Bioluminescent Imaging: Methods and Protocols

 Radiology  Comments Off on Bioluminescent Imaging: Methods and Protocols
Nov 232019
 

This volume provides detailed protocols and methodologies required to perform bioluminescent imaging in multiple stages, enabling the reader to integrate this technology into their laboratory-based imaging experiments. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Bioluminescent Imaging: Methods and Protocols to ensure successful results in the further study of this vital field.

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Functional Neuroimaging in Exercise and Sport Sciences

 Neurology/Neurosurgery, Radiology, Sports Medicine  Comments Off on Functional Neuroimaging in Exercise and Sport Sciences
Nov 212019
 

Regular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting “physical health”, but also for the central nervous system believed to promote “brain health”. Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a “multimodal imaging” perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.
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Molecular Imaging: Radiopharmaceuticals for PET and SPECT

 Radiology  Comments Off on Molecular Imaging: Radiopharmaceuticals for PET and SPECT
Nov 202019
 

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.
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Contrast Media: Safety Issues and ESUR Guidelines Ed 2

 Radiology  Comments Off on Contrast Media: Safety Issues and ESUR Guidelines Ed 2
Nov 202019
 

Two years only after the publication of the ? rst edition of “Contrast media – Safety issues and ESUR guidelines” in our book series Medical Radiology in 2006, it appeared that a second edition was urgently needed. The ? rst edition was indeed an exceptional success with our readership and sold out rapidly, but moreover the safety of MR contrast media urgently required a reappraisal after the publication of a new and dramatic adverse reaction to some of the gadolini- based agents: the so called NSF syndrome. I am very much indebted to Professor Henrik S. Thomsen and his academic colleagues from the ESUR Contrast Medium Safety Committee for accepting the task to prepare a second edition of their remarkable book.Within a record short period of time they have been able to complete this fully revised new volume. It offers to the readers a comprehensive overview of all problems related to the use of contrast media in modern radiology and of our latest knowledge and insights in the mechanisms of adverse reactions related to contrast media. It answers all questions that radiologists and referring physicians are confronted with in their daily practice when they consider the administration of these agents to their patients.
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Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches

 Endocrinology/Metabolism/Diabetes Mellitus, Radiology  Comments Off on Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
Nov 182019
 

This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.

The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

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Ultrasound Imaging: Advances and Applications

 Radiology  Comments Off on Ultrasound Imaging: Advances and Applications
Nov 182019
 

Diagnostic and Therapeutic Ultrasound has recently taken an explosive growth for better safer, economic, mobile and high quality healthcare.  This technology is very appealing for medical applications because it is non-ionizing, non-invasive and it is available in most of the medical and clinical facilities. Its low cost, when compared with other medical image modalities, makes it one of the preferred tools for medical monitoring, follow-up and diagnosis. Besides the traditional fields of Cardiology and Obstetrics, where it is extensively used for long time, it has became also very useful in the diagnosis of diseases of the prostate, liver and coronaries and carotids atherosclerosis.
However, Ultrasound images present poor quality, very low signal to noise ratio and a lot of artifacts.  The extraction of useful information from Ultrasound data for diagnosis is a challenge task that makes this medical image modality a very active field of research. The difficulties are being overcome and novel and advanced methods are being proposed for detection, characterization and segmentation of abnormalities in several organs.  In fact, Ultrasound application range is vast, covering almost all organs of the human body, including the brain where Tran-cranial Doppler Ultrasound is very important to assess the brain vasculature.
This book presents some of the recent advances in Ultrasound imaging technology covering several organs and techniques in a Biomedical Engineering (BME) perspective. The focus of the book is in the algorithms, methodologies and systems developed by multidisciplinary research teams of engineers and physicians for Computer-Aided Diagnosis (CAD) purposes.
Cardiovascular and Cancer, the most common life-threatening diseases in western countries, are two of the most important topics focused in the book. However, other advanced issues are also presented such as Intravascular Ultrasound, 3D US and Ultrasound in Computer-Aided Surgery (CAS).  Some chapters are direct contributions from medical research groups where Ultrasound has also received great attention in the last decade. By this, new techniques based on Ultrasound were introduced in the clinical practice for diagnosis and therapeutics, mainly in hospital facilities.

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Iterative-Interpolation Super-Resolution Image Reconstruction: A Computationally Efficient Technique

 Radiology  Comments Off on Iterative-Interpolation Super-Resolution Image Reconstruction: A Computationally Efficient Technique
Nov 182019
 

To my wife, Mitu – Vivek Bannore Preface Preface In many imaging systems, under-sampling and aliasing occurs frequently leading to degradation of image quality. Due to the limited number of sensors available on the digital cameras, the quality of images captured is also limited. Factors such as optical or atmospheric blur and sensor noise can also contribute further to the d- radation of image quality. Super-Resolution is an image reconstruction technique that enhances a sequence of low-resolution images or video frames by increasing the spatial resolution of the images. Each of these low-resolution images contain only incomplete scene information and are geometrically warped, aliased, and – der-sampled. Super-resolution technique intelligently fuses the incomplete scene information from several consecutive low-resolution frames to reconstruct a hi- resolution representation of the original scene. In the last decade, with the advent of new technologies in both civil and mi- tary domain, more computer vision applications are being developed with a demand for high-quality high-resolution images. In fact, the demand for high- resolution images is exponentially increasing and the camera manufacturing te- nology is unable to cope up due to cost efficiency and other practical reasons.
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Cardiac CT Imaging: Diagnosis of Cardiovascular Disease Edition 2

 Cardiovascular, Radiology  Comments Off on Cardiac CT Imaging: Diagnosis of Cardiovascular Disease Edition 2
Nov 162019
 

CT is an accurate technique for assessing cardiac structure and function, but advances in computing power and scanning technology have resulted in increased popularity. It is useful in evaluating the myocardium, coronary arteries, pulmonary veins, thoracic aorta, pericardium, and cardiac masses; because of this and the speed at which scans can be performed, CT is even more attractive as a cost-effective and integral part of patient evaluation. This book collates all the current knowledge of cardiac CT and presents it in a clinically relevant and practical format appropriate for both cardiologists and radiologists. The images have been supplied by an experienced set of contributing authors and represent the full spectrum of cardiac CT. As increasing numbers have access to cardiac CT scanners, this book provides all the relevant information on this modality. This is an extensive update of the previous edition bringing the reader up-to-date with the immense amount of updated content in the discipline.
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Image Guided Dermatologic Treatments

 Dermatology, Radiology  Comments Off on Image Guided Dermatologic Treatments
Nov 152019
 

This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the appropriate imaging technologies for specific clinical dermal disorders.
A detailed and up-to-date overview of image-guided treatments is provided. The initial chapters on benign and inflammatory diseases are precursors to advanced chapters on hidradenitis suppurativa and pigmented lesion analysis. A dedicated chapter on melanoma skin cancer and malignant melanoma is followed by updated concepts of melanoma treatment, including genetic markers and PET/CT to monitor therapeutic success. Further chapters address such topics as dermal trauma from foreign bodies and burns, scar imaging, fillers complications and podiatric imaging. Chapters on optical coherence tomography and reflectance confocal microscopy complete the coverage.
All chapters were written by dermatologists trained in ultrasound diagnosis, interventional radiologists, dermatopathologists and specialists in advanced optical and microscopic dermatologic analysis, providing a reference guide to noninvasive diagnosis techniques and image guided minimally invasive treatment options. As such, Image Guided Dermatologic Treatments will be an invaluable asset for clinicians in medical and allied fields where dermatologic diagnosis using the least invasive option is required.

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Imaging Flow Cytometry: Methods and Protocols

 Radiology  Comments Off on Imaging Flow Cytometry: Methods and Protocols
Nov 142019
 

This detailed volume for the first time explores techniques and protocols involving quantitative imaging flow cytometry (IFC), which has revolutionized our ability to analyze cells, cellular clusters, and populations in a remarkable fashion. Beginning with an introduction to technology, the book continues with sections addressing protocols for studies on the cell nucleus, nucleic acids, and FISH techniques using an IFC instrument, immune response analysis and drug screening, IFC protocols for apoptosis and cell death analysis, as well as morphological analysis and the identification of rare cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Imaging Flow Cytometry: Methods and Protocols will be a critical source for all laboratories seeking to implement IFC in their research studies.

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