Category Archives: Pharmacology

Pharmaceutical Statistics: Practical and Clinical Applications, Fourth Edition, Revised and Expanded (Drugs and the Pharmaceuti

The fourth edition of this text includes a disk with special programs to aid in problem analysis. The text presents fresh material on concept conformity and release targets and describes linear regression and correlation, the analysis of variance and crossover designs.
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The Prescribing Pharmacist

By Barry Strickland-Hodge, Mary-Claire Kennedy

Prescribing has traditionally been the responsibility of medical doctors but independent prescribing courses are now firmly established in the UK and increasing numbers of healthcare professionals have taken on prescribing responsibilities.

The Prescribing Pharmacist reflects these changes, beginning with an overview of pharmacist prescribing and continuing with an exploration of consultation, patient clinical assessment, team working, and understanding cultural and religious issues and ethics. Internal and external influences on the new prescriber are considered, as well as medicines optimisation. The authors also look at prescribing for specific patient groups, such as the elderly, the very young, pregnant women and breast-feeding women, and finally move on to specific medicines that require special care when prescribing. Each chapter of the book refers and links to the Royal Pharmaceutical Society framework written in 2016, A Competency Framework for All Prescribers, which is reproduced, with permission.

Written by a team of pharmacy experts, this book is intended for any pharmacist who is thinking of becoming an independent prescriber, those on pharmacy courses and those who are already qualified as independent or supplementary pharmacist prescribers, who may use it as a reminder of important points covered on their course.

Contents include:

List of abbreviations
An introduction to pharmacist prescribing
The consultation, diagnostic process, diagnosis and influences on prescribing
Patient clinical assessment
Patient partnership and prescribing
Prescribing for specific groups of patients
Medicines requiring particular care when prescribing
Appendix : A Competency Framework for All Prescribers

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Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis

The scientific monograph provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
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Pharmacy Calculations for Pharmacy Technicians

This book is divided into eight units containing 33 chapters and over 400 practice problems.

Unit 1: Essential Skills

As with any subject, you must master some basic material before you can tackle the main subject. The following topics are cover in Unit 1.

The Metric System
Apothecary/Avoirdupois/Household Systems
Ratios
Dimensional Analysis and Ratio Proportion
Rounding Numbers
Unit 2: Auxiliary Subjects

Unit 2 covers a few subjects which you may or may not need, depending on your school and/or practice.

Scientific Notation
Significant Figures
Roman Numerals
Unit 3: Unit Conversions

Converting between the various units of measurements used in pharmacy is an essential skill and mastering this unit will set you up for success in the more complex calculations.

Unit Conversions-The Basics
Unit Conversions Within the Metric System
Unit Conversions Within the Household System
Unit Conversions Between Metric, Household and Apothecary
Unit Conversions Involving Hours and Minutes
Unit 4: Dosage Calculations

This unit starts by covering the terminology then moves on to the various ways to set up and solve the problems. Three levels of problems follow, starting with easy, one-step problems, and moving on to more complex problems.

Dosage Calculations-The Basics
Dosage Calculations Levels 1, 2, and 3
Body Surface Area Dosing Calculations
Unit 5: IV Flow Rate Calculations

As with the dosage calculation unit, this unit starts off with the basics then moves on to calculations, starting with easy calculations and progressing to more complex calculations.

IV Flow Rate Calculations-The Basics
IV Flow Rate Calculations Level 1 and 3
IV Flow Rate Adjustments
Unit 6: Percent and Ratio Strength Calculations

As a pharmacy technician, you will encounter drugs expressed in a percent strength every day and it is important that you master this unit.

Percent
Percent Strength
Percent Error
Ratio Strength
Unit 7: Concentrations/Dilutions/Reconstitution Calculations

No pharmacy calculation course would be complete without a section on concentrations and dilutions. The knowledge gained in the previous unit will come in handy here.

Concentrations and Dilutions
Powder Volume Calculations
Serial Dilution
Unit 8: Miscellaneous Subjects

Be sure to take the self-assessment exam and work on any problem areas.

Milliequivalent Calculations
Temperature Conversion Calculations
Pharmacy Calculation Puzzles
Self-Assessment Exam

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Benzodiazepines and GHB: Detection and Pharmacology (Forensic Science and Medicine)

Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol® and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today’s most effective methods for detecting these widely abused drugs that are sometimes found associated with criminal acts.
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BNF 80 (British National Formulary) September 2020 (80th Revised edition)

The British National Formulary (BNF) is the first choice for concise medicines information. Trusted by healthcare professionals across the world to support confident decision-making at the point of care. The new edition (BNF 80) provides up-to-date guidance on prescribing, dispensing, and administering medicines, plus legal and professional guidelines.

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Pediatric Pharmacotherapy

Pediatric Pharmacotherapy focuses on the unique therapeutic needs of neonates, infants, children, and adolescents. Patients in these age groups offer challenges distinct from those of adult patients. Drugs behave differently in this population—medications may not be absorbed, distributed, metabolized, or eliminated in the same manner as in adults, causing increased or decreased efficacy or safety. For a long time, pharmacotherapy educators have been without a source for concise pediatric-specific pharmacotherapy information. In order to close this gap in the literature, ACCP has recruited experts in pediatric pharmacy to write this comprehensive textbook—a resource essential for students, residents, and any clinician involved in the care of pediatric patients. Contents include information on specific disease states, as well as drug selection and use, monitoring of effectiveness and toxicity, prevention of medication errors, and patient/caregiver education. Chapters cover the intro
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Exercise and Sport Pharmacology

Exercise and Sport Pharmacology is an essential book for teaching upper-level undergraduates or entry-level graduate students about how drugs can affect exercise and how exercise can affect the action of drugs. It leads students through the related pathology, exercise physiology, and drug action of many of today’s chronically used medications, and discusses how drugs can affect exercise performance.

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Evidence-based Psychopharmacology

This book presents a comprehensive overview of recent advances in evidence-based pharmacological treatment of psychiatric disorders. There have been very significant developments in our understanding of the methods for systematically reviewing literature, assessing clinical trials and optimizing decision making. The book explores these issues and applies the lessons learned to the practical management of major psychiatric conditions, addressing issues such as selecting the best first-line psychopharmacological intervention for a particular disorder, how long a particular intervention should be continued, and identifying the next-best treatment strategy should the first agent fail.
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Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

In response to the US FDA’s Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the principles and latest statistical methodologies used when modifying trial procedures based on accrued data of ongoing clinical trials. The book also gives a well-balanced summary of current regulatory perspectives.

The first several chapters focus on the fundamental theory behind adaptive trial design, the application of the Bayesian approach to adaptive designs, and the impact of potential population shift due to protocol amendments. The book then presents a variety of statistical methods for group sequential design, classical design, dose-finding trials, Phase I/II and Phase II/III seamless adaptive designs, multiple stage seamless adaptive trial design, adaptive randomization trials, hypotheses-adaptive design, and treatment-adaptive design. It also covers predictive biomarker diagnostics for new drug development, clinical strategies for endpoint selection in translational research, the role of independent data monitoring committees in adaptive clinical trials, the enrichment process in targeted clinical trials for personalized medicine, applications of adaptive designs that use genomic or genetic information, adaptive trial simulation, and the efficiency of adaptive design. The final chapters discuss case studies as well as standard operating procedures for good adaptive practices.

With contributions from leading clinical researchers in the pharmaceutical industry, academia, and regulatory agencies, this handbook offers an up-to-date, complete treatment of the principles and methods of adaptive design and analysis. Along with reviewing recent developments, it examines issues commonly encountered when applying adaptive design methods in clinical trials.

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