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Pharmacology Toxicology

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Tox

Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
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Toxicology

Maternal-Fetal Toxicology, Third Edition,: A Clinician’s Guide (Medical Toxicology)

This totally revised and expanded reference presents a problem-based approach to the teratogenic risks of exposure to drugs, chemicals, viruses, and radiation during pregnancy-containing updated material on treatment programs and management approaches, as well as systematic reviews and meta-analyses of specific xenobiotics. Offers entirely new features such as clinical case studies at the beginning of most chapters, as well as end-of-chapter solutions! Summarizing recentlarge-scale prospective studies on the safety of drugs in pregnancy, initiated by the Motherisk Program in Toronto in collaboration with several American services, the Third Edition of Maternal-Fetal Toxicology provides ·the latest analysis on alcohol consumption during pregnancy and the diagnosis of fetal alcohol syndrome ·a guide for herbal products in pregnancy ·timely information for the evaluation of fetal safety in chemical industries ·up-to-the-minute treatment for epilepsy and other chronic conditions in pregnancy ·current management of the neonatal abstinence syndrome ·modern uses of herbal medicine in pregnancy and during lactation ·and more! Written by a multidisciplinary team of experts in the field, Maternal-Fetal Toxicology, Third Edition, is a practical and well-researched reference for all obstetricians/gynecologists, toxicologists, family physicians, pharmacologists, pediatricians, nurses, pharmacists, poison control specialists, geneticists, and upper-level undergraduate, graduate, and medical school students in these disciplines.
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Forensic Medicine Toxicology

Fundamentals of Analytical Toxicology: Clinical and Forensic Edition 2

Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques.
This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results.
Written by a prominent team of experienced practitioners, this volume:
Focuses on analytical, statistical, and pharmacokinetic principles
Describes basic methodology, including colour tests and immunoassay and enzyme-based assays
Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation
Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides
Includes discussion of ‘designer drugs’ (novel pharmaceutical substances NPS)
Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.

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Toxicology

New Horizons in Predictive Toxicology: Current Status and Application

Toxicology continues to be a major cause of product attrition; in addition the implementation of REACH is having an impact on our need to continually improve our capabilities to predict potential safety concerns earlier. This unique book provides a comprehensive review and discussion on the status of predictive toxicology and its application. This is a critical hot topic and an area of continuing importance and the book is timely in providing a leading and expert treatise. Chapters cover the current approaches in predictive toxicology including in silico, in vitro and in vivo. In addition, examples of how these approaches can be integrated to improve the safety assessment to humans are covered. There is also discussion of current approaches for biomarker identification and application (eg omics approaches).
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Toxicology

Veterinary Toxicology

A vast number of substances potentially toxic to animals exist, including pesticides, household cleaning products, agricultural chemicals, automotive products, human prescription and non-prescription drugs, herbal remedies, and poisonous plants and animals. With such huge numbers of potential toxins, it is impossible foe veterinarians to be knowledgeable about all of them. But because some poisonings can cause illness or even death within only minutes to hours after exposure, immediate access to reliable information on diagnosis and treatment is essential. Often intoxications involve new drugs or chemical products for which very little or no published veterinary toxicity data is available.

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Toxicology

Computational Systems Toxicology

This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.
Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.

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Toxicology

Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition

Toxicology’s gold-standard text – completely updated to reflect the latest breakthroughs and discoveries 

A Doody’s Core Title for 2019! 

Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere.

Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:
•General Principles of Toxicology
•Disposition of Toxicants
•Non-Organ Directed Toxicity
•Target Organ Toxicity
•Toxic Agents
•Environmental Toxicology
•Applications of Toxicology

Many new contributors capture the progress made in toxicology over the past few years:
This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book.

Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals.

A true “essential”
If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology – written by experts, and presented in full color, your search ends here.

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Toxicology

Principles of Toxicology: Environmental and Industrial Applications Edition 3

A fully updated and expanded edition of the bestselling guide on toxicology and its practical application
• Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards
• New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology
• Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
• Includes case histories and examples from industry demonstrate the application of toxicological principles
• Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms

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Toxicology

General Toxicology

Natural toxicants have been known from ancient times and man used them to gain various benefits by producing remedies, preserving goods or using them as a means for homicide. During the past century many new, toxicologically undefined industrial substances were introduced to the environment. It was an inevitable risk that substances dangerous to man, biota and environment, every man should contribute by being aware of his surroundings. In “General Toxicology” the vastness of the toxicological scope is presented by outlining the possible encounter with toxicants of different origins, their fate in the human body and the effects produced. The book smoothly introduces the reader to the basic principles and mechanisms in the body exposed to ubiquitous foreign substances. The path from the exposure to xenobiotics to final effects is to encompass basic aspects of toxicokinetics, i.e. absorption, distribution, biotransformation and excretion of the substances. The mechanisms of adverse health effects are outlined by the insight in toxicodynamic processes which explains the difference between acute and chronic exposures. The occurrence, physico-chemical properties and toxicity of most important categories of both natural and anthropogenic toxicants including detailed depiction of the poisoning symptoms, are described in the important new book.
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Pharmacology Toxicology

PARP as a Therapeutic Target (Handbooks in Pharmacology and Toxicology)

Recent research in cell death mechanisms has rekindled interest in PARP’s (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors’ dual actions of preventing cell death and abating inflammation have demonstrated remarkable acute effects in animal models of various diseases. PARP as a Therapeutic Target covers the clinical aspects of this up-and-coming drug that counteracts the damage done by free radicals. Leading international experts currently working on ways to apply it share their views of recent developments and future directions of PARP research. They discuss its therapeutic potential in various disease conditions, such as ischemia, diabetes, cancer, arthritis, inflammatory bowel disease, and septic shock.The intensified PARP drug development effort has raised expectations for possible clinical trials in the near future to establish the tolerance of PARP inhibitors in healthy humans, its efficacy in treating patients with different diseases, and the long term effect of PARP inhibition. PARP as a Therapeutic Target provides a comprehensive understanding of how PARP works to aid in the better design of its inhibitors for therapeutic purposes.
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