Nijkamp and Parnham’s Principles of Immunopharmacology

 Immunology, Pharmacology  Comments Off on Nijkamp and Parnham’s Principles of Immunopharmacology
Jan 082020
 

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks.
The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests.

Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions.

The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

GET IT FREE HERE

https://nitroflare.com/view/DBB9A61DD107C2C/3030108090.epub

https://nitroflare.com/view/39FDCDA9204FFDC/3030108090.pdf

ALTERNATIVE LINK

pdf Format

https://filejoker.net/zwh85xjnrfna

epub Format

https://filejoker.net/7lmf2lyak53h

Share Button

Deoxynucleoside Analogs In Cancer Therapy

 Oncology, Pharmacology  Comments Off on Deoxynucleoside Analogs In Cancer Therapy
Jan 042020
 

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.
GET IT FREE HERE
.
ALTERNATIVE LINK
.
Share Button

The Pharmacist Guide to Implementing Pharmaceutical Care

 Pharmacology  Comments Off on The Pharmacist Guide to Implementing Pharmaceutical Care
Jan 042020
 

Through the contributions of global experts, this book meets the growing need to understand the implementation and development of pharmaceutical care. Pharmaceutical Care Implementation details the clinical pharmacist’s role in providing care to different kind of patients using clinical strategies that improve humanistic, economic and clinical outcomes.
Written with a focus for students and pharmacists, this book offers multiple scenarios that serve to improve technical skills. These examples show step-by-step implementation processes from pharmacists who have worked for many years in these fields: drug-related problems, pharmaceutical care in different settings (community, hospital, home care), research outcomes, communication skills, indicators, advertising, remuneration of practice, standards, guidelines, protocols and teaching approaches for universities.
Readers will use this book to:- Improve their skills to prevent, detect and solve drug-related problems – Understand the characteristics of care for patients in different settings- Consolidate knowledge from different global research outcomes- Develop and improve communication skills to establish relationships with patients and healthcare professionals.- Learn to use indicators, standards,guidelines,and protocols to guide and evaluate pharmaceutical care performance- Use different tools to advertise pharmaceutical care services- Document pharmaceutical care practices and create evidence for remuneration

GET IT  FREE HERE

https://nitroflare.com/view/4C72A351D1F2B2F/331992575X.rar

Share Button

Molecular Pharmacognosy Edition 2

 Pharmacology  Comments Off on Molecular Pharmacognosy Edition 2
Dec 182019
 

This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.
GET IT FREE HERE
.
ALTERNATIVE LINK
.
epub format
.
pdf format
Share Button

Targeting Enzymes for Pharmaceutical Development: Methods and Protocols

 Pharmacology  Comments Off on Targeting Enzymes for Pharmaceutical Development: Methods and Protocols
Dec 162019
 

This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals. Consisting of three sections, the book delves into recent biocomputing and bioinformatics protocols, state-of-the art modern biophysical, electrophoretic, and chromatographic methods and high-throughput screening approaches, as well as detailed protocols and examples of the inhibition analysis and evaluation of selected enzymes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Targeting Enzymes for Pharmaceutical Development: Methods and Protocols serves as a vital reference for academics and industry professionals working on expanding our understanding of the wide range of important enzyme targets

GET IT FREE HERE

https://nitroflare.com/view/EF910822797C1E7/1071601628.pdf

ALTERNATIVE LINK

https://filejoker.net/ol8xjz0cr9hm

Share Button

Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing

 Pharmacology  Comments Off on Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing
Dec 152019
 

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field.Covers a wide range of topics in a systematic manner with an emphasis on industrial applicationsProvides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineeringAddresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogsHighlights the impact of biocatalysis on green chemistryContains numerous graphics to illustrate concepts and techniquesBiocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

GET IT FREE HERE

https://nitroflare.com/view/24CAD1482965821/0470823143_Biocatalysis.pdf

ALTERNATIVE LINK

https://filejoker.net/sh8gbh8xhtkg

 

Share Button

BNF 78 (British National Formulary) September 2019 78th Revised Edition

 Internal Medicine, Pharmacology  Comments Off on BNF 78 (British National Formulary) September 2019 78th Revised Edition
Dec 082019
 

Compiled with the advice of clinical experts and continually updated to reflect the latest evidence from credible sources worldwide, the new edition of the British National Formulary 78 (BNF) provides up-to-date guidance on prescribing, dispensing, and administering medicines. Access to the latest edition of the BNF is vital for healthcare professionals, as it reflects current best practice as well as legal and professional guidelines relating to the uses of medicines.
NICE has accredited the editorial process used by the British National Formulary to produce its resources.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Pharmaceutical Competitive Intelligence for the Regulatory Affairs Professional

 Pharmacology  Comments Off on Pharmaceutical Competitive Intelligence for the Regulatory Affairs Professional
Dec 062019
 

This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry.  It provides an overview of processes that the regulatory affairs professional must take into account when evaluating data impacting product-based risk evaluations. These apply particularly to evaluations that focus on outputs such as regulatory approval, or the commercial impact of product labeling on the sales forecast over a limited timeframe. The Brief also provides an overview of intellectual property assessment that can impact a product’s lifespan on the market due to patent protection itself (or loss of patent protection) or via regulatory exclusivity. Case examples are discussed to illustrate the importance of keeping up with the ever-changing regulations, and how to interpret them in the context of CI. In addition, there is a section on virtual data rooms (VDRs) which currently function as the cornerstone of due diligence investigations. While aimed primarily at regulatory affairs professionals in the United States, this publication provides a useful adjunct for other pharmaceutical executives, especially those new to product-based investments, and regulatory affairs professionals in other regions. ​
GET IT FREE HERE
ALTERNATIVE LINK
Share Button

Systems Pharmacology and Pharmacodynamics

 Pharmacology  Comments Off on Systems Pharmacology and Pharmacodynamics
Dec 032019
 

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Amazon

GET IT FREE HERE

https://nitroflare.com/view/0A23E2A145E613F/Systems_Pharmacology_and_Pharmacodynamics.pdf

ALTERNATIVE LINK

https://filejoker.net/vulunx83f45c

Share Button

Human Pharmaceuticals in the Environment: Current and Future Perspectives

 Pharmacology  Comments Off on Human Pharmaceuticals in the Environment: Current and Future Perspectives
Dec 022019
 

Human interaction with the environment remains one of the most pervasive facets of modern society. In a world characterized by rapid population growth, unprecedented global trade and digital communications, energy security, natural resource scarcities, climatic changes and environmental quality, emerging diseases and public health, biodiversity and habitat modifications are routinely touted by the popular press as they canvas global political agendas and scholarly endeavors.
GET IT FREE HERE
ALTERNATIVE LINK
Share Button