Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques.
This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results.
Written by a prominent team of experienced practitioners, this volume:
Focuses on analytical, statistical, and pharmacokinetic principles
Describes basic methodology, including colour tests and immunoassay and enzyme-based assays
Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation
Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides
Includes discussion of ‘designer drugs’ (novel pharmaceutical substances NPS)
Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.
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A vast number of substances potentially toxic to animals exist, including pesticides, household cleaning products, agricultural chemicals, automotive products, human prescription and non-prescription drugs, herbal remedies, and poisonous plants and animals. With such huge numbers of potential toxins, it is impossible foe veterinarians to be knowledgeable about all of them. But because some poisonings can cause illness or even death within only minutes to hours after exposure, immediate access to reliable information on diagnosis and treatment is essential. Often intoxications involve new drugs or chemical products for which very little or no published veterinary toxicity data is available.
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This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.
Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.
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A Doody’s Core Title for 2019!
Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere.
Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:
•General Principles of Toxicology
•Disposition of Toxicants
•Non-Organ Directed Toxicity
•Target Organ Toxicity
•Applications of Toxicology
Many new contributors capture the progress made in toxicology over the past few years:
This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book.
Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals.
A true “essential”
If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology – written by experts, and presented in full color, your search ends here.
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A fully updated and expanded edition of the bestselling guide on toxicology and its practical application
• Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards
• New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology
• Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
• Includes case histories and examples from industry demonstrate the application of toxicological principles
• Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms
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