Immunology and Psychiatry: From Basic Research to Therapeutic Interventions

 Immunology, Neurology/Neurosurgery, Psychiatry  Comments Off on Immunology and Psychiatry: From Basic Research to Therapeutic Interventions
Nov 082019
 

Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette`s, Alzheimer`s, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

The Adenosinergic System: A Non-Dopaminergic Target in Parkinson’s Disease

 Neurology/Neurosurgery, Toxicology  Comments Off on The Adenosinergic System: A Non-Dopaminergic Target in Parkinson’s Disease
Nov 072019
 

Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson`s Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson`s Disease, (2) an overview of neuroimaging studies in human death and disease and (3) a study of urate as a possible biomarker and neuroprotectant.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Fundamentals of Neurodegeneration and Protein Misfolding Disorders

 Neurology/Neurosurgery  Comments Off on Fundamentals of Neurodegeneration and Protein Misfolding Disorders
Nov 062019
 

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

GET IT FREE HERE

https://nitroflare.com/view/019B30D494E3B3F/3319221167.epub

https://nitroflare.com/view/BA832EB1D2D7206/3319221167.pdf

ALTERNATIVE LINK

https://filejoker.net/r0kmmnm3cirz

https://filejoker.net/vsale4mxhnir

Share Button

Clinical Neurology – 2018

 Neurology/Neurosurgery  Comments Off on Clinical Neurology – 2018
Nov 032019
 

Topics include: evaluation of weakness, neuropathy, myasthenia gravis, demyelinating disease including MS and Guillain-Barre, carpal tunnel, cerebellar disorders, movement disorders (tics, Tourette, dystonia..), tremors, Parkinsons, cerebral palsy, ALS, seizures, strokes, headaches, coma, cervical spine problems, low back pain, radiculopathy, sciatica, myofacial pain, sacroiliac dysfunction, ankylosing spondylitis and pseudo-neurological syndromes.

GET IT FREE HERE

https://nitroflare.com/view/879DDC96422DDDC/B004XN4GVO.epub

ALTERNATIVE LINK

https://filejoker.net/ivrhtp31aecz

Share Button

Heat Shock Proteins in Neuroscience

 Neurology/Neurosurgery  Comments Off on Heat Shock Proteins in Neuroscience
Nov 022019
 

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders.
Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Development and Engineering of Dopamine Neurons

 Neurology/Neurosurgery  Comments Off on Development and Engineering of Dopamine Neurons
Nov 022019
 

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Depathologizing Psychopathology: The Neuroscience of Mental Illness and Its Treatment

 Neurology/Neurosurgery  Comments Off on Depathologizing Psychopathology: The Neuroscience of Mental Illness and Its Treatment
Oct 312019
 

This brief, accessible treatise harnesses the neurophysiological processes of learning to create an innovative and powerful approach to therapy. It sets out a non-pathologizing alternative not only to the current medicalized conception of diagnosis and treatment but also to the labeling of relatively normal reactions to stressors and upsets as illnesses. Rooted in the neurobiology of human learning, the book’s approach to treatment, Neuro-Cognitive Learning Therapy, characterizes maladaptive behavior patterns as learned responses to upsetting conditions―processes which can be unlearned. In addition, the coverage includes a clinical teaching guide for bringing NCLT theory and methods into the training curriculum.
This groundbreaking volume:

  • Proposes a non-stigmatizing learning model for therapy, Neuro-Cognitive Learning Therapy.
  • Introduces the concept of the connectome and explains its critical role in mental health and illness.
  • Differentiates between the unconscious and automaticity in cognition and behavior.
  • Addresses the applicability of NCLT to biologically-based mental disorders.
  • Offers case studies illustrating NCLT in contrast with commonly-used approaches.
  • Includes a chapter-by-chapter clinical teaching guide with therapeutic principles and discussion questions.
  • Provides a comprehensive therapeutic framework for practitioners of all orientations.

Depathologizing Psychopathology gives neuropsychologists, psychiatrists, clinical social workers, and child and school psychologists new ways of thinking about mental illness and learning about learning for a bold new step in the evolution of mind/brain knowledge.

GET IT FREE HERE

https://nitroflare.com/view/C55BF9127C2C6CC/3319309080.pdf

ALTERNATIVE LINK

https://filejoker.net/y41kmm7gyv3h

Share Button

Brain Degeneration and Dementia in Sub-Saharan Africa

 Neurology/Neurosurgery  Comments Off on Brain Degeneration and Dementia in Sub-Saharan Africa
Oct 302019
 

The proposed book is based on the workshop “Brain Degenerations and Emerging Mental Health Challenges in Sub-Saharan Africa” which was held in Kampala, Uganda, on February 1-3, 2012. The contributors will present snapshots of dementia as well as pediatric and adult brain damage within a specifically African context. Topics addressed include, but are not limited to, HIV/AIDS, malaria, nutritional and vitamin deficiencies, environmental toxicity and Alzheimer’s Disease. The proposal has been approved by the editors of the Advances in Experimental Medicine and Biology for inclusion in the series.

GET IT FREE HERE

https://nitroflare.com/view/BF76F34C7E9985A/1493924559.pdf

ALTERNATIVE LINK

https://filejoker.net/w3o7qcbf8ngy

Share Button

The Benefits of Natural Products for Neurodegenerative Diseases

 Neurology/Neurosurgery  Comments Off on The Benefits of Natural Products for Neurodegenerative Diseases
Oct 302019
 

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

GET IT FREE HERE

https://nitroflare.com/view/BC5A7A68A10F69D/3319283812.pdf

ALTERNATIVE LINK

https://filejoker.net/xbfzarpkhtic

Share Button

Central Nervous System Intraoperative Cytopathology

 Neurology/Neurosurgery  Comments Off on Central Nervous System Intraoperative Cytopathology
Oct 292019
 

This book covers the full spectrum of benign and malignant conditions of the central nervous system with an emphasis on common disorders. It contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button