Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease

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Jan 132019
 

This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson’s disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
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The Neurobiology of Criminal Behavior

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Jan 132019
 

Criminological theory dating back one hundred years has been aware of the need to develop a neurobiology of extroversion, impulsivity, frontal-lobe dysfunction, and aggressive behavior, yet in the twentieth century criminologists have largely forsaken this psychobiological legacy.The Neurobiology of Criminal Behavior looks at this legacy with reference to a variety of neurobiological methodologies currently in vogue. The authors are all distinguished researchers who have contributed considerably to their respective fields of psychiatry, psychology, psychobiology, and neuroscience.
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The Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease

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Jan 132019
 

Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.
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Practitioner’s Guide to Symptom Base Rates in Clinical Neuropsychology

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Jan 132019
 

This volume is intended to serve as an aid in the process of differential diagnosis which frequently confronts neuropsychologists. The guide is a compendium of information of the base rates of symptoms across a variety of disorders which neuropsychologists encounter. In addition to serving as a convenient source of information on symptom base rates, this volume also contains detailed cross referencing of symptoms across disorders.This book is intended for use by clinical neuropsychologists and psychologists.
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Dyslexia: Different Brain, Different Behavior

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Jan 122019
 

Dyslexia: Different Brain, Different Behavior is intended for anyone with an interest in how processing deficits of the developing human brain may contribute to failures in reading and spelling. Readers will learn about how different brain activity measures may help to understand the complexity of language specific and domain general functions underlying reading, how atypical brain structures may be responsible for failures in the reading performance, and how the brain activity pattern of dyslexics may change from childhood to adulthood. Dyslexia: Different Brain, Different Behavior is a valuable resource for researchers, graduate students, educators and other professionals in the fields of psycholinguistics, speech pathology, neuropsychology, cognitive development, educational psychology, school psychology, developmental psychology, child development and language acquisition.
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Neurosurgical Management of Pain

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Jan 122019
 

Neurosurgical Management of Pain presents the full range of procedures for the management of chronic, intractable pain. Criteria for patient selection, the details of operative techniques, risks, complications, and expected outcomes are offered for a wide variety of anatomic, ablative, and augmentative neurosurgical procedures for the treatment of pain. Chapters on the latest neuroaugmentative advances utilizing electrical stimulation and implantable drug infusion systems are included as well as a useful section providing algorithms and guidelines for evaluation and treatment of specific pain syndromes. Over 100 exquisite line drawings and photographs augment the text. For both the trainee and experienced neurosurgeon, this volume is invaluable for acquiring the critical judgement and clinical skills necessary to apply these procedures.
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Introduction to Neural and Cognitive Modeling, Third Edition

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Jan 082019
 

This textbook provides a general introduction to the field of neural networks. Thoroughly revised and updated from the previous editions of 1991 and 2000, the current edition concentrates on networks for modeling brain processes involved in cognitive and behavioral functions. Part one explores the philosophy of modeling and the field’s history starting from the mid-1940s, and then discusses past models of associative learning and of short-term memory that provide building blocks for more complex recent models. Part two of the book reviews recent experimental findings in cognitive neuroscience and discusses models of conditioning, categorization, category learning, vision, visual attention, sequence learning, behavioral control, decision making, reasoning, and creativity. The book presents these models both as abstract ideas and through examples and concrete data for specific brain regions.

The book includes two appendices to help ground the reader: one reviewing the mathematics used in network modeling, and a second reviewing basic neuroscience at both the neuron and brain region level. The book also includes equations, practice exercises, and thought experiments

Review
‘Newly updated with advances in cognitive neuroscience and modeling, this introductory textbook provides a remarkable overview of the whole field of neural and cognitive modeling, from its inception nearly a century ago to the most recent advances. The beginner can easily gain an overview of the principles of modeling, while the advanced student will find ample mathematical detail and practical simulation exercises. This new edition will be my go-to text for advanced undergraduates and graduate students looking for an introduction to the subject.’ Professor Joshua W. Brown, Indiana University, USA

‘Levine’s book achieves an impressive synthesis of historical trends and current research results in both biological and artificial neural network research. This synthesis clarifies that the currently popular Deep Learning is just one contribution to this burgeoning field, and one that does not incorporate many of the most powerful properties of biological learning. Levine’s book provides an accessible introduction to many of these properties, while also reviewing important properties of neural models of vision and visual attention, sequence learning and performance, executive function, and decision-making, among its other expository accomplishments.’ Stephen Grossberg, Boston University, USA

About the Author
Daniel S. Levine is Professor of Psychology at the University of Texas at Arlington. He is a Fellow and former President of the International Neural Network Society. His research involves computational modeling of brain processes in decision making and cognitive-emotional interactions

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Neuropsychodynamic Psychiatry

 Neurology/Neurosurgery, Psychiatry  Comments Off on Neuropsychodynamic Psychiatry
Jan 062019
 

This book presents a comprehensive neuropsychodynamic strategy for treating psychiatric disorders. Rather than pursuing an exclusively biological, psychological, or psychodynamic approach, it offers a methodology that links all three aspects in a unifying, integrative model. Central to this approach is the view of the brain as a bio-psychosocial organ in a neuro-ecological model, rather than the purely neuronal model often presupposed in current neuroscience and psychiatry.
Moreover, the book views psychopathological symptoms as spatiotemporal disorders of the altered spatiotemporal structure spanning the brain and its surrounding world. The relation between one of the core symptoms and altered neuronal activity calls for the development of integrated, circular neuropsychodynamic models of psychopathological symptoms in severe psychiatric disorders and their treatment.

 

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Neurobiology of Decision-Making

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Jan 032019
 

Until now decision-making has been studied in the fields of psychology, artificial intelligence, and economics – to name just a few – while neuroscientific research has paid only little attention to it. But now the importance of decision-making has become indisputable, especially in the context of reasoning processes that culminate in the personal and social decisions that define rationality. This book contains articles by leading researchers in experimental neuroanatomy, neurophysiology, neuropsychology, neurochemistry, neurocomputation, experimental psychology, and philosophy, discussing the contributions made by these disciplines to the emerging field of neurobiology of decision-making.
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Serotoninergic Neurons and 5-HT Receptors in the CNS

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Jan 022019
 

This volume provides an up-to-date and comprehensive overview of the anatomy, physiology, and basic and applied pharmacology of CNS serotonin neurons and serotonin receptor subtypes required for understanding the role(s) of serotonin in brain function and in behavior. The book comprises 28 chapters on various aspects of CNS serotonin neurons, such as their development, plasticity and transduction mechanisms, their structural and functional components involved in synaptic transmission, their physiological properties, their role in behavior, their putative involvement in neuropsychiatric diseases, and their role as targets of drugs used in the treatment of CNS disorders.
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