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Label-Free Monitoring of Cells in vitro

This book is dedicated to label-free, non-invasive monitoring of cell-based assays and it comprises the most widely applied techniques. Each approach is described and critically evaluated by an expert in the field such that researchers get an overview on what is possible and where the limitations are. The book provides the theoretical basis for each technique as well as the most successful and exciting applications.
Label-free bioanalytical techniques have been known for a long time as valuable tools to monitor adsorption processes at the solid-liquid interface in general – and biomolecular interaction analysis (BIA) in particular. The underlying concepts have been progressively transferred to the analysis of cell-based assays. The strength of these approaches is implicitly given with the name `label-free`: the readout is independent of any label, reagent or additive that contaminates the system under study and potentially affects its properties. Thus, label-free techniques provide an unbiased analytical perspective in the sense that the sample is not manipulated by additives but pure. They are commonly based on physical principles and read changes in integral physical properties of the sample like refractive index, conductivity, capacitance or elastic modulus to mention just a few. Even though it is not implied in the name, label-free approaches usually monitor the cells under study non-invasively meaning that the amplitude of the signal (e.g. electric field strength, mechanical elongation) that is used for the measurement is too low to interfere or affect. In contrast to label-based analytical techniques that are commonly restricted to a single reading at a predefined time point, label-free approaches allow for a continuous observation so that the dynamics of the biological system or reaction become accessible.

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Processes of Visuospatial Attention and Working Memory

This volume covers a broad range of current research topics addressing the function of visuospatial attention and working memory. It discusses a variety of perspectives ranging from evolutionary and genetic underpinnings to neural substrates/computational processes and the connection between attention and working memory. Contributions address the topic at the molecular, system and evolutionary scales and will be of interest to a range of audiences from animal behaviour specialists, experimental psychologists to clinicians in the field of psychiatry and neurology.
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An Introduction to Systems Biology: Design Principles of Biological Circuits, Second Edition

by Uri Alon (Author)

Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade.

Features:

Includes seven new chapters
The new edition has 189 exercises, the previous edition had 66
Offers new examples relevant to human physiology and disease

Praise for the first edition:
… superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. – Nature

[This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology … It assumes no prior knowledge of or even interest in biology … One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. … Alon’s book should become a standard part of the training of graduate students. – Physics Today

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Deep Learning Techniques for Biomedical and Health Informatics

This book presents a collection of state-of-the-art approaches for deep-learning-based biomedical and health-related applications. The aim of healthcare informatics is to ensure high-quality, efficient health care, and better treatment and quality of life by efficiently analyzing abundant biomedical and healthcare data, including patient data and electronic health records (EHRs), as well as lifestyle problems. In the past, it was common to have a domain expert to develop a model for biomedical or health care applications; however, recent advances in the representation of learning algorithms (deep learning techniques) make it possible to automatically recognize the patterns and represent the given data for the development of such model.
This book allows new researchers and practitioners working in the field to quickly understand the best-performing methods. It also enables them to compare different approaches and carry forward their research in an important area that has a direct impact on improving the human life and health.
It is intended for researchers, academics, industry professionals, and those at technical institutes and R&D organizations, as well as students working in the fields of machine learning, deep learning, biomedical engineering, health informatics, and related fields.

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Textbook of Male Genitourethral Reconstruction

This textbook provides a guide to reconstructive surgery of genitourethral problems in male patients. The first section covers all aspects of urethral reconstruction, including the functional anatomy of the urethra, etiology, epidemiology, and demographic differences in urethral pathology. The second section focuses on surgical reconstruction of penile and scrotal anomalies and dysfunctions.
Textbook of Male Genitourethral Reconstruction aims to aid the management of male genitourethral reconstruction patients by reviewing the recent advancements in technology and surgical technique. This book is relevant to urologists, plastic and reconstructive surgeons, medical students, and health care professionals working within urology and plastic surgery.

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Chronic Disease Management

This book focuses on optimizing management and outcomes rather than on routine diagnosis of chronic disease. The reader learns proven methods for treating the most common chronic conditions that they see in daily practice. Chapters are structured to help physicians adopt evidence-based management techniques specific for each condition. Special emphasis is placed on the use of action plans and educational resources for promoting patient self-management.
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Lower Urinary Tract Symptoms in Adults: A Clinical Approach

This book provides an in-depth insight into the symptoms and symptom complexes affecting the lower urinary tract and the underlying causative conditions. The emphasis throughout is practical and clinical, with coverage of all levels of the patient pathway. In addition to the extensive guidance on diagnostic assessment and interpretation, the management of voiding and storage lower urinary tract symptoms, including incontinence, is fully described and potential complications and neurological conditions are discussed. Information is also included on relevant basic science and epidemiology.
Lower Urinary Tract Symptoms in Adults: A Clinical Approach will be an ideal source of expert knowledge for practitioners in functional urology, urogynecology, and neuro-urology gerontology.

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Vascular Complications in Human Disease: Mechanisms and Consequences

Recently, there have been several major advances in our understanding of the causes of diseases affecting the heart, lungs, kidneys, skin and blood vessels. This book offers a concise and carefully composed collection of reviews on vascular biology. Each chapter is written by an internationally respected authority in the field and is a state of the art review of important parts of basic and clinical science.
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CT Evaluation of Coronary Artery Disease

Cardiovascular diseases are the leading cause of death in Western countries. In non-fatal cases, they are associated with a decreased quality of life as well as a substantial economic burden to society. Most sudden cardiac events are related to the complications of a non-stenosing marginal plaque. For this reason, the ability to properly identify the atherosclerotic plaque with a rapid, non-invasive technique is of utmost clinical interest in therapeutic planning. Coronary CT angiography produces high-quality images of the coronary arteries, in addition to defining their location and the extent of the atherosclerotic involvement. Proper knowledge of the equipment, adequate preparation of the patient, and accurate evaluation of the images are essential to obtaining a consistent clinical diagnosis in every case. With its clear and concise presentation of CT imaging of the coronary arteries, this volume provides general practitioners and cardiologists with a basic understanding of the technique. For radiologists with no direct experience in cardiac imaging, the book serves as an important source of information on coronary pathophysiology and anatomy.
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Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education Second Edition Edition 2

This book is written to help clinical and basic researchers, as well as graduate students, in the understanding of hemodynamics. Recent developments in genetics and molecular biology as well as new non-invasive measurement techniques, make it possible to measure and understand the hemodynamics of heart and vessels better than ever before. Hemodynamics make it possible to characterize, in a quantitative way, the function of the heart and the arterial system, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. The layout of the book provides a short and essential overview of individual topics. It is designed as a quick reference guide and each chapter can stand alone. The chapters are written to define the basic and applied principles of the hemodynamic topic. If more details or broader perspectives are desired, the reader can refer to related chapters to which the text refers, or the textbooks listed in the `Reference books` section in Appendix 5. Each chapter starts with a `box` containing a figure and caption that give the basic aspects of each topic. Chapters end with the section, `Physiological and Clinical Relevance` that puts the information from the chapter into perspective. The section in between, `Description` can be used to get more detailed information and find relevant references.
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