Jun 202016
 

Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics


By (author): Ellen Matloff

Genetic testing and counseling for cancer have made great strides in recent years. The popular demand for advanced screening, advances in testing, and the response of insurance companies and corporations have all served to shape this important area of cancer risk management.
 
This practical, user-friendly guidebook allows you to search by disease site for the hereditary cancer syndromes relevant to your patient’s cancer. This handy resource will help you formulate questions when expanding that patient’s personal and family history, identify the genes that are most relevant, determine whether to refer that patient for genetic counseling and testing, and guide the patient’s long-term management based on the patient’s mutation-positive or –negative status. The guidebook will be of equal value to the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician’s assistant, advanced practice nurse, and any other clinician counseling a patient who has had cancer.
 
Look inside and discover…
• Informative overview summarizes the history and current state of genetic cancer testing.
• Site-specific chapters help you locate essential facts quickly.
• Expert contributors share their years of experience in genetic testing and counseling.
• Timely insights address key medical, ethical, legal, and financial implications of genetic cancer testing.
 
Be sure your patients have the advance information they need…
Pick up your copy today!

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Jun 152016
 

Mechanisms of Gene Regulation


By (author): Carsten Carlberg, Ferdinand Molnár

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines.

A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”.

The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

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Jun 152016
 

Molecular Genetics of Asthma (Methods in Molecular Biology)


Presenting topics from the basic application of molecular genetics to more complex gene expression analysis using different models of study, this detailed volume explores asthma through the lens of genetics, considered to play an essential role in the etiopathogenesis of the disease.  Since asthma is a complex disease, this book is designed to provide a review of the most useful techniques with examples of their applications in specific laboratory protocols. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Molecular Genetics of Asthma serves as an ideal guide to researchers investigating this vital field of study.

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Jun 142016
 

Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment


Highly Commended in the Obstetrics and Gynaecology category of the 2010 BMA Medical Book Competition

Brand new edition of the world’s leading text on prenatal diagnosis

This 6th Edition of Genetic Disorders and the Fetus maintains it’s pre-eminence as the major repository of facts about prenatal diagnosis. It provides a critical analysis and synthesis of established and new knowledge based on the long experience of authorities in their respective fields. A broad international perspective is presented through authoritative contributions from authors in 11 countries. All chapters and guidelines have been updated to reflect contemporary practice. New chapters have been introduced on:

  • The use of chromosomal microarrays in prenatal diagnosis
  • The social, legal and public policy issues with special reference to international approaches
  • The important peroxisomal and related fatty acid oxidation disorders

Extensive tables and clear illustrations assist in differential diagnosis, gene identification and diagnostic modes. The recognition of many new and unresolved challenges should provide inspiration for novel research initiatives. The guidance provided and the insights and perspectives of these authors make this volume a valuable and indispensable resource for all whose focus is securing fetal health through prenatal diagnosis.

Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment is an essential resource for all engaged in prenatal genetic diagnosis, especially obstetricians, maternal-fetal medicine specialists, medical geneticists, genetic counsellors, and pediatricians, but also many other specialties.

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Jun 062016
 

Auditory and Vestibular Research: Methods and Protocols (Methods in Molecular Biology)


This second edition expands upon the previous volume with new and updated chapters. Auditory and Vestibular Research: Methods and Protocols, Second Edition guides readers through protocols on cell culture, tissue engineering, nanotechnology, high-throughput screening, and physiology.  Chapters on physiology cover techniques that include optical coherence tomography, patch clamping, and photostimulation of caged neurotransmitters.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Auditory and Vestibular Research: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

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Jun 042016
 

An Atlas of Preimplantation Genetic Diagnosis: An Illustrated Textbook & Reference for Clinicians, Second Edition (Encyclopedia of Visual Medicine Series)


By (author): Yury Verlinsky, Anver Kuliev

Extensively illustrated, this atlas is a manual for the establishment and realization of PGD within the framework of assisted reproduction and genetics services. Fully revised and updated, the atlas includes descriptions of the authors’ pioneering work on polar body based PGD for genetic and chromosomal disorders. The authors’ novel experience of PGD for late-onset disorders with genetic predisposition will be of special interest. Their accumulated PGD experience for poor-prognosis IVF patients presents further evidence of the improvement of clinical outcome and the requirement for meiotic error testing for a higher accuracy of preselecting aneuploidy-free embryos for transfer.
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Jun 012016
 

Craniofacial Embryogenetics & Development, 2nd edition


Features: Used Book in Good Condition
By (author): Geoffrey H. Sperber

Recent advances in genetics, molecular biology, diagnostic imaging and surgical techniques require a substantial understanding of prenatal development morphogenesis. The clinical significance of the normal mechanisms of embryogenesis, developmental failures and consequent craniofacial anomalies is of increasing concern to plastic and orofacial surgeons, otolaryngologists, orthodontists, neonatologists, and speech pathologists.
Clinicians dealing with malformations needing comprehension of the exponential expansion of information on molecular genomics, dysgenesis, teratology and the etiology of syndromes and anomalies are served by this book s succinct contents. While providing clinicians with a basic background for treating craniofacial anomalies, this text will also appeal to teratologists, embryologists, and anatomists.
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Jun 012016
 

Human Genetics


Features: Chromosomes Gametes Meieosis
By (author): Ricki Lewis

Today human genetics is for everyone. It is about variation more than about illnesses and increasingly about the common rather than about the rare. Once an obscure science or an occasional explanation for an odd collection of symptoms human genetics is now part of everyday conversation. By coming to know genetic backgrounds people can control their environments in more healthy ways. Genetic knowledge is therefore both informative and empowering. The 10th edition of Human Genetics: Concepts and Applications shows students how and why that is true.
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May 262016
 

RNA Regulation, 2 Volume Set (Current Topics from the Encyclopedia of Molecular Cell Biology and Molecular Medicine)


Based on one of the leading encyclopedic resources in cell and molecular biology worldwide, this two-volume work contains more than 75% new content, not previously published in the Encyclopedia. All the other chapters have been carefully updated.
The result is a comprehensive overview of the different functions of the various forms of RNA in living organisms, with each contributor carefully selected and an internationally recognized expert on his or her field. Special focus is on the different forms of expression regulation through RNA, with medical applications in the treatment of diseases — from cancers and immune responses to infections and aging — covered in detail. At least 45 of the 55 articles are new content previously not published in the Encyclopedia.
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May 162016
 

Genetics of Melanoma (Cancer Genetics)


This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.

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