Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neuro-Oncology covers the pathophysiology, diagnosis, classification, and management of tumours of the nervous system. The book provides a comprehensive overview of tumour subtypes, in accordance with WHO classifications, along with management plans for adult and paediatric populations. The international team of co-editors ensures that expert commentaries on existing
and wide-reaching diagnostic and treatment guidelines (including NCCN and ESMO) are accessible by a global audience.
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Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this pharmacology book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies.
Beautifully illustrated throughout, each chapter in this cancer pharmacology guide contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more.
Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to oncology pharmacotherapy.
Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents
Describes how chemotherapy, targeted therapy, immunotherapy, hormonal therapy, work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities
Over 135 highly stylized images and numerous comprehensive tables
Covers challenges related to drug development, drug approval and regulatory issues in relation to anticancer treatments
All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales
Purchase includes access to the ebook for use on most mobile devices or computers
Publisher: Springer Publishing
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Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer.
The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field.
- Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field
- Covers the basic principles and science behind cancer immunotherapy and tumor immunology
- Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies
- Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities
- Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy
- Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs
- Purchase includes access to the eBook for use on most mobile devices or computers
- Publisher: Springer Publishing Company
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“Updated and expanded, this Second Edition of Essentials of Clinical Radiation Oncology continues to provide a succinct and effective review of the most important studies in the field. Organized by disease topic and grouped by body part, each chapter employs structured sections for targeted information retrieval and retention. Chapters begin with a “”Quick Hit”” overview of each disease summarizing the most significant paradigms before moving into dedicated summaries on epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigm, and medical management. An evidence-based question-and-answer section concludes each chapter, which pairs commonly encountered clinical questions with answers connecting historical context and pertinent clinical studies to better inform decision-making and treatment planning.
Providing the latest treatment paradigms and guidelines, this comprehensive second edition now outlines the evidence and must-know considerations for using radiation therapy with immunotherapy, the strategies for metastasis-directed therapy for oligometastatic disease, and much more. Written for the practicing radiation oncologist, related practitioner, and radiation oncology resident entering the field, this “”one-stop”” resource is the go-to reference for everyday practice.
- Structured sections offer high-yield information for targeted review
- Cites need-to-know clinical studies and treatment guidelines in evidence-based question-and-answer format
- Each chapter has been reviewed and updated to include the most recent and relevant studies
- New chapters on spine tumors, thyroid cancer, sinonasal tumors, cholangiocarcinoma, renal cell carcinoma, multiple myeloma and plasmacytoma, miscellaneous pediatric tumors, and treatment of oligometastatic disease from underlying cancers
- Designed for quick reference with comprehensive tables on treatment options and patient selection, workup, and prognostic factors by disease site
- Purchase includes digital access for use on most mobile devices or computers
- Publisher: Demos Medical Publishing, an imprint of Springer Publishing Company
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For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff’s Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today’s board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests.
Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers.
Features three online practice tests per specialty that follow the ABIM exams blueprint, ensuring that complex content is delivered in easily digestible segments for more efficient review.
Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care.
Uniquely designed as both a standalone review and a study companion to Abeloff’s Clinical Oncology and Hematology: Basic Principles and Practice.
Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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This book provides a comprehensive introduction to current state-of-the-art auto-segmentation approaches used in radiation oncology for auto-delineation of organs-of-risk for thoracic radiation treatment planning. Containing the latest, cutting edge technologies and treatments, it explores deep-learning methods, multi-atlas-based methods, and model-based methods that are currently being developed for clinical radiation oncology applications. Each chapter focuses on a specific aspect of algorithm choices and discusses the impact of the different algorithm modules to the algorithm performance as well as the implementation issues for clinical use (including data curation challenges and auto-contour evaluations).
This book is an ideal guide for radiation oncology centers looking to learn more about potential auto-segmentation tools for their clinic in addition to medical physicists commissioning auto-segmentation for clinical use.
- Up-to-date with the latest technologies in the field
- Edited by leading authorities in the area, with chapter contributions from subject area specialists
- All approaches presented in this book are validated using a standard benchmark dataset established by the Thoracic Auto-segmentation Challenge held as an event of the 2017 Annual Meeting of American Association of Physicists in Medicine
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Diagnostic Pathology: Familial Cancer Syndromes features a comprehensive review of the top 56 inherited tumor syndromes associated with neoplasms, which every surgical pathologists diagnoses in their daily sign-out practice. With over 175 chapters and written by well-known experts in the field, this book seeks to help surgical pathologists, clinicians, fellows, and residents understand the critical differences in diagnosing familial tumors and differentiating these from the sporadic counterpart. Besides the well-described pathology of these syndromes, the clinical implications on diagnosing these syndromes are also presented in detail. This book will guide pathologists and clinicians to master diagnostic criteria when diagnosing tumors associated with inherited tumor syndromes.
The chapters are organized in 3 parts:
The 1st part, “Overview of Syndromes” has the detailed description of the major syndromes within 56 chapters, genes involved, associated tumors, and diagnostic criteria. This part also contains tables that may be helpful in better classifying the diseases and the associated syndromes. Each syndrome described includes all benign and malignant tumors occurring in that specific syndrome including the differential diagnosis.
The 2nd part, “Syndromes By Specific Diagnosis”, discusses in detail, the diseases occurring within the syndromes described in part 1. The diagnoses are conveniently grouped according to the gland/organ/tissue involved.
Distinct diseases are described by highlighting the characteristics of the tumors according to the different syndromes in which they occur. The book describes in detail some of the distinct characteristics of tumors found in inherited tumor syndromes that distinguishes these tumors from tumors in a sporadic setting. Each diagnosis includes definitions, terminology, etiology, pathogenesis, demographics, clinical presentations, therapy, prognosis, gross and microscopic pathology, differential diagnoses, and special studies including immunohistochemistry and molecular/genetics. Every diagnosis is discussed in concise, bulleted text that highlights the most diagnostically significant factors.
The 3rd part is “Syndromes by Organ Location”. This is also divided by organ/subspecialty and distributed among 40 chapters. This part has tables with “easy-to-find” possible syndromes by organ, with numerous tables including the differential diagnosis.
Augmenting the text discussion are numerous gorgeous medical images, including clinical images, gross pathology, histology, and a wide range of special and immunohistochemical stains. Each image is carefully annotated to highlight the most diagnostically significant factors.
Finally, this book features the classic benefits of all Amirsys® titles, including time-saving bulleted text, key facts in each chapter, stunning annotated images, extensive index, and Amirsys eBook Advantage™, an online version of the print book with larger images and fully searchable text.
· Tables for easy reference and thorough understanding
· 3 parts divided up for ease of understanding of familial syndromes as related to syndrome overviews, specific diagnoses, and organ location
· Features the classic benefits of all Amirsys® titles, including time-saving bulleted text, Key Facts in each chapter, stunning annotated images, and an extensive index
· Amirsys eBook Advantage™, an online version of the print book with fully searchable text
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The treatment of cancer is being revolutionized by drugs that modulate the immune system, offering the prospect of long-term response and extended survival for many patients with advanced incurable cancer. A plethora of new drugs are being incorporated into current standards of care but many questions remain unanswered – and new ones emerge – about how to use these exciting new drugs to best effect. A good understanding of immune-oncology is therefore becoming increasingly important to keep up to date with this rapidly changing field. ‘Fast Facts: Immuno-Oncology’ takes you from the fundamentals of immunology through to the new concepts of immunoediting and immunotherapy and likely future directions. Whether you are a practicing oncologist, oncology health professional, medical student, cancer researcher or industry professional, this book provides all you need to know about immuno-oncology, concisely summarized. Contents: • Components of the immune system • How cancers evade the immune system • How cancer immunotherapy works • Clinical use of immune checkpoint inhibitors • The future of immuno-oncology • Useful resources
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