Rare Rheumatic Diseases of Immunologic Dysregulation

 Immunology, Rheumatology  Comments Off on Rare Rheumatic Diseases of Immunologic Dysregulation
Nov 162018

This book is a practical, user-friendly guide for diagnosing and treating patients with rare rheumatic diseases of immunologic dysregulation. Covering uncommon diseases such as IgG4-Related Disease, Castleman’s Disease, and Felty Syndrome, chapters aggregate information from case reports and anecdotal literature to create a single, comprehensive handbook for treating patients.
Each chapter provides historical perspective and epidemiology; a literature review (including research trials, translational research, historical and current case reports, and case series); pathogenesis; clinical presentation; laboratory evaluation; imaging; histopathology; treatment; and outcomes. Rare Rheumatic Diseases of Immunologic Dysregulation is an invaluable resource for rheumatologists, rheumatology fellows, and clinical immunologists to better diagnose and treat patients with rare rheumatic diseases.







Share Button

Liver Immunology: Principles and Practice

 Immunology  Comments Off on Liver Immunology: Principles and Practice
Nov 102018

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall.  In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases –  primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others.  This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients.  Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases.  This volume will again be a must-read for clinicians at all levels, investigators and students.





Share Button

Human Immunodeficiency Virus Reverse Transcriptase

 Immunology  Comments Off on Human Immunodeficiency Virus Reverse Transcriptase
Oct 252018

The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes.

Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus.

The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.





Share Button

Primary Immunodeficiency Diseases: A Molecular & Cellular Approach, 2 edition

 Genetics, Immunology  Comments Off on Primary Immunodeficiency Diseases: A Molecular & Cellular Approach, 2 edition
Oct 232018

The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders–disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders.

Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency.

The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.





Share Button

Stromal Immunology

 Immunology  Comments Off on Stromal Immunology
Sep 272018

Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.







Share Button

Advances in Comparative Immunology

 Immunology  Comments Off on Advances in Comparative Immunology
Sep 222018

Immunologists, perhaps understandably, most often concentrate on the human immune system, an anthropocentric focus that has resulted in a dearth of information about the immune function of all other species within the animal kingdom. However, knowledge of animal immune function could help not only to better understand human immunology, but perhaps more importantly, it could help to treat and avoid the blights that affect animals, which consequently affect humans.
Take for example the mass death of honeybees in recent years – their demise, resulting in much less pollination, poses a serious threat to numerous crops, and thus the food supply. There is a similar disappearance of frogs internationally, signaling ecological problems, among them fungal infections.

This book aims to fill this void by describing and discussing what is known about non-human immunology. It covers various major animal phyla, its chapters organized in a progression from the simplest unicellular organisms to the most complex vertebrates, mammals. Chapters are written by experts, covering the latest findings and new research being conducted about each phylum.
Edwin L. Cooper is a Distinguished Professor in the Laboratory of Comparative Immunology, Department of Neurobiology at UCLA’s David Geffen School of Medicine.







Share Button

Biomaterials and Immune Response: Complications, Mechanisms and Immunomodulation (Devices, Circuits, and Systems)

 Immunology  Comments Off on Biomaterials and Immune Response: Complications, Mechanisms and Immunomodulation (Devices, Circuits, and Systems)
Sep 112018

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials.





Share Button

Review of Medical Microbiology and Immunology, Twelfth Edition

 Immunology, Microbiology  Comments Off on Review of Medical Microbiology and Immunology, Twelfth Edition
Sep 022018

The most concise, easy-to-use, and frequently updated review of the medically important aspects microbiology and immunology
Essential for USMLE and medical microbiology course exam preparation, Review of Medical Microbiology, 12e provides a high-yield review of the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology.





Share Button

Review of Microbiology and Immunology, 6th edition

 Immunology, Microbiology  Comments Off on Review of Microbiology and Immunology, 6th edition
Aug 212018

• The only MCQ book in any subject written by textbook authors.

• Thoroughly revised, updated and fully colored edition.

• All image based microbiology MCQs of 2016 came from this book.

• Facts and concepts have been taken from latest editions of Harrison (19th), Park (23rd), Jawetz (25th), Apurba Sastry’s Essentials of Medical Microbiology, Apurba Sastry’s Essentials of Medical Parasitology and Ananthanarayan (9th edition).

• Latest updates included such as BMW Rule 2016, Zika, H1N1, Ebola virus, Polio eradication, Vaccine-derived PolioVirus (VDPV), MERS CoV, etc.

• Includes questions along with explanatory answers of AIIMS (2000-2016 Nov), PGI (2000-2016 Nov), JIPMER (2009-2016 Nov), All India (2000-2012), DNB (2000-2012) and recent questions from other national level examinations (2013-2016).

• Contains recent MCQs from state entrance exams such as APPG (2000-2016), TNPG (2009-2016), MHPG (2009-2016), West Bengal PG (2012-2016), COMEDK (2013-2016), CMC Vellore 2016 and latest MCQs from other national and state entrances.

• Image-based question bank is strengthened with new images (more than 500 images are included).

• Only MCQs book on Microbiology written by the subject specialty and textbook authors.

• Interactive 2 hours DVD containing Apurba Sastry’s Microbiology Discussion.

• Chapter-wise concise text in a new layout for enabling students to study antegrade manner and important points given in separate boxes.

• Chapter-wise MCQs with detailed explanations given from previous year exams of National and State exams including DNB and NEET pattern questions.

• Hundred percent authentic and correct answers with updated references.

• More emphasis is given to the sections, like Immunology, Parasitology and Mycology.

• Enriched with lots of tables, flowcharts and mnemonics for better recall by the students.

• Useful for interns, students preparing for entrance exams and for second professional students.

• Author online support for clarification of doubts.

• A must-buy book for All India, AIIMS, PGI, JIPMER, DNB FMGE and state entrance exams.





Share Button

Fundamental Immunology (7th edition)

 Immunology  Comments Off on Fundamental Immunology (7th edition)
Aug 142018

This standard-setting textbook has defined the field of immunology since 1984, and is now in its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage readers expect. This comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Share Button