Aflatoxins: Food Sources, Occurrence and Toxicological Effects

 Toxicology  Comments Off on Aflatoxins: Food Sources, Occurrence and Toxicological Effects
Nov 152019
 

Progress in understanding the biology of Aspergillus has greatly improved with the new techniques in genome sequencing and the developed molecular tools that enable rapid genetic analysis of individual genes. Particularly, the genetics of aflatoxin synthesis is regarded as a model to gain insight into fungal secondary metabolism. This compilation discusses topics that include the prevalence of aflatoxin B1 in cereals; contamination exposure, toxicology and control of aflatoxins in food and feed; immunosuppressive actions of aflatoxin; hazards and regulations; toxicological effects, risk assessment and legislation for aflatoxins; and the threat aflatoxins have on the economy and health.
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The Adenosinergic System: A Non-Dopaminergic Target in Parkinson’s Disease

 Neurology/Neurosurgery, Toxicology  Comments Off on The Adenosinergic System: A Non-Dopaminergic Target in Parkinson’s Disease
Nov 072019
 

Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson`s Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson`s Disease, (2) an overview of neuroimaging studies in human death and disease and (3) a study of urate as a possible biomarker and neuroprotectant.
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Toxicologic Pathology for Non-Pathologists

 Pathology, Toxicology  Comments Off on Toxicologic Pathology for Non-Pathologists
Nov 032019
 

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances.

Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

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Clinical Toxinology in Asia Pacific and Africa

 Toxicology  Comments Off on Clinical Toxinology in Asia Pacific and Africa
Oct 242019
 

Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized. The conditions comprise of clinical aspects such as the diagnosis, management, and prevention of snakebite envenoming, scorpion sting, mushroom toxins, plant toxins, and other natural toxins. Clinical toxinology also deals with the ecology, epidemiology, regional differences, and varieties of fauna accounting for different envenoming manifestations.

This handbook includes 30 chapters addressing various topics on clinical toxinology such as the epidemiology and management of snakebites in different Asian and African countries, disability following snakebite, effect of snake venoms on hemostasis, socioeconomic aspects of snakebites, therapeutic application of snake venom, scorpion sting in the Middle East, jellyfish sting, etc. These titles are written by experts currently working in the subspecialty, many of whom have first-hand experience in the relevant research fields. In virtually all the topics, appropriate illustrations are provided to simplify comprehension including tables, figures and pictures.

This reference work on Clinical Toxinology in Asia Pacific and Africa, in the Toxinology handbook series, is designed to keep readers abreast with new knowledge and experience in toxinology regionally and globally. Toxinologists, researchers, scientists, and experts in this field from various working areas considered it necessary to collect all the aspects of clinical toxinology in a single, handy handbook. This can be used by medical students, postgraduate students, general practitioners, specialists in internal medicine, critical care physicians, emergency physicians, and anesthetists worldwide.

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Botulinum Toxin Treatment of Pain Disorders

 Toxicology  Comments Off on Botulinum Toxin Treatment of Pain Disorders
Oct 242019
 

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and patient interviews.
Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories.

Botulinum Toxin Treatment of Pain Disorders will prove an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

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Modern Poisons: A Brief Introduction to Comtemporary Toxicology

 Toxicology  Comments Off on Modern Poisons: A Brief Introduction to Comtemporary Toxicology
Jul 272018
 

Traditional toxicology textbooks tend to be doorstops: tomes filled with important but seemingly abstract chemistry and biology. Meanwhile, magazine and journal articles introduce students to timely topics such as EPA and endocrine disruption or the carcinogenic effects of pesticides, but don’t provide the fundamentals needed to understand the science of toxicity. Written by a professor of toxicology, Modern Poisons bridges this gap.
This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts of the field such as the dose-response relationship and the concept, first introduced by Ambroise Pare in the sixteenth century, that a chemical’s particular action depends on its inherent chemical nature. The author goes on to show exactly how chemicals enter the body and elicit their toxic effect, as well as the body’s methods of defence.

With the fundamentals established, Kolok digs into advances in toxicology, tracing the field’s development from World War II to the present clay. The book examines both technical discoveries and their impacts on public policy. Highlights include studies of endocrine-disrupting chemicals in toiletries and prescriptions, the emerging science on prions, and our growing understanding of epigenetics.

Readers learn not only how toxic exposure affects people and wildlife, but about the long-term social and environmental consequences of our chemicals. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of, and curiosity about, this fast-changing field.

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Toxicology of Herbal Products

 Toxicology  Comments Off on Toxicology of Herbal Products
Mar 282017
 

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Medical Toxicology: Antidotes and Anecdotes

 Toxicology  Comments Off on Medical Toxicology: Antidotes and Anecdotes
Mar 262017
 

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Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition

 Toxicology  Comments Off on Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition
Mar 242017
 

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Developmental and Reproductive Toxicology: A Practical Approach (3rd Edition)

 Reproductive Health, Toxicology  Comments Off on Developmental and Reproductive Toxicology: A Practical Approach (3rd Edition)
Jan 302017
 

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