Heart Failure: Pharmacologic Management

 Cardiovascular, Pharmacology  Comments Off on Heart Failure: Pharmacologic Management
Jun 302020
 

Now there is an up-to-date guide for optimizing pharmacologic therapy in treating patients with heart failure. Reflecting current practice at leading medical centers, Heart Failure: Pharmacologic Management provides both the biologic and pathologic underpinnings of each pharmacologic agent in current use. It also supplies detailed discussions of the clinical investigations that support current understanding of the risks and benefits associated with the use of these drugs. Thorough references make the book useful to the novice as well as the experienced clinician.Initial chapters focus on agents that are considered standard care:diuretics ACE inhibitors angiotensin receptor antagonists aldosterone antagonists beta-blockersThe discussion moves to agents currently under investigation:Vasopressin antagonists erythropoietinNext, the authors consider some controversial drugs:inotropic agents antiarrhythmic drugs anticoagulantsAn insightful examination of pharmacogenetics considers:how studies of the genetic profile of patients helps determine which patient populations are most likely to respond to a given class of drugs the potential use of pharmacogenetics to tailor a pharmacologic regimen for maximum benefit and minimum riskMultidrug pharmacy for heart failure therapyAn extremely helpful concluding chapter provides a roadmap of drugs with which to approach the patient with heart failure, along with an overview of the skills you need to use it most effectively. This straightforward, step-by-step algorithm will save you countless hours of research and help you make your prescribing decisions with confidence.
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Microbiological Contamination Control in Pharmaceutical Clean Rooms

 Microbiology, Pharmacology  Comments Off on Microbiological Contamination Control in Pharmaceutical Clean Rooms
Jun 252020
 

Contamination control in pharmaceutical clean rooms has developed from a jumble of science and engineering, knowledge of what has worked well or badly in the past, dependent upon the technology available at the time the clean room was built and subsequent technological developments. Surrounding it all is a blanket of regulations. Taking a multidisciplinary approach, Microbiological Contamination Control for Pharmaceutical Clean Rooms neatly clarifies some of the perceived problems surrounding contamination control in pharmaceutical industry clean rooms.

The book helps you satisfy domestic and international regulations and prevent your organization from suffering the consequences of non-compliance. It includes up-to-date information on microbiological contamination in sterile manufacturing, microbiological media fills, microbiological environmental monitoring, control in aqueous-based, non-sterile pharmaceuticals, rapid testing methods, and clean room contamination control. This valuable guide brings you up to date on the types of techniques available, the scientific principles that underpin them, and the practicalities and limitations of each.

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Clinical Pharmacology During Pregnancy

 Ob/Gynae, Pharmacology  Comments Off on Clinical Pharmacology During Pregnancy
Jun 202020
 

Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.

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Experiments in Pharmaceutical Chemistry, Second Edition

 Pharmacology  Comments Off on Experiments in Pharmaceutical Chemistry, Second Edition
Jun 152020
 

Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75 experiments, expanding the range of topics to 22 major areas of pharmaceutical chemistry. These include biochemical groups, botanical classes important to pharmacy, and major drug classifications:

Carbohydrates
Lipids
Proteins
Enzymes
Inorganics
Vitamins
Steroids
Plant Acids
Flavonoids
Alkaloids
Tannins
Resins
Glycosides
Gums
Balsams
Volatile Oils
Analgesics
Anesthetics
Sulfa Drugs (Sulfonamides)
Psychotropic Drugs
Antibiotics
Nucleic Acids

Sections contain introductions to basic concepts underlying the fields addressed and a specific bibliography relating to each field. Each experiment provides detailed instructions in a user-friendly format, and can be carried out, in most cases, without the need for expensive instrumentation. This comprehensive laboratory manual offers much-needed instructional material for teaching laboratory classes in pharmaceutical chemistry. The breadth of subject matter covered provides a variety of choices for structuring a laboratory course.

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Polyamine Drug Discovery

 Pharmacology  Comments Off on Polyamine Drug Discovery
Jun 142020
 

Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.

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Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy

 Pathology, Pharmacology, Physiology  Comments Off on Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy
Jun 102020
 

This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.

Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.

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Pharmacy Practice Research Methods Edition 2

 Pharmacology  Comments Off on Pharmacy Practice Research Methods Edition 2
May 202020
 

The first edition of Pharmacy Practice Research Methods provided a contemporary overview of pharmacy practice research, discussing relevant theories, methodologies, models and techniques. It included chapters on a range of quantitative, qualitative, action research and mixed methods as well as management theories underpinning change in pharmacy practice.
This new edition of the book is much broader and more diversified. It includes the quality improvement methods in pharmacy practice research, focusing on the key differences between high and low-income countries with regard to pharmacy practice research, as well as the main challenges faced when conducting such research – areas of significant global interest. In addition, a number of the chapters covering fast-moving fields where new methods have been developed and published have been updated. Featuring seven new topics and presenting future trends, the book also explains in detail methods used in covert and overt observations in pharmacy practice, as well as methods involved in realist research, which are important to countries seeking to produce evidence-based information in this area.

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Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (Human Perspectives in Health)

 Pharmacology  Comments Off on Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (Human Perspectives in Health)
May 152020
 

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
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Katzung & Trevor’s Pharmacology Examination and Board Review,12th Edition

 Pharmacology  Comments Off on Katzung & Trevor’s Pharmacology Examination and Board Review,12th Edition
May 102020
 

SCORE YOUR HIGHEST ON MEDICAL PHARMACOLOGY COURSE AND BOARD EXAMS WITH THE WORLD’S BESTSELLING PHARMACOLOGY REVIEW BOOK!

From the authors of the field’s most trusted textbook, Katzung & Trevor’s Basic & Clinical Pharmacology, this full-color resource delivers a clear, concise review of fundamental concepts, backed by more than 800 questions and answers. The chapter-based approach facilitates use with course notes or larger texts.

EVERYTHING YOU NEED TO EXCEL:

• Concise discussion of the major concepts that underlie basic principles or specific drug groups in every chapter
• Full-color tables and figures (many new to this edition)
• Review questions followed by answers and explanations
• Two comprehensive 100-question practice exams, followed by answer keys and explanations for correct answers
• Diagrams that visually organize drug groups and concepts
• A list of high-yield terms and definitions you must know
• Skill Keeper Questions that prompt you to go back and review previous material to understand the link between topics
• A checklist of tasks you should be able to perform upon completion of the chapter
• Summary Tables that list the important drugs and include key information about their mechanism of action and effects, clinical uses, pharmacokinetics, drug interactions, and toxicities
• An Appendix of test taking strategies for the highest score possible

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Advances in Pharmaceutical Biotechnology: Recent Progress and Future Applications

 Pharmacology  Comments Off on Advances in Pharmaceutical Biotechnology: Recent Progress and Future Applications
May 052020
 

This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, and animals to produce low and high molecular weight compounds useful as therapeutics. Pharmaceutical biotechnology has flourished since the advent of recombinant DNA technology and metabolic engineering, supported by the well-developed bioprocess technology. A large number of monoclonal antibodies and therapeutic proteins have been approved, delivering meaningful contributions to patients’ lives, and the techniques of biotechnology are also a driving force in modern drug discovery. Due to this rapid growth in the importance of biopharmaceuticals and the techniques of biotechnologies to modern medicine and the life sciences, the field of pharmaceutical biotechnology has become an increasingly important component in the education of pharmacists and pharmaceutical scientists. This book will serve as a complete one-stop source on the subject for undergraduate and graduate pharmacists, pharmaceutical science students, and pharmaceutical scientists in industry and academia.

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