Drug Resistance in Cancer Cells

 Oncology, Pharmacology  Comments Off on Drug Resistance in Cancer Cells
Feb 162020

It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosis and treatment of individuals would die of cancer (Jemal et al. 2008). Since the vast majority of patients dying of cancer will have had anticancer therapy, both conventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of multidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger definition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original definition of multi drug resistance as simply the resistance to multiple agents that occurs in the course of normal cancer progression.This resistance is likely to be mediated by many factors.
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Oncofertility Fertility Preservation for Cancer Survivors

 Oncology  Comments Off on Oncofertility Fertility Preservation for Cancer Survivors
Feb 122020

While cancer survival rates have increased steadily over the last several decades, particularly among younger patients, the more aggressive forms of treatment that have made this possible often compromise a cancer patient’s ability to later have biological children. In the past, pregnancy after cancer was largely unheard of. Today it is increasingly a possibility due to high survivorship rates in general and emerging reproductive technologies that give patients and their families options at the time of diagnosis to ensure a patient’s future fertility (cryopreservation of ovarian tissue).
Oncofertility has emerged as an interdisciplinary field bridging biomedical, social sciences and examines issues regarding an individual’s fertility options, choice and goals in light of cancer diagnosis, treatment and survivorship.

Written by leaders in this evolving field, the volume covers various aspects: medical, ethical and social.


“Fertility is often a major concern for cancer survivors. This text addresses the complex reproductive issues associated with the treatment of malignant diseases. Recognized leaders in the field discuss scientific advances, application of modern technology, psychosocial implications, ethical considerations, and current options for men and women confronted with therapies that affect fertility.”

Steven T. Rosen, M.D.

Series Editor



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Small-molecule Transcription Factor Inhibitors in Oncology

 Oncology  Comments Off on Small-molecule Transcription Factor Inhibitors in Oncology
Feb 042020

by Khondaker Miraz Rahman (Editor, Contributor), David E Thurston (Editor, Contributor)

Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be “reprogrammed”, leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually declining, transcription factor inhibition is the next hot topic for oncology research and merits much attention. This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors. It also presents the evidence that this important protein class can be modulated in a number of ways to develop novel classes of therapeutic agents. The broad range of aspects covered by the book is noteworthy and renders it enormously valuable. This title serves as a unique reference book for postgraduates, academic researchers and practitioners working in the fields of biochemistry, biotechnology, cell and molecular biology and bio-inorganic chemistry



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Networked cancer: affect, narrative and measurement

 Oncology  Comments Off on Networked cancer: affect, narrative and measurement
Feb 042020

This book investigates how individual cancer narratives change in an age of networked social media. Through a range of case studies, it shows that a new type of entrepreneurial cancer narrative is currently evolving. This narrative is characterised by using illness to build projects and produce various forms of economic and social value, to stimulate affectively involved and large-scale public participation and to communicate across various social media platforms. Networked cancer: Affect, Narrative and Measurement offers a theoretical framework for understanding this entrepreneurial cancer narrative through an introduction focusing on the key concepts of illness narrative, social media and affect. The chapters examine the importance of connective mobilization, virality, experimental selfies, dark affects and new commemorative practices for understanding entrepreneurial cancer narratives. This study will be of great interest to scholars of media and cultural studies, as well as those interested in narrative medicine, health communication and affect and participation.
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Radiation Oncology Advances

 Oncology  Comments Off on Radiation Oncology Advances
Jan 312020

This book provides an up-to-date comprehensive overview of the exciting new developments shaping the current and future practice of radiation oncology. Advances in treatment planning and delivery, in biological targeted therapies combined with radiation and in functional and molecular imaging are all covered in a single volume. All of these advances are discussed by leading experts in the field and with a critical evaluation of their clinical relevance throughout.
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Prostate Cancer: Understand the Disease and its Treatment, 4th Edition

 Oncology  Comments Off on Prostate Cancer: Understand the Disease and its Treatment, 4th Edition
Jan 282020

In Canada, one man in seven risks developing prostate cancer. It is the most frequently diagnosed cancer in men and its incidence has increased by 30 percent since 1988. While most commonly diagnosed after age 70, prostate cancer can also occur in men in their forties and fifties.

Like other forms of cancer, this disease affects not only the patient but also his family. At the time of diagnosis, there are many questions that need to be answered. This book provides a simple, concise, practical guide to help patients understand prostate cancer. Now in its third edition, it has, over the years, become an indispensable reference work. It is an outstanding source of information on the prevention and causes of prostate cancer, its early diagnosis and the treatment options available, including their side effects and complications.



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Atlas of PET-CT Imaging in Oncology: A Case-Based Guide to Image Interpretation

 Oncology, Radiology  Comments Off on Atlas of PET-CT Imaging in Oncology: A Case-Based Guide to Image Interpretation
Jan 262020

This atlas is a case-based guide to the interpretation of FDG PET-CT images in clinical scenarios faced by physicians during the routine practice of oncology. The book aims to help the practitioner to overcome diagnostic dilemmas through familiarization with the physiologic distribution of FDG, normal variants and benign findings. The main focus, however, is the imaging of major oncological diseases. Different pathologies are addressed in individual chapters comprising teaching files of cases, each of which corresponds to a common indication for PET-CT imaging, such as metabolic characterization of lesions, staging, restaging and evaluation of response to therapy. Each case is accompanied by an explanation of the patient’s history, interpretation of the PET-CT study, and a teaching point often supported by relevant literature. This book will be of great value to residents and practitioners in nuclear medicine, radiology, oncology, radiation oncology and nuclear medicine technology.



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Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular Applications

 Neurology/Neurosurgery, Oncology  Comments Off on Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular Applications
Jan 232020

by Constantinos G. Hadjipanayis (Author), Walter Stummer (Author)

The definitive textbook on state-of-the-art fluorescence-guided neurosurgery

Advances in fluorescence-guided surgery (FGS) have resulted in a paradigm shift in neurosurgical approaches to neuro-oncological and cerebrovascular pathologies. Edited by two of the foremost authorities on the topic, Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular Applications encompasses the depth and breadth of this groundbreaking, still nascent technology. The book reflects significant contributions made by world renowned neurosurgeons Constantinos Hadjipanayis, Walter Stummer, and esteemed contributors on the growing uses of 5-aminolevulinic acid (5-ALA) and other FGS agents.

The European Medicine Agency approved 5-ALA in 2007, heralding the birth of FGS globally. In 2017, the U.S. Food and Drug Administration approved 5-ALA (Gleolan) as an imaging agent to facilitate realtime detection and visualization of malignant tissue during glioma surgery. In the two decades since Dr. Stummer’s initial description of 5-ALA FGS in a human patient, major strides have been made in its practical applications, leading to improved resection outcomes. As FGS is increasingly incorporated into neurosurgical practice, it holds promise for future innovations. Generously-illustrated and enhanced with online videos, this textbook is the definitive resource on the subject.

Key Features

The improved efficacy of 5-ALA for resecting high- and low-grade gliomas, recurrences, meningiomas, brain metastases, spinal cord tumors, pediatric brain tumors, and other adult tumors
The future of fluorescence, including potentially powerful new fluorophores molecularly targeted specifically to tumors
The use of the fluorescent agent indocyanine green (ICG) for brain tumors, cerebral aneurysms, AVMs, and cerebral vascularization
Special topics such as fluorescein, illuminating tumor paint, confocal microscopy, Raman spectroscopy, and integrating FGS with intraoperative imaging and brain mapping
This single accessible reference presents the current state-of-the-art on this emerging, exciting surgical technology. As such, it is a must-have for neurosurgical residents, fellows, and practicing neurosurgeons.




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epub Link


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Supportive Cancer Care with Chinese Medicine

 Oncology  Comments Off on Supportive Cancer Care with Chinese Medicine
Jan 232020

Cancer is a chronic disease. There are increasing cancer survivors after curative cancer treatment and this makes supportive cancer care an important area that more attention is needed. Chinese medicine has a long history of practice; it has aroused much interest from both Oriental and Western countries. A number of laboratory evidences and clinical trials demonstrated the effectiveness and ef?cacies of Chinese medicine for supportive cancer care. This book attempts to take a comprehensive approach to overview the different areas of Chinese medicine for supportive cancer care.



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Oncologic Critical Care

 Critical Care, Oncology  Comments Off on Oncologic Critical Care
Jan 212020

This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care.





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