Immune-based Cancer Treatment: The T Iymphocyte Response

 Immunology, Oncology  Comments Off on Immune-based Cancer Treatment: The T Iymphocyte Response
Apr 192019
 


The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies.

It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

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Exercise Immunology

 Immunology  Comments Off on Exercise Immunology
Apr 172019
 


Exercise immunology is an important, emerging sub-discipline within exercise physiology, concerned with the relationship between exercise, immune function and infection risk. This book offers a comprehensive, up-to-date and evidence-based introduction to exercise immunology, including the physiological and molecular mechanisms that determine immune function and the implications for health and performance in sport and everyday life.

Written by a team of leading exercise physiologists, the book describes the characteristics of the immune system and how its components are organised to form an immune response. It explains the physiological basis of the relationship between stress, physical activity, immune function and infection risk, and identifies the ways in which exercise and nutrition interact with immune function in athletes and non-athletes. The book shows students how to evaluate the strengths and limitations of the evidence linking physical activity, immune system integrity and health, and explains why exercise is associated with anti-inflammatory effects that are potentially beneficial to long-term health.

Every chapter includes useful features, such as clear summaries, definitions of key terms, discussions of seminal research studies and practical guidelines for athletes on ways to minimise infection risk, with additional learning resources available on a companion website. This is an essential textbook for any course on exercise immunology or advanced exercise physiology.

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Synthetic Immunology

 Immunology  Comments Off on Synthetic Immunology
Apr 172019
 

This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world.

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Antimicrobial Peptides: Properties, Functions and Role in Immune Response

 Immunology  Comments Off on Antimicrobial Peptides: Properties, Functions and Role in Immune Response
Mar 302019
 

Antimicrobial peptides (AMPs) are small peptides which exhibit broad-spectrum antimicrobial activity and often activity against virus. In addition, AMPs exert several functions including endotoxin neutralization, chemotactic and immunomodulating activities, angiogenesis, and wound repair. In this book, the authors discuss the innate immune system and lipopolysaccharides; the biological role of fish antimicrobial peptides; casein-derived peptides; antimicrobial peptides in intestinal inflammation and infection; insect antimicrobial peptides in immunity and mechanisms of action; potential of AMPs as therapeutic tools against infectious disease; and how LC-MS/MS-based quantitative protein profiling can aid mechanistic studies of antimicrobial peptides.

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From Basic to Clinical Immunology

 Immunology  Comments Off on From Basic to Clinical Immunology
Mar 242019
 

This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with clinical comments that complete the whole picture.

Immunology is a complex science, which requires a simplified approach in order to be taught and understood effectively. This book is based on the authors’ long experience in teaching undergraduate, postgraduate students and interns both basic and clinical immunology.

Reviewing a variety of important components related to the immune system, it is clearly and logically structured, and enriched by figures, tables and boxes with important immunology definitions. Each chapter has its own bibliography, and most units include links to electronic quizzes and audio files to accompany readers step by step. This easy-to-follow volume concludes with suggestions for future study. It is a valuable resource for undergraduate and postgraduate students, as well as medical practitioners.

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Immune System Modelling and Simulation

 Immunology  Comments Off on Immune System Modelling and Simulation
Mar 212019
 

The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works.

C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today’s immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time.

The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

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Lippincott’s Illustrated Q&A Review of Microbiology and Immunology

 Immunology, Microbiology  Comments Off on Lippincott’s Illustrated Q&A Review of Microbiology and Immunology
Mar 142019
 

Lippincott’s Illustrated Q&A Review of Microbiology and Immunology offers up-to-date, clinically relevant board-style questions-perfect for course review and board prep! Approximately 500 multiple-choice questions with detailed answer explanations cover frequently tested topics in bacteriology, virology, mycology, parasitology, infectious disease, basic immunology, and clinical immunology. The book is heavily illustrated with photos of clinical manifestations or of gram-stained organisms, parasite eggs, oocysts or other parasitic stages, or pathologic specimens.

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Artificial Immune Systems and Their Applications

 Immunology  Comments Off on Artificial Immune Systems and Their Applications
Mar 112019
 

Artificial immune systems are highly distributed systems based on the principles of the natural system. This is a new and rapidly growing field offering powerful and robust information processing capabilities for solving complex problems. Like artificial neural networks, artificial immune systems can learn new information, recall previously learned information, and perform pattern recognition in a highly decentralized fashion. This volume provides an overview of the immune system from the computational viewpoint. It discusses computational models of the immune system and their applications, and provides a wealth of insights on immunological memory and the effects of viruses in immune response. It will be of professional interest to scientists, academics, vaccine designers, and practitioners.
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Systems Immunology : An Introduction to Modeling Methods for Scientists

 Immunology  Comments Off on Systems Immunology : An Introduction to Modeling Methods for Scientists
Mar 072019
 

New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined.

Readers from immunology, quantitative biology, and applied physics will benefit from the following:

– Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels.
– An overview of basic concepts in modeling and data analysis.
– Coverage of topics where mechanistic modeling has contributed substantially to current understanding.
– Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

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The Immune System (Your Body How It Works)

 Anatomy, Immunology  Comments Off on The Immune System (Your Body How It Works)
Mar 042019
 

Examines the workings of a complex structure, the body’s defense against disease and infection.

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