This is Volume 6: Nervous System Agents, of Burger’s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Alzheimer’s Disease: Search for Therapeutics, Cognition Enhancers and Drugs to Treat Eating and Body Weight Disorders.
To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0.
For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley/bmcdd
This new edition in the established and well-respected series Veterinary Self-Assessment Color Reviews covers all aspects of veterinary dentistry. Each case consists of one or more questions, illustrated by stimulating visual material including imaging and color clinical photographs.
The 228 cases appear in random order, just as they would in practice, and are presented as self-assessment problems comprising integrated questions and detailed explanations designed to educate as well as to provide answers.
Written by well-respected experts in the field, this new edition of a bestseller has been completely updated and includes more than 50 new cases. The book is an excellent resource for exam preparation or for practitioners in their continuing professional development.
This book covers current topics related to the use of proteomic strategies in cancer therapy as well as anticipated challenges that may arise from its application in daily practice. It details current technologies used in proteomics, examines the use proteomics in cell signaling, presents clinical applications of proteomics in cancer therapy, and looks at the role of the FDA in regulating the use of proteomics.
Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. “Screening” remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.
As healthcare moves from volume to value, payment models and delivery systems will need to change their focus from the individual patient to a population orientation. This will move our economic model from that of a “sick system” to a system of care focused on prevention, boosting patient engagement, and reducing medical expenditures. This new focus will shift traditional financial accountability from the payer model to provider directed models. Population Health: An Implementation Guide to Improve Outcomes and Lower Costs covers not only the rationale for this transition, but also outlines successful practice models that are built to thrive in these new market dynamics. Besides the philosophical and the cultural aspects of these new models, it details the implementation and strategic initiatives required to succeed in today’s value- and population-oriented healthcare environment.
Describing what population health is, the book explains why it represents an opportunity for healthcare delivery systems, public health agencies, community-based organizations, and other entities to work together to improve health outcomes in the communities they serve.
The book clarifies how the new models will impact healthcare providers, how to manage populations, and how to handle the risk factors involved. It details new delivery models, such as primary care and medical neighborhoods, and outlines the value proposition of screening and prevention in assigned populations.
Vitrification in Assisted Reproduction presents standard and new cryopreservation techniques in detail, outlining those that have resulted in success, and providing recommended means for overcoming typically encountered problems.
This new edition provides a much broader range of clinical application and data to demonstrate its contribution to the use of vitrified oocytes and embryos. The book also discusses new areas in the field of assisted reproductive technology such as oocyte banking, preimplantion diagnostics at the blastocyst stage, and the burgeoning adoption of elective single embryo transfer.
Written by expert scientists and clinical embryologists, this book will help you to consistently and predictably apply vitrification as an important therapeutic strategy in assisted reproduction.
In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays.This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided.
Use the GPU Successfully in Your Radiotherapy Practice
With its high processing power, cost-effectiveness, and easy deployment, access, and maintenance, the graphics processing unit (GPU) has increasingly been used to tackle problems in the medical physics field, ranging from computed tomography reconstruction to Monte Carlo radiation transport simulation. Graphics Processing Unit-Based High Performance Computing in Radiation Therapy collects state-of-the-art research on GPU computing and its applications to medical physics problems in radiation therapy.
Tackle Problems in Medical Imaging and Radiotherapy
The book first offers an introduction to the GPU technology and its current applications in radiotherapy. Most of the remaining chapters discuss a specific application of a GPU in a key radiotherapy problem. These chapters summarize advances and present technical details and insightful discussions on the use of GPU in addressing the problems. The book also examines two real systems developed with GPU as a core component to accomplish important clinical tasks in modern radiotherapy.
Translate Research Developments to Clinical Practice
Written by a team of international experts in radiation oncology, biomedical imaging, computing, and physics, this book gets clinical and research physicists, graduate students, and other scientists up to date on the latest in GPU computing for radiotherapy. It encourages you to bring this novel technology to routine clinical radiotherapy practice.
Features: Used Book in Good Condition By (author): Allan Shor
This unique book is required reading for every medical practitioner. It is the only published text on this very important new disease. It examines all aspects of the subject including the circumstances in which the germ may be found, its specific pathological features and methods of diagnosing the lesion. Its author discovered Chlamydia pneumoniae germs in atheroma lesions and is a world authority in this very specialized field of pathology.