Jul 252017
 

Decoding Neural Circuit Structure and Function: Cellular Dissection Using Genetic Model Organisms


This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes.

Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how identified circuit elements contribute to visual perception and behavior.

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Jul 252017
 

Reconstructing the War Injured Patient


This text provides a comprehensive and state-of-the art approach to reconstruction of the war injured patient tailored to the types of injuries and patients mostly encountered from the Arab region over the past few years at the American University of Beirut Medical Center, one of the largest tertiary care and referral centers in the area and its affiliated hospitals. The book discusses in detail evidence of literature, new research data and new perspectives about the management and reconstruction of all types of injuries: ophthalmic, head and neck, upper and lower limb bone and soft tissue trauma, trunk, visceral and urogenital injuries as well as vascular and central and peripheral nerve injuries. It also highlights the social burden of these injuries as well as the importance of rehabilitation and psychological support for the war injured. The most recent findings of the change in the microbiology of these wounds and their treatment modifications are also discussed.

Reconstructing the War Injured Patient will serve as a valuable resource for surgeons, clinicians and researchers dealing with and interested in the multiple facets of current war casualty care all the way from the battlefields to the long-term chronic rehabilitation. It includes concise yet comprehensive overviews of the current status of the war casualty patient reconstruction domain. It will help guide patient management based on evidence from literature, clinical and surgical experience and ongoing research. It will also help stimulate investigative efforts in this dynamic and active field of war medicine. 
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Jul 242017
 

Wilcox’s Surgical Anatomy of the Heart


By (author): Robert H. Anderson, Diane E. Spicer, Anthony M. Hlavacek, Andrew C. Cook, Carl L. Backer

The revised fourth edition of this classic textbook on cardiac anatomy written from the stance of the cardiac surgeon features many new images, including computed tomography angiography. The provision of multiple high quality surgical and pathological photographs makes it essential reading for cardiac surgeons, and of great value to cardiologists, surgical pathologists, radiologists and anaesthetists. The book will also be a valuable reference resource for any healthcare professional or researcher who needs to understand detailed cardiac anatomy. The book begins by describing the surgical approaches to the heart. It goes on to discuss the normal surgical anatomy of the cardiac chambers, the valves, and the systems for circulation and conduction within the heart. This provides the essential anatomical information required to assess and interpret the malformations, lesions and abnormalities discussed in the remainder of the book.
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Jul 242017
 

Pharmacology, Doping and Sports: A Scientific Guide for Athletes, Coaches, Physicians, Scientists and Administrators


The work of dope testers is constantly being obstructed by the development of ever harder-to-trace new forms of banned substances. Organisations such as the World Anti-Doping Association and the United States Anti-Doping Agency are pioneering cutting-edge techniques designed to keep competition at the highest level fair and safe, and must ensure that their drug testing laboratories adhere to the highest scientific standards. In Pharmacology, Doping and Sports these techniques and procedures are explained by the anti-doping experts who practice them.

Broad-ranging in scope, this book examines the effects of performance-enhancing substances on the athlete’s health; the role of anti-doping procedures as an ethical question, and explains the background to, and the emergence of, the anti-doping movement. The book also offers in-depth analysis of key scientific matters, such as:

  • standard analytical and diagnostic tests for sports doping
  • regulatory standards for laboratory proficiency
  • common performance-enhancing techniques such as anabolic and designer steroids, blood doping, growth hormones, and gene doping
  • carbon-isotope ratio testing.

Written by some of the world’s leading authorities on the science of sports doping, Pharmacology, Doping and Sports provides an invaluable study of up-to-the-minute anti-doping techniques. This book is essential reading for all sports scientists, coaches, policy-makers, students and athletes interested in the science or ethics of doping in sport.

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Jul 242017
 

The Nocebo Effect: Overdiagnosis and Its Costs


Features: The Nocebo Effect Overdiagnosis and Its Costs
By (author): Stewart Justman

The Nocebo Effect documents the transformation of normal problems into medical ones and brings out the risks of this inflationary practice. One notable risk is that people labeled as sick may find themselves living up to their label through the alchemy of the nocebo effect.
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Jul 242017
 

Handbook of Immunological Properties of Engineered Nanomaterials (Frontiers in Nanobiomedical Research)


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By (author): Marina A Dobrovolskaia, Scott E McNeil

The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.

The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Readership: Researchers, academics, undergraduates and graduates in toxicology, immunotoxicology and nanomedicine, and industry (small and mid biotech companies and big pharmaceutical companies), as well as regulatory agencies (EPA, FDA) and physicians.

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Jul 242017
 

Computational Neurology and Psychiatry (Springer Series in Bio-/Neuroinformatics)


This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational psychiatry, including the study of pathological behavior due to impaired functional connectivity, pathophysiological activity, and/or aberrant decision-making. Further, it discusses the data analysis techniques that will be required to analyze the increasing amount of data being generated about the brain. Lastly, the book offers some tips on the application of computational models in the field of quantitative systems pharmacology. Mainly written for computational scientists eager to discover new application fields for their model, this book also benefits neurologists and psychiatrists  wanting to learn about new methods.

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Jul 242017
 

Seizures in Critical Care: A Guide to Diagnosis and Therapeutics (Current Clinical Neurology)


Updated and expanded to provide the neurologic, intensive and critical care communities a comprehensive guide to common critical care illnesses and seizures, this third edition remains the premier resource on seizures in critical care. In addition to covering etiology, pathophysiology, diagnosis, differential diagnosis and treatment options, chapters feature the latest technologies and treatments and integrate current literature. This unique and specialized text offers neurologists, intensivists, neurosurgeons, trauma surgeons, epileptologists, electrophysiologists and residents in various specialties clarity on this challenging set of comorbidities.
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Jul 242017
 

Sociology of Diagnosis (Advances in Medical Sociology, Vol. 12)


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By (author): PJ McGann

Diagnosis is central to medical practice, medical knowledge and research, medicalization dynamics, and health and illness experience. Embedded in social relations, diagnoses reflect and shape social dynamics and cultural concerns. Diagnoses are integral to resource allocation, form the basis for identities, and may become a focal point of turf battles and contested authority. Some diagnoses are willingly embraced, whereas others are strenuously resisted. Some diagnoses come and go as fashions; others persist. A sociological approach to diagnosis therefore occupies a complex intersection of diverse subfields including medical sociology, sociology of knowledge, mental health, deviance, social control, sociology of science, social movements, the body, sexualities, gender, and health and illness. This volume explores the breadth of diagnosis and diagnoses through empirical reports, conceptual work, and theoretical statements from diverse perspectives. Reflecting the multi-faceted nature of the emerging field, the book is arranged in five sections: Frameworks, Context, Contestation, Identity, and Social Control. Sociology of Diagnosis thus provides both a starting point for discussion and means with which to organize the nascent conceptual landscape.
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Jul 242017
 

New Perspectives on Paternalism and Health Care (Library of Ethics and Applied Philosophy)


This work sets the stage regarding debates about paternalism and health care for years to come. The anthology is organized around four parts: i) The concept of paternalism and theoretical issues regarding the idea of anti-paternalism, ii) strategies for justifying different forms of paternalism, iii) paternalism in psychiatry and psychotherapy, iv) paternalism and public health, and v) paternalism and reproductive medicine. Medical paternalism was arguably one of the main drivers of debates in medical ethics and has led to a wide acknowledgement of the value of patient autonomy. However, more recent developments in health care, such as the increasing significance of public health measures and the commercialization of medical services, have led to new social circumstances and hence to the need to rethink issues regarding paternalism. This work provides an invaluable source for many scholars and practitioners, since it deals in new and original ways with one of the main and oldest issue in health care ethics.?

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