Tag Archives: Toxicology

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight.
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health.
This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

GET IT FREE HERE

https://nitroflare.com/view/6E5406EFCA4BD10/Toxicological_Effects_of_Perfluoroalkyl_and_Polyfluoroalkyl_.pdf

Share Button

Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.
These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

GET IT FREE HERE

https://nitroflare.com/view/FC1D9356E4B50EA/3319473840.pdf

Share Button

Lu’s Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment, 5th Edition

Decades of research and teaching experience are compiled in the authoritative and highly awaited new edition of this classic text. For the utmost in reader convenience and comprehension, Lu’s Basic Toxicology uses easy-to-understand terminology, and separate subject and chemical indexes. Providing clarity and insight into this rapidly evolving subject, this guide provides new information on: over-the-counter preparations lactation occupational toxicology Written by two key opinion leaders in toxicology, this text also covers the essentials of: why chemicals target specific organs and systems, and commonly used procedures for assessing risk associated with these chemicals chemicals that cause: cancer, mutations, congenital malformations, and organ or system specific effects host and environmental factors that modify the effects of specific chemicals, including: food additives; pesticides; metals; pollutants in air, water, and soil; and toxicants encountered in workplaces
GET IT FREE HERE
Share Button

Beating Drug Tests and Defending Positive Results: A Toxicologist’s Perspective

A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies. This practice was first initiated by President Ronald Reagan when he ordered federal agencies to drug test federal employees involved in sensitive positions as well as positions involving public safety. As a practicing toxicologist, Dr. Amitava Dasgupta is involved with the pre-employment drug testing at his own hospital and aptly shares his expertise in Beating Drug Tests and Defending Positive Results: A Toxicologist’s Perspective, which covers all major issues concerning how people try to beat drug tests and defend positive test results. In each chapter, extensive references are cited so that readers can access more information on a particular topic that may interest them. The book will undoubtedly prove helpful to toxicologists, medical technologists, pathologists, human resources professionals and anyone interested in workplace drug testing.
GET IT FREE HERE
Share Button

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Tox

Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
GET IT FREE HERE
Share Button

Maternal-Fetal Toxicology, Third Edition,: A Clinician’s Guide (Medical Toxicology)

This totally revised and expanded reference presents a problem-based approach to the teratogenic risks of exposure to drugs, chemicals, viruses, and radiation during pregnancy-containing updated material on treatment programs and management approaches, as well as systematic reviews and meta-analyses of specific xenobiotics. Offers entirely new features such as clinical case studies at the beginning of most chapters, as well as end-of-chapter solutions! Summarizing recentlarge-scale prospective studies on the safety of drugs in pregnancy, initiated by the Motherisk Program in Toronto in collaboration with several American services, the Third Edition of Maternal-Fetal Toxicology provides ·the latest analysis on alcohol consumption during pregnancy and the diagnosis of fetal alcohol syndrome ·a guide for herbal products in pregnancy ·timely information for the evaluation of fetal safety in chemical industries ·up-to-the-minute treatment for epilepsy and other chronic conditions in pregnancy ·current management of the neonatal abstinence syndrome ·modern uses of herbal medicine in pregnancy and during lactation ·and more! Written by a multidisciplinary team of experts in the field, Maternal-Fetal Toxicology, Third Edition, is a practical and well-researched reference for all obstetricians/gynecologists, toxicologists, family physicians, pharmacologists, pediatricians, nurses, pharmacists, poison control specialists, geneticists, and upper-level undergraduate, graduate, and medical school students in these disciplines.
GET IT FREE HERE
Share Button

Fundamentals of Analytical Toxicology: Clinical and Forensic Edition 2

Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques.
This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results.
Written by a prominent team of experienced practitioners, this volume:
Focuses on analytical, statistical, and pharmacokinetic principles
Describes basic methodology, including colour tests and immunoassay and enzyme-based assays
Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation
Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides
Includes discussion of ‘designer drugs’ (novel pharmaceutical substances NPS)
Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.

[amazon template=iframe image&asin=1119122341]

GET IT FREE HERE

https://nitroflare.com/view/E4839A231681A8B/1119122341.pdf

Share Button

New Horizons in Predictive Toxicology: Current Status and Application

Toxicology continues to be a major cause of product attrition; in addition the implementation of REACH is having an impact on our need to continually improve our capabilities to predict potential safety concerns earlier. This unique book provides a comprehensive review and discussion on the status of predictive toxicology and its application. This is a critical hot topic and an area of continuing importance and the book is timely in providing a leading and expert treatise. Chapters cover the current approaches in predictive toxicology including in silico, in vitro and in vivo. In addition, examples of how these approaches can be integrated to improve the safety assessment to humans are covered. There is also discussion of current approaches for biomarker identification and application (eg omics approaches).
[amazon template=iframe image&asin=1849730512]
GET IT FREE HERE
Share Button

Veterinary Toxicology

A vast number of substances potentially toxic to animals exist, including pesticides, household cleaning products, agricultural chemicals, automotive products, human prescription and non-prescription drugs, herbal remedies, and poisonous plants and animals. With such huge numbers of potential toxins, it is impossible foe veterinarians to be knowledgeable about all of them. But because some poisonings can cause illness or even death within only minutes to hours after exposure, immediate access to reliable information on diagnosis and treatment is essential. Often intoxications involve new drugs or chemical products for which very little or no published veterinary toxicity data is available.

[amazon template=iframe image&asin=9380179286]

GET IT FREE HERE

https://nitroflare.com/view/D5B77097A9764C5/9380179286.pdf

Share Button

Computational Systems Toxicology

This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.
Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.

[amazon template=iframe image&asin=1493927779]

GET IT FREE HERE

https://nitroflare.com/view/E705A4F38762299/1493927779.pdf

ALTERNATIVE LINK

https://filejoker.net/sdx8ev1c46by

Share Button