Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body

 Toxicology  Comments Off on Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body
Mar 212019
 

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.
Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:
• Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
• Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
• Describes the intravenous route of administration for the therapeutic management of ocular disease
• Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
• Summarizes various toxicological principles and the testing of nanoproducts
Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where “practical” is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book’s goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

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Nutrition, Fertility, and Human Reproductive Function

 Nutrition  Comments Off on Nutrition, Fertility, and Human Reproductive Function
Mar 212019
 

One in six couples around the world experience infertility. Before undertaking expensive and intrusive assisted reproductive treatment such as in vitro fertilization, many seek advice from their physicians or dietitians on what foods and supplements might enhance their fertility. But health practitioners are often ill equipped to provide dietary recommendations in a scientifically based manner. Nutrition, Fertility, and Human Reproductive Function provides a comprehensive guide to clinicians on how they can best advise their patients to optimise fertility and reproductive function through optimal nutrition.

Taking a holistic or “whole-of-life” approach, the book reviews the role of nutrition in human fertility and explores its effect on male and female reproductive physiology. Problem-orientated topics are arranged in chapters that each cover a specific clinical topic of interest, allowing easy reference by the practicing clinician. From the female perspective, the book covers the role of nutrition on essential reproductive processes such as ovulation, early embryo development, implantation, and sexual function, together with nutrition’s influence on the duration of the reproductive life span. In the male context, it examines the effect of nutrition on hormone and sperm production as well as sexual function. The book also includes information on evidence-based complementary health approaches such as Traditional Chinese Medicine (TCM) and naturopathy.

This book draws on the wide experience of several respected leaders in clinical nutrition who combine research expertise with clinical insight. The information contained herein will enable clinicians to make the best recommendations for their patients for optimising fertility.

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Brachytherapy, Second Edition: Applications and Techniques

 Radiology  Comments Off on Brachytherapy, Second Edition: Applications and Techniques
Mar 212019
 

Since the first edition was published in 2006, Phillip M. Devlin’s Brachytherapy has been acknowledged as the essential book on the practice. In this updated new edition, all chapters covering cancer sites have been significantly revised. Organized for specialists in several fields, Brachytherapy contains site-specific chapters that discuss how the evolving role of advanced image guidance has demonstrated greater efficacy and less toxicity. Clinical vignettes with images now accompany all site-specific chapters. The chapter on prostate brachytherapy has been expanded to include other indications in the genitourinary system, and there are two entirely new chapters–one chronicling the history of brachytherapy and the other detailing the emergence of skin brachytherapy.

Dr. Devlin, a leading world authority on brachytherapy, has assembled other leaders in the field from world-renowned radiation oncology programs to enrich this comprehensive text. From new data on medical outcomes to the costs and benefits of running a brachytherapy practice, Brachytherapy, Second Edition is the first and last word on what still is considered the most conformal radiotherapy technique in the field.

In the new edition:

Over 300 images accompany the chapter text and clinical vignettes
Essential tables and spreadsheets enhance the chapter on running a brachytherapy practice
Ten years of technological advancements are assimilated and reviewed in each site-specific chapter

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Immune System Modelling and Simulation

 Immunology  Comments Off on Immune System Modelling and Simulation
Mar 212019
 

The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works.

C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today’s immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time.

The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

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PET/CT in Brain Disorders

 Neurology/Neurosurgery  Comments Off on PET/CT in Brain Disorders
Mar 212019
 

This well-illustrated pocket book offers up-to-date guidance on the clinical and research applications of PET/CT in the most common neurological and neuro-oncological disorders. The opening chapters cover the pros and cons of widely used radiological imaging techniques, scanners, and radiopharmaceuticals, with emphasis on the state of the art hybrid modalities, primarily PET/CT but also PET/MRI. Helpful information is provided on the clinical and research tracers used in neurodegenerative diseases, movement disorders, epilepsy and brain tumours. These four killers are then discussed in detail, highlighting the role of PET/CT and targeted tracers in their assessment and in radiotherapy planning. In addition, the clinical applications of PET/MRI are considered. Throughout, many images are included to better explain the diseases and the role of hybrid imaging, and the final chapter presents a large sample of teaching cases and files that will assist in daily clinical practice. The book has been compiled under the auspices of the British Nuclear Medicine Society. It will be an excellent asset for nuclear medicine physicians, radiologists, radiographers, neurologists and neurosurgeons.
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Journal of Prosthodontics on Dental Implants

 Dentistry  Comments Off on Journal of Prosthodontics on Dental Implants
Mar 212019
 

The Journal of Prosthodontics has been the official publication of the American College of Prosthodontics for more than 20 years. In excess of 1,000 peer–reviewed articles on a wide variety of subjects are now in print, representing a treasure chest of history and valuable information on a myriad of topics of interest to the specialty of prosthodontics.

Journal of Prosthodontics on Dental Implants is a best of compilation of the journal s articles from a number of years, focusing exclusively on the multiple applications of osseointegrated implants: for the management of the partially edentulous patient, management of the completely edentulous patient, and management of patients with maxillofacial defects. Sections also relate to in–vitro studies and general considerations to round out the readership selections.

Whether you re a subscriber who s looking for implant articles in one convenient collection or a clinician with a focus on implant dentistry looking to improve your knowledge base, Journal of Prosthodontics on Dental Implants is a must–have for your personal library.

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Natural Therapies for Overcoming Opioid Dependency: Control Pain and Recover from Addiction…

 Miscellaneous  Comments Off on Natural Therapies for Overcoming Opioid Dependency: Control Pain and Recover from Addiction…
Mar 212019
 

With opioid dependency at epidemic levels, Catherine Browne, a doctor of acupuncture and Oriental medicine, provides an accessible and practical guide to the effective use of natural therapies in helping people wean off opioids, manage withdrawal symptoms, and address pain without opioids.

Drawing on her extensive clinical experience, Dr. Browne explains how Chinese medicine, acupuncture and acupressure, herbs, essential oils, nutritional supplements, meditation, and exercise can be used to address addiction and restore the body to optimal functioning. Individuals and families who are struggling with addiction, as well as medical practitioners and holistic healthcare professionals, will find help and encouragement in Dr. Browne’s detailed protocols and advice for integrating natural therapies with traditional medical treatment.

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Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders

 Neurology/Neurosurgery  Comments Off on Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders
Mar 212019
 

by Sanjeev Kumar Gupta (Author, Editor), Srinivasan Venkatesan (Editor), S.P. Goswami (Editor), Rajeev Kumar (Editor)

Neurodevelopmental disorders encompass a group of conditions that can typically manifest during early childhood. These include intellectual disabilities, communication disorders, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), specific learning disorder (SLD), and motor disorders. Early identification and assessment can be a valuable tool in determining diagnosis, prognosis, functional abilities, and formulating clinical intervention for both children and adults with neurodevelopmental disorders.

Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders is an essential reference source that discusses and disseminates contributions covering recent trends in diagnosis, assessment, and intervention techniques. Featuring research on topics such as clinical linguistics, neural connectivity, and animal-assisted therapy, this book is ideally designed for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neural and developmental disorder identification and strategies for clinician support and therapies

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Computational Neuroendocrinology (Wiley-INF Masterclass in Neuroendocrinology Series)

 Endocrinology/Metabolism/Diabetes Mellitus, Neurology/Neurosurgery  Comments Off on Computational Neuroendocrinology (Wiley-INF Masterclass in Neuroendocrinology Series)
Mar 212019
 

Neuroendocrinology with its well defined functions, inputs, and outputs, is one of the most fertile grounds for computational modeling in neuroscience. But modeling is often seen as something of a dark art. This book aims to display the power of modeling approaches in neuroendocrinology, and to showcase its potential for understanding these complex systems.
A recurring theme in neuroendocrinology is rhythms. How are rhythms generated, and what purpose do they serve? Are these two questions inextricably intertwined?
This book is written for innocents, presuming no math beyond high school or computing beyond calculators. It seeks to lead the curious into the thinking of the modeler, providing the tools to the reader to understand models, and even develop their own, giving life to paper diagrams. The diverse chapters, from ion channels to networks, systems, and hormonal rhythms, each tell the story of a model serving to join the hard won dots of experimentation, mapping a new understanding, and revealing hidden knowledge.

• Written by a team of internationally renowned researchers
• Both print and enhanced e-book versions are available
• Illustrated in full colour throughout
This is the fourth volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

• Written by a team of internationally renowned researchers
• Both print and enhanced e-book versions are available
• Illustrated in full colour throughout
This is the fourth volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

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This May Hurt a Bit: Reinventing Canada’s Health Care System

 Miscellaneous  Comments Off on This May Hurt a Bit: Reinventing Canada’s Health Care System
Mar 212019
 

Some painful news: Canada no longer has the best health-care system in the world.

How might we fix Canada’s health-care system? Why would we want to? What’s stopping us from doing so? These three questions lie at the heart of this in-depth exploration of one of the biggest political and personal issues facing Canadians.

Skyvington explains why change has to occur, in light of the implications of doing nothing, and describes how Canadians can and must get involved to save our health-care system.

This May Hurt a Bit is meant to provide a blueprint for change once those in charge finally acknowledge the most inconvenient truth — namely, that Canada’s health-care system is in poor health.

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