Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease

 Immunology  Comments Off on Multichain Immune Recognition Receptor Signaling: From Spatiotemporal Organization to Human Disease
Feb 262020
 

This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.
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West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response

 Immunology, Infectious Diseases, Pathology  Comments Off on West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response
Feb 252020
 

In West Nile Encephalitis Virus Infection, leading scientists and researchers discuss the West Nile virus, a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Its appearance in the Western Hemisphere in 1999, and the corresponding increase in global disease burden over the last decade has been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. While the topics in this book are focused on the West Nile virus, they are broad in scope ranging from understanding vector transmission patterns to the dynamics of structural transitions of proteins on the surface of the virion. The editor and contributors of West Nile Encephalitis Virus Infection offer their expertise in this up-to-date and cutting-edge anthology, which will be of broad use to readers from a variety of backgrounds including clinical infectious disease, epidemiology, virology, immunology, and vector biology.
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Interaction of Nanomaterials with the Immune System

 Immunology  Comments Off on Interaction of Nanomaterials with the Immune System
Feb 172020
 

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma.
Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

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Renal Cell Carcinoma: Molecular Biology, Immunology, and Clinical Management (Current clinical Oncology)

 Immunology  Comments Off on Renal Cell Carcinoma: Molecular Biology, Immunology, and Clinical Management (Current clinical Oncology)
Feb 022020
 

Leading clinicians and researchers critically survey a decade of clinical, biological, and pathological knowledge, and show how it is best applied to the management of both localized and advanced renal cell carcinoma. Their discussions include the latest developments in molecular genetics and immune dysfunction, and fully treat the roles of partial nephrectomy, radical nephrectomy, and laparoscopy. Also discussed are screening for renal cell carcinoma, diagnosis and staging, paraneoplastic syndromes, and prognostic factors in metastatic disease. The physicians further explore novel therapeutic aspects including the use of interferon, Interleukin-2, therapy for metastatic renal cell carcinoma, monoclonal antibody therapies, and antiangiogenic treatments to name a few. Summarizing a decade of scientific and therapeutic innovation, Renal Cell Carcinoma offers all physicians and clinical investigators treating kidney cancer today’s gold-standard compendium of practical knowledge about the nature, diagnosis, and treatment of this difficult disease.
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Hepatitis C Virus Disease: Immunobiology and Clinical Applications

 Immunology  Comments Off on Hepatitis C Virus Disease: Immunobiology and Clinical Applications
Jan 242020
 

Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volume, written by experts in the field, covers the most recent advances in the study of HCV, moving from basic research to clinical applications. The first chapters of this volume analyze the full spectrum of immune responses to HCV. The volume also includes contributions that explain the state of the art in IFN-alpha treatment of HCV patients.
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The Breakthrough: Immunotherapy and the Race to Cure Cancer

 Immunology, Oncology  Comments Off on The Breakthrough: Immunotherapy and the Race to Cure Cancer
Jan 182020
 

For thousands of years, physicians observed cases of “spontaneous remissions” from cancer. These sudden and dramatic cancer cures were chalked up to magic or miracle. In fact it was the immune system, mysteriously unleashed.
Now scientists have learned to recreate that miracle with medicines so new that cancer patients- and even many doctors- don’t realize they exist.
From the New York Times bestselling author of The Good Nurse comes an empowering and accessible story of the discoveries of the tricks cancer uses to avoid the immune system, and the important new cancer immunotherapies already unleashing the immune system to fight – and beat – the disease.
Four years in the writing, THE BREAKTHROUGH is an “exciting read” about the discoveries which received the 2018 Nobel Prize winning discoveries in October, and a dramatic and exciting turning point in our relationship with a disease that has for too long defined us.
For decades, scientists have puzzled over one of medicine’s most confounding mysteries: Why doesn’t our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses-tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer’s “penicillin moment,” a revolutionary discovery in our understanding of cancer and how to beat it.
In THE BREAKTHROUGH, Graeber guides us through the surprisingly recent scientific discoveries that change the way we will treat- and maybe even beat- cancer in the years to come.
Amazingly, many patients, and even many doctors, are not fully aware of what many are calling our “penicillin moment” with cancer. With literally thousands of new therapies that harness the power of the immune system to recognize and fight cancer in clinical trials, it’s never been more important for patients to understand their choices, and empowered to ask better questions. In the new war against cancer, information is now a crucial weapon.
Groundbreaking, riveting, and expertly told, THE BREAKTHROUGH is a scientific mystery story about the quest to unleash our natural ability to recognize and defeat cancer, told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.

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Allergy and Immunotoxicology in Occupational Health

 Immunology, Toxicology  Comments Off on Allergy and Immunotoxicology in Occupational Health
Jan 172020
 

This book offers a collection of the latest clinical and research findings related to allergies, one of the most frequently treated conditions in occupational medicine. The chapters not only cover asthma but also elaborate on contact dermatitis, rhinitis, and other allergic conditions, providing readers with a comprehensive overview of the substances disrupting autoimmunity and their effects on the human body. Allergy and Immunotoxicology in Occupational Health is a valuable resource for professionals and researchers in the occupational health sector, who will discover novel insights into immune effects, providing a foundation for future considerations of the health impairments caused by environmental and occupational exposure to these substances.

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https://nitroflare.com/view/457951B82693F59/Allergy_and_Immunotoxicology_in_Occupational_Health.pdf

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Nijkamp and Parnham’s Principles of Immunopharmacology

 Immunology, Pharmacology  Comments Off on Nijkamp and Parnham’s Principles of Immunopharmacology
Jan 082020
 

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.
The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.

Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.

The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

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HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

 Immunology  Comments Off on HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research
Dec 182019
 

This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.

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Mucosal Immunology and Virology

 Immunology  Comments Off on Mucosal Immunology and Virology
Dec 162019
 

An understanding of virus infection and the underlying role of the immune system in protection against these diseases is vital in today’s medical climate. Previously, only symptoms could be treated, as there were no antiviral therapies. The increasing amounts of research and the huge number of discoveries of immunologic agents and pathways has led to the opportunity to look to the basic physiology of the various disease process as never before. This book is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process.
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