The Breakthrough: Immunotherapy and the Race to Cure Cancer

 Immunology, Oncology  Comments Off on The Breakthrough: Immunotherapy and the Race to Cure Cancer
Jan 182020
 

For thousands of years, physicians observed cases of “spontaneous remissions” from cancer. These sudden and dramatic cancer cures were chalked up to magic or miracle. In fact it was the immune system, mysteriously unleashed.
Now scientists have learned to recreate that miracle with medicines so new that cancer patients- and even many doctors- don’t realize they exist.
From the New York Times bestselling author of The Good Nurse comes an empowering and accessible story of the discoveries of the tricks cancer uses to avoid the immune system, and the important new cancer immunotherapies already unleashing the immune system to fight – and beat – the disease.
Four years in the writing, THE BREAKTHROUGH is an “exciting read” about the discoveries which received the 2018 Nobel Prize winning discoveries in October, and a dramatic and exciting turning point in our relationship with a disease that has for too long defined us.
For decades, scientists have puzzled over one of medicine’s most confounding mysteries: Why doesn’t our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer’s “penicillin moment,” a revolutionary discovery in our understanding of cancer and how to beat it.
In THE BREAKTHROUGH, Graeber guides us through the surprisingly recent scientific discoveries that change the way we will treat- and maybe even beat- cancer in the years to come.
Amazingly, many patients, and even many doctors, are not fully aware of what many are calling our “penicillin moment” with cancer. With literally thousands of new therapies that harness the power of the immune system to recognize and fight cancer in clinical trials, it’s never been more important for patients to understand their choices, and empowered to ask better questions. In the new war against cancer, information is now a crucial weapon.
Groundbreaking, riveting, and expertly told, THE BREAKTHROUGH is a scientific mystery story about the quest to unleash our natural ability to recognize and defeat cancer, told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.

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Allergy and Immunotoxicology in Occupational Health

 Immunology, Toxicology  Comments Off on Allergy and Immunotoxicology in Occupational Health
Jan 172020
 

This book offers a collection of the latest clinical and research findings related to allergies, one of the most frequently treated conditions in occupational medicine. The chapters not only cover asthma but also elaborate on contact dermatitis, rhinitis, and other allergic conditions, providing readers with a comprehensive overview of the substances disrupting autoimmunity and their effects on the human body. Allergy and Immunotoxicology in Occupational Health is a valuable resource for professionals and researchers in the occupational health sector, who will discover novel insights into immune effects, providing a foundation for future considerations of the health impairments caused by environmental and occupational exposure to these substances.

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Nijkamp and Parnham’s Principles of Immunopharmacology

 Immunology, Pharmacology  Comments Off on Nijkamp and Parnham’s Principles of Immunopharmacology
Jan 082020
 

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.
The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.

Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.

The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

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HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

 Immunology  Comments Off on HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research
Dec 182019
 

This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.

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Mucosal Immunology and Virology

 Immunology  Comments Off on Mucosal Immunology and Virology
Dec 162019
 

An understanding of virus infection and the underlying role of the immune system in protection against these diseases is vital in today’s medical climate. Previously, only symptoms could be treated, as there were no antiviral therapies. The increasing amounts of research and the huge number of discoveries of immunologic agents and pathways has led to the opportunity to look to the basic physiology of the various disease process as never before. This book is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process.
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Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

 Immunology, Infectious Diseases  Comments Off on Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
Dec 142019
 

This definitive and comprehensive account of the human herpes viruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein Barr virus, cytomegalovirus and varicella-zoster virus. The diseases they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology if infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth and the volume is fully up to date both scientifically and in terms of clinical guidelines for patient care. The text is generously illustrated throughout and fully referenced to the latest research and developments.

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Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies

 Immunology  Comments Off on Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies
Dec 102019
 

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions.
Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology.

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Encyclopedia of Medical Immunology: Allergic Diseases

 Immunology  Comments Off on Encyclopedia of Medical Immunology: Allergic Diseases
Dec 032019
 

Volume Allergic Diseases is a comprehensive, multi-authored reference work, offering a broad appeal to microbiologists, immunologists, and infectious disease specialists. The volume explores all aspects of allergic diseases, body systems and vaccines. Emphasis is placed on genetics, physiology, metabolism, pathogenesis, and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia brings together an outstanding collection of contributions by top scientists in a variety of fields.
The entries are listed alphabetically and provide full references.
The volume covers the following topics:
• Food Allergy and gastrointestinal Allergic Diseases
• Insect Allergy
• Allergy Diagnosis and Testing
• Allergy Treatment: Pharmacotherapy
• Asthma and Other Allergic Lower Respiratory Disease
• Biology of IgE, Mast Cells and Eosinophils
• Specific Allergens Causing Human Disease
• Atopic Dermatitis, Urticaria and Dermatologic Allergy
• Allergy Treatment: Immunotherapy, Immunomodulator Therapy and Allergen Avoidance

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Neonatal Immunity (Contemporary Immunology)

 Immunology  Comments Off on Neonatal Immunity (Contemporary Immunology)
Nov 292019
 

A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
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Killer Cell Dynamics: Mathematical and Computational Approaches to Immunology

 Immunology  Comments Off on Killer Cell Dynamics: Mathematical and Computational Approaches to Immunology
Nov 282019
 

This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.
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