinology: The Scientific Basis of Clinical Practice
Dec 222017
 

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