Handbook of Clinical Pediatric Endocrinology, 2 edition

 Endocrinology/Metabolism/Diabetes Mellitus, Pediatrics  Comments Off on Handbook of Clinical Pediatric Endocrinology, 2 edition
Aug 182019
 

This revised edition of Charles Brook’s Handbook of Clinical Pediatric Endocrinology provides endocrinologists and pediatricians in training with a fully up-to-date clinical guide presenting evidence-based practice in the diagnosis, treatment, and management of pediatric endocrine disorders. New chapters include “Endocrine complications of chronic disease” and “Endocrine neoplasia.” In addition, the chapter structure has been revamped for easier access and now includes: a key points overview, multiple-choice questions for self-assessment, common errors/pitffalls (in treatment, diagnosis, etc.) boxes, a key weblinks box, a table comparing different society guidelines, diagnostic decision trees, therapeutics decision trees, and a summary.

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The mRNA Metabolism in Human Disease

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on The mRNA Metabolism in Human Disease
Aug 102019
 


The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer.
This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.

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Clinical Endocrinology and Diabetes Mellitus

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Clinical Endocrinology and Diabetes Mellitus
Aug 052019
 

This is the first comprehensive textbook on endocrinology and diabetes mellitus. It is intended to provide a linking bridge between the practice of clinical medicine and science of endocrinology by presenting condensed, authoritative, updated, scientific information. This book presents a balanced and evidencebased account of various endocrinology problems. Provides insights into various types of common and not so common complexities on disease and its management. The T2DM is potentially preventable with lifestyle modifications and medication. Similarly nutritional deficiency diseases like goitre, metabolic bone diseases are also preventable. This book provides an insight about new developments about the endocrines and their dysfunctional states which are not described in the common textbook study material. It explains how clinical intervention with appropriate tests and early diagnosis the onset of a disease could be prevented/delayed to save patients from avoidable complications. This book in two volumes is divided into six parts and further in subsections begins with a brief account of relevant embryology, applied anatomy and physiology. To help the readers understand better the clinical problem and management approach, several tables and figures are given. PART 1: GENERAL ENDOCRINOLOGY, Section 1: Basic Endocrinology; Section 2: Anterior Pituitary; Section 3: Hypothalamus; Section 4: Posterior Pituitary; Section 5: Neuroendocrinology; Section 6: Psychoendocrinology; Section 7: Thyroid Gland; Section 8: Adrenal Gland; Section 9: Pineal Gland; Section 10: Gut Hormones; Section 11: Lipids Metabolism; Sectiion 12: Obesity; Section 13: Mineral Metabolism; Osteoporosis and Metabolic Bone Disease; PART 2: REPRODUCTIVE ENDOCRINOLOGY, Section 14: Development of Gonads, Sexual Differentiation and Intersex; Section 15: Reproductive Endocrinology: Male Factors; Section 16: Reproductive Endocrinology: Female Factors; Section 17: Endocrinology of Female Breast and Gestation; PART 3: PAEDIATRIC ENDOCRINOLOGY, Section 18. Growth and Development; Section 19: Hypo-and Hyperthyroidism in Children; Section 20: Congenital Adrenal Hyperplasia (CAH); PART 4: IMAGING AND RADIO-DIAGNOSIS IN ENDOCRINOLOGY, Section 21: Imaging in Endocrinology; Section 22: Mammography and Imaging; PART 5: SPECIAL TOPICS, Section 23: Special Topics in Endocrinology; PART 6: DIABETOLOGY, Section 24: Glucose Metabolism and Hypoglycaemia; Section 25: Diabetes Mellitus and Insulin Resistance; Section 26: Diagnosis and Management of Diabetes Mellitus; Section 27: Hyperglycaemic Effects on Other Body Systems; Section 28: Chronic Diabetic Complications; Section 29: Acute Metabolic Complications of Diabetes Mellitus, Section 30. Special Topics in Diabetes Mellitus.
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Jul 312019
 

This book covers all one needs to know about the utility of endomicroscopy in the diagnosis and management of gastrointestinal diseases. It provides a comprehensive description of the latest in diagnostic criteria and advances in the basic science pertaining to endomicroscopy of the gastrointestinal system. Each chapter introduces the key histologic, endoscopic, and endomicroscopic features of common gastrointestinal conditions, with generous illustration using typical images. The book will provide the practicing physicians with the principles of practice, and procedural techniques of endomicroscopy, as well as demonstrate the bench-to-bedside translational potential of endomicrosocpy in helping endoscopists manage their patients’ gastrointestinal conditions.

This book fills an enormous gap in providing a much needed atlas in GI endomicroscopic diagnosis. Readers can learn the diagnostic criteria of various gastrointestinal conditions as illustrated by high quality endoscopic, endomicroscopic and histology images.

It contains the most extensive review of currently published studies of endomicroscopy in gastrointestinal conditions. It has numerous high quality endomicroscopic images along with high definition endoscopy and histology images illustrating the common gastrointestinal diseases. It will provide a platform for standardizing endomicroscopic practice and learning.

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8 edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8 edition
Jul 252019
 

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.

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Atlas of Atherosclerosis and Metabolic Syndrome

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Jul 162019
 

In this updated fifth edition of the Atlas of Atherosclerosis and Metabolic Syndrome (formerly the Atlas of Atherosclerosis), the editors have compiled a comprehensive update on the field of atherosclerosis. This four-color atlas includes detailed legends and extensive reference listings for hundreds of illustrations, algorithms, schematics, and images. This new edition focuses more closely on metabolic syndrome, as well as comprehensively covering many other topics including diabetes and vascular risk, obesity management, dietary concerns, drug treatment, gender and ethnicity differences, and many others. The striking, four-color format combined with the breadth of information it contains make this book an invaluable resource for physicians, cardiologists, and all professionals involved in the study and treatment of atherosclerosis.
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Clinical Urologic Endocrinology: Principles for Men’s Health

 Endocrinology/Metabolism/Diabetes Mellitus, Urology  Comments Off on Clinical Urologic Endocrinology: Principles for Men’s Health
Jul 062019
 


Clinical Urologic Endocrinology: Principles for Men’s Health provides an organized, accessible reference on men’s endocrinological health.

Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo and there is a strong need for a book which provides guidance for practitioners who support men in their reproductive and sexual concerns. This book covers in depth the key issues in male reproductive health in one easy-to-use resource.

Clinical Urologic Endocrinology: Principles for Men’s Health is a valuable reference for urologists, endocrinologists, internal medicine physicians, family medicine physicians, sex therapists, and allied health professionals providing care for men in the areas of sexual health, fertility, and men’s endocrinological health.

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Menstrual Cycle Related Disorders: Volume 7: Frontiers in Gynecological Endocrinology

 Endocrinology/Metabolism/Diabetes Mellitus, Ob/Gynae  Comments Off on Menstrual Cycle Related Disorders: Volume 7: Frontiers in Gynecological Endocrinology
Jul 052019
 

This volume discusses menstrual cycle related disorders, which are a major concern from adolescence to menopause.
Starting from hypothalamic pituitary gonadal axis regulation, it analyzes the characteristics and treatments of hypothalamic amenorrhea and eating disorders, as well as polycystic ovary and adolescent hyperandrogenism. It also examines the importance of body composition and physical performance. The book particularly focuses on the diagnosis of and therapies for hormone-related headaches, the management of trans sexuality in the gynecological outpatient area, dysfunctional uterine bleeding and premature ovarian insufficiency. Further, it analyzes the basic, clinical and therapeutic aspects of endometriosis, as well as the important opportunities that SPRMs (selective progesterone receptor modulators) offer in contraception and fibroid therapy.
This book is a useful tool for gynecologists, endocrinologists and general practitioners, and is a valuable resource for all physicians involved in women’s health.

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Pitt Ford’s Problem-Based Learning in Endodontology

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Pitt Ford’s Problem-Based Learning in Endodontology
Jun 082019
 

Pitt Ford’s Problem-Based Learning in Endodontology combines the theory and practice of endodontics, providing the reader with information that is both clinically relevant to everyday practice and also evidence based.

It includes a wealth of cases that span topics such as the maintenance of a vital pulp, root canal treatment, surgical endodontics and trauma. Each case is accompanied by full colour photographs and/or radiographs that illustrate the key stages in diagnosis, treatment planning, treatment and prognosis. In addition, the detailed commentary provides information on viable alternative treatment strategies, rationale (biologic considerations) for the treatment described, evaluation of the current evidence for/against the course of treatment and finally the prognosis.

The book allows the reader to apply their existing knowledge to a range of clinical scenarios and to gain new knowledge and apply it to further clinical situations. In addition the reader will be encouraged to transfer knowledge and diagnostic skills from one problem to another and guided to improve their self-directed learning and reflective skills.

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Diabetes and Wellbeing

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Diabetes and Wellbeing
May 192019
 

Diabetes and Wellbeing presents a range of effective psychological principles proven to positively impact the emotional wellbeing of individuals with type 1 and 2 diabetes. The guide takes an explicitly CBT approach to motivate sufferers in essential self-care tasks. * Written in a practical style, for those newly diagnosed with diabetes, individuals managing its challenges for many years, and healthcare professionals * Reveals how the stress of daily diabetes management can affect an individual s ability to stay motivated and engaged in essential self-care tasks that are vital for good health * Presents proven techniques for improving emotional wellbeing * First book to take an explicitly CBT approach to diabetes, simultaneously drawing on solution-focused behavioural therapy and mindfulness approaches * Fills the gap information of this kind among healthcare professionals and individuals with diabetes

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