Mar 262017
 

Liquid Biopsies in Solid Tumors (Cancer Drug Discovery and Development)


This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.


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Mar 262017
 

Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases (Progress in Inflammation Research)


As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature.

Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success?

In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.

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Mar 262017
 

Medical Toxicology: Antidotes and Anecdotes


By (author): Steven M. Marcus

A collection of challenging and unusual cases from the author’s extensive experience as a Medical Toxicologist, these cases demonstrate medical problem solving and differential diagnosis in action from the perspective of an experienced clinician. Written in an engaging style and giving a fascinating account of some complex cases from real practice, this book will provide a good supplementary learning text for graduate students or those at an early stage in their professional career.
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Mar 262017
 

Indoor Air Quality in Healthcare Facilities (SpringerBriefs in Public Health)


This interdisciplinary guide offers background, research findings, and practical strategies for assessing and improving air quality in hospitals and other healthcare settings. Positing good air quality as critical to patient and staff well-being, it identifies disease-carrying microbes, pollutants, and other airborne toxins and their health risks, and provides localized interventions for reducing transmission of pathogens. Effective large-scale approaches to air quality control are also outlined, from green building materials to hygienic HVAC and air treatment practices. Its thoroughness of coverage makes this book a vital resource for professionals involved in every aspect of health service facilities, from planning and construction to maintenance and management.

Among the topics covered:

  • Existing guidelines in indoor air quality: the case study of hospital environments
  • Hospital environments and epidemiology of healthcare-associated infections
  • Analysis of microorganisms in hospital environments and potential risks
  • Legionella indoor air contamination in healthcare environments
  • HVAC system design in healthcare facilities and control of aerosol contaminants
  • Assessment of indoor air quality in inpatient wards

Indoor Air Quality in Healthcare Facilities imparts up-to-date expertise to a variety of professional readers, including hospitals’ technical and management departments, healthcare facilities’ chief medical officers, hospital planners, sport and thermal building designers, public health departments, and students of universities and schools of hygiene.

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Mar 252017
 

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Mar 252017
 

Integrated Modular Treatment for Borderline Personality Disorder: A Practical Guide to Combining Effective Treatment Methods


Features: CAMBRIDGE UNIVERSITY PRESS
By (author): W. John Livesley

This clinical guide describes a different way to treat borderline personality disorder. Rather than using the currently available therapies, the author presents a trans-theoretical approach that combines the essential elements of all effective treatments. The book offers a framework for understanding the nature and origins of borderline personality disorder that is used to define treatment targets and strategies. Building on this foundation, systems for organizing treatment are presented around change mechanisms common to all effective therapies. Interventions are presented in modules, allowing therapists to select treatment according to the needs of patients. Treatment is explained by dividing therapy into phases, each addressing different problems. Methods are described to promote engagement, manage suicidality, treat crises, improve emotional regulation, restructure maladaptive interpersonal behaviours, construct a new sense of self and identity, and build a life worth living. The volume will interest mental health professionals from all disciplines and different levels of expertise.
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Mar 252017
 

Cognitive Neuroscience of Memory Consolidation (Studies in Neuroscience, Psychology and Behavioral Economics)


This edited volume provides an overview the state-of-the-art in the field of cognitive neuroscience of memory consolidation. In a number of sections, the editors collect contributions of leading researchers . The topical focus lies on current issues of interest such as memory consolidation including working and long-term memory. In particular, the role of sleep in relation to memory consolidation will be addressed. The target audience primarily comprises research experts in the field of cognitive neuroscience but the book may also be beneficial for graduate students.
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Mar 252017
 

The Praeger Handbook of Chiropractic Health Care: Evidence-Based Practices


Features: The Praeger Handbook of Chiropractic Health Care Evidence Based Practices

What does scientific research show about the effectiveness of chiropractic care? How are chiropractors trained and what do they do? When should one turn to chiropractic care, and how does one select a practitioner? This book answers all of these questions and more.

• Provides an easy-to-read and scientifically valid resource for lay readers and students as well as health professionals, offering an evidence-based approach to chiropractic care

• Presents an up-to-date overview of the scientific evidence on the effectiveness of chiropractic care for many common conditions, demystifies what chiropractors do, and explains their training, scope of practice, and commonly used procedures

• Identifies training and licensure requirements for chiropractors in all 50 U.S. states, useful for college students or anyone considering a career change to chiropractic health care

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Mar 252017
 

Sex Differences in Sports Medicine


By (author): Ellen Casey MD, Monica Rho MD, Joel Press MD

This is the first book dedicated to the musculoskeletal, physiological, hormonal, and other differences between the sexes as they manifest in sports medicine. Organized anatomically from head to toe, this unique reference focuses on the sex-specific differences of men and women to inform clinical care and the management of common sports injuries. Other chapters cover nutrition, hormones, concussion, pain, sports cardiology and pulmonology, and the particular care of adolescent and geriatric patients. The editors have assembled a world-class team of specialists to collaborate on each chapter, and specially commissioned illustrations and tables help visualize the data and findings.

While some books focus on “the female athlete” as a discrete category, this book discusses how the many physical stresses of athletics affect both sexes based on the inherent biological differences. The goal is to foster a more comprehensive understanding of the latest research and practice in sports medicine as it applies to all patients. As the field of sports medicine has grown exponentially over the last few decades, this book will serve as an essential resource for physicians, trainers, coaches, and anyone involved in athletics and medicine.

Key Features:

  • Provides an evidence-based review of how sex differences affect the risk of injury, presentation, and clinical course of sports-related injuries
  • Anatomically based chapters highlight differences in static structures, dynamic movement, and pathology between the sexes
  • Authors summarize key differences at the end of each chapter
  • Includes special chapters on running and throwing, sports cardiology, sports pulmonology, nutrition, and unique athlete populations
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Mar 252017
 

Histamine Receptors as Drug Targets (Methods in Pharmacology and Toxicology)


This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques.

Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
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