Category Archives: Statistics

Statistics Workbook for Evidence-based Health Care

This concise, easy to understand and learner-friendly book invites the readers to actively particpate in the understanding of medical statistical concepts that are frequently used in health care research and evidence-based practice worldwide.Knowing that the best way to learn statistical concepts is to use them, the authors employ real examples and articles from health science literature, complete with the complexities that real life presents, in an approach that will help bring researchers and clinicians one step closer towards being statistical savvy and better able to critically read research literature and interpret the results.A practical hands-on workbook for individual or group exercisesTeaches how to understand statistical methods when reading journals, and how to use them in clinical researchEmphasizes the use of statistics in evidence-based researchRelevant for anyone needing to use statistics, this workbook is an ideal resource for all health care professionals and students, especially those learning and practising evidence-based medicine.
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HIV Transmission: Statistical Modelling

This book presents models describing HIV transmission rates at population level, discussing the main statistical methods and analytical interventions. It also assesses the practical applicability of the various modelling techniques, offering readers insights into what methods are available and, more importantly, when they should be used to address HIV transmission at global level. The book includes realistic simulation models fitted to clarify the rate of HIV mother-to-child transmission (HIV MTCT), and substantiates the conclusions that can be drawn as well as the appropriate time for making global-level clinical decisions concerning people living with HIV/AIDS (PLHIVs). Intended for students, academics and researchers, the book offers more than just an introduction to the topic – it also features in-depth, yet easy-to-understand, descriptions of a new mathematical/statistical HIV mother-to-child transmission model, making it a useful resource for clinicians, public health workers and policymakers involved in implementing HIV-prevention programmes at national /global level.
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Statistical Monitoring of Clinical Trials: A Unified Approach

The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion (“the B-value”) – irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials.
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Applied Statistics in Biomedicine and Clinical Trials Design: Selected Papers from 2013 ICSA/ISBS Joint Statistical Meet

This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The 6 sections cover Bayesian methods in biomedical research; Diagnostic medicine and classification; Innovative Clinical Trials Design; Modelling and Data Analysis; Personalized Medicine; and Statistical Genomics. The real world applications are in clinical trials, diagnostic medicine and genetics. The peer-reviewed contributions were solicited and selected from some 400 presentations at the annual meeting of the International Chinese Statistical Association (ICSA), held with the International Society for Biopharmaceutical Statistics (ISBS). The conference was held in Bethesda in June 2013, and the material has been subsequently edited and expanded to cover the most recent developments.
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Statistical Literacy for Clinical Practitioners

This textbook on statistics is written for students in medicine, epidemiology, and public health. It builds on the important role evidence-based medicine now plays in the clinical practice of physicians, physician assistants and allied health practitioners. By bringing research design and statistics to the fore, this book can integrate these skills into the curricula of professional programs. Students, particularly practitioners-in-training, will learn statistical skills that are required of today’s clinicians. Practice problems at the end of each chapter and downloadable data sets provided by the authors ensure readers get practical experience that they can then apply to their own work.

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Medical Statistics at a Glance

Medical Statistics at a Glance provides a concise and accessible introduction and revision aid for undergraduate medical students and anyone wanting a straightforward introduction to this complex subject. Following the familiar, easy-to-use at a Glance format, each topic is presented as a double-page spread with key facts accompanied by clear, informative tables, formulae and graphs.This new edition of Medical Statistics at a Glance:Contains a second colour throughout to enhance the visual appeal, making the subject even easier to understand Features worked examples on each topic, with emphasis on computer analysis of data rather than hand calculations Includes new topics on Rates and Poisson regression, Generalised linear models, Explanatory variables in statistical models and Regression models for clustered data. Has an accompanying website http://www.medstatsaag.com/containing supplementary material including multiple choice questions (MCQs) with annotated answers for self-assessmentMedical Statistics at a Glance will appeal to all medical students, junior doctors and researchers in biomedical and pharmaceutical disciplines.Reviews of the last edition”All medical professionals will come across statistics in their daily work and so a proper understanding of these concepts is invaluable. This is brought to you in this easily comprehensible succinct textbook..I unreservedly recommend this book to all medical students, especially those that dislike reading reams of text. This is one book that will not sit on your shelf collecting dust once you have graduated and will also function as a reference book.”4th Year Medical Student. Barts and the London Chronicle, Spring 2003,vol.5, issue 1
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Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs

A complete guide to the key statistical concepts essential for the design and construction of clinical trials
As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis.
Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features:
Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials
Over 100 contributions from leading academics, researchers, and practitioners
An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group
Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.

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Statistics for Nursing and Allied Health

This introductory textbook explores the role of research in health care and focuses in particular on the importance of organizing and describing research data using basic statistics. The goal of the text is to teach students how to analyze data and present the results of evidence-based data analysis. Based on the commonly-used SPSS software, a comprehensive range of statistical techniques—both parametric and non-parametric—are presented and explained. Examples are given from nursing, health administration, and health professions, followed by an opportunity for students to immediately practice the technique.
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Fundamental Statistics for the Behavioral Sciences

David Howell’s practical approach focuses on the context of statistics in behavioral research, with an emphasis on looking before leaping; investigating the data before jumping into a test. This provides you with an understanding of the logic behind the statistics: why and how certain methods are used rather than just doing techniques by rote. Learn faster and understand more because Howell’s texts moves you beyond number crunching, allowing you to discover the meaning of statistical results and how they relate to the research questions being asked.
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Controversial Statistical Issues in Clinical Trials (Chapman & Hall CRC Biostatistics Series)


In clinical trial practice, controversial statistical issues inevitably occur regardless of the compliance with good statistical practice and good clinical practice. But by identifying the causes of the issues and correcting them, the study objectives of clinical trials can be better achieved. Controversial Statistical Issues in Clinical Trials covers commonly encountered controversial statistical issues in clinical trials and, whenever possible, makes recommendations to resolve these problems. The book focuses on issues occurring at various stages of clinical research and development, including early-phase clinical development (such as bioavailability/bioequivalence), bench-to-bedside translational research, and late-phase clinical development. Numerous examples illustrate the impact of these issues on the evaluation of the safety and efficacy of the test treatment under investigation. The author also offers recommendations regarding possible resolutions of the problems. Written by one of the preeminent experts in the field, this book provides a useful desk reference and state-of-the art examination of problematic issues in clinical trials for scientists in the pharmaceutical industry, medical/statistical reviewers in government regulatory agencies, and researchers and students in academia.
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