This book provides up-to-date information on all aspects of orofacial pain biomarkers. It opens by presenting background information on clinical phenotypes and the neurobiological substrates underlying chronic orofacial pain and by explaining the potential role of biomarkers in the diagnosis, prognostic evaluation, and treatment of orofacial pain. The main section of the book examines the contribution of human and animal studies to the field of biomarkers for orofacial pain and discusses biomarkers for masticatory muscle pain, temporomandibular joint pain, neuropathic face pain, and autonomic nervous system involvement in trigeminal facial pain. The potential impacts of the immune system on orofacial pain biomarkers and candidate gene phenotypes with possible links to chronic orofacial pain conditions are also addressed, and differences and similarities between saliva and serum biomarkers for pain are explained as well. The final section covers research-related issues in assessment methods and statistical analyses used in evaluating biomarkers, identifies future challenges and suggests new directions in the field.
This book focuses on neuro-engineering and neural computing, a multi-disciplinary field of research attracting considerable attention from engineers, neuroscientists, microbiologists and material scientists. It explores a range of topics concerning the design and development of innovative neural and brain interfacing technologies, as well as novel information acquisition and processing algorithms to make sense of the acquired data. The book also highlights emerging trends and advances regarding the applications of neuro-engineering in real-world scenarios, such as neural prostheses, diagnosis of neural degenerative diseases, deep brain stimulation, biosensors, real neural network-inspired artificial neural networks (ANNs) and the predictive modeling of information flows in neuronal networks. The book is broadly divided into three main sections including: current trends in technological developments, neural computation techniques to make sense of the neural behavioral data, and application of these technologies/techniques in the medical domain in the treatment of neural disorders.
This edited volume provides an overview the state-of-the-art in the field of cognitive neuroscience of memory consolidation. In a number of sections, the editors collect contributions of leading researchers . The topical focus lies on current issues of interest such as memory consolidation including working and long-term memory. In particular, the role of sleep in relation to memory consolidation will be addressed. The target audience primarily comprises research experts in the field of cognitive neuroscience but the book may also be beneficial for graduate students.
Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today’s destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer’s, Parkinson’s and Huntington’s disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
Features: Routledge By (author): Theodore J. Chapin, Lori A. Russell-Chapin
The fields of neurobiology and neuropsychology are growing rapidly, and neuroscientists now understand that the human brain has the capability to adapt and develop new living neurons by engaging new tasks and challenges throughout our lives, essentially allowing the brain to rewire itself. In Neurotherapy and Neurofeedback, accomplished clinicians and scholars Lori Russell-Chapin and Ted Chapin illustrate the importance of these advances and introduce counselors to the growing body of research demonstrating that the brain can be taught to self-regulate and become more efficient through neurofeedback (NF), a type of biofeedback for the brain. Students and clinicians will come away from this book with a strong sense of how brain dysregulation occurs and what kinds of interventions clinicians can use when counseling and medication prove insufficient for treating behavioral and psychological symptoms.
The novelty of this book’s approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, psychological profile, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and on psychological resilience the authors hope that this book can lead to the development of better treatment strategies for functional recovery from brain damage.
Features: Brain Informatics and Health International Conference BIH 2014 Warsaw Poland August 11 14 2014 Proceedings Lecture Notes in Computer Science
This book constitutes the proceedings of the International Conference on Brain Informatics and Health, BIH 2014, held in Warsaw, Poland, in August 2014, as part of 2014 Web Intelligence Congress, WIC 2014. The 29 full papers presented together with 23 special session papers were carefully reviewed and selected from 101 submissions. The papers are organized in topical sections on brain understanding; cognitive modelling; brain data analytics; health data analytics; brain informatics and data management; semantic aspects of biomedical analytics; healthcare technologies and systems; analysis of complex medical data; understanding of information processing in brain; neuroimaging data processing strategies; advanced methods of interactive data mining for personalized medicine.
Features: Small Molecule Therapeutics for Schizophrenia Topics in Medicinal Chemistry
The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.