The Cancer Chronicles: Unlocking Medicine’s Deepest Mystery

 Oncology  Comments Off on The Cancer Chronicles: Unlocking Medicine’s Deepest Mystery
May 232019
 

When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.

Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body.

Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

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Fundamentals of Tests and Measures for the Physical Therapist Assistant

 Miscellaneous  Comments Off on Fundamentals of Tests and Measures for the Physical Therapist Assistant
May 232019
 

Fundamentals of Tests and Measures for the Physical Therapist Assistant provides students with the tools required to interpret the physical therapy evaluation and replicate the measurements and tests. This text guides students in learning how to utilize case information and documentation furnished by the PT to assist in the follow-up treatment.

Key Features Include:

– Relevant anatomy and terminology review
– Comprehensive coverage of tests and measures arranged by system
– Pertinent documentation examples
– Excellent photographs and graphics
– Easy-to-understand descriptions and explanations

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Nail Disorders : A Comprehensive Approach

 Dermatology  Comments Off on Nail Disorders : A Comprehensive Approach
May 232019
 

Nail disorders are a specialized group of disorders which are often neglected during post graduate teaching. This book aims to provide a comprehensive review covering the diagnostic and therapeutic aspects of nail disorders. It discusses the basics of nail unit, common conditions like infections, tumors and genetic diseases, diagnostic armamentarium involved in nail diseases like KOH mount, onychoscopy, imaging and surgical management of nail diseases which includes anesthesia of nail unit, nail biopsy and advanced nail procedures including video demonstration of such procedures. This book elaborates on nails in systemic diseases and briefly covers nail cosmetics and nail photography.

Key Features

– Comprehensively reviews nail disorders
– Includes diagnosis, therapeutic and surgical aspect
– Discusses Onychoscopy
– Reviews the importance of nail photography

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DNA Topoisomerases: Methods and Protocols

 Miscellaneous  Comments Off on DNA Topoisomerases: Methods and Protocols
May 232019
 

Due to their importance to cell biology, DNA topology-altering enzymes, collectively DNA topoisomerases and gyrases, have been studied thoroughly from a biochemical perspective, yet the expansion of research at the molecular and cellular levels continues to show a great deal of promise. In DNA Topoisomerases: Methods and Protocols, experts in the field present a compendium of protocols that extends into the new areas of research that have been recently uncovered in order to elucidate the methodology needed to study topoisomerases in the molecular and cellular context. The volume examines subjects such as the analysis of DNA topologies and the interaction of topoisomerases with DNA as tools to measure topoisomerase functions, the binding of topoisomerases to specific sites in the genomes of eukaryotes, including origins of DNA replication, as well as exploration of perturbed topoisomerase function. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols, and notes on trouble-shooting and avoiding known pitfalls.Cutting-edge and easy-to-use, DNA Topoisomerases: Methods and Protocols provides key content which reflects an expanded understanding of the functions of these essential enzymes in the hope of inspiring researchers to further important discoveries in this dynamic field.
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Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management

 Infectious Diseases  Comments Off on Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management
May 232019
 

This monograph takes stock of our current knowledge on the evolutionary ecology of infectious diseases, and sets out the goals for the management of virulent pathogens. Throughout the text, the fundamental concepts and techniques underlying the models are carefully explained in a unique series of integrated boxes.
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Intraoperative Neurophysiology: A Comprehensive Guide to Monitoring and Mapping, Second Edition

 Neurology/Neurosurgery  Comments Off on Intraoperative Neurophysiology: A Comprehensive Guide to Monitoring and Mapping, Second Edition
May 232019
 


by Mirela V. Simon MD (Editor)

Completely revised and updated second edition of the leading reference on intraoperative neurophysiology, this book covers IOM from the most basic theoretical and technical concepts to the most sophisticated procedures, placing them within the specific surgical context. Written by a multidisciplinary team of experts from Massachusetts General Hospital/Harvard Medical School, Intraoperative Neurophysiology provides a step-by-step approach to monitoring and mapping for a wide variety of complex surgical procedures by progressively building on prior learned material. Covering everything from set-up to troubleshooting and medical management, this book presents an integrated blueprint for choosing the right tests and customizing IOM procedures to the demands of each surgical challenge.

Comprehensive in scope and filled with over 650 helpful illustrations, tables, and neurophysiologic recordings to aid interpretative understanding, this expanded edition includes practical examples of monitoring and mapping and details the importance of an individualized approach to IOM. A highly visual book, it continues to serve as a primary resource for physicians and technologists involved in monitoring to help reduce the operative risk of neurological damage in surgical patients.

New to the Second Edition:

Extensively broadened coverage of critical topics including mapping procedures brain mapping, and primary neurophysiologic testing in the operating room
Six entirely new chapters on pediatric neuromonitoring, cerebral aneurysms, electrocorticography, deep brain stimulation, intradural extramedullary tumors, and cardiac procedures
Enhanced decompressive and deformity correction surgery chapters with added description of surgical steps and mechanisms of injury
Over 650 high-quality images to enrich and instruct readers
100 multiple-choice questions and answers with rationales referenced back to the chapters for targeted review
Includes digital access to the eBook

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Precision Radiation Oncology

 Oncology, Radiology  Comments Off on Precision Radiation Oncology
May 232019
 

by Bruce G. Haffty (Author), Sharad Goyal (Author)

Precision medicine is a rapidly-evolving field in the management of cancer. The use of novel molecular or genetic signatures in local-regional management is still in its infancy. Precision Radiation Oncology demystifies this state-of-the-art research and technology.

By describing current existing clinical and pathologic features, and focusing on the ability to improve outcomes in cancer using radiation therapy, this book discusses incorporating novel genomic- or biology-based biomarkers in the treatment of patients moving radiation oncology into precision/personalized medicine. Precision Radiation Oncology provides readers with an overview of the new developments of precision medicine in radiation oncology, further advancing the integration of new research findings into individualized radiation therapy and its clinical applications

About the Author
BRUCE HAFFTY, M.D. is an international expert in breast radiation oncology. He is a professor and chairman in the Department of Radiation Oncology at Rutgers Robert Wood Johnson Medical School, Rutgers New Jersey Medical School, and Rutgers Cancer Institute of New Jersey. He also serves as Chief of Staff of the Rutgers Cancer Institute.

SHARAD GOYAL, M.D. is a professor and division chief of Radiation Oncology in the Department of Radiology at the George Washington University School of Medicine and Health Sciences. He is a board-certified radiation oncologist whose clinical practice is primarily focused on breast and brain cancers.

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The Science and Regulations of Naturally Derived Complex Drugs

 Pharmacology  Comments Off on The Science and Regulations of Naturally Derived Complex Drugs
May 232019
 

This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend throughout the product development cycle from raw material control to clinical study design. The regulatory landscape is rapidly changing as new types of complex mixtures are introduced into clinical trials and to the market (e.g., traditional Chinese medicines and medical marijuana products), while older products are facing generic competition for the first time (e.g., enoxaparin). The future outlook for complex generic drug products, as opposed to the more commonly developed targeted single agent drug products is not clear. The risks pertaining to lack of a full understanding of raw material control, process and controls in manufacture, as well as characterization of a complex mixture were seen vividly during the heparin crisis of 2008. As such powerful lessons have been learned about the regulatory science specific to complex products. The Science and Regulations of Naturally Derived Complex Drugs addresses the interests among industry, academics, and government on the issues surrounding the future development of mixtures for medicinal use.
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The Auditory System: Anatomy, Physiology, and Clinical Correlates, Second Edition

 Anatomy, Physiology  Comments Off on The Auditory System: Anatomy, Physiology, and Clinical Correlates, Second Edition
May 232019
 

by Frank E. Musiek;Jane A. Baran (Author)

This updated, second edition of The Auditory System: Anatomy, Physiology, and Clinical Correlates remains an essential text for audiology students and clinicians. The text is designed to provide comprehensive coverage of the anatomy and physiology of the central and peripheral auditory systems. Readers will benefit from the important link between science and clinical practice, with integrated clinical correlates found in each chapter.
Key Features:

Presents balanced coverage of both the peripheral and central auditory systems
Integrated clinical correlates establish the link between science and practice
Substantial use of review articles and secondary sources enhances general understanding
Numerous anatomical sketches and photographs supplement learning
New to this Edition:

A newly designed two-color interior provides increased readability
A new chapter providing an overview of normal development of the auditory system, plasticity of the central auditory system, and aging effects on the peripheral and central auditory systems
A number of new illustrations *New and updated information on synaptic ribbons, neuropharmacology of cochlear function, cryoloop cooling, and the vascular network of the brainstem
Updated references, review articles, and readings
Access to a PluralPlus companion website that includes PowerPoint lecture slides and an image bank
The Auditory System: Anatomy, Physiology, and Clinical Correlates, Second Edition is an essential text for graduate programs in audiology and a valuable reference for audiologists at any stage of their career

About the Author
Frank E. Musiek, PhD, CCC-A, is Professor and Director of the NeuroAudiology Lab, Dept. of Speech Language and Hearing Sciences University of Arizona. He is Professor Emeritus at the University of Connecticut and former Professor and Director of Audiology at the Dartmouth Hitchcock Medical Center. He is the 2007 AAA Recipient of the James Jerger Career Award for Research in Audiology, the 2010 recipient of The Honors of The American Speech, Language and Hearing Association for his contributions to Audiology and Auditory Neuroscience , and Recipient of Book of the Year Award for the 2007 Handbook of Central Processing Disorder Vol. I and II (with Gail Chermak co- editor). He has published over 200 articles and over 40 book chapters in the areas of auditory evoked potentials, central auditory disorders, neuroaudiology and auditory neuroanatomy. He has authored or edited 11 books. He has served on numerous national and international committees, editorial boards and task forces including chairing the 2010 AAA task force for clinical practice guidelines for CAPD and the 2016 Academy Research Conference (ARC) on CAPD.

Jane A. Baran, PhD is Professor Emerita in the Department of Communication Disorders at the University of Massachusetts Amherst. Her primary research and clinical interests are in the areas of (central) auditory processing disorders, auditory evoked potentials, and neuroanatomy and neurophysiology of the auditory system. She is coauthor of three books, Neuroaudiology: Case Studies, The Auditory System: Anatomy, Physiology and Clinical Correlates, and Disorders of the Auditory System. In addition, she has authored or co-authored a number of journal articles and book chapters in the areas of normal and disordered auditory processing, language processing, auditory evoked potentials, and auditory neuroanatomy and neurophysiology. She has presented numerous research papers and educational workshops at regional, national, and internationals meetings. Dr. Baran is a Fellow of the American Speech-Language-Hearing Association (ASHA), the 2001 Recipient of the Clinical Educators Award from the American Academy of Audiology, a 2005 Recipient of a Recognition Award for Special Contributions to Higher Education from ASHA, and the 2013 Recipient of the Journal of the American Academy of Audiology Editor s Award. She also is one of a select group of scholars to receive the Carnegie National Scholar Fellowship Award from the Carnegie Foundation for the Advancement of Teaching and Learning

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Fundamentals of Children’s Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students

 Pathology, Physiology  Comments Off on Fundamentals of Children’s Applied Pathophysiology: An Essential Guide for Nursing and Healthcare Students
May 232019
 

by Elizabeth Gormley-Fleming (Editor), Ian Peate (Editor)

Fundamentals of Children’s Applied Pathophysiology introduces nursing and healthcare students to the pathophysiology of the child, and offers an applied full-colour visual approach throughout. Explaining the anatomy of the human body, and the effects of disease or illness on normal physiology, it enables the reader to develop the understanding, knowledge, and skills required to provide safe and effective high-quality care to children and their families.

KEY FEATURES:

Written by an experienced author team
Filled with superb full-colour illustrations
Packed with learning features, including key words, test-your-knowledge, exercises, further reading, and learning outcomes
Includes case studies to help readers understand how to apply the knowledge in clinical practice
Contains links to clinical observations, vital signs to look out for, investigations boxes, red flags to indicate essential information to be aware of when providing care, and medication alerts
Fundamentals of Children’s Applied Pathophysiology is an ideal book for pre-registration nursing students, including child and adult nurses, as well as for all healthcare professionals who come into contact with children and their families.

A companion website is available at www.wileyfundamentalseries.com/childpathophysiology featuring:

Multiple-choice questions
Further resources
Word-search exercises
Glossaries
Crosswords
‘Fill in the blanks’ exercises
True or false questions
For more information on the complete range of Wiley nursing publishing, please visit: www.wiley.com

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Wiley Healthcare books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewnursingbooks.com to find out more.

About the Author

ELIZABETH GORMLEY-FLEMING is Head of Department for Nursing (Children’s, Learning Disability and Mental Health) and Social Work, University of Hertfordshire, UK.

IAN PEATE OBE FRCN is Visiting Professor of Nursing, Editor-in-Chief of the British Journal of Nursing, and Head of School, School of Health Studies, Gibraltar

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