An Elegant Defense: The Extraordinary New Science of the Immune System: A Tale in Four Lives

 Immunology  Comments Off on An Elegant Defense: The Extraordinary New Science of the Immune System: A Tale in Four Lives
Jun 232019
 

Magnificently reported and soulfully crafted, An Elegant Defense is an epic, first-of-its-kind exploration of the human immune system and the secrets of health, by the Pulitzer Prize–winning New York Times journalist

“One of those rare nonfiction books that transcends the genre. … Fascinating and engrossing. … I highly recommend this extraordinary book.” —DOUGLAS PRESTON

“Vividly told. … Explicates for the lay reader the intricate biology of our immune system.” —JEROME GROOPMAN, New York Review of Books

A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel’s An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.

The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.

For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.

Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.

Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

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Essentials of Clinical Immunology, 6 edition

 Immunology  Comments Off on Essentials of Clinical Immunology, 6 edition
Jun 212019
 

Essentials of Clinical Immunology provides the most up-to-date, core information required to understand diseases with an immunological basis. Clinically focussed, the sixth edition of this classic text presents theoretical and practical information in a simple yet thorough way.

Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients.

Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter.

A companion website at immunologyclinic provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology

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Encyclopedia of Immunology Research

 Immunology  Comments Off on Encyclopedia of Immunology Research
Jun 172019
 

This book presents current research in the study of immulogy. Topics discussed include TLR agonists as immune adjuvants; modulating immune response with CpG-Oligodeoxynucleotide through the skin; evolution of immusuppression in liver transplantation; the role of pharmacogemics in tailoring immusuppressive therapy for liver transplant recipients; sunlight induced immusuppression; antibiotic resistance and probiotics; and, antibiotic resistance in food lactic

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Autophagy, Infection, and the Immune Response

 Immunology  Comments Off on Autophagy, Infection, and the Immune Response
Jun 152019
 


Autophagy, Infection, and the Immune Response provides a unified overview of the roles of cellular autophagy during microbial infection.

Introductory chapters ground the reader by laying out the autophagic pathway from a cellular perspective, and listing assays available for measuring autophagy. Subsequent chapters address virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma.

Designed as a resource for those interested in initiating studies on the relationship between autophagy and infection or immunity, the book combines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.

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Vaccine Nation: America’s Changing Relationship with Immunization

 Immunology  Comments Off on Vaccine Nation: America’s Changing Relationship with Immunization
Jun 112019
 


With employers offering free flu shots and pharmacies expanding into one-stop shops to prevent everything from shingles to tetanus, vaccines are ubiquitous in contemporary life. The past fifty years have witnessed an enormous upsurge in vaccines and immunization in the United States: American children now receive more vaccines than any previous generation, and laws requiring their immunization against a litany of diseases are standard.

Yet, while vaccination rates have soared and cases of preventable infections have plummeted, an increasingly vocal cross section of Americans have questioned the safety and necessity of vaccines. In Vaccine Nation, Elena Conis explores this complicated history and its consequences for personal and public health.

Vaccine Nation opens in the 1960s, when government scientists—triumphant following successes combating polio and smallpox—considered how the country might deploy new vaccines against what they called the “milder” diseases, including measles, mumps, and rubella. In the years that followed, Conis reveals, vaccines fundamentally changed how medical professionals, policy administrators, and ordinary Americans came to perceive the diseases they were designed to prevent. She brings this history up to the present with an insightful look at the past decade’s controversy over the implementation of the Gardasil vaccine for HPV, which sparked extensive debate because of its focus on adolescent girls and young women. Through this and other examples, Conis demonstrates how the acceptance of vaccines and vaccination policies has been as contingent on political and social concerns as on scientific findings.

By setting the complex story of American vaccination within the country’s broader history, Vaccine Nation goes beyond the simple story of the triumph of science over disease and provides a new and perceptive account of the role of politics and social forces in medicine.

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Immunological Tolerance: Methods and Protocols

 Immunology  Comments Off on Immunological Tolerance: Methods and Protocols
May 302019
 


This edition provides a detailed, up-to-date overview of methods used in the field of immune tolerance. Chapters guide readers through tolerogenic cell types, isolating tolerogenic cell populations for study and therapeutic utility, multiple methods to study the mechanisms underpinning tolerance, methods to induce tolerance through thymus progenitors, and methods to assess the breakdown of immune tolerance in specific pathological conditions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Immunological Tolerance: Methods and Protocols aims to ensure successful results in the further study of this vital field.

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Immune Checkpoint Blockade: Methods and Protocols

 Immunology  Comments Off on Immune Checkpoint Blockade: Methods and Protocols
May 302019
 

This detailed volume describes a series of techniques that are essential for evaluating the efficacy of new checkpoint blockade therapies as well as understanding the mechanisms behind the therapies that have already been approved. Beginning with a section on describing the tumor microenvironment and evaluating the immune system at a systemic level, the book continues by covering functional assays that provide answers to questions that may be raised after studying the immune system and its responses to immunotherapies, as well as the use of animal models in this research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Immune Checkpoint Blockade: Methods and Protocols serves to aid researchers in furthering our understanding of checkpoint blockage as well as the study of tumor immunology and the development of new immunotherapies.

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Allogeneic Stem Cell Transplantation

 Immunology  Comments Off on Allogeneic Stem Cell Transplantation
May 272019
 

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today’s best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
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Deja Review Microbiology & Immunology, Second Edition

 Immunology, Microbiology  Comments Off on Deja Review Microbiology & Immunology, Second Edition
May 092019
 

MAXIMUM RETENTION–MINIMAL TIME “I wish I had a copy of this book during my microbiology course … excellent for classroom studies during the first two years of medical school.” — Judy Vu, Third Year Medical Student, University of Utah School of Medicine “I really enjoyed ‘pimping’ friends with questions from this book as a review for Step 1.” — Pete Pelletier, Third Year Medical Student, University of Utah School of Medicine “This excellent book covers the material second year medical students need to study for exams. It could easily be used in a small group to review. 3 Stars.”–Doody’s Review Service Deja Review: Microbiology and Immunology boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column “flashcard” Q&A format–specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Great for last minute review of high-yield facts, Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on your course exams and the USMLE Step 1. Active recall questions allow you to understand, not just memorize, the content Clinical vignettes at the end of chapters prepare you for board-style questions Portable size for study on the go–fits in your white coat pocket Bookmark included to guide you through easy-to-use flashcard presentation

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The Blood-Brain Barrier in Health and Disease, Volume One: Morphology, Biology and Immune Function

 Immunology, Neurology/Neurosurgery  Comments Off on The Blood-Brain Barrier in Health and Disease, Volume One: Morphology, Biology and Immune Function
May 042019
 

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium.

In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier.

This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

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