Type 1 Diabetes in Adults

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Type 1 Diabetes in Adults
Sep 112019
 

At a time of dramatic increases in the prevalence of obesity, it is appropriate that Type 2 diabetes has received a great deal of attention by the endocrinology community. Clearly, the management of insulin resistance and cardiovascular risk is a critical issue. However, it is important to also acknowledge and address Type 1 diabetes, whose prevalence is also increasing, and whose management remains complex. Currently it is estimated that 10-15% of those with diabetes carry the diagnosis of Type 1 diabetes, and frequently the diagnosis is not straightforward, as many clinicians recognize that more adults previously thought to have Type 2 diabetes actually have late-onset Type 1 diabetes (also termed latent autoimmune diabetes of the adult or L.A.D.A.). Over the last decade tools for the management of Type 1 diabetes have also evolved; therefore, clinicians now have the opportunity to more closely replicate normal physiologic insulin secretion with either basal-bolus insulin therapy or continuous subcutaneous insulin infusions. While these advancements allow clinicians to manage patients with Type 1 diabetes better, they also add complexity to patient treatment. An updated text to address the concepts behind the recognition of new onset Type 1 diabetes in adults, the ongoing care of adults with established Type 1 diabetes, and future potential therapies and devices is warranted to review these issues for both endocrinologists and primary care providers with an interest in diabetes. As part of the Oxford American Endocrinology Library, this volume stands as a concise guide in the treatment of Type 1 Diabetes in adults. The authors briefly examine the classification and pathophysiology of Type 1 diabetes (including predication and prevention and L.A.D.A.) and address management (blood glucose monitoring, insulin therapy, and Continuous Subcutaneous Insulin Infusion) and complications (Hyperglycemia, Retinocpathy, Nephro

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Role of Phenolic Phytochemicals in Diabetes Management: Phenolic Phytochemicals and Diabetes

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Role of Phenolic Phytochemicals in Diabetes Management: Phenolic Phytochemicals and Diabetes
Aug 292019
 

This book summarizes the latest research trends in phytophenolic therapy for the management of diabetes. It discusses the various mechanisms of action of phytophenolics present in food, fruits and plants that can be used to control/reverse diabetic conditions. Further, it addresses the synergistic interactions of phytophenolics with anti-diabetic drugs, as understanding them can yield valuable insights for complementary and alternative medicine. In closing, it discusses the important aspects of nanotechnology-based targeted delivery and improving the bioavailability of phenolic phytochemicals, two major areas of research in phytotherapy of diabetes.

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Aldehyde Dehydrogenases: From Alcohol Metabolism to Human Health and Precision Medicine

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Aldehyde Dehydrogenases: From Alcohol Metabolism to Human Health and Precision Medicine
Aug 292019
 


This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed.
It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.

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Endoscopic Management of Colorectal T1

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Aug 222019
 

This book provides the latest information on diagnosis and treatment strategies for colorectal T1(SM) carcinoma including endoscopic resection, and pathologic diagnosis and treatment following resection. Due to constant advances, the curative phase after the endoscopic resection of carcinomas has extended, shifting the endpoints of diagnosis and treatment strategies. This book thoroughly summarizes the latest findings, explained with the help of abundant color figures, and will serve as a basis for further discussions and advances in this field.
Endoscopic Management of Colorectal T1(SM) Carcinoma offers a valuable resource for colonoscopists, colorectal surgeons, and pathologists at all levels. The readers will discover diverse perspectives, provided by the contributing authors, and extensive discussions that are analyzed from Asian perspectives, which often differ from those found in Western texts.

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Handbook of Clinical Pediatric Endocrinology, 2 edition

 Endocrinology/Metabolism/Diabetes Mellitus, Pediatrics  Comments Off on Handbook of Clinical Pediatric Endocrinology, 2 edition
Aug 182019
 

This revised edition of Charles Brook’s Handbook of Clinical Pediatric Endocrinology provides endocrinologists and pediatricians in training with a fully up-to-date clinical guide presenting evidence-based practice in the diagnosis, treatment, and management of pediatric endocrine disorders. New chapters include “Endocrine complications of chronic disease” and “Endocrine neoplasia.” In addition, the chapter structure has been revamped for easier access and now includes: a key points overview, multiple-choice questions for self-assessment, common errors/pitffalls (in treatment, diagnosis, etc.) boxes, a key weblinks box, a table comparing different society guidelines, diagnostic decision trees, therapeutics decision trees, and a summary.

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The mRNA Metabolism in Human Disease

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on The mRNA Metabolism in Human Disease
Aug 102019
 


The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer.
This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.

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Clinical Endocrinology and Diabetes Mellitus

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Clinical Endocrinology and Diabetes Mellitus
Aug 052019
 

This is the first comprehensive textbook on endocrinology and diabetes mellitus. It is intended to provide a linking bridge between the practice of clinical medicine and science of endocrinology by presenting condensed, authoritative, updated, scientific information. This book presents a balanced and evidencebased account of various endocrinology problems. Provides insights into various types of common and not so common complexities on disease and its management. The T2DM is potentially preventable with lifestyle modifications and medication. Similarly nutritional deficiency diseases like goitre, metabolic bone diseases are also preventable. This book provides an insight about new developments about the endocrines and their dysfunctional states which are not described in the common textbook study material. It explains how clinical intervention with appropriate tests and early diagnosis the onset of a disease could be prevented/delayed to save patients from avoidable complications. This book in two volumes is divided into six parts and further in subsections begins with a brief account of relevant embryology, applied anatomy and physiology. To help the readers understand better the clinical problem and management approach, several tables and figures are given. PART 1: GENERAL ENDOCRINOLOGY, Section 1: Basic Endocrinology; Section 2: Anterior Pituitary; Section 3: Hypothalamus; Section 4: Posterior Pituitary; Section 5: Neuroendocrinology; Section 6: Psychoendocrinology; Section 7: Thyroid Gland; Section 8: Adrenal Gland; Section 9: Pineal Gland; Section 10: Gut Hormones; Section 11: Lipids Metabolism; Sectiion 12: Obesity; Section 13: Mineral Metabolism; Osteoporosis and Metabolic Bone Disease; PART 2: REPRODUCTIVE ENDOCRINOLOGY, Section 14: Development of Gonads, Sexual Differentiation and Intersex; Section 15: Reproductive Endocrinology: Male Factors; Section 16: Reproductive Endocrinology: Female Factors; Section 17: Endocrinology of Female Breast and Gestation; PART 3: PAEDIATRIC ENDOCRINOLOGY, Section 18. Growth and Development; Section 19: Hypo-and Hyperthyroidism in Children; Section 20: Congenital Adrenal Hyperplasia (CAH); PART 4: IMAGING AND RADIO-DIAGNOSIS IN ENDOCRINOLOGY, Section 21: Imaging in Endocrinology; Section 22: Mammography and Imaging; PART 5: SPECIAL TOPICS, Section 23: Special Topics in Endocrinology; PART 6: DIABETOLOGY, Section 24: Glucose Metabolism and Hypoglycaemia; Section 25: Diabetes Mellitus and Insulin Resistance; Section 26: Diagnosis and Management of Diabetes Mellitus; Section 27: Hyperglycaemic Effects on Other Body Systems; Section 28: Chronic Diabetic Complications; Section 29: Acute Metabolic Complications of Diabetes Mellitus, Section 30. Special Topics in Diabetes Mellitus.
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Jul 312019
 

This book covers all one needs to know about the utility of endomicroscopy in the diagnosis and management of gastrointestinal diseases. It provides a comprehensive description of the latest in diagnostic criteria and advances in the basic science pertaining to endomicroscopy of the gastrointestinal system. Each chapter introduces the key histologic, endoscopic, and endomicroscopic features of common gastrointestinal conditions, with generous illustration using typical images. The book will provide the practicing physicians with the principles of practice, and procedural techniques of endomicroscopy, as well as demonstrate the bench-to-bedside translational potential of endomicrosocpy in helping endoscopists manage their patients’ gastrointestinal conditions.

This book fills an enormous gap in providing a much needed atlas in GI endomicroscopic diagnosis. Readers can learn the diagnostic criteria of various gastrointestinal conditions as illustrated by high quality endoscopic, endomicroscopic and histology images.

It contains the most extensive review of currently published studies of endomicroscopy in gastrointestinal conditions. It has numerous high quality endomicroscopic images along with high definition endoscopy and histology images illustrating the common gastrointestinal diseases. It will provide a platform for standardizing endomicroscopic practice and learning.

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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8 edition

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8 edition
Jul 252019
 

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.

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Atlas of Atherosclerosis and Metabolic Syndrome

 Endocrinology/Metabolism/Diabetes Mellitus  Comments Off on Atlas of Atherosclerosis and Metabolic Syndrome
Jul 162019
 

In this updated fifth edition of the Atlas of Atherosclerosis and Metabolic Syndrome (formerly the Atlas of Atherosclerosis), the editors have compiled a comprehensive update on the field of atherosclerosis. This four-color atlas includes detailed legends and extensive reference listings for hundreds of illustrations, algorithms, schematics, and images. This new edition focuses more closely on metabolic syndrome, as well as comprehensively covering many other topics including diabetes and vascular risk, obesity management, dietary concerns, drug treatment, gender and ethnicity differences, and many others. The striking, four-color format combined with the breadth of information it contains make this book an invaluable resource for physicians, cardiologists, and all professionals involved in the study and treatment of atherosclerosis.
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