Aug 162016
 

Inflammasome Signaling and Bacterial Infections (Current Topics in Microbiology and Immunology)


This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

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Aug 132016
 

Non-coding RNAs and Inter-kingdom Communication


This book presents a state-of-the-art compilation of articles on the role of non-coding RNAs as pivotal molecules for establishing functional relationships between different organisms. It also describes how non-coding RNA molecules can act as dynamic communication devices and how they modulate the interaction between different kingdoms. It describes examples including viruses, bacteria, fungi, and higher organisms such as protozoa that are involved in pathogenic or symbiotic interactions, and the roles of different families of non-coding RNAs within these relationships. Each chapter provides readers molecular and functional insights, breaking down the subjacent mechanisms and exploring their functional implications and future applications. More than sixty years after the foundation of the “RNA tie club” by George Gamow, new roles for non-coding RNA molecules are starting to be revealed.
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Aug 122016
 

Cases in Clinical Infectious Disease Practice


By (author): Okechukwu Ekenna

In the era of cost cutting and lack of adequate health insurance for many patients, clinical skills and time spent with patients are not adequately compensated. Yet, these dwindling and underpaid skills – good history taking, observation of and listening to patients, and physical examination of patients – remain very essential to making and reaching a complete and accurate diagnosis. Expensive laboratory and imaging diagnostics while very relevant, should not replace these age-old skills that have served to enhance and maintain the doctor-patient relationship and human connection, a connection that is often necessary for healing.

Cases in Clinical Infectious Disease Practice uses case studies to illustrate how the infectious disease clinician processes and integrates data to arrive at a diagnosis. This type of hands-on approach, invaluable in training programs, is utilized to take the reader through initial patient encounter, through the history and physical examination, to simple laboratory findings and stains, to a final diagnosis, in a way that is easily accessible to clinicians, students, and laboratory personnel working with clinical specimens.

  • Appeals to practitioners of all levels, with focus on patients with common problems or complications of common infections without heavy technical language
  • Emphasizes basic clinical skills including history taking, observation, epidemiology, and physical exam, as well as simple laboratory tests, explaining how they lead to a reasonable diagnosis
  • Presents cases seen first-hand within the community setting, reflective of cases or situations a resident or student is likely to encounter in the real world after training

Cases in Clinical Infectious Disease Practice is an essential resource for clinicians, graduate and medical school students, and others conducting medical and clinical microbiology or infectious disease research on real patients.

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Aug 112016
 

Immunology and Immunopathogenesis of Malaria (Current Topics in Microbiology and Immunology)


Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines.

This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.

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Aug 042016
 

Antimocrobial Photodynamic Inactivation and Antitumor Photodynamic Therapy with Fullerenes (Iop Concise Physics)


By (author): Lucas F De Freitas, Michael R Hamblin

This book provides detailed and current information on using fullerenes (bucky-balls) in photodynamic therapy (PDT), one of the most actively studied applications of photonic science in healthcare. This will serve as a useful source for researchers working in photomedicine and nanomedicine, especially those who are investigating PDT for cancer treatment and infectious disease treatment. The book runs the gamut from an introduction to the history and chemistry of fullerenes and some basic photochemistry, to the application of fullerenes as photosensitizers for cancer and antimicrobial inactivation.
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Jul 282016
 

Quasispecies: From Theory to Experimental Systems (Current Topics in Microbiology and Immunology)


This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. 

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Jul 282016
 

Long Non-coding RNAs in Human Disease (Current Topics in Microbiology and Immunology)


This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

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Jul 172016
 

The Human Superorganism: How the Microbiome Is Revolutionizing the Pursuit of a Healthy Life


By (author): Rodney Dietert PhD

“Eyeopening… Fascinating… may presage a paradigm shift in medicine.” 
Kirkus Reviews (starred review)
“Teeming with information and big ideas… Outstanding.”
Booklist (starred review)

The origin of asthma, autism, Alzheimer’s, allergies, cancer, heart disease, obesity, and even some kinds of depression is now clear. Award-winning researcher on the microbiome, professor Rodney Dietert presents a new paradigm in human biology that has emerged in the midst of the ongoing global epidemic of noncommunicable diseases.

     The Human Superorganism makes a sweeping, paradigm-shifting argument. It demolishes two fundamental beliefs that have blinkered all medical thinking until very recently: 1) Humans are better off as pure organisms free of foreign microbes; and 2) the human genome is the key to future medical advances. The microorganisms that we have sought to eliminate have been there for centuries supporting our ancestors. They comprise as much as 90 percent of the cells in and on our bodies—a staggering percentage! More than a thousand species of them live inside us, on our skin, and on our very eyelashes. Yet we have now significantly reduced their power and in doing so have sparked an epidemic of noncommunicable diseases—which now account for 63 percent of all human deaths. 

     Ultimately, this book is not just about microbes; it is about a different way to view humans. The story that Dietert tells of where the new biology comes from, how it works, and the ways in which it affects your life is fascinating, authoritative, and revolutionary. Dietert identifies foods that best serve you, the superorganism; not new fad foods but ancient foods that have made sense for millennia. He explains protective measures against unsafe chemicals and drugs. He offers an empowering self-care guide and the blueprint for a revolution in public health. We are not what we have been taught. Each of us is a superorganism. The best path to a healthy life is through recognizing that profound truth.

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Release date July 12, 2016.

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Jul 132016
 

Advances in Microbiology, Infectious Diseases and Public Health: Volume 2 (Advances in Experimental Medicine and Biology)


This Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology.

The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields.

Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.

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Jun 252016
 

Burton’s Microbiology for the Health Sciences, North American Edition


By (author): Paul Engelkirk PhD MT(ASCP)

Prepare your students for success in their future careers with Burton’s Microbiology for the Health Sciences, 10e. Featuring a clear and friendly writing style that emphasizes the relevance of microbiology to a career in the health professions, the Tenth Edition offers a dramatically updated art program, new case studies that provide a real-life context for the content, the latest information on bacterial pathogens, an unsurpassed array of online teaching and learning resources, and much more.
 
To ensure content mastery, this market-leading book for the one-semester course clarifies concepts, defines key terms, and is packed with in-text learning tools that make the content inviting and easy to understand. The Tenth Edition provides a wide range of online teaching and learning resources to save you time and help your students succeed.
 
Instructor Resources:
  • An Image Bank featuring all figures and tables from the book enhances lecture and exam preparation.
  • A robust Test Generator, loaded with pre-made, text-specific questions, saves time and makes creating and printing tests easy.
  • Lesson Plans make teaching from the text easier.
  • PowerPoint Slides speed lecture preparation.
  • An Instructor’s Guide provides additional resources for every chapter.
 
Student Resources:
  • A chapter-by-chapter Study Guide helps students master key concepts.
  • Additional Self-Assessment Exercises for each chapter help students build confidence and gauge their progress
  • Lists of Key Terms in each chapter help students master the vocabulary of the field.
  • Special “Insight,” “Increase Your Knowledge,” and “Critical thinking” sections provide additional insight, as well as fun facts on selected topics from the text.
  • Student Quiz Bank– over 500 questions—give students unlimited opportunities for practice and review.
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