Tag Archives: Toxicology

Introduction To Immunotoxicology 1st Edition

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotoxicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro methods, biomarkers of immunotixicity and risk assessment.

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Developmental Immunotoxicology

Despite rapidly increasing interest in developmental immunotoxicology, there is not yet a textbook focused on this hot area of research. Developmental Immunotoxicology fills the void with overviews of immune system development in experimental animal and human models, and discusses the complex issues related to the evolution of developmental immunology and risk assessment.

This text describes different models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as they relate to developmental immunotoxicology.

Using a didactic approach, Developmental Immunotoxicology provides an explanatory overview of this cutting-edge field for toxicologists, immunologists, and developmental biologists. It provides a lucid account of this area of research-proposing answers to some questions and stimulating debate on those questions yet to be addressed by the research community.

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Cosmeceuticals and Active Cosmetics (Cosmetic Science and Technology Series) 3rd Edition

Cosmeceuticals and Active Cosmetics discusses the science of nearly two dozen cosmeceuticals used today. This third edition provides ample evidence on specific cosmeceutical substances, their classes of use, skin conditions for which they are used, and points of interest arising from other considerations, such as toxicology and manufacturing. The book discusses both cosmetic and therapeutic uses of cosmeceuticals for various conditions including rosacea, dry skin, alopecia, eczema, seborrheic dermatitis, purpura, and vitiligo.

 

Active ingredients in the following products are discussed: caffeine, curcumin, green tea, Rhodiola rosea, milk thistle, and more. Also covered are topical peptides and proteins, amino acids and derivatives, antioxidants, vitamins E and C, niacinamide, botanical extracts, and biomarine actives. Providing ample scientific references, this book is an excellent guide to understanding the science behind the use of cosmeceuticals to treat a variety of dermatological conditions.

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Toxicology of Chemical Respiratory Hypersensitivity

Review of respiratory allergy and asthma caused by exposure to chemicals and proteins in the workplace. Includes an overview of respiratory allergy, clinical aspects of respiratory sensitization, and risk management. For students and researchers. 7 contributors, 2 U.S.
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Alternative Toxicological Methods 1st Edition

Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientists present what has been accomplished thus far in developing acceptable alternatives to traditional animal toxicological assessment and provide potentially new initiatives.

In over 40 chapters, the book addresses 7 themes, beginning with the validation and regulatory acceptance of alternatives in the US, the UK, and Western Europe. Then the book covers methods based on the mechanisms of eye irritation at the ocular surface, dermal toxicity testing, and assessing neurotoxicity. It also includes a case study in the use of alternatives to determine the mechanism of sulfur mustard action and discusses the role of transgenics and toxicokinetics in the development of alternative toxicity tests. Finally the book presents recent innovations in alternatives, including the use of archival data, and in silico techniques.

Focusing on the science and not the politics, Alternative Toxicological Methods concisely discusses the application of state-of-the-art methods and explores cutting-edge research related to developing and validating alternatives to animal testing. This book will benefit toxicologists, cosmetic chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officers in their quest for applying the 3Rs to the use of animals in toxicological testing of drug candidates, chemicals, and cosmetics.

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Forensic Toxicology: Mechanisms and Pathology

Designed for upper-level undergraduate and graduate-level courses, Forensic Toxicology: Mechanisms and Pathology introduces toxicology concepts from a forensic perspective. The book provides an understanding of the mechanistic basis of the action of drugs and toxins, addressing their physiologic and pathologic consequences on the affected organ system. It is this essential connection of toxicology to physiology and biological systems that provides the basis for the toxicologist to understand the basis of behavioral effects of drugs, and for the forensic pathologist to determine cause of death when drugs may be involved.
The book gives an overview of organ system physiology and pathology, and the ways in which toxins and drugs affect those systems. Case histories, photographs of gross pathology, and photomicrographs further illustrate the processes and effects of toxic substances on the body. The book also focuses on technological advances in the field and includes cases that demonstrate real-world consequences of the effects of toxins upon organ systems, such as impairment in a DUI case or the fatal induction of cardiac arrhythmia.
A comprehensive introduction to pathology and toxicologic concepts, Forensic Toxicology: Mechanisms and Pathology describes the means for identifying types of toxins as well as the key patterns and impacts of drug and toxin processes within the body.

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Brainstorming Questions in Toxicology

Brainstorming Questions in Toxicology is designed to serve as a comprehensive, quick reference supplement for various examinations that include sections on toxicology. It reflects the breadth and multidisciplinary nature of toxicology with an objective approach to the subject. With 3500 short questions and answers, multiple choice questions, true/false or correct/incorrect statements, fill in the blanks, and matching the statements, this book is a helpful tool for students, teachers and toxicologists preparing for licensure and certification exams. It is also a resource or refresher for toxicologists working in pharmacy, medical, clinical and forensic toxicology, veterinary, and other related fields such as environment and eco-toxicology.

Key Features:

Serves as a refresher for academicians and professionals in the field of toxicology
Provides an essential guide for the student who needs a study aid for toxicology and the teacher of toxicology who needs inspiration when composing questions for their students
Supplements in-house training courses in toxicology that exist in some pharmaceutical and chemical industries

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Environmental Toxicology: Current Developments (Environmental Topics Series, Volume 7)

Because our chemical environment affects our physical and mental well-being, it is a matter of increasing concern and is therefore attracting much research effort. This timely collection of essays highlights current developments in the field of environmental toxicology. Chapters analyze the carcinogenic, mutagenic, genotoxic, and neurotoxic effects of both anthropogenic and natural toxins in the soil, air, and water around us, as well as in our workplace and diet. The book also examines the effects of toxins on other organisms, as well as the techniques, policies, and management strategies employed in studying and controlling environmental pollutants. It will be an essential reference to a variety of personnel in environmental studies and public health.

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Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight.
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health.
This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

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Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.
These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

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