Brain Source Localization Using EEG Signal Analysis

 Neurology/Neurosurgery  Comments Off on Brain Source Localization Using EEG Signal Analysis
Feb 152018
 

 

Of the research areas devoted to biomedical sciences, the study of the brain remains a field that continually attracts interest due to the vast range of people afflicted with debilitating brain disorders and those interested in ameliorating its effects. To discover the roots of maladies and grasp the dynamics of brain functions, researchers and practitioners often turn to a process known as brain source localization, which assists in determining the source of electromagnetic signals from the brain. Aiming to promote both treatments and understanding of brain ailments, ranging from epilepsy and depression to schizophrenia and Parkinson’s disease, the authors of this book provide a comprehensive account of current developments in the use of neuroimaging techniques for brain analysis. Their book addresses a wide array of topics, including EEG forward and inverse problems, the application of classical MNE, LORETA, Bayesian based MSP, and its modified version, M-MSP. Within the ten chapters that comprise this book, clinicians, researchers, and field experts concerned with the state of brain source localization will find a store of information that can assist them in the quest to enhance the quality of life for people living with brain disorders.
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The 2 x 4 Model: A Neuroscience-Based Blueprint for the Modern Integrated Addiction and Mental Health Treatment System

 Neurology/Neurosurgery  Comments Off on The 2 x 4 Model: A Neuroscience-Based Blueprint for the Modern Integrated Addiction and Mental Health Treatment System
Feb 152018
 

 

Over a quarter century of studies have shown that addictions, mental illnesses, and their combinations (dual diagnoses) are pervasive in the general population. Meanwhile, emerging neuroscience is revealing that the neurodevelopmental basis of major mental illness and addiction diseases are tightly interconnected and often unified pathologies of the brain. This science calls into question the profound split between the addiction and mental health fields that define our fragmented research, professional training, and treatment delivery systems―a split that leaves most patients out of reach of adequate professional expertise and evidence-based standards of care. The 2 x 4 Model, as described in this translational textbook of Addiction Psychiatry, is the essential blueprint and operational manual for the fully integrated, expertly staffed, Dual Diagnosis clinic― a clinic that is maximally capable and efficient in treating the full spectrum of addictions, mental illness, and their comorbidities, through integration of psychotherapies and medications, by one team under one roof. Replication of 2 x 4 Model Clinics into a national system would allow widespread access to excellent, transparent standards of Addiction Psychiatry as a decisive measure against mass incarceration and the exploding health care crisis of untreated addictions, all while rebuilding brain health as a core public health, social and economic imperative of modern society.

 

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http://nitroflare.com/view/50F79A3A12B0438/1498773052.pdf

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Hyperkinetic Movement Disorders (Contemporary Neurology Series)

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Feb 142018
 

Hyperkinetic Movement Disorders the latest edition to the Contemporary Neurology Series, will cover the signs, the pathophysiology, the genetics (where applicable), and the treatment options of each form of hyperkinetic movement disorder. There is a presentation of clinically-focused information regarding the full spectrum of neurological and psychiatric conditions characterized by involuntary movements. With Parkinson’s disease as the most common hypokinetic movement disorder, the book expands on other hyperkinetic movement disorders where substantial progress has been made in the understanding of the role of the basal ganglia in the pathophysiology of these hyperkinesia disorders and in motor control, muscle tone, posture, and cognitive processes. Although therapies that target pathogenesis are still lacking, effective management of hyperkinetic movement disorders demands that physicians are knowledgeable about current and novel pharmacological and surgical approaches. Following background information about how to approach hyperkinetic movement disorders and the neural circuitry underlying them, there are individual chapters that cover tremor, dystonia, Huntington’s disease (and other choreas, athetosis, ballism), Tourette’s syndrome (and other tic disorders), habits, mannerisms, compulsions, stereotypies, myoclonus, drug-induced disorders, Wilson’s disease, hyperkinetic movement disorders with a peripheral trigger and those of unclear origin, and psychogenic movement disorders. Chapters include sections on clinical phenomenology, etiology and pathogenesis and therapy. There are also on-line resources for clinicians and patients to refer to as well. The experienced authors have specifically selected scientific and other published information that best helps clinicians understand, diagnose and optimally treat hyperkinetic movement disorders. The authors’ approach is comprehensive yet focused and practical with an emphasis on clinical care

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http://nitroflare.com/view/964407CA1796C48/019992564X_Hyperkinetic.pdf

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Cannabinoids and the Brain by Linda A. Parker

 Neurology/Neurosurgery  Comments Off on Cannabinoids and the Brain by Linda A. Parker
Feb 142018
 

The cannabis plant has been used for recreational and medicinal purposes for more than 4,000 years, but the scientific investigation into its effects has only recently yielded useful results. In this book, Linda Parker offers a review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic uses.

Parker describes the discovery of tetrahydocannbinol (THC), the main psychoactive component of cannabis, and the further discovery of cannabinoid receptors in the brain. She explains that the brain produces chemicals similar to THC, which act on the same receptors as THC, and shows that the endocannabinoid system is involved in all aspects of brain functioning. Parker reports that cannabis contains not only the psychoactive compound THC, but also other compounds of potential therapeutic benefit, and that one of them, cannabidiol (CBD), shows promise for the treatment of pain, anxiety, and epilepsy. Parker reviews the evidence on cannabinoids and anxiety, depression, mood, sleep, schizophrenia, learning and memory, addiction, sex, appetite and obesity, chemotherapy-induced nausea, epilepsy, and such neurodegenerative disorders as multiple sclerosis and Alzheimer’s Disease. Each chapter also links the scientific evidence to historical and anecdotal reports of the medicinal use of cannabis.

As debate about the medical use of marijuana continues, Parker’s balanced and objective review of the fundamental science and potential therapeutic effects of cannabis is especially timely.

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http://nitroflare.com/view/9C5E75DE3EB7E3B/Cannabinoids_and_the_Brain.pdf

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Alzheimer’s Disease and Dementia

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Feb 132018
 

 

Alzheimer’s is swiftly on the rise: it is estimated that every 67 seconds, someone develops the disease. For many, the words “Alzheimer’s disease” or “dementia” immediately denote severe mental loss and, perhaps, madness. Indeed, the vast majority of media coverage of Alzheimer’s disease (AD) and other types of dementia focuses primarily on the losses experienced by people diagnosed and the terrible burden felt by care partners yearning for a “magic bullet” drug cure.

Providing an accessible, question-and-answer-format primer on what touches so many lives, and yet so few of us understand, Alzheimer’s Disease and Dementia: What Everyone Needs to Know® contributes what is urgently missing from public knowledge: unsparing investigation of their causes and manifestations, and focus on the strengths possessed by people diagnosed. Steven R. Sabat mines a large body of research to convey the genetic and biological aspects of Alzheimer’s disease, its clinical history, and, most significantly, to reveal the subjective experience of those with Alzheimer’s or dementia. By clarifying the terms surrounding dementia and Alzheimer’s, which are two distinct conditions, Sabat corrects dangerous misconceptions that plague our understanding of memory dysfunction and many other significant abilities that people with AD and dementia possess even in the moderate to severe stages. People diagnosed with AD retain awareness, thinking ability, and sense of self; crucially, Sabat demonstrates that there are ways to facilitate communication even when the person with AD has great difficulty finding the words he or she wants to use. From years spent exploring and observing the points of view and experiences of people diagnosed, Sabat strives to inform as well as to remind readers of the respect and empathy owed to those diagnosed and living with dementia.

Alzheimer’s Disease and Dementia conveys this type of information and more, which, when applied by family and professional caregivers, will help improve the quality of life of those diagnosed as well as of those who provide support and care.

“Professor Sabat’s international renown as an expert in the field stems from his advocacy of a humane approach to people with different types of dementia, including Alzheimer’s disease. In this new book his views are presented with typical clarity. What he says can only be helpful both to people living with dementia and to their friends, families and professional carers. It’s vintage Sabat: always look to the social environment; what’s going on in the brain is never the end of the story! And he tells the story with remarkable sympathy and expertise.”–Julian C Hughes, RICE Professor of Old Age Psychiatry, University of Bristol

“Steve Sabat’s widely recognized and resonant voice has infused a transformative and compelling humanity into our personal and cultural narratives about people with dementia across the globe. His thought-provoking, compassionate, and instructive content throughout this new book is grounded in his core and profoundly important message–to never give up on the person by giving in to the diagnosis.” - Lisa Snyder, MSW, LCSW , Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego

“It has helped me become more hopeful for a better future for all people with dementia, and I believe this book will help others find ways to live with dementia, as it informs those without dementia how to support us to do that. There is a gross and systemic underestimation of the capacity of people with dementia, even in the later stages of the disease. This book focuses on our capacity, and what we can still do to find meaning and purpose in our lives.”- Kate Swaffer, Chair, CEO, & Co-founder, Dementia Alliance International

Steven R. Sabat, Professor Emeritus of Psychology at Georgetown University, is a three-time recipient of the Edward B. Bunn Award for excellence in teaching and a recipient of the College Dean’s Award and College Academic Council Award for excellence in teaching at Georgetown. His research has focused on the remaining cognitive and social strengths, and the subjective experience of people with Alzheimer’s disease. He is the author of The Experience of Alzheimer’s Disease: Life Through a Tangled Veil (Blackwell Publishers, 2001) and co-editor of Dementia: Mind, Meaning, and the Person (Oxford University Press, 2006

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Advanced MR Neuroimaging: From Theory to Clinical Practice

 Neurology/Neurosurgery, Radiology  Comments Off on Advanced MR Neuroimaging: From Theory to Clinical Practice
Feb 132018
 

 

Over the last decade, some of the greatest achievements in the field of neuroimaging have been related to remarkable advances in magnetic resonance techniques, including diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. Such techniques have provided valuable insights into tissue microstructure, microvasculature, metabolism and brain connectivity.

Previously available mostly in research environments, these techniques are now becoming part of everyday clinical practice in a plethora of clinical MR systems. Nevertheless, despite growing interest and wider acceptance, there remains a lack of a comprehensive body of knowledge on the subject, exploring the intrinsic complexity and physical difficulty of the techniques.

This book focuses on the basic principles and theories of diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. It also explores their clinical applications and places emphasis on the associated artifacts and pitfalls with a comprehensive and didactic approach.

This book aims to bridge the gap between research applications and clinical practice. It will serve as an educational manual for neuroimaging researchers and radiologists, neurologists, neurosurgeons, and physicists with an interest in advanced MR techniques. It will also be a useful reference text for experienced clinical scientists who wish to optimize their multi-parametric imaging approach.

 

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http://nitroflare.com/view/4B2FCF6A28F60A1/1498755232.pdf

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The Enteric Nervous System: 30 Years Later

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Feb 132018
 

Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to become the discipline of ‘Neurogastroenterology’. In 2014, the main Australasian Neuroscience Society meeting was held in Adelaide, Australia, providing the perfect opportunity to recreate a follow-up ENS meeting. As such, the ‘ENS II 2014 meeting’ aimed to identify how far the field of enteric neuroscience had developed, where the future was heading, and what technological advances had been made to address current and future unresolved questions. 30 speakers from around the world were invited to give talks and revisit the original expectations, the advances made since, and the future directions of ENS research. These discussions included three generations of investigators from 7 different countries. This publication represents the majority of proceedings from the ‘The Enteric Nervous System II 2014’ conference, which was held on February 1st - 2nd 2014 at the National Wine Centre of Australia, Adelaide. This meeting was an Official satellite meeting of the 34th Annual Meeting of Australasian Neuroscience Society, which was also held in Adelaide. The 20 contributions contained within this submission are from international researchers in the field of the ENS, who reviewed the advances made since the first meeting in the early 1980s and summarizes the present and future perspectives of neuro-gastroenterology. Some colleagues could not attend but did send greetings and their messages are included in these proceedings.
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Infections of the Central Nervous System, Fourth Edition

 Infectious Diseases, Neurology/Neurosurgery  Comments Off on Infections of the Central Nervous System, Fourth Edition
Feb 132018
 

Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions.

Features:
Every chapter has been extensively revised and updated, nearly half with new author teams
NEW chapter on acute encephalitis
NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease
NEW color design and color images
Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content
Evidence-based references

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http://nitroflare.com/view/3EFE99521F0CCE3/1451173725.pdf

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Creativity: The Human Brain in the Age of Innovation

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Feb 132018
 

What is the nature of human creativity? What are the brain processes behind its mystique? What are the evolutionary roots of creativity? How does culture help shape individual creativity? Creativity: The Human Brain in the Age of Innovation by Elkhonon Goldberg is arguably the first ever book to address these and other questions in a way that is both rigorous and engaging, demystifying human creativity for the general public. The synthesis of neuroscience and the humanities is a unique feature of the book, making it of interest to an unusually broad range of readership. Drawing on a number of cutting-edge discoveries from brain research as well as on his own insights as a neuroscientist and neuropsychologist, Goldberg integrates them with a wide-ranging discussion of history, culture, and evolution to arrive at an original, compelling, and at times provocative understanding of the nature of human creativity. To make his argument, Goldberg discusses the origins of language, the nature of several neurological disorders, animal cognition, virtual reality, and even artificial intelligence. In the process, he takes the reader to different times and places, from antiquity to the future, and from Western Europe to South-East Asia. He makes bold predictions about the future directions of creativity and innovation in society, their multiple biological and cultural roots and expressions, about how they will shape society for generations to come, and even how they will change the ways the human brain develops and ages.

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http://nitroflare.com/view/804234E919DC314/0190466499.epub

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Surgery of the Spine and Spinal Cord: A Neurosurgical Approach

 Neurology/Neurosurgery, Surgery  Comments Off on Surgery of the Spine and Spinal Cord: A Neurosurgical Approach
Feb 122018
 

This book offers essential guidance on selecting the most appropriate surgical management option for a variety of spinal conditions, including idiopathic problems, and degenerative disease. While the first part of the book discusses the neuroanatomy and biomechanics of the spine, pain mechanisms, and imaging techniques, the second guides the reader through the diagnostic process and treatment selection for disorders of the different regions of the spine, based on the principles of evidence-based medicine. I.e., it clearly explains why a particular technique should be selected for a specific patient on the basis of the available evidence, which is carefully reviewed. The book identifies potential complications and highlights technical pearls, describing newer surgical techniques and illustrating them with the help of images and accompanying videos. Though primarily intended for neurosurgeons, the book will also be of interest to orthopaedic surgeons, specialists in physical medicine, and pain specialists. ​

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http://nitroflare.com/view/22AFE670C3F20A5/3319276115_Surgery1bst.pdf

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