Low-level light therapy (or photobiomodulation therapy) is a rapidly growing approach to treating a wide range of diseases and disorders that afflict humanity. This Tutorial Text covers the basic molecular and cellular mechanisms of action, applications for treating diseases in animal models, and its use in clinical trials and therapeutic practice in patients. Other topics include the two basic chromophores and how they trigger the signaling pathways, activation of transcription factors, and mobilization of stem cells; how the light-source design and the relevant energy parameters can affect the outcome of therapy; and the physics and tissue-optics principles that concern LLLT.
Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine, Massachusetts General Hospital, an Associate Professor of Dermatology, Harvard Medical School and affiliated faculty at Harvard-MIT Division of Health Science and Technology. He directs a laboratory of around a dozen scientists who work in photodynamic therapy and photobiomodulation. He has published 412 peer-reviewed articles, holds 10 patents, is Editor or Associate Editor for 10 journals and serves on NIH Study-Sections. He has an h-factor of 88 and over 30,000 citations. He has authored/edited 12 proceedings volumes together with ten other major textbooks on PDT and photomedicine. Dr Hamblin was honored by election as a Fellow of SPIE in 2011, received the 1st Endre Mester Lifetime Achievement Award from NAALT in 2017 and will receive the Outstanding Career Award from the Dose Response Society in 2018.
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