A Theory of Unborn Life: From Abortion to Genetic Manipulation

 Genetics  Comments Off on A Theory of Unborn Life: From Abortion to Genetic Manipulation
Feb 092020
 

In light of new biomedical technologies, such as artificial reproduction, stem cell research, genetic selection and design, the question of what we owe to future persons-and unborn life more generally-is as contested as ever. In A Theory of Unborn Life: From Abortion to Genetic Manipulation, author Anja J. Karnein provides a novel theory that shows how our commitments to persons can help us make sense of our obligations to unborn life. We should treat embryos that will develop into persons in anticipation of these persons. But how viable is this theory? Moreover, what does it mean to treat embryos in anticipation of the future persons they will develop into?
Exploring the attractiveness of this approach for Germany and the U.S. – two countries with very different legal approaches to valuing unborn life-Karnein comes to startling conclusions to some of today’s greatest ethical and legal debates. Under Karnein’s theory, abortion and stem cell research are legitimate, since embryos that do not have mothers willing to continue to assist their growth have no way of developing into persons. However, Karnein also contends that where the health of embryos is threatened by third parties or even by the women carrying them, embryos need to be treated with the same care due to the children that emerge from them. In the case of genetic manipulation, it is important to respect future persons like our contemporaries, respecting their independence as individuals as well as the way they enter this world without modification. Genetic interventions are therefore only legitimate for insuring that future persons have the necessary physical and mental endowment to lead independent lives so as to be protected from being dominated by their contemporaries. Evincing polarization and dogma, Karnein’s clean, philosophically-driven analysis provides a sound ethical foundation for the interpretation of any variety of legal dilemmas surrounding unborn life.

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Genetic Research on Addiction: Ethics, the Law, and Public Health

 Genetics  Comments Off on Genetic Research on Addiction: Ethics, the Law, and Public Health
Feb 072020
 

The manner in which genetic research associated with addiction is conducted, interpreted and translated into clinical practice and policy initiatives raises important social, ethical and legal issues. Genetic Research on Addiction fulfils two key aims; the first is to identify the ethical issues and requirements arising when carrying out genetically-based addiction research, and the second is to explore the ethical, legal and public policy implications of interpreting, translating and applying this research. The book describes research guidelines on human protection issues such as improving the informed consent process, protecting privacy, responsibilities to minors and determining whether to accept industry funding. The broader public health policy implications of the research are explored and guidelines offered for developing effective social interventions. Highly relevant for clinicians, researchers, academics and policy-makers in the fields of addiction, mental health and public policy.
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Beyond Our Genes: Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance

 Genetics  Comments Off on Beyond Our Genes: Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance
Feb 052020
 

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look.
This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy.
This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

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Born and Made: An Ethnography of Preimplantation Genetic Diagnosis

 Genetics  Comments Off on Born and Made: An Ethnography of Preimplantation Genetic Diagnosis
Feb 022020
 

Are new reproductive and genetic technologies racing ahead of a society that is unable to establish limits to their use? Have the “new genetics” outpaced our ability to control their future applications? This book examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called “designer baby” method. Using detailed empirical evidence, the authors show that far from being a runaway technology, the regulation of PGD over the past fifteen years provides an example of precaution and restraint, as well as continual adaptation to changing social circumstances. Through interviews, media and policy analysis, and participant observation at two PGD centers in the United Kingdom, Born and Made provides an in-depth sociological examination of the competing moral obligations that define the experience of PGD.

Among the many novel findings of this pathbreaking ethnography of reproductive biomedicine is the prominence of uncertainty and ambivalence among PGD patients and professionals–a finding characteristic of the emerging “biosociety,” in which scientific progress is inherently paradoxical and contradictory. In contrast to much of the speculative futurology that defines this field, Born and Made provides a timely and revealing case study of the on-the-ground decision-making that shapes technological assistance to human heredity.

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Present Knowledge of Rice Genetics and Cytogenetics (Rice Genetics Collection)

 Genetics  Comments Off on Present Knowledge of Rice Genetics and Cytogenetics (Rice Genetics Collection)
Jan 172020
 

“The Rice Genetics Collection” of past symposia and other selected literature contains nearly 4,400 pages of searchable information on rice genetics and cytogenetics published by the IRRI and its partners since 1964. In addition to the five genetics symposia held at 5-year intervals since 1985, the collection contains classic publications that kicked off significant reporting on these subjects in the early 1960s. This collection is a comprehensive and historical documentation on the subject of rice genetics, spanning 45 years of research and scholarly work.This technical bulletin on the “Present Knowledge of Rice Genetics and Cytogenetics”, written in 1964 by the late Te-Tzu Chang, a renowned geneticist, provided the first effort to bring together in one medium the voluminous multilanguage literature on these important subjects. It contains seven chapters on topics dealing with the Oryza species and species relationships; the origin and indigenous center of cultivated rices; cytological and cytogenetical studies, and their evaluation in relation to rice breeding; geographical groups of cultivated rices and intervarietal hybrid sterility in Oryza sativa; and areas requiring new or renewed research efforts.
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Genetic Basis of Oral Health Conditions

 Dentistry, Genetics  Comments Off on Genetic Basis of Oral Health Conditions
Dec 182019
 

This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patient’s condition is pure “bad luck”, whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.

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Genetic Causes of Cardiac Disease

 Cardiovascular, Genetics  Comments Off on Genetic Causes of Cardiac Disease
Dec 102019
 

This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease. Written and edited by leading clinicians and scientists involved in the analysis and therapy of genetic cardiac disorders, it discusses the genetic causes of a variety of cardiac diseases, such as the complex genetics and etiology of congenital heart diseases. It also explores sex differences in prevalent diseases, genetics-based therapeutic strategies and the use of various animal models and alternatives.
The book is intended for research scientists and clinical scientists in the cardiovascular field, human geneticists and cardiologists.

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Genetics : a guide for students and practitioners of nursing and health care

 Genetics, Nursing  Comments Off on Genetics : a guide for students and practitioners of nursing and health care
Dec 072019
 

From the
Foreword by Candy Cooley: “What a delight it is … to read a book which takes complex scientific concepts and ensures they are understandable by all.”
With activities and answers, reflection points and a glossary, this interactive textbook supports the ‘Fit for Practice in the Genetics Era’ competence framework, offering an introduction to the theory of genetics and then using common genetic conditions/disorders as case studies to help students apply theory to practice and examine the service user experience. Genetics is written by an experienced teacher of health care sciences and is ideal for students of nursing, healthcare and for a wide range of health care practitioners.

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Color Atlas of Genetics Edition 5

 Genetics  Comments Off on Color Atlas of Genetics Edition 5
Dec 052019
 

Ever since the International Human Genome Project achieved its extraordinary goal of sequencing and mapping the entire human genome, represented by approximately 3 billion base pairs, with its far-reaching implications for understanding the causes of human genetic disorders and their diagnosis, progress in the field has not slowed down.
In the fifth edition of the bestselling Color Atlas of Genetics, readers will be rewarded with a complete and current overview of the field, with an emphasis on the interface between fundamental principles and practical applications in medicine and the role of signaling pathways in causing diseases.
Using the acclaimed Flexibook format designed for easy visual learning and retention, the atlas is invaluable for students, clinicians, and scientists interested in staying up to date in this fast-evolving area.
New fully illustrated topics in the revised fifth edition of the atlas include:
An overview of disorders resulting from structural changes of the genome (genomic disorders)
Abnormal imprinting patterns
Examples of impaired signal pathways (laminopathies, fibrillinopathies, cohesinopathies, and others)
The CRISPR-Cas system
Genetic features of the aging processes
Disorders due to rearrangements of chromatin in the cell nucleus, and others
With almost 200 stunning color plates explained by concise texts on the opposite pages, including tables presenting useful data, a glossary of terms, key references, and online resources, the atlas presents clear and accessible concepts. It is an excellent refresher for investigators in any field of medicine or biology.

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Essentials of Genetics (10th Edition)

 Genetics  Comments Off on Essentials of Genetics (10th Edition)
Dec 042019
 

Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today’s students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topic chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasize ethical considerations that genetics is bringing into everyday life. The accompanying Mastering Genetics online platform includes new tutorials on topics such as CRISPR-Cas and epigenetics, and new Dynamic Study Modules, which support student learning of key concepts and prepare them for class.

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