PARP as a Therapeutic Target (Handbooks in Pharmacology and Toxicology)

 Pharmacology, Toxicology  Comments Off on PARP as a Therapeutic Target (Handbooks in Pharmacology and Toxicology)
Feb 262020

Recent research in cell death mechanisms has rekindled interest in PARP’s (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors’ dual actions of preventing cell death and abating inflammation have demonstrated remarkable acute effects in animal models of various diseases. PARP as a Therapeutic Target covers the clinical aspects of this up-and-coming drug that counteracts the damage done by free radicals. Leading international experts currently working on ways to apply it share their views of recent developments and future directions of PARP research. They discuss its therapeutic potential in various disease conditions, such as ischemia, diabetes, cancer, arthritis, inflammatory bowel disease, and septic shock.The intensified PARP drug development effort has raised expectations for possible clinical trials in the near future to establish the tolerance of PARP inhibitors in healthy humans, its efficacy in treating patients with different diseases, and the long term effect of PARP inhibition. PARP as a Therapeutic Target provides a comprehensive understanding of how PARP works to aid in the better design of its inhibitors for therapeutic purposes.
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Pharmaceutical Process Scale-Up

 Pharmacology  Comments Off on Pharmaceutical Process Scale-Up
Feb 262020

Keeping pace with the increased influence of PAT in the pharmaceutical industry, this completely updated reference spans the latest research and regulations, technologies, and expert solutions for every significant aspect of pharmaceutical process scale-up-clearly introducing readers to the theoretical concept of dimensional analysis to quantify similar processes on varying scales.
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BRS Pharmacology (Board Review Series) 7th Edition

 Pharmacology  Comments Off on BRS Pharmacology (Board Review Series) 7th Edition
Feb 192020

The popular BRS series format presents concise coverage of the general principles of drug mechanisms and detailed descriptions of how drugs act on major body systems, delivering vital information in a succinct, streamlined approach favored by today’s students. This trusted review also familiarizes students with the pharmacologic principles of toxicology and details essential information on drugs used to treat anemia, disorders of hemostasis, infectious diseases, and cancer.
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Drug Resistance in Cancer Cells

 Oncology, Pharmacology  Comments Off on Drug Resistance in Cancer Cells
Feb 162020

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosis and treatment of individuals would die of cancer (Jemal et al. 2008). Since the vast majority of patients dying of cancer will have had anticancer therapy, both conventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of multidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger definition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original definition of multi drug resistance as simply the resistance to multiple agents that occurs in the course of normal cancer progression.This resistance is likely to be mediated by many factors.
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The Clozapine Handbook: Stahl’s Handbooks (Stahl’s Essential Psychopharmacology Handbooks)

 Pharmacology, Psychiatry  Comments Off on The Clozapine Handbook: Stahl’s Handbooks (Stahl’s Essential Psychopharmacology Handbooks)
Feb 152020

Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.
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Medical Pharmacology at a Glance

 Pharmacology  Comments Off on Medical Pharmacology at a Glance
Feb 052020

Medical Pharmacology at a Glance is recognised as an excellent starting point for pharmacology study. This international best-seller is the perfect companion for all medical and health students, providing an accessible, visual overview of pharmacology.
This 8th edition has been extensively updated, especially in the areas of anaesthetics, drugs used in AIDs, cardiovascular drugs, drugs used in anxiety, depression and schizophrenia, urological drugs, drug metabolism, as well as practical concerns such as drug indications and side effects.
Ideal for USMLE and pharmacology exam revision, Medical Pharmacology at a Glance features:
• The basic principles of drug action, interaction, absorption and excretion
• Chapters based on diseases or syndrome, for efficient clinical learning
• An emphasis on drug mechanisms
• References to the pathophysiology of disease, to aid understanding of drug choice and action
• Case studies with questions and full explanation of answers



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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
Jan 262020

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.


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Pharmacotherapy of Diabetes: New Developments: Improving Life and Prognosis for Diabetic Patients

 Endocrinology/Metabolism/Diabetes Mellitus, Pharmacology  Comments Off on Pharmacotherapy of Diabetes: New Developments: Improving Life and Prognosis for Diabetic Patients
Jan 242020

Diabetes is a huge and growing healthcare worry, especially in Western countries. The treatment of both types – 1 and 2 – of this disease has changed radically over the past few years. This work provides an overview of all the changes that will come to be implemented in clinical practice. Summarizing all aspects of treatment, this book delineates the large amount of research work that has been completed over the last few years into the relief of complications in diabetes and vascular medicine in general.
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Modern Pharmaceutics, Two Volume Set, Fifth Edition

 Pharmacology  Comments Off on Modern Pharmaceutics, Two Volume Set, Fifth Edition
Jan 232020

This new edition brings you up-to-date on the role of pharmaceutics and its future paradigms in the design of medicines. Contributions from over 30 international thought leaders cover the core disciplines of pharmaceutics and the impact of biotechnology, gene therapy, and cell therapy on current findings. Modern Pharmaceutics helps you stay current with the basic sciences, systems, applications, and advances in drug development—from materials used in formulations and dosage form design and manufacture, to testing in clinical trials.

Improve research and development strategies with brand new content on:
• methods of in vivo imaging of dosage forms
• excipients, tablets, and aerosols—from physical chemistry to dosage form
• solid state drug delivery
• biotechnology-based pharmaceuticals
• modern evaluation techniques for medicinal products
• pharmaceutical nanotechnology
• pharmaceutical physics
• pediatric and geriatric medication
• routes of administration
• paradigms in pharmaceutical research



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Applied Therapeutics – The Clinical Use of Drugs (Koda Kimble and Youngs Applied Therapeutics) North American 11th Edition

 Pharmacology  Comments Off on Applied Therapeutics – The Clinical Use of Drugs (Koda Kimble and Youngs Applied Therapeutics) North American 11th Edition
Jan 222020

Continually revised and updated for over 40 years, Applied Therapeutics: The Clinical Use of Drugs is the gold standard for patient-centered drug therapeutics. With its acclaimed case-based approach, the Eleventh Edition promotes mastery and application of the fundamentals of drug therapeutics. Featuring contributions from more than 200 experienced clinicians, every chapter has been revised and updated to reflect our ever-changing knowledge of drugs and the application of this knowledge to the individualized therapy of patients. As you progress from the General Principles section to chapters on specific diseases, you will benefit from practical problem-solving techniques that help you devise effective evidence-based drug treatment plans.
Given the evolving educational needs of students, this edition has been thoughtfully revised to align with the five Institute of Medicine (IOM) core competencies (patient-centered care, interdisciplinary teams, evidence-based practice, quality improvement, and informatics), as well as current pharmacy educational outcomes and the North American Pharmacist Licensure Examination (NAPLEX) competency statements. These strategies ensure relevance to contemporary pharmacy and preparation for pharmacy practice.
Features to help design safe, effective drug therapy and prepare students for evidence-based practice:

  • Approximately 900 case studies challenge you to integrate and apply therapeutic principles in the context of specific clinical situations, cultivating the critical-thinking skills needed to optimize patient outcomes.
  • Core Principles listed at the beginning of each chapter keep you focused on key content and direct you to specific case studies that enable you to explore critical concepts and gain further understanding of how they apply to evidence-based decision making.
  • New chapters address important recent topics and developments. Drug interactions, pharmacogenomics and personalized medicine, and interprofessional education and practice are included in General Principles; systemic lupus erythematosus in Immunologic Disorders; developmental disorders in Psychiatric Disorders and Substance Abuse; and prostate cancer in Hematology and Oncology. In addition, a chapter has been redesigned to focus on Care of the Critically Ill Adult, which now complements the chapter on Care of the Critically Ill Child.



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