Medicinal Chemistry with Pharmaceutical Product Development

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Nov 112020

This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.
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Advances in Neuropharmacology: Drugs and Therapeutics

 Neurology/Neurosurgery, Pharmacology  Comments Off on Advances in Neuropharmacology: Drugs and Therapeutics
Nov 102020

Here is a comprehensive overview of the drugs that act on the central and peripheral nervous systems. This volume thoroughly describes the diseases associated with the nervous system and the drugs used for their treatment while also looking at the current status of these drugs and their future potential and challenges.

Divided into three sections, the book first focuses on the drugs that affect the functions of the autonomic nervous system to produce therapeutic effects. These drugs may act presynaptically by manipulating the genesis, storage, and secretion, and by blocking the action of neurotransmitters. Some drugs may trigger or impede postsynaptic receptors. Section 2 focuses on drugs that affect the central nervous system, including antianxiety drugs, sedative and hypnotic drugs, antidepressant drugs, antipsychotic drugs, antiepileptic drugs, and many more. It covers the pharmacological management of various diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and others. The last section offers explanations of neurochemical interactions with the aim to develop drugs that have beneficial effects on neurochemical imbalances. This section demonstrates models to assess the transport of drugs across the blood-brain barrier and nanomedicine to treat brain disorders.

This rich compilation provides thorough and extensive research updates on the important advances in neuropharmacological drugs and drug therapy from experienced and eminent academicians, researchers, and scientists from throughout the world.


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100 Cases in Clinical Pharmacology, Therapeutics and Prescribing

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Nov 052020

100 Cases in Clinical Pharmacology, Therapeutics and Prescribing explores scenarios commonly seen by medical students and junior doctors in the ward, emergency department, outpatient clinic or in general practice in which an understanding of pharmacology and sound prescribing practice is central to successful clinical management and safe patient care. A succinct summary of the patient’s history, examination and any initial investigations is followed by questions on the diagnosis and management of the case. The answer includes a detailed discussion on each topic, providing practical advice on how to deal with the challenges that occur when prescribing, including planning, drug calculations, prescription review and adverse drug reactions. The book will be invaluable during clinical placements and is an ideal companion during preparation for the Prescribing Safety Assessment
Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. These true-to-life cases will teach students and junior doctors to prescribe appropriately, and to hone their diagnostic and management skills.


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Pharmacy Practice Research Methods Edition 2

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Oct 282020

The first edition of Pharmacy Practice Research Methods provided a contemporary overview of pharmacy practice research, discussing relevant theories, methodologies, models and techniques. It included chapters on a range of quantitative, qualitative, action research and mixed methods as well as management theories underpinning change in pharmacy practice.
This new edition of the book is much broader and more diversified. It includes the quality improvement methods in pharmacy practice research, focusing on the key differences between high and low-income countries with regard to pharmacy practice research, as well as the main challenges faced when conducting such research – areas of significant global interest. In addition, a number of the chapters covering fast-moving fields where new methods have been developed and published have been updated. Featuring seven new topics and presenting future trends, the book also explains in detail methods used in covert and overt observations in pharmacy practice, as well as methods involved in realist research, which are important to countries seeking to produce evidence-based information in this area.

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Pharmaceutical Parallel Trade in the UK

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Oct 252020

Parallel trade in pharmaceuticals within the EU involves the legal repacking and reselling of genuine medicines and dates back to the 1970s when a number of pharmacists realized that drug prices varied significantly between member states. By 2002, the UK market for parallel-distributed pharmaceuticals represented ?1,300 million. It is now the largest market in Europe. Parallel importing is controversial. On the one hand, there are the importers, who argue that they are pursuing a legitimate business in a free-trade area, making significant profits through price mark-ups. On the other hand, manufacturers point out that the price differentials that lead to parallel importing are not the result of market prices, but caused by price and reimbursement regulation by governments. If market pricing were permitted, the problem would be much reduced. The main concern of this study, however, is to establish whether patient safety is put at risk by parallel importing. Does repackaging endanger quality control and hygiene, and does parallel importing increase the chances of counterfeit products entering legal supply channels. In the first part, the authors, both from the Health and Social Care Unit at the LSE, set out in detail the facts on parallel trade from continental Europe to the UK, taking into account legislative, regulatory and economic issues. In the second part, a series of experts considers the evidence of product tampering and quality control, as well as the risk of counterfeiting, in order to tackle the sizeable question of the extent to which it is possible to protect patients without erecting barriers to legal trade.
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Pharmaceutical Statistics: Practical and Clinical Applications, Fourth Edition, Revised and Expanded (Drugs and the Pharmaceuti

 Pharmacology  Comments Off on Pharmaceutical Statistics: Practical and Clinical Applications, Fourth Edition, Revised and Expanded (Drugs and the Pharmaceuti
Oct 232020

The fourth edition of this text includes a disk with special programs to aid in problem analysis. The text presents fresh material on concept conformity and release targets and describes linear regression and correlation, the analysis of variance and crossover designs.
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The Prescribing Pharmacist

 Pharmacology  Comments Off on The Prescribing Pharmacist
Oct 202020

By Barry Strickland-Hodge, Mary-Claire Kennedy

Prescribing has traditionally been the responsibility of medical doctors but independent prescribing courses are now firmly established in the UK and increasing numbers of healthcare professionals have taken on prescribing responsibilities.

The Prescribing Pharmacist reflects these changes, beginning with an overview of pharmacist prescribing and continuing with an exploration of consultation, patient clinical assessment, team working, and understanding cultural and religious issues and ethics. Internal and external influences on the new prescriber are considered, as well as medicines optimisation. The authors also look at prescribing for specific patient groups, such as the elderly, the very young, pregnant women and breast-feeding women, and finally move on to specific medicines that require special care when prescribing. Each chapter of the book refers and links to the Royal Pharmaceutical Society framework written in 2016, A Competency Framework for All Prescribers, which is reproduced, with permission.

Written by a team of pharmacy experts, this book is intended for any pharmacist who is thinking of becoming an independent prescriber, those on pharmacy courses and those who are already qualified as independent or supplementary pharmacist prescribers, who may use it as a reminder of important points covered on their course.

Contents include:

List of abbreviations
An introduction to pharmacist prescribing
The consultation, diagnostic process, diagnosis and influences on prescribing
Patient clinical assessment
Patient partnership and prescribing
Prescribing for specific groups of patients
Medicines requiring particular care when prescribing
Appendix : A Competency Framework for All Prescribers


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Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis

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Oct 192020

The scientific monograph provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.

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Pharmacy Calculations for Pharmacy Technicians

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Oct 052020

This book is divided into eight units containing 33 chapters and over 400 practice problems.

Unit 1: Essential Skills

As with any subject, you must master some basic material before you can tackle the main subject. The following topics are cover in Unit 1.

The Metric System
Apothecary/Avoirdupois/Household Systems
Dimensional Analysis and Ratio Proportion
Rounding Numbers
Unit 2: Auxiliary Subjects

Unit 2 covers a few subjects which you may or may not need, depending on your school and/or practice.

Scientific Notation
Significant Figures
Roman Numerals
Unit 3: Unit Conversions

Converting between the various units of measurements used in pharmacy is an essential skill and mastering this unit will set you up for success in the more complex calculations.

Unit Conversions-The Basics
Unit Conversions Within the Metric System
Unit Conversions Within the Household System
Unit Conversions Between Metric, Household and Apothecary
Unit Conversions Involving Hours and Minutes
Unit 4: Dosage Calculations

This unit starts by covering the terminology then moves on to the various ways to set up and solve the problems. Three levels of problems follow, starting with easy, one-step problems, and moving on to more complex problems.

Dosage Calculations-The Basics
Dosage Calculations Levels 1, 2, and 3
Body Surface Area Dosing Calculations
Unit 5: IV Flow Rate Calculations

As with the dosage calculation unit, this unit starts off with the basics then moves on to calculations, starting with easy calculations and progressing to more complex calculations.

IV Flow Rate Calculations-The Basics
IV Flow Rate Calculations Level 1 and 3
IV Flow Rate Adjustments
Unit 6: Percent and Ratio Strength Calculations

As a pharmacy technician, you will encounter drugs expressed in a percent strength every day and it is important that you master this unit.

Percent Strength
Percent Error
Ratio Strength
Unit 7: Concentrations/Dilutions/Reconstitution Calculations

No pharmacy calculation course would be complete without a section on concentrations and dilutions. The knowledge gained in the previous unit will come in handy here.

Concentrations and Dilutions
Powder Volume Calculations
Serial Dilution
Unit 8: Miscellaneous Subjects

Be sure to take the self-assessment exam and work on any problem areas.

Milliequivalent Calculations
Temperature Conversion Calculations
Pharmacy Calculation Puzzles
Self-Assessment Exam


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Benzodiazepines and GHB: Detection and Pharmacology (Forensic Science and Medicine)

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Oct 052020

Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol® and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today’s most effective methods for detecting these widely abused drugs that are sometimes found associated with criminal acts.
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