AJCC Cancer Staging Atlas: A Companion to the Seventh Editions of the AJCC Cancer Staging Manual and Handbook (2nd edition)

 Oncology  Comments Off on AJCC Cancer Staging Atlas: A Companion to the Seventh Editions of the AJCC Cancer Staging Manual and Handbook (2nd edition)
Feb 012018
 

 

Significantly expanded, expertly and beautifully illustrated, The AJCC Cancer Staging Atlas, 2nd Edition, offers more than 600 illustrations created exclusively for this new edition and is fully updated to reflect the concepts discussed in the 7th Edition of both the AJCC Cancer Staging Manual and its companion Handbook. This Atlas illustrates the TNM classifications of all cancer sites and types included in the 7th Edition of the Manual and visually conceptualizes the TNM classifications and stage groupings. Specifically designed for simplicity and precision, the drawings have been verified through multi-disciplinary review to ensure accuracy and relevancy for clinical use. Every illustration provides detailed anatomic depictions to clarify critical structures and to allow the reader to instantly visualize the progressive extent of malignant disease. In addition, nodal maps are included for each site, appropriate labeling has been incorporated to identify significant anatomic structures, and each illustration is accompanied by an explanatory legend. The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.

 

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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism

 Endocrinology/Metabolism/Diabetes Mellitus, Oncology  Comments Off on Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism
Feb 012018
 

 

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.​
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Lung Cancer

 Oncology  Comments Off on Lung Cancer
Jan 312018
 

Lung cancer is the most common cause of death from cancer worldwide - it is estimated to cause nearly one in five cancer deaths. Most lung cancer patients are diagnosed late and for many of them, there are currently no curative therapy options available, meaning long-term survival is still low. Nevertheless, enormous progress has been made in the field during the last decade. This Monograph provides a comprehensive overview of the current knowledge of and advances in lung cancer, covering areas such as: screening; tobacco control; COPD; diagnosis; therapy; and treatment of early stage lung cancer from both a surgeon’s and radiation oncologist’s perspective. Very recent achievements in innovative fields, such as targeted therapies and immunotherapies, are also discussed.
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Oncoplastic and Reconstructive Breast Surgery

 Oncology, Surgery  Comments Off on Oncoplastic and Reconstructive Breast Surgery
Jan 302018
 

 

Oncoplastic and reconstructive surgery combines the most up-to-date techniques in plastic surgery with surgery for breast cancer, providing optimal oncologic and aesthetic results by means of a single procedure. This book demonstrates why oncoplastic surgery represents such an exciting tool for surgeons who undertake breast surgery. Fundamental principles and basic concepts are clearly outlined, and diverse techniques are presented by acknowledged experts from across the world. The emphasis is very much on a “how to do” approach, with detailed guidance and advice on the various techniques. The informative text is supported by a wealth of color illustrations, and accompanying videos of procedures are available via the publisher’s website. Reconstructive Breast Cancer Surgery will serve as an ideal reference work that will help surgical fellows and specialists to learn about indications and selection of patients, to master technical skills, and to manage complications effectively.
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Inflammation and Cancer

 Oncology  Comments Off on Inflammation and Cancer
Jan 302018
 

 

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
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Techniques and Methodological Approaches in Breast Cancer Research

 Oncology  Comments Off on Techniques and Methodological Approaches in Breast Cancer Research
Jan 302018
 

 

This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
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Living Out Loud: Sports, Cancer, and the Things Worth Fighting For

 Oncology  Comments Off on Living Out Loud: Sports, Cancer, and the Things Worth Fighting For
Jan 302018
 

“Time is something that cannot be bought, it cannot be wagered with God, and it is not in endless supply. Time is simply how you live your life.” —Craig Sager

Thanks to an eccentric wardrobe filled with brightly colored suits and a love of sports that knows no bounds, Craig Sager is one of the most beloved and recognizable broadcasters on television. So when the sports world learned that he was diagnosed with acute myeloid leukemia (AML) there was an outpouring of love and support from everyone who was inspired by his colorful life and his fearless decision to continue doing the job he loved—despite being told that he would have only three-to-six months to live. Sager has undergone three stem cell transplants—with his son as the donor for two of them—and more than twenty chemotherapy cycles since his diagnosis.

In Living Out Loud, Craig Sager shares incredible stories from his remarkable career and chronicles his heroic battle. Whether he’s sprinting across Wrigley Field mid-game as a college student with cops in pursuit, chasing down Hank Aaron on the field for an interview after Aaron broke Babe Ruth’s home run record, running with the bulls in Pamplona, or hunkering down to face the daunting physical challenges of fighting leukemia, Craig Sager is always ready to defy expectations, embrace life, and live it to the fullest.

Including a foreword by Charles Barkley and with unique insight from his son Craig Sager II, this entertaining, honest, and introspective account of a life lived in sports reveals the enduring lessons Sager has learned throughout his career and reminds you that no matter what life throws at you, to always look at the bright side.

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Cancer in the Spine: Comprehensive Care

 Oncology  Comments Off on Cancer in the Spine: Comprehensive Care
Jan 292018
 

 

Distinguished physicians and researchers from prestigious Cancer Centers around the world offer their expertise in current and innovative management of cancer in the spine. These authors bring together the latest thinking from diverse fields of medicine to provide, in one volume, a guide to coordinated management of all aspects of spinal tumors covering chemo- and radiation therapy, pain management, diagnostic radiology, as well as reconstructive surgery and palliative care. Highlights include management of vertebral metastases, innovations in radiotherapy, treatment of pathological fractures, curative strategies for primary malignancies, as well as a guide to pain management and end-of-life care.
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Inflammation, Aging and Cancer: Biological Injustices to Molecular Village of Immunity that Guard Health

 Oncology  Comments Off on Inflammation, Aging and Cancer: Biological Injustices to Molecular Village of Immunity that Guard Health
Jan 282018
 

 

This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis.
The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis.
Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers.
Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival.

The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.

 

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Breast Imaging

 Oncology, Radiology  Comments Off on Breast Imaging
Jan 282018
 

 

Early detection of breast cancer with screening mammography is still the best method we have in saving countless women’s lives and decreasing the harms of overtreatment. This textbook encompasses relevant topics in daily patient care with breast imaging to technical innovations for improving breast cancer detection and treatment.
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